Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study

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Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study. / Tischmann, Lea; Drummen, Mathijs; Gatta-Cherifi, Blandine; Raben, Anne; Fogelholm, Mikael; Hartmann, Bolette; Holst, Jens Juul; Matias, Isabelle; Cota, Daniela; Mensink, Ronald P; Peters, Joris; Westerterp-Plantenga, Margriet S; Adam, Tanja C.

In: Nutrients, Vol. 11, 2269, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Tischmann, L, Drummen, M, Gatta-Cherifi, B, Raben, A, Fogelholm, M, Hartmann, B, Holst, JJ, Matias, I, Cota, D, Mensink, RP, Peters, J, Westerterp-Plantenga, MS & Adam, TC 2019, 'Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study', Nutrients, vol. 11, 2269. https://doi.org/10.3390/nu11102269

APA

Tischmann, L., Drummen, M., Gatta-Cherifi, B., Raben, A., Fogelholm, M., Hartmann, B., ... Adam, T. C. (2019). Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study. Nutrients, 11, [2269]. https://doi.org/10.3390/nu11102269

Vancouver

Tischmann L, Drummen M, Gatta-Cherifi B, Raben A, Fogelholm M, Hartmann B et al. Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study. Nutrients. 2019;11. 2269. https://doi.org/10.3390/nu11102269

Author

Tischmann, Lea ; Drummen, Mathijs ; Gatta-Cherifi, Blandine ; Raben, Anne ; Fogelholm, Mikael ; Hartmann, Bolette ; Holst, Jens Juul ; Matias, Isabelle ; Cota, Daniela ; Mensink, Ronald P ; Peters, Joris ; Westerterp-Plantenga, Margriet S ; Adam, Tanja C. / Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study. In: Nutrients. 2019 ; Vol. 11.

Bibtex

@article{6cda7e3fb49f45e490458d249ce81305,
title = "Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study",
abstract = "Favorable eects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 5.9 years; body mass index (BMI) 28.9 3.9 kg/m2) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25{\%}:45{\%}:30{\%} or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15{\%}:55{\%}:30{\%} of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (−56.6{\%} compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = −0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.",
keywords = "Faculty of Science, Protein, Endocannabinoids, Hunger, Satiety, Gut peptides, Weight maintenance, Obesity",
author = "Lea Tischmann and Mathijs Drummen and Blandine Gatta-Cherifi and Anne Raben and Mikael Fogelholm and Bolette Hartmann and Holst, {Jens Juul} and Isabelle Matias and Daniela Cota and Mensink, {Ronald P} and Joris Peters and Westerterp-Plantenga, {Margriet S} and Adam, {Tanja C}",
note = "CURIS 2019 NEXS 305",
year = "2019",
doi = "10.3390/nu11102269",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",

}

RIS

TY - JOUR

T1 - Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study

AU - Tischmann, Lea

AU - Drummen, Mathijs

AU - Gatta-Cherifi, Blandine

AU - Raben, Anne

AU - Fogelholm, Mikael

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Matias, Isabelle

AU - Cota, Daniela

AU - Mensink, Ronald P

AU - Peters, Joris

AU - Westerterp-Plantenga, Margriet S

AU - Adam, Tanja C

N1 - CURIS 2019 NEXS 305

PY - 2019

Y1 - 2019

N2 - Favorable eects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 5.9 years; body mass index (BMI) 28.9 3.9 kg/m2) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (−56.6% compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = −0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.

AB - Favorable eects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 5.9 years; body mass index (BMI) 28.9 3.9 kg/m2) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (−56.6% compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = −0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.

KW - Faculty of Science

KW - Protein

KW - Endocannabinoids

KW - Hunger

KW - Satiety

KW - Gut peptides

KW - Weight maintenance

KW - Obesity

U2 - 10.3390/nu11102269

DO - 10.3390/nu11102269

M3 - Journal article

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

M1 - 2269

ER -

ID: 227696323