Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. / Dirksen, C; Jørgensen, N B; Bojsen-Møller, K N; Kielgast, U; Jacobsen, S H; Clausen, T R; Worm, D; Hartmann, B; Rehfeld, J F; Damgaard, M; Madsen, J L; Madsbad, S; Holst, Jens Juul; Hansen, D L.

In: International Journal of Obesity, Vol. 37, 19.02.2013, p. 1452-1459.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dirksen, C, Jørgensen, NB, Bojsen-Møller, KN, Kielgast, U, Jacobsen, SH, Clausen, TR, Worm, D, Hartmann, B, Rehfeld, JF, Damgaard, M, Madsen, JL, Madsbad, S, Holst, JJ & Hansen, DL 2013, 'Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass', International Journal of Obesity, vol. 37, pp. 1452-1459. https://doi.org/10.1038/ijo.2013.15

APA

Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Jacobsen, S. H., Clausen, T. R., Worm, D., Hartmann, B., Rehfeld, J. F., Damgaard, M., Madsen, J. L., Madsbad, S., Holst, J. J., & Hansen, D. L. (2013). Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. International Journal of Obesity, 37, 1452-1459. https://doi.org/10.1038/ijo.2013.15

Vancouver

Dirksen C, Jørgensen NB, Bojsen-Møller KN, Kielgast U, Jacobsen SH, Clausen TR et al. Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. International Journal of Obesity. 2013 Feb 19;37:1452-1459. https://doi.org/10.1038/ijo.2013.15

Author

Dirksen, C ; Jørgensen, N B ; Bojsen-Møller, K N ; Kielgast, U ; Jacobsen, S H ; Clausen, T R ; Worm, D ; Hartmann, B ; Rehfeld, J F ; Damgaard, M ; Madsen, J L ; Madsbad, S ; Holst, Jens Juul ; Hansen, D L. / Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. In: International Journal of Obesity. 2013 ; Vol. 37. pp. 1452-1459.

Bibtex

@article{7a34064af26643b99887dddfbe8ee610,
title = "Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass",
abstract = "Objective:To identify factors contributing to the variation in weight loss after Roux-en-Y gastric bypass (RYGB).Design:Cross-sectional study of patients with good (excess body mass index lost (EBL) >60%) and poor weight loss response (EBL 12 months after RYGB and a lean control group matched for age and gender.Materials and methods:Sixteen patients with good weight loss response, 17 patients with poor weight loss response, and eight control subjects were included in the study. Participants underwent dual energy X-ray absorptiometry scan, indirect calorimetry and a 9 h multiple-meal test with measurements of glucose, insulin, total bile acids (TBA), glucagon-like peptide (GLP)-1, peptide YY(3-36) (PYY), cholecystokinin (CCK), ghrelin, neurotensin and pancreatic polypeptide (PP) as well as assessment of early dumping and appetite.Results:Suppression of hunger was more pronounced in the good than the poor responders in response to the multiple-meal test (P=0.006). In addition, the good responders had a larger release of GLP-1 (P=0.009) and a greater suppression of ghrelin (P=0.037) during the test, whereas the postprandial secretion of CCK was highest in the poor responders (P=0.005). PYY, neurotensin, PP and TBA release did not differ between the RYGB-operated groups. Compared with control subjects, patients had exaggerated release of GLP-1 (P",
author = "C Dirksen and J{\o}rgensen, {N B} and Bojsen-M{\o}ller, {K N} and U Kielgast and Jacobsen, {S H} and Clausen, {T R} and D Worm and B Hartmann and Rehfeld, {J F} and M Damgaard and Madsen, {J L} and S Madsbad and Holst, {Jens Juul} and Hansen, {D L}",
year = "2013",
month = feb,
day = "19",
doi = "10.1038/ijo.2013.15",
language = "English",
volume = "37",
pages = "1452--1459",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass

AU - Dirksen, C

AU - Jørgensen, N B

AU - Bojsen-Møller, K N

AU - Kielgast, U

AU - Jacobsen, S H

AU - Clausen, T R

AU - Worm, D

AU - Hartmann, B

AU - Rehfeld, J F

AU - Damgaard, M

AU - Madsen, J L

AU - Madsbad, S

AU - Holst, Jens Juul

AU - Hansen, D L

PY - 2013/2/19

Y1 - 2013/2/19

N2 - Objective:To identify factors contributing to the variation in weight loss after Roux-en-Y gastric bypass (RYGB).Design:Cross-sectional study of patients with good (excess body mass index lost (EBL) >60%) and poor weight loss response (EBL 12 months after RYGB and a lean control group matched for age and gender.Materials and methods:Sixteen patients with good weight loss response, 17 patients with poor weight loss response, and eight control subjects were included in the study. Participants underwent dual energy X-ray absorptiometry scan, indirect calorimetry and a 9 h multiple-meal test with measurements of glucose, insulin, total bile acids (TBA), glucagon-like peptide (GLP)-1, peptide YY(3-36) (PYY), cholecystokinin (CCK), ghrelin, neurotensin and pancreatic polypeptide (PP) as well as assessment of early dumping and appetite.Results:Suppression of hunger was more pronounced in the good than the poor responders in response to the multiple-meal test (P=0.006). In addition, the good responders had a larger release of GLP-1 (P=0.009) and a greater suppression of ghrelin (P=0.037) during the test, whereas the postprandial secretion of CCK was highest in the poor responders (P=0.005). PYY, neurotensin, PP and TBA release did not differ between the RYGB-operated groups. Compared with control subjects, patients had exaggerated release of GLP-1 (P

AB - Objective:To identify factors contributing to the variation in weight loss after Roux-en-Y gastric bypass (RYGB).Design:Cross-sectional study of patients with good (excess body mass index lost (EBL) >60%) and poor weight loss response (EBL 12 months after RYGB and a lean control group matched for age and gender.Materials and methods:Sixteen patients with good weight loss response, 17 patients with poor weight loss response, and eight control subjects were included in the study. Participants underwent dual energy X-ray absorptiometry scan, indirect calorimetry and a 9 h multiple-meal test with measurements of glucose, insulin, total bile acids (TBA), glucagon-like peptide (GLP)-1, peptide YY(3-36) (PYY), cholecystokinin (CCK), ghrelin, neurotensin and pancreatic polypeptide (PP) as well as assessment of early dumping and appetite.Results:Suppression of hunger was more pronounced in the good than the poor responders in response to the multiple-meal test (P=0.006). In addition, the good responders had a larger release of GLP-1 (P=0.009) and a greater suppression of ghrelin (P=0.037) during the test, whereas the postprandial secretion of CCK was highest in the poor responders (P=0.005). PYY, neurotensin, PP and TBA release did not differ between the RYGB-operated groups. Compared with control subjects, patients had exaggerated release of GLP-1 (P

U2 - 10.1038/ijo.2013.15

DO - 10.1038/ijo.2013.15

M3 - Journal article

C2 - 23419600

VL - 37

SP - 1452

EP - 1459

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -

ID: 45840612