Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications

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Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications. / Urizar, Adriana Ibarra; Prause, Michala; Wortham, Matthew; Sui, Yinghui; Thams, Peter; Sander, Maike; Christensen, Gitte Lund; Billestrup, Nils.

In: Molecular and Cellular Endocrinology, Vol. 496, 110524 , 2019.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Urizar, AI, Prause, M, Wortham, M, Sui, Y, Thams, P, Sander, M, Christensen, GL & Billestrup, N 2019, 'Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications', Molecular and Cellular Endocrinology, vol. 496, 110524 . https://doi.org/10.1016/j.mce.2019.110524

APA

Urizar, A. I., Prause, M., Wortham, M., Sui, Y., Thams, P., Sander, M., ... Billestrup, N. (2019). Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications. Molecular and Cellular Endocrinology, 496, [110524 ]. https://doi.org/10.1016/j.mce.2019.110524

Vancouver

Urizar AI, Prause M, Wortham M, Sui Y, Thams P, Sander M et al. Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications. Molecular and Cellular Endocrinology. 2019;496. 110524 . https://doi.org/10.1016/j.mce.2019.110524

Author

Urizar, Adriana Ibarra ; Prause, Michala ; Wortham, Matthew ; Sui, Yinghui ; Thams, Peter ; Sander, Maike ; Christensen, Gitte Lund ; Billestrup, Nils. / Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications. In: Molecular and Cellular Endocrinology. 2019 ; Vol. 496.

Bibtex

@article{dae805d2cc584c63b3d9d1ca860c6317,
title = "Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications",
abstract = "Decreased insulin secretory capacity in Type 2 diabetes mellitus is associated with beta-cell dedifferentiation and inflammation. We hypothesize that prolonged exposure of beta-cells to low concentrations of IL-1 beta induce beta-cell dedifferentiation characterized by impaired glucose-stimulated insulin secretion, reduced expression of key beta-cell genes and changes in histone modifications at gene loci known to affect beta-cell function. Ten days exposure to IL-1 beta at non-cytotoxic concentrations reduced insulin secretion and beta-cell proliferation and decreased expression of key beta-cell identity genes, including MafA and Ucn3 and decreased H3K27ac at the gene loci, suggesting that inflammatory cytokines directly affects the epigenome. Following removal of IL-1 beta, beta-cell function was normalized and mRNA expression of beta-cell identity genes, such as insulin and Ucn3 returned to pre-stimulation levels. Our findings indicate that prolonged exposure to low concentrations of IL-1 beta induces epigenetic changes associated with loss of beta-cell identity as observed in Type 2 diabetes",
keywords = "Beta-cell dysfunction, Histone modifications, Beta-cell dedifferentiation, Cytokines, Proliferation, Insulin secretion",
author = "Urizar, {Adriana Ibarra} and Michala Prause and Matthew Wortham and Yinghui Sui and Peter Thams and Maike Sander and Christensen, {Gitte Lund} and Nils Billestrup",
year = "2019",
doi = "10.1016/j.mce.2019.110524",
language = "English",
volume = "496",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications

AU - Urizar, Adriana Ibarra

AU - Prause, Michala

AU - Wortham, Matthew

AU - Sui, Yinghui

AU - Thams, Peter

AU - Sander, Maike

AU - Christensen, Gitte Lund

AU - Billestrup, Nils

PY - 2019

Y1 - 2019

N2 - Decreased insulin secretory capacity in Type 2 diabetes mellitus is associated with beta-cell dedifferentiation and inflammation. We hypothesize that prolonged exposure of beta-cells to low concentrations of IL-1 beta induce beta-cell dedifferentiation characterized by impaired glucose-stimulated insulin secretion, reduced expression of key beta-cell genes and changes in histone modifications at gene loci known to affect beta-cell function. Ten days exposure to IL-1 beta at non-cytotoxic concentrations reduced insulin secretion and beta-cell proliferation and decreased expression of key beta-cell identity genes, including MafA and Ucn3 and decreased H3K27ac at the gene loci, suggesting that inflammatory cytokines directly affects the epigenome. Following removal of IL-1 beta, beta-cell function was normalized and mRNA expression of beta-cell identity genes, such as insulin and Ucn3 returned to pre-stimulation levels. Our findings indicate that prolonged exposure to low concentrations of IL-1 beta induces epigenetic changes associated with loss of beta-cell identity as observed in Type 2 diabetes

AB - Decreased insulin secretory capacity in Type 2 diabetes mellitus is associated with beta-cell dedifferentiation and inflammation. We hypothesize that prolonged exposure of beta-cells to low concentrations of IL-1 beta induce beta-cell dedifferentiation characterized by impaired glucose-stimulated insulin secretion, reduced expression of key beta-cell genes and changes in histone modifications at gene loci known to affect beta-cell function. Ten days exposure to IL-1 beta at non-cytotoxic concentrations reduced insulin secretion and beta-cell proliferation and decreased expression of key beta-cell identity genes, including MafA and Ucn3 and decreased H3K27ac at the gene loci, suggesting that inflammatory cytokines directly affects the epigenome. Following removal of IL-1 beta, beta-cell function was normalized and mRNA expression of beta-cell identity genes, such as insulin and Ucn3 returned to pre-stimulation levels. Our findings indicate that prolonged exposure to low concentrations of IL-1 beta induces epigenetic changes associated with loss of beta-cell identity as observed in Type 2 diabetes

KW - Beta-cell dysfunction

KW - Histone modifications

KW - Beta-cell dedifferentiation

KW - Cytokines

KW - Proliferation

KW - Insulin secretion

U2 - 10.1016/j.mce.2019.110524

DO - 10.1016/j.mce.2019.110524

M3 - Review

C2 - 31362031

VL - 496

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

M1 - 110524

ER -

ID: 228452365