Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight

Research output: Contribution to journalJournal articlepeer-review

Standard

Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight. / Sonne, M P; Højbjerre, L; Alibegovic, A C; Vaag, A; Stallknecht, B; Dela, F.

In: Journal of Vascular Research, Vol. 47, No. 2, 2009, p. 139-47.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Sonne, MP, Højbjerre, L, Alibegovic, AC, Vaag, A, Stallknecht, B & Dela, F 2009, 'Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight', Journal of Vascular Research, vol. 47, no. 2, pp. 139-47. https://doi.org/10.1159/000235968

APA

Sonne, M. P., Højbjerre, L., Alibegovic, A. C., Vaag, A., Stallknecht, B., & Dela, F. (2009). Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight. Journal of Vascular Research, 47(2), 139-47. https://doi.org/10.1159/000235968

Vancouver

Sonne MP, Højbjerre L, Alibegovic AC, Vaag A, Stallknecht B, Dela F. Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight. Journal of Vascular Research. 2009;47(2):139-47. https://doi.org/10.1159/000235968

Author

Sonne, M P ; Højbjerre, L ; Alibegovic, A C ; Vaag, A ; Stallknecht, B ; Dela, F. / Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight. In: Journal of Vascular Research. 2009 ; Vol. 47, No. 2. pp. 139-47.

Bibtex

@article{e716ac20365f11df8ed1000ea68e967b,
title = "Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight",
abstract = "BACKGROUND: Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22). METHODS: Insulin sensitivity and endothelial function was studied with venous occlusion plethysmography and intra-arterial infusions of adenosine and acetylcholine, before and during a hyperinsulinemic isoglycemic clamp. RESULTS: Forearm blood flow response to systemic hyperinsulinemia was diminished in LBW compared to controls (p < 0.05). Fractional arteriovenous glucose extraction was similar, and consequently insulin-stimulated forearm glucose clearance was diminished in LBW compared with controls (0.8 +/- 0.09 vs. 1.4 +/- 0.36 ml x 100 ml(-1) x min(-1), respectively, p < 0.05). Forearm blood flow response to adenosine and acetylcholine with or without insulin stimulation did not differ between groups. Whole-body glucose uptake was lower in LBW than controls (8.7 +/- 0.5 and 9.1 +/- 0.6 mg x min(-1) x kg(-1) lean body mass); however, this was not significant. CONCLUSIONS: Forearm blood flow response to insulin is impaired in LBW, whereas the response to adenosine and acetylcholine is preserved. The impaired insulin-mediated increase in bulk flow in LBW may be due to an impairment of insulin-mediated capillary recruitment independent of - or preceding - whole-body insulin resistance in LBW subjects.",
author = "Sonne, {M P} and L H{\o}jbjerre and Alibegovic, {A C} and A Vaag and B Stallknecht and F Dela",
note = "Keywords: Acetylcholine; Adenosine; Adult; Biological Transport; Blood Glucose; Case-Control Studies; Endothelium, Vascular; Forearm; Glucose Clamp Technique; Humans; Hyperemia; Hyperinsulinism; Infant, Low Birth Weight; Infant, Newborn; Inflammation Mediators; Infusions, Intra-Arterial; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Plethysmography; Regional Blood Flow; Time Factors; Vasodilation; Vasodilator Agents",
year = "2009",
doi = "10.1159/000235968",
language = "English",
volume = "47",
pages = "139--47",
journal = "Journal of Vascular Research",
issn = "1018-1172",
publisher = "S Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight

AU - Sonne, M P

AU - Højbjerre, L

AU - Alibegovic, A C

AU - Vaag, A

AU - Stallknecht, B

AU - Dela, F

N1 - Keywords: Acetylcholine; Adenosine; Adult; Biological Transport; Blood Glucose; Case-Control Studies; Endothelium, Vascular; Forearm; Glucose Clamp Technique; Humans; Hyperemia; Hyperinsulinism; Infant, Low Birth Weight; Infant, Newborn; Inflammation Mediators; Infusions, Intra-Arterial; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Plethysmography; Regional Blood Flow; Time Factors; Vasodilation; Vasodilator Agents

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22). METHODS: Insulin sensitivity and endothelial function was studied with venous occlusion plethysmography and intra-arterial infusions of adenosine and acetylcholine, before and during a hyperinsulinemic isoglycemic clamp. RESULTS: Forearm blood flow response to systemic hyperinsulinemia was diminished in LBW compared to controls (p < 0.05). Fractional arteriovenous glucose extraction was similar, and consequently insulin-stimulated forearm glucose clearance was diminished in LBW compared with controls (0.8 +/- 0.09 vs. 1.4 +/- 0.36 ml x 100 ml(-1) x min(-1), respectively, p < 0.05). Forearm blood flow response to adenosine and acetylcholine with or without insulin stimulation did not differ between groups. Whole-body glucose uptake was lower in LBW than controls (8.7 +/- 0.5 and 9.1 +/- 0.6 mg x min(-1) x kg(-1) lean body mass); however, this was not significant. CONCLUSIONS: Forearm blood flow response to insulin is impaired in LBW, whereas the response to adenosine and acetylcholine is preserved. The impaired insulin-mediated increase in bulk flow in LBW may be due to an impairment of insulin-mediated capillary recruitment independent of - or preceding - whole-body insulin resistance in LBW subjects.

AB - BACKGROUND: Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22). METHODS: Insulin sensitivity and endothelial function was studied with venous occlusion plethysmography and intra-arterial infusions of adenosine and acetylcholine, before and during a hyperinsulinemic isoglycemic clamp. RESULTS: Forearm blood flow response to systemic hyperinsulinemia was diminished in LBW compared to controls (p < 0.05). Fractional arteriovenous glucose extraction was similar, and consequently insulin-stimulated forearm glucose clearance was diminished in LBW compared with controls (0.8 +/- 0.09 vs. 1.4 +/- 0.36 ml x 100 ml(-1) x min(-1), respectively, p < 0.05). Forearm blood flow response to adenosine and acetylcholine with or without insulin stimulation did not differ between groups. Whole-body glucose uptake was lower in LBW than controls (8.7 +/- 0.5 and 9.1 +/- 0.6 mg x min(-1) x kg(-1) lean body mass); however, this was not significant. CONCLUSIONS: Forearm blood flow response to insulin is impaired in LBW, whereas the response to adenosine and acetylcholine is preserved. The impaired insulin-mediated increase in bulk flow in LBW may be due to an impairment of insulin-mediated capillary recruitment independent of - or preceding - whole-body insulin resistance in LBW subjects.

U2 - 10.1159/000235968

DO - 10.1159/000235968

M3 - Journal article

C2 - 19729960

VL - 47

SP - 139

EP - 147

JO - Journal of Vascular Research

JF - Journal of Vascular Research

SN - 1018-1172

IS - 2

ER -

ID: 18787683