Azocompounds as generators of defined radical species: Contributions and challenges for free radical research

Research output: Contribution to journalReviewpeer-review

Standard

Azocompounds as generators of defined radical species : Contributions and challenges for free radical research. / López-Alarcón, Camilo; Fuentes-Lemus, Eduardo; Figueroa, Juan David; Dorta, Eva; Schöneich, Christian; Davies, Michael J.

In: Free Radical Biology and Medicine, Vol. 160, 2020, p. 78-91.

Research output: Contribution to journalReviewpeer-review

Harvard

López-Alarcón, C, Fuentes-Lemus, E, Figueroa, JD, Dorta, E, Schöneich, C & Davies, MJ 2020, 'Azocompounds as generators of defined radical species: Contributions and challenges for free radical research', Free Radical Biology and Medicine, vol. 160, pp. 78-91. https://doi.org/10.1016/j.freeradbiomed.2020.06.021

APA

López-Alarcón, C., Fuentes-Lemus, E., Figueroa, J. D., Dorta, E., Schöneich, C., & Davies, M. J. (2020). Azocompounds as generators of defined radical species: Contributions and challenges for free radical research. Free Radical Biology and Medicine, 160, 78-91. https://doi.org/10.1016/j.freeradbiomed.2020.06.021

Vancouver

López-Alarcón C, Fuentes-Lemus E, Figueroa JD, Dorta E, Schöneich C, Davies MJ. Azocompounds as generators of defined radical species: Contributions and challenges for free radical research. Free Radical Biology and Medicine. 2020;160:78-91. https://doi.org/10.1016/j.freeradbiomed.2020.06.021

Author

López-Alarcón, Camilo ; Fuentes-Lemus, Eduardo ; Figueroa, Juan David ; Dorta, Eva ; Schöneich, Christian ; Davies, Michael J. / Azocompounds as generators of defined radical species : Contributions and challenges for free radical research. In: Free Radical Biology and Medicine. 2020 ; Vol. 160. pp. 78-91.

Bibtex

@article{2471b92ebab74854af8ef5c21bb1b0e8,
title = "Azocompounds as generators of defined radical species: Contributions and challenges for free radical research",
abstract = "Peroxyl radicals participate in multiple processes involved in critical changes to cells, tissues, pharmacueticals and foods. Some of these reactions explain their association with degenerative pathologies, including cardiovascular and neurological diseases, as well as cancer development. Azocompounds, and particularly AAPH (2,2′-Azobis(2-methylpropionamidine) dihydrochloride), a cationic water-soluble derivative, have been employed extensively as sources of model peroxyl radicals. A considerable number of studies have reported mechanistic data on the oxidation of biologically-relevant targets, the scavenging activity of foods and natural products, and the reactions with, and responses of, cultured cells. However, despite the (supposed) experimental simplicity of using azocompounds, the chemistry of peroxyl radical production and subsequent reactions is complicated, and not always considered in sufficient depth when analyzing experimental data. The present work discusses the chemical aspects of azocompounds as generators of peroxyl (and other) radicals, together with their contribution to our understanding of biochemistry, pharmaceutical and food chemistry research. The evidence supporting a role for the formation of alkoxyl (RO•) and other radicals during thermal and photochemical decomposition of azocompounds is assessed, together with the potential influence of such species on the reactions under study.",
keywords = "AAPH, Alkoxyl radicals, Azocompounds, Cell cultures, Erythrocytes, Foods, Natural products, Peroxyl radicals, Protein oxidation, Scavenging activity",
author = "Camilo L{\'o}pez-Alarc{\'o}n and Eduardo Fuentes-Lemus and Figueroa, {Juan David} and Eva Dorta and Christian Sch{\"o}neich and Davies, {Michael J.}",
year = "2020",
doi = "10.1016/j.freeradbiomed.2020.06.021",
language = "English",
volume = "160",
pages = "78--91",
journal = "Free Radical Biology & Medicine",
issn = "0891-5849",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Azocompounds as generators of defined radical species

T2 - Contributions and challenges for free radical research

AU - López-Alarcón, Camilo

AU - Fuentes-Lemus, Eduardo

AU - Figueroa, Juan David

AU - Dorta, Eva

AU - Schöneich, Christian

AU - Davies, Michael J.

PY - 2020

Y1 - 2020

N2 - Peroxyl radicals participate in multiple processes involved in critical changes to cells, tissues, pharmacueticals and foods. Some of these reactions explain their association with degenerative pathologies, including cardiovascular and neurological diseases, as well as cancer development. Azocompounds, and particularly AAPH (2,2′-Azobis(2-methylpropionamidine) dihydrochloride), a cationic water-soluble derivative, have been employed extensively as sources of model peroxyl radicals. A considerable number of studies have reported mechanistic data on the oxidation of biologically-relevant targets, the scavenging activity of foods and natural products, and the reactions with, and responses of, cultured cells. However, despite the (supposed) experimental simplicity of using azocompounds, the chemistry of peroxyl radical production and subsequent reactions is complicated, and not always considered in sufficient depth when analyzing experimental data. The present work discusses the chemical aspects of azocompounds as generators of peroxyl (and other) radicals, together with their contribution to our understanding of biochemistry, pharmaceutical and food chemistry research. The evidence supporting a role for the formation of alkoxyl (RO•) and other radicals during thermal and photochemical decomposition of azocompounds is assessed, together with the potential influence of such species on the reactions under study.

AB - Peroxyl radicals participate in multiple processes involved in critical changes to cells, tissues, pharmacueticals and foods. Some of these reactions explain their association with degenerative pathologies, including cardiovascular and neurological diseases, as well as cancer development. Azocompounds, and particularly AAPH (2,2′-Azobis(2-methylpropionamidine) dihydrochloride), a cationic water-soluble derivative, have been employed extensively as sources of model peroxyl radicals. A considerable number of studies have reported mechanistic data on the oxidation of biologically-relevant targets, the scavenging activity of foods and natural products, and the reactions with, and responses of, cultured cells. However, despite the (supposed) experimental simplicity of using azocompounds, the chemistry of peroxyl radical production and subsequent reactions is complicated, and not always considered in sufficient depth when analyzing experimental data. The present work discusses the chemical aspects of azocompounds as generators of peroxyl (and other) radicals, together with their contribution to our understanding of biochemistry, pharmaceutical and food chemistry research. The evidence supporting a role for the formation of alkoxyl (RO•) and other radicals during thermal and photochemical decomposition of azocompounds is assessed, together with the potential influence of such species on the reactions under study.

KW - AAPH

KW - Alkoxyl radicals

KW - Azocompounds

KW - Cell cultures

KW - Erythrocytes

KW - Foods

KW - Natural products

KW - Peroxyl radicals

KW - Protein oxidation

KW - Scavenging activity

UR - http://www.scopus.com/inward/record.url?scp=85089516426&partnerID=8YFLogxK

U2 - 10.1016/j.freeradbiomed.2020.06.021

DO - 10.1016/j.freeradbiomed.2020.06.021

M3 - Review

C2 - 32771519

AN - SCOPUS:85089516426

VL - 160

SP - 78

EP - 91

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

ER -

ID: 251307748