Hypochlorite-induced oxidation of amino acids, peptides and proteins
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Hypochlorite-induced oxidation of amino acids, peptides and proteins. / Hawkins, C L; Pattison, D I; Davies, Michael Jonathan.
In: Amino Acids, Vol. 25, No. 3-4, 12.2003, p. 259-74.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Hypochlorite-induced oxidation of amino acids, peptides and proteins
AU - Hawkins, C L
AU - Pattison, D I
AU - Davies, Michael Jonathan
PY - 2003/12
Y1 - 2003/12
N2 - Activated phagocytes generate the potent oxidant hypochlorite (HOCl) via the release of the enzyme myeloperoxidase and hydrogen peroxide. HOCl is known to react with a number of biological targets including proteins, DNA, lipids and cholesterol. Proteins are likely to be major targets for reaction with HOCl within a cell due to their abundance and high reactivity with HOCl. This review summarizes information on the rate of reaction of HOCl with proteins, the nature of the intermediates formed, the mechanisms involved in protein oxidation and the products of these reactions. The predicted targets for reaction with HOCl from kinetic modeling studies and the consequences of HOCl-induced protein oxidation are also discussed.
AB - Activated phagocytes generate the potent oxidant hypochlorite (HOCl) via the release of the enzyme myeloperoxidase and hydrogen peroxide. HOCl is known to react with a number of biological targets including proteins, DNA, lipids and cholesterol. Proteins are likely to be major targets for reaction with HOCl within a cell due to their abundance and high reactivity with HOCl. This review summarizes information on the rate of reaction of HOCl with proteins, the nature of the intermediates formed, the mechanisms involved in protein oxidation and the products of these reactions. The predicted targets for reaction with HOCl from kinetic modeling studies and the consequences of HOCl-induced protein oxidation are also discussed.
KW - Amino Acids
KW - Catalysis
KW - Humans
KW - Hydrogen Peroxide
KW - Hypochlorous Acid
KW - Kinetics
KW - Oxidation-Reduction
KW - Peptides
KW - Peroxidase
KW - Proteins
U2 - 10.1007/s00726-003-0016-x
DO - 10.1007/s00726-003-0016-x
M3 - Journal article
C2 - 14661089
VL - 25
SP - 259
EP - 274
JO - Amino Acids
JF - Amino Acids
SN - 0939-4451
IS - 3-4
ER -
ID: 138274719