Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate

Research output: Contribution to journal › Journal article › peer-review

Standard

Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate. / Amin, Harish; Holst, Jens Juul; Hartmann, Bolette; Wallace, Laurie; Wright, Jim; Sigalet, David L.

In: Pediatrics, Vol. 121, No. 1, 01.2008, p. e180-6.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Amin, H, Holst, JJ, Hartmann, B, Wallace, L, Wright, J & Sigalet, DL 2008, 'Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate', Pediatrics, vol. 121, no. 1, pp. e180-6. https://doi.org/10.1542/peds.2007-1461

APA

Amin, H., Holst, J. J., Hartmann, B., Wallace, L., Wright, J., & Sigalet, D. L. (2008). Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate. Pediatrics, 121(1), e180-6. https://doi.org/10.1542/peds.2007-1461

Vancouver

Amin H, Holst JJ, Hartmann B, Wallace L, Wright J, Sigalet DL. Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate. Pediatrics. 2008 Jan;121(1):e180-6. https://doi.org/10.1542/peds.2007-1461

Author

Amin, Harish ; Holst, Jens Juul ; Hartmann, Bolette ; Wallace, Laurie ; Wright, Jim ; Sigalet, David L. / Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate. In: Pediatrics. 2008 ; Vol. 121, No. 1. pp. e180-6.

Bibtex

@article{724fb95c115c40dfa0461fa9ab4c5ed6,
title = "Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate",
abstract = "BACKGROUND: The regulation of intestinal growth and development in human neonates is incompletely understood, which hinders the provision of nutrients enterally. The {"}hindgut{"} hormones glucagon-like peptides 1 and 2 have been shown to play an important role in the regulation of nutrient assimilation, intestinal growth, and function.OBJECTIVE: Our goal was to investigate the production of glucagon-like peptides 1 and 2 in premature human infants and examine the effects of prematurity and feeding on hormone release.PATIENTS AND METHODS: With informed consent, premature infants who were admitted to a tertiary neonatal intensive care nursery (gestational age: 28-32 weeks) were monitored with weekly determinations of postprandial glucagon-like peptide 1 and 2 levels. Comparison studies with groups of normal infants and adults were performed. Hormone levels were obtained by using specific radioimmunoassay for glucagon-like peptide 1 (1-36) and glucagon-like peptide 2 (1-33), modified for small sample volumes; accurate monitoring of enteral intake was performed at all of the sampling time points.RESULTS: Forty-five infants with a mean gestational age of 29.6 +/- 1.9 weeks were studied; fasting levels of both glucagon-like peptides 1 and 2 were elevated. There was no correlation between gestational age and glucagon-like peptide 2 output. However, both glucagon-like peptide 1 and 2 levels were correlated with the caloric value of feeds.CONCLUSIONS: The premature human neonate has significantly higher fasting levels of glucagon-like peptides 1 and 2 compared with adults; feeding increases these levels further. These findings suggest that the proglucagon-derived peptides may have a role in normal intestinal development and nutrient handling.",
keywords = "Adult, Age Factors, Biological Markers, Case-Control Studies, Child, Cohort Studies, Energy Metabolism, Female, Follow-Up Studies, Gastrointestinal Tract, Gestational Age, Glucagon-Like Peptide 1, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Humans, Infant Food, Infant, Newborn, Infant, Premature, Intensive Care Units, Neonatal, Intestinal Absorption, Male, Pregnancy, Probability, Reference Values, Risk Factors",
author = "Harish Amin and Holst, {Jens Juul} and Bolette Hartmann and Laurie Wallace and Jim Wright and Sigalet, {David L}",
year = "2008",
month = jan,
doi = "10.1542/peds.2007-1461",
language = "English",
volume = "121",
pages = "e180--6",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "1",

}

RIS

TY - JOUR

T1 - Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate

AU - Amin, Harish

AU - Holst, Jens Juul

AU - Hartmann, Bolette

AU - Wallace, Laurie

AU - Wright, Jim

AU - Sigalet, David L

PY - 2008/1

Y1 - 2008/1

N2 - BACKGROUND: The regulation of intestinal growth and development in human neonates is incompletely understood, which hinders the provision of nutrients enterally. The "hindgut" hormones glucagon-like peptides 1 and 2 have been shown to play an important role in the regulation of nutrient assimilation, intestinal growth, and function.OBJECTIVE: Our goal was to investigate the production of glucagon-like peptides 1 and 2 in premature human infants and examine the effects of prematurity and feeding on hormone release.PATIENTS AND METHODS: With informed consent, premature infants who were admitted to a tertiary neonatal intensive care nursery (gestational age: 28-32 weeks) were monitored with weekly determinations of postprandial glucagon-like peptide 1 and 2 levels. Comparison studies with groups of normal infants and adults were performed. Hormone levels were obtained by using specific radioimmunoassay for glucagon-like peptide 1 (1-36) and glucagon-like peptide 2 (1-33), modified for small sample volumes; accurate monitoring of enteral intake was performed at all of the sampling time points.RESULTS: Forty-five infants with a mean gestational age of 29.6 +/- 1.9 weeks were studied; fasting levels of both glucagon-like peptides 1 and 2 were elevated. There was no correlation between gestational age and glucagon-like peptide 2 output. However, both glucagon-like peptide 1 and 2 levels were correlated with the caloric value of feeds.CONCLUSIONS: The premature human neonate has significantly higher fasting levels of glucagon-like peptides 1 and 2 compared with adults; feeding increases these levels further. These findings suggest that the proglucagon-derived peptides may have a role in normal intestinal development and nutrient handling.

AB - BACKGROUND: The regulation of intestinal growth and development in human neonates is incompletely understood, which hinders the provision of nutrients enterally. The "hindgut" hormones glucagon-like peptides 1 and 2 have been shown to play an important role in the regulation of nutrient assimilation, intestinal growth, and function.OBJECTIVE: Our goal was to investigate the production of glucagon-like peptides 1 and 2 in premature human infants and examine the effects of prematurity and feeding on hormone release.PATIENTS AND METHODS: With informed consent, premature infants who were admitted to a tertiary neonatal intensive care nursery (gestational age: 28-32 weeks) were monitored with weekly determinations of postprandial glucagon-like peptide 1 and 2 levels. Comparison studies with groups of normal infants and adults were performed. Hormone levels were obtained by using specific radioimmunoassay for glucagon-like peptide 1 (1-36) and glucagon-like peptide 2 (1-33), modified for small sample volumes; accurate monitoring of enteral intake was performed at all of the sampling time points.RESULTS: Forty-five infants with a mean gestational age of 29.6 +/- 1.9 weeks were studied; fasting levels of both glucagon-like peptides 1 and 2 were elevated. There was no correlation between gestational age and glucagon-like peptide 2 output. However, both glucagon-like peptide 1 and 2 levels were correlated with the caloric value of feeds.CONCLUSIONS: The premature human neonate has significantly higher fasting levels of glucagon-like peptides 1 and 2 compared with adults; feeding increases these levels further. These findings suggest that the proglucagon-derived peptides may have a role in normal intestinal development and nutrient handling.

KW - Adult

KW - Age Factors

KW - Biological Markers

KW - Case-Control Studies

KW - Child

KW - Cohort Studies

KW - Energy Metabolism

KW - Female

KW - Follow-Up Studies

KW - Gastrointestinal Tract

KW - Gestational Age

KW - Glucagon-Like Peptide 1

KW - Glucagon-Like Peptide 2

KW - Glucagon-Like Peptides

KW - Humans

KW - Infant Food

KW - Infant, Newborn

KW - Infant, Premature

KW - Intensive Care Units, Neonatal

KW - Intestinal Absorption

KW - Male

KW - Pregnancy

KW - Probability

KW - Reference Values

KW - Risk Factors

U2 - 10.1542/peds.2007-1461

DO - 10.1542/peds.2007-1461

M3 - Journal article

C2 - 18166537

VL - 121

SP - e180-6

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 1

ER -

ID: 132049488