TY - JOUR

T1 - Cardiovascular disease markers in type 2 diabetes: the effects of a moderate home-based exercise training programme

AU - Scheede-Bergdahl, Celena

AU - Benee Olsen, David

AU - Reving, Danny

AU - Boushel, Robert

AU - Dela, Flemming

N1 - Keywords: Biological Markers; Blood Glucose; Body Composition; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelin-1; Exercise Therapy; Glucose Tolerance Test; Hemoglobin A, Glycosylated; Home Care Services; Humans; Insulin; Intercellular Adhesion Molecule-1; Male; Middle Aged; Oxygen Consumption; Program Evaluation; Time Factors; Treatment Outcome; Vascular Cell Adhesion Molecule-1; von Willebrand Factor

PY - 2009

Y1 - 2009

N2 - Patients with T2DM have an increased risk of CVD. Prevention of CVD represents the major goal of all treatment of T2DM, and early intervention in those patients at particularly high risk is important.We measured the insulin sensitivity and plasma biomarkers of CVD to determine whether a home-based exercise training program improves biomarker levels and insulin sensitivity. Patients with T2DM (n=12), IGT (n=4) and healthy control subjects (n=9) were studied before and after eight weeks of exercise training by rowing ergometry at 65-70% of peak oxygen uptake. Conclusions: 1) patients with T2DM have elevated plasma concentrations of CVD biomarkers compared to the matched control and IGT groups; 2) a moderate to vigorous intensity home-based training program did not reduce plasma concentrations of these CVD markers; 3) insulin sensitivity improved as a result of exercise training in the control group, but not in the T2DM group.

AB - Patients with T2DM have an increased risk of CVD. Prevention of CVD represents the major goal of all treatment of T2DM, and early intervention in those patients at particularly high risk is important.We measured the insulin sensitivity and plasma biomarkers of CVD to determine whether a home-based exercise training program improves biomarker levels and insulin sensitivity. Patients with T2DM (n=12), IGT (n=4) and healthy control subjects (n=9) were studied before and after eight weeks of exercise training by rowing ergometry at 65-70% of peak oxygen uptake. Conclusions: 1) patients with T2DM have elevated plasma concentrations of CVD biomarkers compared to the matched control and IGT groups; 2) a moderate to vigorous intensity home-based training program did not reduce plasma concentrations of these CVD markers; 3) insulin sensitivity improved as a result of exercise training in the control group, but not in the T2DM group.

U2 - 10.1177/1479164109341689

DO - 10.1177/1479164109341689

M3 - Journal article

C2 - 20368225

VL - 6

SP - 291

EP - 296

JO - Diabetes and Vascular Disease Research

JF - Diabetes and Vascular Disease Research

SN - 1479-1641

IS - 4

ER -