Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats.

Research output: Contribution to journalJournal articlepeer-review

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Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats. / Holstein-Rathlou, N H; Kanters, J K; Leyssac, P P.

In: Journal of Hypertension, Vol. 6, No. 11, 1988, p. 889-95.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Holstein-Rathlou, NH, Kanters, JK & Leyssac, PP 1988, 'Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats.', Journal of Hypertension, vol. 6, no. 11, pp. 889-95.

APA

Holstein-Rathlou, N. H., Kanters, J. K., & Leyssac, P. P. (1988). Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats. Journal of Hypertension, 6(11), 889-95.

Vancouver

Holstein-Rathlou NH, Kanters JK, Leyssac PP. Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats. Journal of Hypertension. 1988;6(11):889-95.

Author

Holstein-Rathlou, N H ; Kanters, J K ; Leyssac, P P. / Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats. In: Journal of Hypertension. 1988 ; Vol. 6, No. 11. pp. 889-95.

Bibtex

@article{5f011c10abed11ddb5e9000ea68e967b,
title = "Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats.",
abstract = "Since hypertension is associated with changes in the handling of various cations (including sodium and lithium) across the cell membrane, the present study investigated the validity of the lithium clearance method in hypertension by comparing two measures of proximal reabsorption. Thus, fractional lithium excretion and transit time (TT)-occlusion time (OT; e-TT/T) were determined successively in the same spontaneously hypertensive rat (SHR, Okamoto strain). The rats were examined both before and after an acute saline load. The results show that the lithium clearance method can be used for the determination of proximal reabsorption in SHR. Utilizing the lithium clearance method, the changes in renal sodium handling underlying the exaggerated natriuresis were investigated in unanaesthetized catheterized rats. It was found that the exaggerated natriuresis was associated with an increased output from the proximal tubule, whereas no difference in distal sodium handling could be detected between SHR and normotensive Wistar-Kyoto rats (WKY).",
author = "Holstein-Rathlou, {N H} and Kanters, {J K} and Leyssac, {P P}",
note = "Keywords: Animals; Hypertension; Inulin; Kidney Tubules, Proximal; Lithium; Male; Natriuresis; Rats; Rats, Inbred SHR; Rats, Inbred WKY",
year = "1988",
language = "English",
volume = "6",
pages = "889--95",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "11",

}

RIS

TY - JOUR

T1 - Exaggerated natriuresis and lithium clearance in spontaneously hypertensive rats.

AU - Holstein-Rathlou, N H

AU - Kanters, J K

AU - Leyssac, P P

N1 - Keywords: Animals; Hypertension; Inulin; Kidney Tubules, Proximal; Lithium; Male; Natriuresis; Rats; Rats, Inbred SHR; Rats, Inbred WKY

PY - 1988

Y1 - 1988

N2 - Since hypertension is associated with changes in the handling of various cations (including sodium and lithium) across the cell membrane, the present study investigated the validity of the lithium clearance method in hypertension by comparing two measures of proximal reabsorption. Thus, fractional lithium excretion and transit time (TT)-occlusion time (OT; e-TT/T) were determined successively in the same spontaneously hypertensive rat (SHR, Okamoto strain). The rats were examined both before and after an acute saline load. The results show that the lithium clearance method can be used for the determination of proximal reabsorption in SHR. Utilizing the lithium clearance method, the changes in renal sodium handling underlying the exaggerated natriuresis were investigated in unanaesthetized catheterized rats. It was found that the exaggerated natriuresis was associated with an increased output from the proximal tubule, whereas no difference in distal sodium handling could be detected between SHR and normotensive Wistar-Kyoto rats (WKY).

AB - Since hypertension is associated with changes in the handling of various cations (including sodium and lithium) across the cell membrane, the present study investigated the validity of the lithium clearance method in hypertension by comparing two measures of proximal reabsorption. Thus, fractional lithium excretion and transit time (TT)-occlusion time (OT; e-TT/T) were determined successively in the same spontaneously hypertensive rat (SHR, Okamoto strain). The rats were examined both before and after an acute saline load. The results show that the lithium clearance method can be used for the determination of proximal reabsorption in SHR. Utilizing the lithium clearance method, the changes in renal sodium handling underlying the exaggerated natriuresis were investigated in unanaesthetized catheterized rats. It was found that the exaggerated natriuresis was associated with an increased output from the proximal tubule, whereas no difference in distal sodium handling could be detected between SHR and normotensive Wistar-Kyoto rats (WKY).

M3 - Journal article

C2 - 3235836

VL - 6

SP - 889

EP - 895

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 11

ER -

ID: 8440105