Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates

Research output: Contribution to journalJournal articleResearchpeer-review

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Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates. / Vegge, Andreas; Thymann, Thomas; Lund, Pernille; Stoll, Barbara; Bering, Stine Brandt; Hartmann, Bolette; Jelsing, Jacob; Qvist, Niels; Burrin, Douglas G; Jeppesen, Palle Bekker; Holst, Jens Juul; Sangild, Per T.

In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 305, No. 4, 2013, p. G277-G285.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Vegge, A, Thymann, T, Lund, P, Stoll, B, Bering, SB, Hartmann, B, Jelsing, J, Qvist, N, Burrin, DG, Jeppesen, PB, Holst, JJ & Sangild, PT 2013, 'Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 305, no. 4, pp. G277-G285. https://doi.org/10.1152/ajpgi.00064.2013

APA

Vegge, A., Thymann, T., Lund, P., Stoll, B., Bering, S. B., Hartmann, B., ... Sangild, P. T. (2013). Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates. American Journal of Physiology: Gastrointestinal and Liver Physiology, 305(4), G277-G285. https://doi.org/10.1152/ajpgi.00064.2013

Vancouver

Vegge A, Thymann T, Lund P, Stoll B, Bering SB, Hartmann B et al. Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2013;305(4):G277-G285. https://doi.org/10.1152/ajpgi.00064.2013

Author

Vegge, Andreas ; Thymann, Thomas ; Lund, Pernille ; Stoll, Barbara ; Bering, Stine Brandt ; Hartmann, Bolette ; Jelsing, Jacob ; Qvist, Niels ; Burrin, Douglas G ; Jeppesen, Palle Bekker ; Holst, Jens Juul ; Sangild, Per T. / Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates. In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 2013 ; Vol. 305, No. 4. pp. G277-G285.

Bibtex

@article{9f50c422333248ceaf1bedc3ac4e52db,
title = "Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates",
abstract = "Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50{\%} of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22{\%}), energy (79 vs. 64{\%}), and all macronutrients (all parameters P <0.05). These findings were supported by a 200{\%} increase in sucrase and maltase activities, a 50{\%} increase in small intestinal epithelial volume (P <0.05), as well as increased DNA and protein contents and increased total protein synthesis rate in SBS+GLP-2 vs. SBS pigs (+100{\%}, P <0.05). Following intestinal resection in preterm pigs, GLP-2 induced structural and functional adaptation, resulting in a higher relative absorption of fluid and macronutrients. GLP-2 treatment may be a promising therapy to enhance intestinal adaptation and improve digestive function in preterm infants with jejunostomy following intestinal resection.",
author = "Andreas Vegge and Thomas Thymann and Pernille Lund and Barbara Stoll and Bering, {Stine Brandt} and Bolette Hartmann and Jacob Jelsing and Niels Qvist and Burrin, {Douglas G} and Jeppesen, {Palle Bekker} and Holst, {Jens Juul} and Sangild, {Per T}",
note = "CURIS 2013 NEXS 220a",
year = "2013",
doi = "10.1152/ajpgi.00064.2013",
language = "English",
volume = "305",
pages = "G277--G285",
journal = "American Journal of Physiology: Gastrointestinal and Liver Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "4",

}

RIS

TY - JOUR

T1 - Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates

AU - Vegge, Andreas

AU - Thymann, Thomas

AU - Lund, Pernille

AU - Stoll, Barbara

AU - Bering, Stine Brandt

AU - Hartmann, Bolette

AU - Jelsing, Jacob

AU - Qvist, Niels

AU - Burrin, Douglas G

AU - Jeppesen, Palle Bekker

AU - Holst, Jens Juul

AU - Sangild, Per T

N1 - CURIS 2013 NEXS 220a

PY - 2013

Y1 - 2013

N2 - Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50% of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22%), energy (79 vs. 64%), and all macronutrients (all parameters P <0.05). These findings were supported by a 200% increase in sucrase and maltase activities, a 50% increase in small intestinal epithelial volume (P <0.05), as well as increased DNA and protein contents and increased total protein synthesis rate in SBS+GLP-2 vs. SBS pigs (+100%, P <0.05). Following intestinal resection in preterm pigs, GLP-2 induced structural and functional adaptation, resulting in a higher relative absorption of fluid and macronutrients. GLP-2 treatment may be a promising therapy to enhance intestinal adaptation and improve digestive function in preterm infants with jejunostomy following intestinal resection.

AB - Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50% of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22%), energy (79 vs. 64%), and all macronutrients (all parameters P <0.05). These findings were supported by a 200% increase in sucrase and maltase activities, a 50% increase in small intestinal epithelial volume (P <0.05), as well as increased DNA and protein contents and increased total protein synthesis rate in SBS+GLP-2 vs. SBS pigs (+100%, P <0.05). Following intestinal resection in preterm pigs, GLP-2 induced structural and functional adaptation, resulting in a higher relative absorption of fluid and macronutrients. GLP-2 treatment may be a promising therapy to enhance intestinal adaptation and improve digestive function in preterm infants with jejunostomy following intestinal resection.

U2 - 10.1152/ajpgi.00064.2013

DO - 10.1152/ajpgi.00064.2013

M3 - Journal article

C2 - 23764891

VL - 305

SP - G277-G285

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

SN - 0193-1857

IS - 4

ER -

ID: 50205918