Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise. / Pedersen, Philip Juul; Karlsson, Madeleine; Madsen, Mette Flethøj; Trachsel, Dagmar Senta; Kanters, Jørgen K.; Klærke, Dan Arne; Buhl, Rikke.

In: Journal of Veterinary Cardiology, Vol. 18, No. 3, 2016, p. 255-264.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pedersen, PJ, Karlsson, M, Madsen, MF, Trachsel, DS, Kanters, JK, Klærke, DA & Buhl, R 2016, 'Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise', Journal of Veterinary Cardiology, vol. 18, no. 3, pp. 255-264. https://doi.org/10.1016/j.jvc.2016.02.002

APA

Pedersen, P. J., Karlsson, M., Madsen, M. F., Trachsel, D. S., Kanters, J. K., Klærke, D. A., & Buhl, R. (2016). Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise. Journal of Veterinary Cardiology, 18(3), 255-264. https://doi.org/10.1016/j.jvc.2016.02.002

Vancouver

Pedersen PJ, Karlsson M, Madsen MF, Trachsel DS, Kanters JK, Klærke DA et al. Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise. Journal of Veterinary Cardiology. 2016;18(3):255-264. https://doi.org/10.1016/j.jvc.2016.02.002

Author

Pedersen, Philip Juul ; Karlsson, Madeleine ; Madsen, Mette Flethøj ; Trachsel, Dagmar Senta ; Kanters, Jørgen K. ; Klærke, Dan Arne ; Buhl, Rikke. / Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise. In: Journal of Veterinary Cardiology. 2016 ; Vol. 18, No. 3. pp. 255-264.

Bibtex

@article{41719861306a43038034d584b6ed85c5,
title = "Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise",
abstract = "OBJECTIVES: Quantitative measurements of cardiac repolarization, defined as the electrocardiographic QT interval, have important diagnostic implications in humans, as irregularities can trigger potentially fatal ventricular tachyarrhythmia. In both humans and horses, cardiac repolarization is influenced to some extent by heart rate, age, body weight (BW), sex, autonomic tone, and environment. In horses, there is substantial inter-breed variation in size and training, and the aims of this study were therefore to determine the best model describing the QT to RR relationship in breeds of various athletic horses and to test for differences in the QT interval.ANIMALS: Ten Icelandic horses, 10 Arabian horses, 10 Thoroughbreds, 10 Standardbreds, six Coldblood trotters, 10 Warmbloods (dressage) and 10 Warmbloods (show jumping). All horses were geldings.METHODS: QT intervals were measured from resting to peak exercise level and plotted against RR intervals. Data points were fitted with relevant regression models, and the effect of breed, BW, and estimated exercise intensity was examined.RESULTS: For all breeds in this study, the QT interval was best described as a function of RR by the piecewise linear regression model. The breed of horse had a significant effect on the model. There was no systematic effect of BW or estimated exercise intensity, but a high inter-horse variability was observed.CONCLUSIONS: The equine QT interval should preferably be corrected for heart rate according to breed. In addition, the results indicate that equine studies of the QT interval must be designed to eliminate the influence of a large inter-horse variation.",
keywords = "Journal Article",
author = "Pedersen, {Philip Juul} and Madeleine Karlsson and Madsen, {Mette Fleth{\o}j} and Trachsel, {Dagmar Senta} and Kanters, {J{\o}rgen K.} and Kl{\ae}rke, {Dan Arne} and Rikke Buhl",
note = "Copyright {\circledC} 2016 Elsevier B.V. All rights reserved.",
year = "2016",
doi = "10.1016/j.jvc.2016.02.002",
language = "English",
volume = "18",
pages = "255--264",
journal = "Journal of Veterinary Cardiology",
issn = "1760-2734",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise

AU - Pedersen, Philip Juul

AU - Karlsson, Madeleine

AU - Madsen, Mette Flethøj

AU - Trachsel, Dagmar Senta

AU - Kanters, Jørgen K.

AU - Klærke, Dan Arne

AU - Buhl, Rikke

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016

Y1 - 2016

N2 - OBJECTIVES: Quantitative measurements of cardiac repolarization, defined as the electrocardiographic QT interval, have important diagnostic implications in humans, as irregularities can trigger potentially fatal ventricular tachyarrhythmia. In both humans and horses, cardiac repolarization is influenced to some extent by heart rate, age, body weight (BW), sex, autonomic tone, and environment. In horses, there is substantial inter-breed variation in size and training, and the aims of this study were therefore to determine the best model describing the QT to RR relationship in breeds of various athletic horses and to test for differences in the QT interval.ANIMALS: Ten Icelandic horses, 10 Arabian horses, 10 Thoroughbreds, 10 Standardbreds, six Coldblood trotters, 10 Warmbloods (dressage) and 10 Warmbloods (show jumping). All horses were geldings.METHODS: QT intervals were measured from resting to peak exercise level and plotted against RR intervals. Data points were fitted with relevant regression models, and the effect of breed, BW, and estimated exercise intensity was examined.RESULTS: For all breeds in this study, the QT interval was best described as a function of RR by the piecewise linear regression model. The breed of horse had a significant effect on the model. There was no systematic effect of BW or estimated exercise intensity, but a high inter-horse variability was observed.CONCLUSIONS: The equine QT interval should preferably be corrected for heart rate according to breed. In addition, the results indicate that equine studies of the QT interval must be designed to eliminate the influence of a large inter-horse variation.

AB - OBJECTIVES: Quantitative measurements of cardiac repolarization, defined as the electrocardiographic QT interval, have important diagnostic implications in humans, as irregularities can trigger potentially fatal ventricular tachyarrhythmia. In both humans and horses, cardiac repolarization is influenced to some extent by heart rate, age, body weight (BW), sex, autonomic tone, and environment. In horses, there is substantial inter-breed variation in size and training, and the aims of this study were therefore to determine the best model describing the QT to RR relationship in breeds of various athletic horses and to test for differences in the QT interval.ANIMALS: Ten Icelandic horses, 10 Arabian horses, 10 Thoroughbreds, 10 Standardbreds, six Coldblood trotters, 10 Warmbloods (dressage) and 10 Warmbloods (show jumping). All horses were geldings.METHODS: QT intervals were measured from resting to peak exercise level and plotted against RR intervals. Data points were fitted with relevant regression models, and the effect of breed, BW, and estimated exercise intensity was examined.RESULTS: For all breeds in this study, the QT interval was best described as a function of RR by the piecewise linear regression model. The breed of horse had a significant effect on the model. There was no systematic effect of BW or estimated exercise intensity, but a high inter-horse variability was observed.CONCLUSIONS: The equine QT interval should preferably be corrected for heart rate according to breed. In addition, the results indicate that equine studies of the QT interval must be designed to eliminate the influence of a large inter-horse variation.

KW - Journal Article

U2 - 10.1016/j.jvc.2016.02.002

DO - 10.1016/j.jvc.2016.02.002

M3 - Journal article

C2 - 27068842

VL - 18

SP - 255

EP - 264

JO - Journal of Veterinary Cardiology

JF - Journal of Veterinary Cardiology

SN - 1760-2734

IS - 3

ER -

ID: 165711238