[68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction

Research output: Contribution to journalJournal articlepeer-review

Standard

[68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction. / Bentsen, Simon; Clemmensen, Andreas; Loft, Mathias; Flethøj, Mette; Debes, Karina Poulsdóttir; Ludvigsen, Trine Pagh; Larsen, Cecilie Bjørstrup; Kirchhoff, Jeppe; Olsen, Lisbeth Høier; Møller, Jacob Eifer; Andersen, Thomas Lund; Johannesen, Helle Hjorth; Jespersen, Thomas; Kjaer, Andreas.

In: Diagnostics, Vol. 11, No. 10, 1807, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bentsen, S, Clemmensen, A, Loft, M, Flethøj, M, Debes, KP, Ludvigsen, TP, Larsen, CB, Kirchhoff, J, Olsen, LH, Møller, JE, Andersen, TL, Johannesen, HH, Jespersen, T & Kjaer, A 2021, '[68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction', Diagnostics, vol. 11, no. 10, 1807. https://doi.org/10.3390/diagnostics11101807

APA

Bentsen, S., Clemmensen, A., Loft, M., Flethøj, M., Debes, K. P., Ludvigsen, T. P., Larsen, C. B., Kirchhoff, J., Olsen, L. H., Møller, J. E., Andersen, T. L., Johannesen, H. H., Jespersen, T., & Kjaer, A. (2021). [68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction. Diagnostics, 11(10), [1807]. https://doi.org/10.3390/diagnostics11101807

Vancouver

Bentsen S, Clemmensen A, Loft M, Flethøj M, Debes KP, Ludvigsen TP et al. [68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction. Diagnostics. 2021;11(10). 1807. https://doi.org/10.3390/diagnostics11101807

Author

Bentsen, Simon ; Clemmensen, Andreas ; Loft, Mathias ; Flethøj, Mette ; Debes, Karina Poulsdóttir ; Ludvigsen, Trine Pagh ; Larsen, Cecilie Bjørstrup ; Kirchhoff, Jeppe ; Olsen, Lisbeth Høier ; Møller, Jacob Eifer ; Andersen, Thomas Lund ; Johannesen, Helle Hjorth ; Jespersen, Thomas ; Kjaer, Andreas. / [68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction. In: Diagnostics. 2021 ; Vol. 11, No. 10.

Bibtex

@article{53445cb19013482cad53e3d077d23c86,
title = "[68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction",
abstract = "Angiogenesis is crucial in tissue repair and prevents scar tissue formation following an ischemic event such as myocardial infarction. The ischemia induces formation of new capillaries, which have high expression of integrin αvβ3. [68Ga]Ga-NODAGA-E[(cRGDyK)]2 ([68Ga]Ga-RGD) is a promising PET-radiotracer reflecting angiogenesis by binding to integrin αvβ3. A G{\"o}ttingen mini-pig underwent transient catheter-induced left anterior descending artery (LAD) occlusion for 120 min, and after 8 weeks was imaged on a Siemens mMR 3T PET/MR system. A large antero-septal infarction was evident by late gadolinium enhancement (LGE) on the short axis and 2-4 chamber views. The infarcted area corresponded to the area with high [68Ga]Ga-RGD uptake on the fused PET/MR images, with no uptake in the healthy myocardium. To support the hypothesis that [68Ga]Ga-RGD uptake reflects angiogenesis, biopsies were sampled from the infarct border and healthy myocardium. Expression of αvβ3 was evaluated using immunohistochemistry. The staining showed higher αvβ3 expression in the capillaries of the infarct border compared to those in the healthy myocardium. These initial data confirm in vivo detection of angiogenesis using [68Ga]Ga-RGD PET in a translational model, which overall support the method applicability when evaluating novel cardio-protective therapies.",
author = "Simon Bentsen and Andreas Clemmensen and Mathias Loft and Mette Fleth{\o}j and Debes, {Karina Poulsd{\'o}ttir} and Ludvigsen, {Trine Pagh} and Larsen, {Cecilie Bj{\o}rstrup} and Jeppe Kirchhoff and Olsen, {Lisbeth H{\o}ier} and M{\o}ller, {Jacob Eifer} and Andersen, {Thomas Lund} and Johannesen, {Helle Hjorth} and Thomas Jespersen and Andreas Kjaer",
year = "2021",
doi = "10.3390/diagnostics11101807",
language = "English",
volume = "11",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "MDPI AG",
number = "10",

}

RIS

TY - JOUR

T1 - [68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction

AU - Bentsen, Simon

AU - Clemmensen, Andreas

AU - Loft, Mathias

AU - Flethøj, Mette

AU - Debes, Karina Poulsdóttir

AU - Ludvigsen, Trine Pagh

AU - Larsen, Cecilie Bjørstrup

AU - Kirchhoff, Jeppe

AU - Olsen, Lisbeth Høier

AU - Møller, Jacob Eifer

AU - Andersen, Thomas Lund

AU - Johannesen, Helle Hjorth

AU - Jespersen, Thomas

AU - Kjaer, Andreas

PY - 2021

Y1 - 2021

N2 - Angiogenesis is crucial in tissue repair and prevents scar tissue formation following an ischemic event such as myocardial infarction. The ischemia induces formation of new capillaries, which have high expression of integrin αvβ3. [68Ga]Ga-NODAGA-E[(cRGDyK)]2 ([68Ga]Ga-RGD) is a promising PET-radiotracer reflecting angiogenesis by binding to integrin αvβ3. A Göttingen mini-pig underwent transient catheter-induced left anterior descending artery (LAD) occlusion for 120 min, and after 8 weeks was imaged on a Siemens mMR 3T PET/MR system. A large antero-septal infarction was evident by late gadolinium enhancement (LGE) on the short axis and 2-4 chamber views. The infarcted area corresponded to the area with high [68Ga]Ga-RGD uptake on the fused PET/MR images, with no uptake in the healthy myocardium. To support the hypothesis that [68Ga]Ga-RGD uptake reflects angiogenesis, biopsies were sampled from the infarct border and healthy myocardium. Expression of αvβ3 was evaluated using immunohistochemistry. The staining showed higher αvβ3 expression in the capillaries of the infarct border compared to those in the healthy myocardium. These initial data confirm in vivo detection of angiogenesis using [68Ga]Ga-RGD PET in a translational model, which overall support the method applicability when evaluating novel cardio-protective therapies.

AB - Angiogenesis is crucial in tissue repair and prevents scar tissue formation following an ischemic event such as myocardial infarction. The ischemia induces formation of new capillaries, which have high expression of integrin αvβ3. [68Ga]Ga-NODAGA-E[(cRGDyK)]2 ([68Ga]Ga-RGD) is a promising PET-radiotracer reflecting angiogenesis by binding to integrin αvβ3. A Göttingen mini-pig underwent transient catheter-induced left anterior descending artery (LAD) occlusion for 120 min, and after 8 weeks was imaged on a Siemens mMR 3T PET/MR system. A large antero-septal infarction was evident by late gadolinium enhancement (LGE) on the short axis and 2-4 chamber views. The infarcted area corresponded to the area with high [68Ga]Ga-RGD uptake on the fused PET/MR images, with no uptake in the healthy myocardium. To support the hypothesis that [68Ga]Ga-RGD uptake reflects angiogenesis, biopsies were sampled from the infarct border and healthy myocardium. Expression of αvβ3 was evaluated using immunohistochemistry. The staining showed higher αvβ3 expression in the capillaries of the infarct border compared to those in the healthy myocardium. These initial data confirm in vivo detection of angiogenesis using [68Ga]Ga-RGD PET in a translational model, which overall support the method applicability when evaluating novel cardio-protective therapies.

U2 - 10.3390/diagnostics11101807

DO - 10.3390/diagnostics11101807

M3 - Journal article

C2 - 34679505

VL - 11

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 10

M1 - 1807

ER -

ID: 283139185