Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial

Research output: Contribution to journalJournal articlepeer-review

Standard

Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial. / Bjørnshave, Ann; Lykkeboe, Simon; Hartmann, Bolette; Holst, Jens J.; Hermansen, Kjeld; Starup-Linde, Jakob.

In: Diabetic Medicine, Vol. 38, No. 6, e14471, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bjørnshave, A, Lykkeboe, S, Hartmann, B, Holst, JJ, Hermansen, K & Starup-Linde, J 2021, 'Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial', Diabetic Medicine, vol. 38, no. 6, e14471. https://doi.org/10.1111/dme.14471

APA

Bjørnshave, A., Lykkeboe, S., Hartmann, B., Holst, J. J., Hermansen, K., & Starup-Linde, J. (2021). Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial. Diabetic Medicine, 38(6), [e14471]. https://doi.org/10.1111/dme.14471

Vancouver

Bjørnshave A, Lykkeboe S, Hartmann B, Holst JJ, Hermansen K, Starup-Linde J. Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial. Diabetic Medicine. 2021;38(6). e14471. https://doi.org/10.1111/dme.14471

Author

Bjørnshave, Ann ; Lykkeboe, Simon ; Hartmann, Bolette ; Holst, Jens J. ; Hermansen, Kjeld ; Starup-Linde, Jakob. / Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial. In: Diabetic Medicine. 2021 ; Vol. 38, No. 6.

Bibtex

@article{a56b11bece6644ccb8f0b98068f24f04,
title = "Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial",
abstract = "Aims Whey protein may improve bone turnover and have anti-osteoporotic effects. The aim of the present randomised, controlled, crossover trial was to evaluate the effects of a whey protein pre-meal on bone turnover in people with type 2 diabetes and controls.Methods Two groups, matched on sex, age and body mass index, comprising 12 participants with and 12 participants without type 2 diabetes were randomly given a pre-meal of whey protein (20 g) or water, which was consumed 15 min before a fat-rich meal or a fat-rich meal supplemented with 20 g whey protein. During a 360-min period, postprandial responses in bone turnover were examined.Results Osteocalcin, P-procollagen type 1 amino terminal propeptide (P1NP), C-terminal cross-linked telopeptide of type-I collagen (CTX) and parathyroid hormone (PTH) were lower at baseline and PTH, osteocalcin and P1NP were lower during the entire postprandial phase in participants with type 2 diabetes than in participants without type 2 diabetes. We observed similar postprandial responses in bone turnover markers between persons with and without type 2 diabetes. We observed no effect of the whey protein or the water pre-meal on bone turnover markers. The changes were unrelated to secretion of hormones of the gut-bone axis.Conclusion Osteocalcin, P1NP, CTX and PTH all decreased following meal ingestion. We observed no convincing effect of a whey protein pre-meal on bone turnover. However, these results confirm that people with type 2 diabetes have low bone turnover and that the decreased bone formation markers are also extend into the postprandial responses.",
keywords = "bone turnover, type 2 diabetes, meal, gastrointestinal hormones, PARATHYROID-HORMONE, GLUCOSE, SUPPLEMENTATION, RESORPTION, MELLITUS, MARKERS, MECHANISMS, FRACTURES, DENSITY, RISK",
author = "Ann Bj{\o}rnshave and Simon Lykkeboe and Bolette Hartmann and Holst, {Jens J.} and Kjeld Hermansen and Jakob Starup-Linde",
year = "2021",
doi = "10.1111/dme.14471",
language = "English",
volume = "38",
journal = "Diabetic Medicine Online",
issn = "1464-5491",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial

AU - Bjørnshave, Ann

AU - Lykkeboe, Simon

AU - Hartmann, Bolette

AU - Holst, Jens J.

AU - Hermansen, Kjeld

AU - Starup-Linde, Jakob

PY - 2021

Y1 - 2021

N2 - Aims Whey protein may improve bone turnover and have anti-osteoporotic effects. The aim of the present randomised, controlled, crossover trial was to evaluate the effects of a whey protein pre-meal on bone turnover in people with type 2 diabetes and controls.Methods Two groups, matched on sex, age and body mass index, comprising 12 participants with and 12 participants without type 2 diabetes were randomly given a pre-meal of whey protein (20 g) or water, which was consumed 15 min before a fat-rich meal or a fat-rich meal supplemented with 20 g whey protein. During a 360-min period, postprandial responses in bone turnover were examined.Results Osteocalcin, P-procollagen type 1 amino terminal propeptide (P1NP), C-terminal cross-linked telopeptide of type-I collagen (CTX) and parathyroid hormone (PTH) were lower at baseline and PTH, osteocalcin and P1NP were lower during the entire postprandial phase in participants with type 2 diabetes than in participants without type 2 diabetes. We observed similar postprandial responses in bone turnover markers between persons with and without type 2 diabetes. We observed no effect of the whey protein or the water pre-meal on bone turnover markers. The changes were unrelated to secretion of hormones of the gut-bone axis.Conclusion Osteocalcin, P1NP, CTX and PTH all decreased following meal ingestion. We observed no convincing effect of a whey protein pre-meal on bone turnover. However, these results confirm that people with type 2 diabetes have low bone turnover and that the decreased bone formation markers are also extend into the postprandial responses.

AB - Aims Whey protein may improve bone turnover and have anti-osteoporotic effects. The aim of the present randomised, controlled, crossover trial was to evaluate the effects of a whey protein pre-meal on bone turnover in people with type 2 diabetes and controls.Methods Two groups, matched on sex, age and body mass index, comprising 12 participants with and 12 participants without type 2 diabetes were randomly given a pre-meal of whey protein (20 g) or water, which was consumed 15 min before a fat-rich meal or a fat-rich meal supplemented with 20 g whey protein. During a 360-min period, postprandial responses in bone turnover were examined.Results Osteocalcin, P-procollagen type 1 amino terminal propeptide (P1NP), C-terminal cross-linked telopeptide of type-I collagen (CTX) and parathyroid hormone (PTH) were lower at baseline and PTH, osteocalcin and P1NP were lower during the entire postprandial phase in participants with type 2 diabetes than in participants without type 2 diabetes. We observed similar postprandial responses in bone turnover markers between persons with and without type 2 diabetes. We observed no effect of the whey protein or the water pre-meal on bone turnover markers. The changes were unrelated to secretion of hormones of the gut-bone axis.Conclusion Osteocalcin, P1NP, CTX and PTH all decreased following meal ingestion. We observed no convincing effect of a whey protein pre-meal on bone turnover. However, these results confirm that people with type 2 diabetes have low bone turnover and that the decreased bone formation markers are also extend into the postprandial responses.

KW - bone turnover

KW - type 2 diabetes

KW - meal

KW - gastrointestinal hormones

KW - PARATHYROID-HORMONE

KW - GLUCOSE

KW - SUPPLEMENTATION

KW - RESORPTION

KW - MELLITUS

KW - MARKERS

KW - MECHANISMS

KW - FRACTURES

KW - DENSITY

KW - RISK

U2 - 10.1111/dme.14471

DO - 10.1111/dme.14471

M3 - Journal article

C2 - 33259643

VL - 38

JO - Diabetic Medicine Online

JF - Diabetic Medicine Online

SN - 1464-5491

IS - 6

M1 - e14471

ER -

ID: 253649060