GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass. / Guimarães, Marta; Rodrigues, Pedro; Pereira, Sofia S; Nora, Mário; Gonçalves, Gil; Albrechtsen, Nicolai Wewer; Hartmann, Bolette; Holst, Jens Juul; Monteiro, Mariana P.

In: Endocrinology, Diabetes & Metabolism Case Reports, Vol. 2015, 150049, 2015, p. 1-5.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Guimarães, M, Rodrigues, P, Pereira, SS, Nora, M, Gonçalves, G, Albrechtsen, NW, Hartmann, B, Holst, JJ & Monteiro, MP 2015, 'GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass', Endocrinology, Diabetes & Metabolism Case Reports, vol. 2015, 150049, pp. 1-5. https://doi.org/10.1530/EDM-15-0049

APA

Guimarães, M., Rodrigues, P., Pereira, S. S., Nora, M., Gonçalves, G., Albrechtsen, N. W., ... Monteiro, M. P. (2015). GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass. Endocrinology, Diabetes & Metabolism Case Reports, 2015, 1-5. [150049]. https://doi.org/10.1530/EDM-15-0049

Vancouver

Guimarães M, Rodrigues P, Pereira SS, Nora M, Gonçalves G, Albrechtsen NW et al. GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass. Endocrinology, Diabetes & Metabolism Case Reports. 2015;2015:1-5. 150049. https://doi.org/10.1530/EDM-15-0049

Author

Guimarães, Marta ; Rodrigues, Pedro ; Pereira, Sofia S ; Nora, Mário ; Gonçalves, Gil ; Albrechtsen, Nicolai Wewer ; Hartmann, Bolette ; Holst, Jens Juul ; Monteiro, Mariana P. / GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass. In: Endocrinology, Diabetes & Metabolism Case Reports. 2015 ; Vol. 2015. pp. 1-5.

Bibtex

@article{388a689fa4e24821938d9393f8cb5c41,
title = "GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass",
abstract = "Post-prandial hypoglycemia is frequently found after bariatric surgery. Although rare, pancreatic neuroendocrine tumors (pNET), which occasionally are mixed hormone secreting, can lead to atypical clinical manifestations, including reactive hypoglycemia. Two years after gastric bypass surgery for the treatment of severe obesity, a 54-year-old female with previous type 2 diabetes, developed post-prandial sweating, fainting and hypoglycemic episodes, which eventually led to the finding by ultrasound of a 1.8-cm solid mass in the pancreatic head. The 72-h fast test and the plasma chromogranin A levels were normal but octreotide scintigraphy showed a single focus of abnormal radiotracer uptake at the site of the nodule. There were no other clinical signs of hormone secreting pNET and gastrointestinal hormone measurements were not performed. The patient underwent surgical enucleation with complete remission of the hypoglycemic episodes. Histopathology revealed a well-differentiated neuroendocrine carcinoma with low-grade malignancy with positive chromogranin A and glucagon immunostaining. An extract of the resected tumor contained a high concentration of glucagon (26.707 pmol/g tissue), in addition to traces of GLP1 (471 pmol/g), insulin (139 pmol/g) and somatostatin (23 pmol/g). This is the first report of a GLP1 and glucagon co-secreting pNET presenting as hypoglycemia after gastric bypass surgery. Although pNET are rare, they should be considered in the differential diagnosis of the clinical approach to the post-bariatric surgery hypoglycemia patient.LEARNING POINTS: pNETs can be multihormonal-secreting, leading to atypical clinical manifestations.Reactive hypoglycemic episodes are frequent after gastric bypass.pNETs should be considered in the differential diagnosis of hypoglycemia after bariatric surgery.",
author = "Marta Guimar{\~a}es and Pedro Rodrigues and Pereira, {Sofia S} and M{\'a}rio Nora and Gil Gon{\cc}alves and Albrechtsen, {Nicolai Wewer} and Bolette Hartmann and Holst, {Jens Juul} and Monteiro, {Mariana P}",
year = "2015",
doi = "10.1530/EDM-15-0049",
language = "English",
volume = "2015",
pages = "1--5",
journal = "Endocrinology, Diabetes & Metabolism Case Reports",
issn = "2052-0573",
publisher = "BioScientifica Ltd.",

}

RIS

TY - JOUR

T1 - GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass

AU - Guimarães, Marta

AU - Rodrigues, Pedro

AU - Pereira, Sofia S

AU - Nora, Mário

AU - Gonçalves, Gil

AU - Albrechtsen, Nicolai Wewer

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Monteiro, Mariana P

PY - 2015

Y1 - 2015

N2 - Post-prandial hypoglycemia is frequently found after bariatric surgery. Although rare, pancreatic neuroendocrine tumors (pNET), which occasionally are mixed hormone secreting, can lead to atypical clinical manifestations, including reactive hypoglycemia. Two years after gastric bypass surgery for the treatment of severe obesity, a 54-year-old female with previous type 2 diabetes, developed post-prandial sweating, fainting and hypoglycemic episodes, which eventually led to the finding by ultrasound of a 1.8-cm solid mass in the pancreatic head. The 72-h fast test and the plasma chromogranin A levels were normal but octreotide scintigraphy showed a single focus of abnormal radiotracer uptake at the site of the nodule. There were no other clinical signs of hormone secreting pNET and gastrointestinal hormone measurements were not performed. The patient underwent surgical enucleation with complete remission of the hypoglycemic episodes. Histopathology revealed a well-differentiated neuroendocrine carcinoma with low-grade malignancy with positive chromogranin A and glucagon immunostaining. An extract of the resected tumor contained a high concentration of glucagon (26.707 pmol/g tissue), in addition to traces of GLP1 (471 pmol/g), insulin (139 pmol/g) and somatostatin (23 pmol/g). This is the first report of a GLP1 and glucagon co-secreting pNET presenting as hypoglycemia after gastric bypass surgery. Although pNET are rare, they should be considered in the differential diagnosis of the clinical approach to the post-bariatric surgery hypoglycemia patient.LEARNING POINTS: pNETs can be multihormonal-secreting, leading to atypical clinical manifestations.Reactive hypoglycemic episodes are frequent after gastric bypass.pNETs should be considered in the differential diagnosis of hypoglycemia after bariatric surgery.

AB - Post-prandial hypoglycemia is frequently found after bariatric surgery. Although rare, pancreatic neuroendocrine tumors (pNET), which occasionally are mixed hormone secreting, can lead to atypical clinical manifestations, including reactive hypoglycemia. Two years after gastric bypass surgery for the treatment of severe obesity, a 54-year-old female with previous type 2 diabetes, developed post-prandial sweating, fainting and hypoglycemic episodes, which eventually led to the finding by ultrasound of a 1.8-cm solid mass in the pancreatic head. The 72-h fast test and the plasma chromogranin A levels were normal but octreotide scintigraphy showed a single focus of abnormal radiotracer uptake at the site of the nodule. There were no other clinical signs of hormone secreting pNET and gastrointestinal hormone measurements were not performed. The patient underwent surgical enucleation with complete remission of the hypoglycemic episodes. Histopathology revealed a well-differentiated neuroendocrine carcinoma with low-grade malignancy with positive chromogranin A and glucagon immunostaining. An extract of the resected tumor contained a high concentration of glucagon (26.707 pmol/g tissue), in addition to traces of GLP1 (471 pmol/g), insulin (139 pmol/g) and somatostatin (23 pmol/g). This is the first report of a GLP1 and glucagon co-secreting pNET presenting as hypoglycemia after gastric bypass surgery. Although pNET are rare, they should be considered in the differential diagnosis of the clinical approach to the post-bariatric surgery hypoglycemia patient.LEARNING POINTS: pNETs can be multihormonal-secreting, leading to atypical clinical manifestations.Reactive hypoglycemic episodes are frequent after gastric bypass.pNETs should be considered in the differential diagnosis of hypoglycemia after bariatric surgery.

U2 - 10.1530/EDM-15-0049

DO - 10.1530/EDM-15-0049

M3 - Journal article

C2 - 26266036

VL - 2015

SP - 1

EP - 5

JO - Endocrinology, Diabetes & Metabolism Case Reports

JF - Endocrinology, Diabetes & Metabolism Case Reports

SN - 2052-0573

M1 - 150049

ER -

ID: 142293504