Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART

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Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART. / Haugaard, S.B.; Andersen, Ove; Madsbad, Sten; Iversen, Jens Schmidt; Dela, Flemming.

In: Journal of Infection, Vol. 54, No. 1, 2007, p. 89-97.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Haugaard, SB, Andersen, O, Madsbad, S, Iversen, JS & Dela, F 2007, 'Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART', Journal of Infection, vol. 54, no. 1, pp. 89-97. https://doi.org/10.1016/j.jinf.2006.01.003, https://doi.org/10.1016/j.jinf.2006.01.003

APA

Haugaard, S. B., Andersen, O., Madsbad, S., Iversen, J. S., & Dela, F. (2007). Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART. Journal of Infection, 54(1), 89-97. https://doi.org/10.1016/j.jinf.2006.01.003, https://doi.org/10.1016/j.jinf.2006.01.003

Vancouver

Haugaard SB, Andersen O, Madsbad S, Iversen JS, Dela F. Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART. Journal of Infection. 2007;54(1):89-97. https://doi.org/10.1016/j.jinf.2006.01.003, https://doi.org/10.1016/j.jinf.2006.01.003

Author

Haugaard, S.B. ; Andersen, Ove ; Madsbad, Sten ; Iversen, Jens Schmidt ; Dela, Flemming. / Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART. In: Journal of Infection. 2007 ; Vol. 54, No. 1. pp. 89-97.

Bibtex

@article{2411f43020ec11ddbc23000ea68e967b,
title = "Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART",
abstract = "OBJECTIVES: Hyperlactatemia is prevalent in HIV-infected patients on highly active antiretroviral therapy (HAART) and may be associated with depletion of mitochondrial DNA. However, the correlation between fasting lactate and mitochondrial DNA may be weak or absent, implicating that other factors e.g. glucose turnover may contribute to hyperlactatemia. METHODS: HIV-infected patients receiving HAART who had lipodystrophy (LIPO, n=18) or were without lipodystrophy (NONLIPO, n=18) were investigated. Insulin sensitivity (M-value), glucose oxidation rate (GOX) and fasting endogenous glucose production (EGP) were determined by hyperinsulinemic euglycemic clamp, indirect calorimetry and glucose tracer technique, respectively. RESULTS: Fasting p-lactate (median 1.2mmol/L; range 0.6-4.3, n=36) tended to be increased in LIPO (P=0.12); 6 patients (4 LIPO) had lactate >/=2.0mmol/L. Fasting lactate correlated inversely with M-value (P<0.001) and positively with fasting EGP (P<0.05) and fasting GOX (P<0.05), together explaining 51% (R(2), n=36) of the variation in fasting lactate. Lactate increased in NONLIPO (P<0.05) but not in LIPO (P>0.5) during clamp. Incremental (clamp minus fasting value) GOX (P<0.01) was decreased and incremental insulin (P<0.01) was increased in LIPO. CONCLUSIONS: Fasting EGP, GOX and insulin resistance may be major determinants of fasting lactate levels in HIV-infected patients on HAART. Insulin levels per se may not determine plasma lactate in such patients.",
author = "S.B. Haugaard and Ove Andersen and Sten Madsbad and Iversen, {Jens Schmidt} and Flemming Dela",
note = "Keywords: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Glucose; Glucose Clamp Technique; Glucose Oxidase; HIV Infections; Humans; Insulin Resistance; Lactic Acid; Middle Aged",
year = "2007",
doi = "10.1016/j.jinf.2006.01.003",
language = "English",
volume = "54",
pages = "89--97",
journal = "Journal of Infection",
issn = "0163-4453",
publisher = "W.B.Saunders Co. Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART

AU - Haugaard, S.B.

AU - Andersen, Ove

AU - Madsbad, Sten

AU - Iversen, Jens Schmidt

AU - Dela, Flemming

N1 - Keywords: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Glucose; Glucose Clamp Technique; Glucose Oxidase; HIV Infections; Humans; Insulin Resistance; Lactic Acid; Middle Aged

PY - 2007

Y1 - 2007

N2 - OBJECTIVES: Hyperlactatemia is prevalent in HIV-infected patients on highly active antiretroviral therapy (HAART) and may be associated with depletion of mitochondrial DNA. However, the correlation between fasting lactate and mitochondrial DNA may be weak or absent, implicating that other factors e.g. glucose turnover may contribute to hyperlactatemia. METHODS: HIV-infected patients receiving HAART who had lipodystrophy (LIPO, n=18) or were without lipodystrophy (NONLIPO, n=18) were investigated. Insulin sensitivity (M-value), glucose oxidation rate (GOX) and fasting endogenous glucose production (EGP) were determined by hyperinsulinemic euglycemic clamp, indirect calorimetry and glucose tracer technique, respectively. RESULTS: Fasting p-lactate (median 1.2mmol/L; range 0.6-4.3, n=36) tended to be increased in LIPO (P=0.12); 6 patients (4 LIPO) had lactate >/=2.0mmol/L. Fasting lactate correlated inversely with M-value (P<0.001) and positively with fasting EGP (P<0.05) and fasting GOX (P<0.05), together explaining 51% (R(2), n=36) of the variation in fasting lactate. Lactate increased in NONLIPO (P<0.05) but not in LIPO (P>0.5) during clamp. Incremental (clamp minus fasting value) GOX (P<0.01) was decreased and incremental insulin (P<0.01) was increased in LIPO. CONCLUSIONS: Fasting EGP, GOX and insulin resistance may be major determinants of fasting lactate levels in HIV-infected patients on HAART. Insulin levels per se may not determine plasma lactate in such patients.

AB - OBJECTIVES: Hyperlactatemia is prevalent in HIV-infected patients on highly active antiretroviral therapy (HAART) and may be associated with depletion of mitochondrial DNA. However, the correlation between fasting lactate and mitochondrial DNA may be weak or absent, implicating that other factors e.g. glucose turnover may contribute to hyperlactatemia. METHODS: HIV-infected patients receiving HAART who had lipodystrophy (LIPO, n=18) or were without lipodystrophy (NONLIPO, n=18) were investigated. Insulin sensitivity (M-value), glucose oxidation rate (GOX) and fasting endogenous glucose production (EGP) were determined by hyperinsulinemic euglycemic clamp, indirect calorimetry and glucose tracer technique, respectively. RESULTS: Fasting p-lactate (median 1.2mmol/L; range 0.6-4.3, n=36) tended to be increased in LIPO (P=0.12); 6 patients (4 LIPO) had lactate >/=2.0mmol/L. Fasting lactate correlated inversely with M-value (P<0.001) and positively with fasting EGP (P<0.05) and fasting GOX (P<0.05), together explaining 51% (R(2), n=36) of the variation in fasting lactate. Lactate increased in NONLIPO (P<0.05) but not in LIPO (P>0.5) during clamp. Incremental (clamp minus fasting value) GOX (P<0.01) was decreased and incremental insulin (P<0.01) was increased in LIPO. CONCLUSIONS: Fasting EGP, GOX and insulin resistance may be major determinants of fasting lactate levels in HIV-infected patients on HAART. Insulin levels per se may not determine plasma lactate in such patients.

U2 - 10.1016/j.jinf.2006.01.003

DO - 10.1016/j.jinf.2006.01.003

M3 - Journal article

C2 - 16487595

VL - 54

SP - 89

EP - 97

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 1

ER -

ID: 4036144