Connexins and Disease

Research output: Contribution to journalJournal article

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Connexins and Disease. / Delmar, Mario; Laird, Dale W; Naus, Christian C; Nielsen, Morten S; Verselis, Vytautas K; White, Thomas W.

In: Cold Spring Harbor perspectives in biology, Vol. 10, No. 9, a029348, 2018, p. 1-18.

Research output: Contribution to journalJournal article

Harvard

Delmar, M, Laird, DW, Naus, CC, Nielsen, MS, Verselis, VK & White, TW 2018, 'Connexins and Disease', Cold Spring Harbor perspectives in biology, vol. 10, no. 9, a029348, pp. 1-18. https://doi.org/10.1101/cshperspect.a029348

APA

Delmar, M., Laird, D. W., Naus, C. C., Nielsen, M. S., Verselis, V. K., & White, T. W. (2018). Connexins and Disease. Cold Spring Harbor perspectives in biology, 10(9), 1-18. [a029348]. https://doi.org/10.1101/cshperspect.a029348

Vancouver

Delmar M, Laird DW, Naus CC, Nielsen MS, Verselis VK, White TW. Connexins and Disease. Cold Spring Harbor perspectives in biology. 2018;10(9):1-18. a029348. https://doi.org/10.1101/cshperspect.a029348

Author

Delmar, Mario ; Laird, Dale W ; Naus, Christian C ; Nielsen, Morten S ; Verselis, Vytautas K ; White, Thomas W. / Connexins and Disease. In: Cold Spring Harbor perspectives in biology. 2018 ; Vol. 10, No. 9. pp. 1-18.

Bibtex

@article{2f8a518220c44d7585366872ee1979c0,
title = "Connexins and Disease",
abstract = "Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system, cochlea, and skin, as well as cancer and pleiotropic syndromes such as oculodentodigital dysplasia (ODDD). Although incomplete by virtue of space and the extent of the topic, this review emphasizes the fact that connexin function is not only associated with gap junction channel formation. As such, both canonical and noncanonical functions of connexins are fundamental components in the pathophysiology of multiple connexin related disorders, many of them highly debilitating and life threatening. Improved understanding of connexin biology has the potential to advance our understanding of mechanisms, diagnosis, and treatment of disease.",
author = "Mario Delmar and Laird, {Dale W} and Naus, {Christian C} and Nielsen, {Morten S} and Verselis, {Vytautas K} and White, {Thomas W}",
note = "Copyright {\circledC} 2017 Cold Spring Harbor Laboratory Press; all rights reserved.",
year = "2018",
doi = "10.1101/cshperspect.a029348",
language = "English",
volume = "10",
pages = "1--18",
journal = "Cold Spring Harbor Perspectives in Biology",
issn = "1943-0264",
publisher = "Cold Spring Harbor Laboratory Press",
number = "9",

}

RIS

TY - JOUR

T1 - Connexins and Disease

AU - Delmar, Mario

AU - Laird, Dale W

AU - Naus, Christian C

AU - Nielsen, Morten S

AU - Verselis, Vytautas K

AU - White, Thomas W

N1 - Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

PY - 2018

Y1 - 2018

N2 - Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system, cochlea, and skin, as well as cancer and pleiotropic syndromes such as oculodentodigital dysplasia (ODDD). Although incomplete by virtue of space and the extent of the topic, this review emphasizes the fact that connexin function is not only associated with gap junction channel formation. As such, both canonical and noncanonical functions of connexins are fundamental components in the pathophysiology of multiple connexin related disorders, many of them highly debilitating and life threatening. Improved understanding of connexin biology has the potential to advance our understanding of mechanisms, diagnosis, and treatment of disease.

AB - Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system, cochlea, and skin, as well as cancer and pleiotropic syndromes such as oculodentodigital dysplasia (ODDD). Although incomplete by virtue of space and the extent of the topic, this review emphasizes the fact that connexin function is not only associated with gap junction channel formation. As such, both canonical and noncanonical functions of connexins are fundamental components in the pathophysiology of multiple connexin related disorders, many of them highly debilitating and life threatening. Improved understanding of connexin biology has the potential to advance our understanding of mechanisms, diagnosis, and treatment of disease.

UR - http://www.scopus.com/inward/record.url?scp=85028939329&partnerID=8YFLogxK

U2 - 10.1101/cshperspect.a029348

DO - 10.1101/cshperspect.a029348

M3 - Journal article

C2 - 28778872

VL - 10

SP - 1

EP - 18

JO - Cold Spring Harbor Perspectives in Biology

JF - Cold Spring Harbor Perspectives in Biology

SN - 1943-0264

IS - 9

M1 - a029348

ER -

ID: 194908524