Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study
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Differential time responses in inflammatory and oxidative stress markers after a marathon : An observational study. / Larsen, Emil List; Poulsen, Henrik Enghusen; Michaelsen, Cristina; Kjær, Laura Kofoed; Lyngbæk, Mark; Andersen, Emilie Skytte; Petersen-Bønding, Christina; Lemoine, Clara; Gillum, Matthew; Jørgensen, Niklas Rye; Ploug, Thorkil; Vilsbøll, Tina; Knop, Filip Krag; Karstoft, Kristian.
In: Journal of Sports Sciences, Vol. 38, No. 18, 2020, p. 2080-2091.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Differential time responses in inflammatory and oxidative stress markers after a marathon
T2 - An observational study
AU - Larsen, Emil List
AU - Poulsen, Henrik Enghusen
AU - Michaelsen, Cristina
AU - Kjær, Laura Kofoed
AU - Lyngbæk, Mark
AU - Andersen, Emilie Skytte
AU - Petersen-Bønding, Christina
AU - Lemoine, Clara
AU - Gillum, Matthew
AU - Jørgensen, Niklas Rye
AU - Ploug, Thorkil
AU - Vilsbøll, Tina
AU - Knop, Filip Krag
AU - Karstoft, Kristian
PY - 2020
Y1 - 2020
N2 - Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95% CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95%CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. Abbreviations: 8-oxodG: 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography.
AB - Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95% CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95%CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. Abbreviations: 8-oxodG: 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography.
KW - Bone metabolism
KW - exercise
KW - fibroblast growth factor 21
KW - inflammation
KW - oxidative stress
U2 - 10.1080/02640414.2020.1770918
DO - 10.1080/02640414.2020.1770918
M3 - Journal article
C2 - 32530734
AN - SCOPUS:85087130837
VL - 38
SP - 2080
EP - 2091
JO - Journal of Sports Sciences
JF - Journal of Sports Sciences
SN - 0264-0414
IS - 18
ER -
ID: 246869454