Gluco-metabolic effects of oral and intravenous alcohol administration in men

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Gluco-metabolic effects of oral and intravenous alcohol administration in men. / Lanng, Amalie R.; Gasbjerg, Laerke S.; Bergmann, Natasha C.; Bergmann, Sigrid; Heisted, Mads M.; Gillum, Matthew P.; Hartmann, Bolette; Holst, Jens J.; Vilsboll, Tina; Knop, Filip K.

In: Endocrine Connections, Vol. 8, No. 10, 2019, p. 1372-1382.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Lanng, AR, Gasbjerg, LS, Bergmann, NC, Bergmann, S, Heisted, MM, Gillum, MP, Hartmann, B, Holst, JJ, Vilsboll, T & Knop, FK 2019, 'Gluco-metabolic effects of oral and intravenous alcohol administration in men', Endocrine Connections, vol. 8, no. 10, pp. 1372-1382. https://doi.org/10.1530/EC-19-0317

APA

Lanng, A. R., Gasbjerg, L. S., Bergmann, N. C., Bergmann, S., Heisted, M. M., Gillum, M. P., ... Knop, F. K. (2019). Gluco-metabolic effects of oral and intravenous alcohol administration in men. Endocrine Connections, 8(10), 1372-1382. https://doi.org/10.1530/EC-19-0317

Vancouver

Lanng AR, Gasbjerg LS, Bergmann NC, Bergmann S, Heisted MM, Gillum MP et al. Gluco-metabolic effects of oral and intravenous alcohol administration in men. Endocrine Connections. 2019;8(10):1372-1382. https://doi.org/10.1530/EC-19-0317

Author

Lanng, Amalie R. ; Gasbjerg, Laerke S. ; Bergmann, Natasha C. ; Bergmann, Sigrid ; Heisted, Mads M. ; Gillum, Matthew P. ; Hartmann, Bolette ; Holst, Jens J. ; Vilsboll, Tina ; Knop, Filip K. / Gluco-metabolic effects of oral and intravenous alcohol administration in men. In: Endocrine Connections. 2019 ; Vol. 8, No. 10. pp. 1372-1382.

Bibtex

@article{dedbfefb85094bbab1323d84093280ab,
title = "Gluco-metabolic effects of oral and intravenous alcohol administration in men",
abstract = "Background: Ingestion of the calorically dense compound alcohol may cause metabolic disturbances including hypoglycaemia, hepatic steatosis and insulin resistance, but the underlying mechanisms are uncertain. The gastrointestinal tract is well recognised as a major influencer on glucose, protein and lipid metabolism, but its role in alcohol metabolism remains unclear.Objective: To examine the effects of oral and intravenous alcohol, respectively, on plasma concentrations of several gluco-regulatory hormones including serum/plasma insulin, C-peptide, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and fibroblast growth factor 21 (FGF21).Design and methods: In a double-blinded, randomised, crossover design, we subjected 12 healthy men to intragastric ethanol infusion (IGEI) and an isoethanolaemic intravenous ethanol infusion (IVEI) (0.7 g alcohol per kg body weight), respectively, on two separate experimental days.Results: Isoethanolaemia during the two alcohol administration forms was obtained (P = 0.38). During both interventions, plasma glucose peaked after similar to 30 min and thereafter fell below baseline concentrations. GIP and GLP-1 concentrations were unaffected by the two interventions. Insulin concentrations were unaffected by IGEI but decreased during IVEI. C-peptide, insulin secretion rate and glucagon concentrations were lowered similarly during IGEI and IVEI. FGF21 concentrations increased dramatically (nine-fold) and similarly during IGEI and IVEI.Conclusions: Alcohol does not seem to affect the secretion of incretin hormones but decreased insulin and glucagon secretion independently of gut-derived factors. IGEI as well as IVEI potently stimulate FGF21 secretion indicating a gut-independent effect of alcohol on FGF21 secretion in humans.",
keywords = "alcohol, FGF21, glucose, glucagon, incretin hormones, insulin",
author = "Lanng, {Amalie R.} and Gasbjerg, {Laerke S.} and Bergmann, {Natasha C.} and Sigrid Bergmann and Heisted, {Mads M.} and Gillum, {Matthew P.} and Bolette Hartmann and Holst, {Jens J.} and Tina Vilsboll and Knop, {Filip K.}",
year = "2019",
doi = "10.1530/EC-19-0317",
language = "English",
volume = "8",
pages = "1372--1382",
journal = "Endocrine Connections",
issn = "2049-3614",
publisher = "BioScientifica Ltd.",
number = "10",

}

RIS

TY - JOUR

T1 - Gluco-metabolic effects of oral and intravenous alcohol administration in men

AU - Lanng, Amalie R.

AU - Gasbjerg, Laerke S.

AU - Bergmann, Natasha C.

AU - Bergmann, Sigrid

AU - Heisted, Mads M.

AU - Gillum, Matthew P.

AU - Hartmann, Bolette

AU - Holst, Jens J.

AU - Vilsboll, Tina

AU - Knop, Filip K.

PY - 2019

Y1 - 2019

N2 - Background: Ingestion of the calorically dense compound alcohol may cause metabolic disturbances including hypoglycaemia, hepatic steatosis and insulin resistance, but the underlying mechanisms are uncertain. The gastrointestinal tract is well recognised as a major influencer on glucose, protein and lipid metabolism, but its role in alcohol metabolism remains unclear.Objective: To examine the effects of oral and intravenous alcohol, respectively, on plasma concentrations of several gluco-regulatory hormones including serum/plasma insulin, C-peptide, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and fibroblast growth factor 21 (FGF21).Design and methods: In a double-blinded, randomised, crossover design, we subjected 12 healthy men to intragastric ethanol infusion (IGEI) and an isoethanolaemic intravenous ethanol infusion (IVEI) (0.7 g alcohol per kg body weight), respectively, on two separate experimental days.Results: Isoethanolaemia during the two alcohol administration forms was obtained (P = 0.38). During both interventions, plasma glucose peaked after similar to 30 min and thereafter fell below baseline concentrations. GIP and GLP-1 concentrations were unaffected by the two interventions. Insulin concentrations were unaffected by IGEI but decreased during IVEI. C-peptide, insulin secretion rate and glucagon concentrations were lowered similarly during IGEI and IVEI. FGF21 concentrations increased dramatically (nine-fold) and similarly during IGEI and IVEI.Conclusions: Alcohol does not seem to affect the secretion of incretin hormones but decreased insulin and glucagon secretion independently of gut-derived factors. IGEI as well as IVEI potently stimulate FGF21 secretion indicating a gut-independent effect of alcohol on FGF21 secretion in humans.

AB - Background: Ingestion of the calorically dense compound alcohol may cause metabolic disturbances including hypoglycaemia, hepatic steatosis and insulin resistance, but the underlying mechanisms are uncertain. The gastrointestinal tract is well recognised as a major influencer on glucose, protein and lipid metabolism, but its role in alcohol metabolism remains unclear.Objective: To examine the effects of oral and intravenous alcohol, respectively, on plasma concentrations of several gluco-regulatory hormones including serum/plasma insulin, C-peptide, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and fibroblast growth factor 21 (FGF21).Design and methods: In a double-blinded, randomised, crossover design, we subjected 12 healthy men to intragastric ethanol infusion (IGEI) and an isoethanolaemic intravenous ethanol infusion (IVEI) (0.7 g alcohol per kg body weight), respectively, on two separate experimental days.Results: Isoethanolaemia during the two alcohol administration forms was obtained (P = 0.38). During both interventions, plasma glucose peaked after similar to 30 min and thereafter fell below baseline concentrations. GIP and GLP-1 concentrations were unaffected by the two interventions. Insulin concentrations were unaffected by IGEI but decreased during IVEI. C-peptide, insulin secretion rate and glucagon concentrations were lowered similarly during IGEI and IVEI. FGF21 concentrations increased dramatically (nine-fold) and similarly during IGEI and IVEI.Conclusions: Alcohol does not seem to affect the secretion of incretin hormones but decreased insulin and glucagon secretion independently of gut-derived factors. IGEI as well as IVEI potently stimulate FGF21 secretion indicating a gut-independent effect of alcohol on FGF21 secretion in humans.

KW - alcohol

KW - FGF21

KW - glucose

KW - glucagon

KW - incretin hormones

KW - insulin

U2 - 10.1530/EC-19-0317

DO - 10.1530/EC-19-0317

M3 - Journal article

C2 - 31518994

VL - 8

SP - 1372

EP - 1382

JO - Endocrine Connections

JF - Endocrine Connections

SN - 2049-3614

IS - 10

ER -

ID: 229060280