Effect of intermittent fasting and refeeding on insulin action in healthy men.

Research output: Contribution to journalJournal articlepeer-review

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Effect of intermittent fasting and refeeding on insulin action in healthy men. / Halberg, Nils; Henriksen, Morten; Söderhamn, Nathalie; Stallknecht, Bente; Ploug, Thorkil; Schjerling, Peter; Dela, Flemming.

In: Journal of Applied Physiology, Vol. 99, No. 6, 2005, p. 2128-36.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Halberg, N, Henriksen, M, Söderhamn, N, Stallknecht, B, Ploug, T, Schjerling, P & Dela, F 2005, 'Effect of intermittent fasting and refeeding on insulin action in healthy men.', Journal of Applied Physiology, vol. 99, no. 6, pp. 2128-36. https://doi.org/10.1152/japplphysiol.00683.2005

APA

Halberg, N., Henriksen, M., Söderhamn, N., Stallknecht, B., Ploug, T., Schjerling, P., & Dela, F. (2005). Effect of intermittent fasting and refeeding on insulin action in healthy men. Journal of Applied Physiology, 99(6), 2128-36. https://doi.org/10.1152/japplphysiol.00683.2005

Vancouver

Halberg N, Henriksen M, Söderhamn N, Stallknecht B, Ploug T, Schjerling P et al. Effect of intermittent fasting and refeeding on insulin action in healthy men. Journal of Applied Physiology. 2005;99(6):2128-36. https://doi.org/10.1152/japplphysiol.00683.2005

Author

Halberg, Nils ; Henriksen, Morten ; Söderhamn, Nathalie ; Stallknecht, Bente ; Ploug, Thorkil ; Schjerling, Peter ; Dela, Flemming. / Effect of intermittent fasting and refeeding on insulin action in healthy men. In: Journal of Applied Physiology. 2005 ; Vol. 99, No. 6. pp. 2128-36.

Bibtex

@article{8ca45a00aca711ddb5e9000ea68e967b,
title = "Effect of intermittent fasting and refeeding on insulin action in healthy men.",
abstract = "Insulin resistance is currently a major health problem. This may be because of a marked decrease in daily physical activity during recent decades combined with constant food abundance. This lifestyle collides with our genome, which was most likely selected in the late Paleolithic era (50,000-10,000 BC) by criteria that favored survival in an environment characterized by fluctuations between periods of feast and famine. The theory of thrifty genes states that these fluctuations are required for optimal metabolic function. We mimicked the fluctuations in eight healthy young men [25.0 +/- 0.1 yr (mean +/- SE); body mass index: 25.7 +/- 0.4 kg/m(2)] by subjecting them to intermittent fasting every second day for 20 h for 15 days. Euglycemic hyperinsulinemic (40 mU.min(-1).m(-2)) clamps were performed before and after the intervention period. Subjects maintained body weight (86.4 +/- 2.3 kg; coefficient of variation: 0.8 +/- 0.1%). Plasma free fatty acid and beta-hydroxybutyrate concentrations were 347 +/- 18 and 0.06 +/- 0.02 mM, respectively, after overnight fast but increased (P < 0.05) to 423 +/- 86 and 0.10 +/- 0.04 mM after 20-h fasting, confirming that the subjects were fasting. Insulin-mediated whole body glucose uptake rates increased from 6.3 +/- 0.6 to 7.3 +/- 0.3 mg.kg(-1).min(-1) (P = 0.03), and insulin-induced inhibition of adipose tissue lipolysis was more prominent after than before the intervention (P = 0.05). After the 20-h fasting periods, plasma adiponectin was increased compared with the basal levels before and after the intervention (5,922 +/- 991 vs. 3,860 +/- 784 ng/ml, P = 0.02). This experiment is the first in humans to show that intermittent fasting increases insulin-mediated glucose uptake rates, and the findings are compatible with the thrifty gene concept.",
author = "Nils Halberg and Morten Henriksen and Nathalie S{\"o}derhamn and Bente Stallknecht and Thorkil Ploug and Peter Schjerling and Flemming Dela",
note = "Keywords: Adult; Biological Clocks; Blood Glucose; Fasting; Feeding Behavior; Humans; Insulin; Insulin Resistance; Life Style; Male",
year = "2005",
doi = "10.1152/japplphysiol.00683.2005",
language = "English",
volume = "99",
pages = "2128--36",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - Effect of intermittent fasting and refeeding on insulin action in healthy men.

AU - Halberg, Nils

AU - Henriksen, Morten

AU - Söderhamn, Nathalie

AU - Stallknecht, Bente

AU - Ploug, Thorkil

AU - Schjerling, Peter

AU - Dela, Flemming

N1 - Keywords: Adult; Biological Clocks; Blood Glucose; Fasting; Feeding Behavior; Humans; Insulin; Insulin Resistance; Life Style; Male

PY - 2005

Y1 - 2005

N2 - Insulin resistance is currently a major health problem. This may be because of a marked decrease in daily physical activity during recent decades combined with constant food abundance. This lifestyle collides with our genome, which was most likely selected in the late Paleolithic era (50,000-10,000 BC) by criteria that favored survival in an environment characterized by fluctuations between periods of feast and famine. The theory of thrifty genes states that these fluctuations are required for optimal metabolic function. We mimicked the fluctuations in eight healthy young men [25.0 +/- 0.1 yr (mean +/- SE); body mass index: 25.7 +/- 0.4 kg/m(2)] by subjecting them to intermittent fasting every second day for 20 h for 15 days. Euglycemic hyperinsulinemic (40 mU.min(-1).m(-2)) clamps were performed before and after the intervention period. Subjects maintained body weight (86.4 +/- 2.3 kg; coefficient of variation: 0.8 +/- 0.1%). Plasma free fatty acid and beta-hydroxybutyrate concentrations were 347 +/- 18 and 0.06 +/- 0.02 mM, respectively, after overnight fast but increased (P < 0.05) to 423 +/- 86 and 0.10 +/- 0.04 mM after 20-h fasting, confirming that the subjects were fasting. Insulin-mediated whole body glucose uptake rates increased from 6.3 +/- 0.6 to 7.3 +/- 0.3 mg.kg(-1).min(-1) (P = 0.03), and insulin-induced inhibition of adipose tissue lipolysis was more prominent after than before the intervention (P = 0.05). After the 20-h fasting periods, plasma adiponectin was increased compared with the basal levels before and after the intervention (5,922 +/- 991 vs. 3,860 +/- 784 ng/ml, P = 0.02). This experiment is the first in humans to show that intermittent fasting increases insulin-mediated glucose uptake rates, and the findings are compatible with the thrifty gene concept.

AB - Insulin resistance is currently a major health problem. This may be because of a marked decrease in daily physical activity during recent decades combined with constant food abundance. This lifestyle collides with our genome, which was most likely selected in the late Paleolithic era (50,000-10,000 BC) by criteria that favored survival in an environment characterized by fluctuations between periods of feast and famine. The theory of thrifty genes states that these fluctuations are required for optimal metabolic function. We mimicked the fluctuations in eight healthy young men [25.0 +/- 0.1 yr (mean +/- SE); body mass index: 25.7 +/- 0.4 kg/m(2)] by subjecting them to intermittent fasting every second day for 20 h for 15 days. Euglycemic hyperinsulinemic (40 mU.min(-1).m(-2)) clamps were performed before and after the intervention period. Subjects maintained body weight (86.4 +/- 2.3 kg; coefficient of variation: 0.8 +/- 0.1%). Plasma free fatty acid and beta-hydroxybutyrate concentrations were 347 +/- 18 and 0.06 +/- 0.02 mM, respectively, after overnight fast but increased (P < 0.05) to 423 +/- 86 and 0.10 +/- 0.04 mM after 20-h fasting, confirming that the subjects were fasting. Insulin-mediated whole body glucose uptake rates increased from 6.3 +/- 0.6 to 7.3 +/- 0.3 mg.kg(-1).min(-1) (P = 0.03), and insulin-induced inhibition of adipose tissue lipolysis was more prominent after than before the intervention (P = 0.05). After the 20-h fasting periods, plasma adiponectin was increased compared with the basal levels before and after the intervention (5,922 +/- 991 vs. 3,860 +/- 784 ng/ml, P = 0.02). This experiment is the first in humans to show that intermittent fasting increases insulin-mediated glucose uptake rates, and the findings are compatible with the thrifty gene concept.

U2 - 10.1152/japplphysiol.00683.2005

DO - 10.1152/japplphysiol.00683.2005

M3 - Journal article

C2 - 16051710

VL - 99

SP - 2128

EP - 2136

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 6

ER -

ID: 8462292