Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg)

Research output: Contribution to journalJournal articlepeer-review

Standard

Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy : A Randomized Controlled Trial (Oseberg) . / Fatima, Farhat; Hjelmesæth, Jøran; Birkeland, Kåre Inge; Hanne, Gulseth Løvdal; Hertel, Jens Kristoffer; Svanevik, Marius; Sandbu, Rune; Småstuen, Milada Cvancarova; Hartmann, Bolette; Holst, Jens Juul; Hofsø, Dag.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 107, No. 2, dgab643, 2022, p. e756-e766.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Fatima, F, Hjelmesæth, J, Birkeland, KI, Hanne, GL, Hertel, JK, Svanevik, M, Sandbu, R, Småstuen, MC, Hartmann, B, Holst, JJ & Hofsø, D 2022, 'Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg) ', Journal of Clinical Endocrinology and Metabolism, vol. 107, no. 2, dgab643, pp. e756-e766. https://doi.org/10.1210/clinem/dgab643

APA

Fatima, F., Hjelmesæth, J., Birkeland, K. I., Hanne, G. L., Hertel, J. K., Svanevik, M., Sandbu, R., Småstuen, M. C., Hartmann, B., Holst, J. J., & Hofsø, D. (2022). Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg) . Journal of Clinical Endocrinology and Metabolism, 107(2), e756-e766. [dgab643]. https://doi.org/10.1210/clinem/dgab643

Vancouver

Fatima F, Hjelmesæth J, Birkeland KI, Hanne GL, Hertel JK, Svanevik M et al. Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg) . Journal of Clinical Endocrinology and Metabolism. 2022;107(2):e756-e766. dgab643. https://doi.org/10.1210/clinem/dgab643

Author

Fatima, Farhat ; Hjelmesæth, Jøran ; Birkeland, Kåre Inge ; Hanne, Gulseth Løvdal ; Hertel, Jens Kristoffer ; Svanevik, Marius ; Sandbu, Rune ; Småstuen, Milada Cvancarova ; Hartmann, Bolette ; Holst, Jens Juul ; Hofsø, Dag. / Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy : A Randomized Controlled Trial (Oseberg) . In: Journal of Clinical Endocrinology and Metabolism. 2022 ; Vol. 107, No. 2. pp. e756-e766.

Bibtex

@article{813deb9be93f4c35a721c2b686658922,
title = "Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg) ",
abstract = "CONTEXT: Whether Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) differentially affect postprandial gastrointestinal hormones and β-cell function in type 2 diabetes remains unclear.OBJECTIVE: To compare gastrointestinal hormones and β-cell function assessed by an oral glucose tolerance test (OGTT) 5 weeks and 1 year after surgery hypothesizing higher GLP-1 levels and greater β-cell response to glucose after RYGB than after SG.DESIGN, SETTING, PATIENTS, AND INTERVENTIONS: Randomized, triple blind, single-center trial at a tertiary care center in Norway. Primary outcomes; diabetes remission and IVGTT derived β-cell function. Participants with obesity and type 2 diabetes allocated (1:1) to RYGB or SG.MAIN OUTCOME MEASURES: Gastrointestinal hormone profiles and insulin secretion [β-cell glucose sensitivity (β-GS)] derived from 180 minutes OGTTs.RESULTS: 106 patients (67% women), mean (SD) age 48 (10) years. Diabetes remission rates at 1-year were higher after RYGB than after SG, 77% versus 48%, p = 0.002. Incremental area under the curve (iAUC0-180) glucagon-like peptide-1 (GLP-1) and β-GS increased more after RYGB than after SG, 1-year between-group difference 1173 pmol/l*min (95% CI 569 to 1776), p = 0.0010, and 0.45 pmol/kg/min/mmol (95% CI 0.15 to 0.75), p = 0.0032, respectively. Post-surgery, fasting and postprandial ghrelin levels were higher and decremental AUC0-180 ghrelin, iAUC0-180 glucose-dependent insulinotropic polypeptide, and iAUC0-60 glucagon were greater after RYGB than after SG. Diabetes remission at 1 year was associated with higher β-GS and higher GLP-1 secretion.CONCLUSIONS: RYGB was associated with greater improvement in β-cell function and higher postprandial GLP-1 levels than SG.",
author = "Farhat Fatima and J{\o}ran Hjelmes{\ae}th and Birkeland, {K{\aa}re Inge} and Hanne, {Gulseth L{\o}vdal} and Hertel, {Jens Kristoffer} and Marius Svanevik and Rune Sandbu and Sm{\aa}stuen, {Milada Cvancarova} and Bolette Hartmann and Holst, {Jens Juul} and Dag Hofs{\o}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2022",
doi = "10.1210/clinem/dgab643",
language = "English",
volume = "107",
pages = "e756--e766",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy

T2 - A Randomized Controlled Trial (Oseberg)

AU - Fatima, Farhat

AU - Hjelmesæth, Jøran

AU - Birkeland, Kåre Inge

AU - Hanne, Gulseth Løvdal

AU - Hertel, Jens Kristoffer

AU - Svanevik, Marius

AU - Sandbu, Rune

AU - Småstuen, Milada Cvancarova

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Hofsø, Dag

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - CONTEXT: Whether Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) differentially affect postprandial gastrointestinal hormones and β-cell function in type 2 diabetes remains unclear.OBJECTIVE: To compare gastrointestinal hormones and β-cell function assessed by an oral glucose tolerance test (OGTT) 5 weeks and 1 year after surgery hypothesizing higher GLP-1 levels and greater β-cell response to glucose after RYGB than after SG.DESIGN, SETTING, PATIENTS, AND INTERVENTIONS: Randomized, triple blind, single-center trial at a tertiary care center in Norway. Primary outcomes; diabetes remission and IVGTT derived β-cell function. Participants with obesity and type 2 diabetes allocated (1:1) to RYGB or SG.MAIN OUTCOME MEASURES: Gastrointestinal hormone profiles and insulin secretion [β-cell glucose sensitivity (β-GS)] derived from 180 minutes OGTTs.RESULTS: 106 patients (67% women), mean (SD) age 48 (10) years. Diabetes remission rates at 1-year were higher after RYGB than after SG, 77% versus 48%, p = 0.002. Incremental area under the curve (iAUC0-180) glucagon-like peptide-1 (GLP-1) and β-GS increased more after RYGB than after SG, 1-year between-group difference 1173 pmol/l*min (95% CI 569 to 1776), p = 0.0010, and 0.45 pmol/kg/min/mmol (95% CI 0.15 to 0.75), p = 0.0032, respectively. Post-surgery, fasting and postprandial ghrelin levels were higher and decremental AUC0-180 ghrelin, iAUC0-180 glucose-dependent insulinotropic polypeptide, and iAUC0-60 glucagon were greater after RYGB than after SG. Diabetes remission at 1 year was associated with higher β-GS and higher GLP-1 secretion.CONCLUSIONS: RYGB was associated with greater improvement in β-cell function and higher postprandial GLP-1 levels than SG.

AB - CONTEXT: Whether Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) differentially affect postprandial gastrointestinal hormones and β-cell function in type 2 diabetes remains unclear.OBJECTIVE: To compare gastrointestinal hormones and β-cell function assessed by an oral glucose tolerance test (OGTT) 5 weeks and 1 year after surgery hypothesizing higher GLP-1 levels and greater β-cell response to glucose after RYGB than after SG.DESIGN, SETTING, PATIENTS, AND INTERVENTIONS: Randomized, triple blind, single-center trial at a tertiary care center in Norway. Primary outcomes; diabetes remission and IVGTT derived β-cell function. Participants with obesity and type 2 diabetes allocated (1:1) to RYGB or SG.MAIN OUTCOME MEASURES: Gastrointestinal hormone profiles and insulin secretion [β-cell glucose sensitivity (β-GS)] derived from 180 minutes OGTTs.RESULTS: 106 patients (67% women), mean (SD) age 48 (10) years. Diabetes remission rates at 1-year were higher after RYGB than after SG, 77% versus 48%, p = 0.002. Incremental area under the curve (iAUC0-180) glucagon-like peptide-1 (GLP-1) and β-GS increased more after RYGB than after SG, 1-year between-group difference 1173 pmol/l*min (95% CI 569 to 1776), p = 0.0010, and 0.45 pmol/kg/min/mmol (95% CI 0.15 to 0.75), p = 0.0032, respectively. Post-surgery, fasting and postprandial ghrelin levels were higher and decremental AUC0-180 ghrelin, iAUC0-180 glucose-dependent insulinotropic polypeptide, and iAUC0-60 glucagon were greater after RYGB than after SG. Diabetes remission at 1 year was associated with higher β-GS and higher GLP-1 secretion.CONCLUSIONS: RYGB was associated with greater improvement in β-cell function and higher postprandial GLP-1 levels than SG.

U2 - 10.1210/clinem/dgab643

DO - 10.1210/clinem/dgab643

M3 - Journal article

C2 - 34463768

VL - 107

SP - e756-e766

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 2

M1 - dgab643

ER -

ID: 279260375