Effects of bilastine on T-wave morphology and the QTc interval: a randomized, double-blind, placebo-controlled, thorough QTc study

Research output: Contribution to journalJournal articleResearchpeer-review

The International Conference of Harmonisation (ICH) E14 guideline for thorough QT studies requires assessing the propensity of new non-antiarrhythmic drugs to affect cardiac repolarization. The present study investigates whether a composite ECG measure of T-wave morphology (Morphology Combination Score [MCS]) can be used together with the heart rate corrected QT interval (QTc) in a fully ICH E14-compliant thorough QT study to exclude clinically relevant repolarization effects of bilastine, a novel antihistamine.
Original languageEnglish
JournalClinical Drug Investigation
Issue number5
Pages (from-to)339-51
Number of pages13
Publication statusPublished - 1 May 2012

    Research areas

  • Adult, Aza Compounds, Benzimidazoles, Cross-Over Studies, Double-Blind Method, Electrocardiography, Female, Guidelines as Topic, Histamine Antagonists, Humans, Long QT Syndrome, Male, Piperidines, Quinolines, Time Factors, Young Adult

ID: 48052459