Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients

Research output: Contribution to journalJournal articlepeer-review

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Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients. / Morgan, Philip E; Sturgess, Allan D; Davies, Michael Jonathan.

In: Free Radical Research, Vol. 43, No. 2, 02.2009, p. 117-27.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Morgan, PE, Sturgess, AD & Davies, MJ 2009, 'Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients', Free Radical Research, vol. 43, no. 2, pp. 117-27. https://doi.org/10.1080/10715760802623896

APA

Morgan, P. E., Sturgess, A. D., & Davies, M. J. (2009). Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients. Free Radical Research, 43(2), 117-27. https://doi.org/10.1080/10715760802623896

Vancouver

Morgan PE, Sturgess AD, Davies MJ. Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients. Free Radical Research. 2009 Feb;43(2):117-27. https://doi.org/10.1080/10715760802623896

Author

Morgan, Philip E ; Sturgess, Allan D ; Davies, Michael Jonathan. / Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients. In: Free Radical Research. 2009 ; Vol. 43, No. 2. pp. 117-27.

Bibtex

@article{9ceea47daa9d40028051261e3b6be962,
title = "Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients",
abstract = "Serum protein oxidation levels in people with the autoimmune disease systemic lupus erythematosus (SLE) have previously been shown to (a) be elevated at a single time point and (b) correlate with disease activity. This study investigates whether this elevation is a chronic phenomenon, by analysis of multiple serum samples collected from 21 SLE patients and nine controls over a period of up to 38 months. Protein thiols were chronically decreased in SLE patients with stable or variable disease activity compared to controls, whilst protein-bound carbonyls and glycine were chronically increased. 2D-gel analysis of carbonyl distribution showed albumin and immunoglobulins to be particularly affected. In SLE patients with stable disease activity, higher long-term protein oxidation correlated with higher long-term disease activity. SLE patients with variable disease activity exhibited varying correlations between protein oxidation and disease activity markers. These results further support a role for oxidative stress in the pathogenesis of SLE.",
keywords = "Adult, Blood Proteins, Blotting, Western, Case-Control Studies, Cohort Studies, Disease Progression, Electrophoresis, Gel, Two-Dimensional, Female, Humans, Lupus Erythematosus, Systemic, Male, Middle Aged, Oxidation-Reduction, Oxidative Stress, Protein Binding, Severity of Illness Index",
author = "Morgan, {Philip E} and Sturgess, {Allan D} and Davies, {Michael Jonathan}",
year = "2009",
month = feb,
doi = "10.1080/10715760802623896",
language = "English",
volume = "43",
pages = "117--27",
journal = "Free Radical Research",
issn = "1071-5762",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients

AU - Morgan, Philip E

AU - Sturgess, Allan D

AU - Davies, Michael Jonathan

PY - 2009/2

Y1 - 2009/2

N2 - Serum protein oxidation levels in people with the autoimmune disease systemic lupus erythematosus (SLE) have previously been shown to (a) be elevated at a single time point and (b) correlate with disease activity. This study investigates whether this elevation is a chronic phenomenon, by analysis of multiple serum samples collected from 21 SLE patients and nine controls over a period of up to 38 months. Protein thiols were chronically decreased in SLE patients with stable or variable disease activity compared to controls, whilst protein-bound carbonyls and glycine were chronically increased. 2D-gel analysis of carbonyl distribution showed albumin and immunoglobulins to be particularly affected. In SLE patients with stable disease activity, higher long-term protein oxidation correlated with higher long-term disease activity. SLE patients with variable disease activity exhibited varying correlations between protein oxidation and disease activity markers. These results further support a role for oxidative stress in the pathogenesis of SLE.

AB - Serum protein oxidation levels in people with the autoimmune disease systemic lupus erythematosus (SLE) have previously been shown to (a) be elevated at a single time point and (b) correlate with disease activity. This study investigates whether this elevation is a chronic phenomenon, by analysis of multiple serum samples collected from 21 SLE patients and nine controls over a period of up to 38 months. Protein thiols were chronically decreased in SLE patients with stable or variable disease activity compared to controls, whilst protein-bound carbonyls and glycine were chronically increased. 2D-gel analysis of carbonyl distribution showed albumin and immunoglobulins to be particularly affected. In SLE patients with stable disease activity, higher long-term protein oxidation correlated with higher long-term disease activity. SLE patients with variable disease activity exhibited varying correlations between protein oxidation and disease activity markers. These results further support a role for oxidative stress in the pathogenesis of SLE.

KW - Adult

KW - Blood Proteins

KW - Blotting, Western

KW - Case-Control Studies

KW - Cohort Studies

KW - Disease Progression

KW - Electrophoresis, Gel, Two-Dimensional

KW - Female

KW - Humans

KW - Lupus Erythematosus, Systemic

KW - Male

KW - Middle Aged

KW - Oxidation-Reduction

KW - Oxidative Stress

KW - Protein Binding

KW - Severity of Illness Index

U2 - 10.1080/10715760802623896

DO - 10.1080/10715760802623896

M3 - Journal article

C2 - 19096973

VL - 43

SP - 117

EP - 127

JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

IS - 2

ER -

ID: 129670499