Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

Standard

Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors. / Spiess, Katja; Rosenkilde, Mette Marie.

G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. ed. / Craig W. Stevens. Humana Press, 2014. p. 45-64 (Methods in Pharmacology and Toxicology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

Harvard

Spiess, K & Rosenkilde, MM 2014, Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors. in CW Stevens (ed.), G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. Humana Press, Methods in Pharmacology and Toxicology, pp. 45-64.

APA

Spiess, K., & Rosenkilde, M. M. (2014). Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors. In C. W. Stevens (Ed.), G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era (pp. 45-64). Humana Press. Methods in Pharmacology and Toxicology

Vancouver

Spiess K, Rosenkilde MM. Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors. In Stevens CW, editor, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. Humana Press. 2014. p. 45-64. (Methods in Pharmacology and Toxicology).

Author

Spiess, Katja ; Rosenkilde, Mette Marie. / Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors. G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. editor / Craig W. Stevens. Humana Press, 2014. pp. 45-64 (Methods in Pharmacology and Toxicology).

Bibtex

@inbook{6af6bc48fb2447e984d96f0e1e213d11,
title = "Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors",
abstract = "During co-evolution with their hosts, viruses have developed several survival strategies that involve exploitation of 7TM receptors. These include virus-encoded 7TM receptors and ligands and viral regulation of endogenous receptors. Many functional properties have been ascribed to virus-exploited 7TM receptors, and although the list of putative functions is steadily growing, the presence and/or utilization of 7TM receptors are still poorly understood for many of these. This review focuses on three well described functional properties: 1) the immune evasion strategies, exemplified by γ1-herpesvirus-encoded BILF1 receptors, the human cytomegalovirus (HCMV)-encoded US28 receptor and the Epstein-Barr virus (EBV)-regulated EBI2 (or GPR183), 2) the tissue tropism and virus-dissemination properties, exemplified by the murine CMV-encoded M33, and 3) the tumorigenic properties, exemplified by the human herpesvirus 8 (HHV8)-encoded ORF74, HCMV-US28 and EBV-BILF1. Given the general high “druggability” of 7TM receptors, and the recent progress in the understanding of in particular immune evasive functions of the virus-exploited 7TM receptors, we put a special emphasis on the progress of novel anti-viral therapeutic tools ",
author = "Katja Spiess and Rosenkilde, {Mette Marie}",
year = "2014",
language = "English",
isbn = " 978-1-62703-778-5 ",
series = "Methods in Pharmacology and Toxicology",
publisher = "Humana Press",
pages = "45--64",
editor = "Stevens, {Craig W.}",
booktitle = "G Protein-Coupled Receptor Genetics",
address = "United States",

}

RIS

TY - CHAP

T1 - Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors

AU - Spiess, Katja

AU - Rosenkilde, Mette Marie

PY - 2014

Y1 - 2014

N2 - During co-evolution with their hosts, viruses have developed several survival strategies that involve exploitation of 7TM receptors. These include virus-encoded 7TM receptors and ligands and viral regulation of endogenous receptors. Many functional properties have been ascribed to virus-exploited 7TM receptors, and although the list of putative functions is steadily growing, the presence and/or utilization of 7TM receptors are still poorly understood for many of these. This review focuses on three well described functional properties: 1) the immune evasion strategies, exemplified by γ1-herpesvirus-encoded BILF1 receptors, the human cytomegalovirus (HCMV)-encoded US28 receptor and the Epstein-Barr virus (EBV)-regulated EBI2 (or GPR183), 2) the tissue tropism and virus-dissemination properties, exemplified by the murine CMV-encoded M33, and 3) the tumorigenic properties, exemplified by the human herpesvirus 8 (HHV8)-encoded ORF74, HCMV-US28 and EBV-BILF1. Given the general high “druggability” of 7TM receptors, and the recent progress in the understanding of in particular immune evasive functions of the virus-exploited 7TM receptors, we put a special emphasis on the progress of novel anti-viral therapeutic tools

AB - During co-evolution with their hosts, viruses have developed several survival strategies that involve exploitation of 7TM receptors. These include virus-encoded 7TM receptors and ligands and viral regulation of endogenous receptors. Many functional properties have been ascribed to virus-exploited 7TM receptors, and although the list of putative functions is steadily growing, the presence and/or utilization of 7TM receptors are still poorly understood for many of these. This review focuses on three well described functional properties: 1) the immune evasion strategies, exemplified by γ1-herpesvirus-encoded BILF1 receptors, the human cytomegalovirus (HCMV)-encoded US28 receptor and the Epstein-Barr virus (EBV)-regulated EBI2 (or GPR183), 2) the tissue tropism and virus-dissemination properties, exemplified by the murine CMV-encoded M33, and 3) the tumorigenic properties, exemplified by the human herpesvirus 8 (HHV8)-encoded ORF74, HCMV-US28 and EBV-BILF1. Given the general high “druggability” of 7TM receptors, and the recent progress in the understanding of in particular immune evasive functions of the virus-exploited 7TM receptors, we put a special emphasis on the progress of novel anti-viral therapeutic tools

M3 - Book chapter

SN - 978-1-62703-778-5

T3 - Methods in Pharmacology and Toxicology

SP - 45

EP - 64

BT - G Protein-Coupled Receptor Genetics

A2 - Stevens, Craig W.

PB - Humana Press

ER -

ID: 138866130