Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial

Research output: Contribution to journalJournal articleResearchpeer-review

Aims/hypothesis The aim was to investigate whether an intensive lifestyle intervention, with high volumes of exercise, improves beta cell function and to explore the role of low-grade inflammation and body weight.

Methods This was a randomised, assessor-blinded, controlled trial. Ninety-eight individuals with type 2 diabetes (duration

Results At baseline, individuals were 54.8 years (SD 8.9), 47% women, type 2 diabetes duration 5 years (IQR 3-8) and HbA(1c)was 49.3 mmol/mol (SD 9.2); 6.7% (SD 0.8). The intensive lifestyle group showed 40% greater improvement in the disposition index compared with the standard care group (ratio of geometric mean change [RGM] 1.40 [95% CI 1.01, 1.94]) from baseline to 12 months' follow-up. Plasma concentration of IL-1 receptor antagonist (IL-1ra) decreased 30% more in the intensive lifestyle group compared with the standard care group (RGM 0.70 [95% CI 0.58, 0.85]). Statistical single mediation analysis estimated that the intervention effect on the change in IL-1ra and the change in body weight explained to a similar extent (59%) the variance in the intervention effect on the disposition index.

Conclusions/interpretation Our findings show that incorporating an intensive lifestyle intervention, with high volumes of exercise, in individuals with type 2 diabetes has the potential to improve beta cell function, associated with a decrease in low-grade inflammation and/or body weight.

Original languageEnglish
JournalDiabetologia
Number of pages13
ISSN0012-186X
DOIs
Publication statusE-pub ahead of print - 2020

    Research areas

  • Beta cell function, Exercise, Glycaemic control, Insulin secretion, Insulin sensitivity, Low-grade inflammation, Type 2 diabetes, BETA-CELL FUNCTION, ORAL GLUCOSE-TOLERANCE, INSULIN SENSITIVITY, WEIGHT-LOSS, EXERCISE, RESISTANCE, MELLITUS, MUSCLE

ID: 248026609