64Cu loaded liposomes as positron emission tomography imaging agents

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

64Cu loaded liposomes as positron emission tomography imaging agents. / Petersen, Anncatrine Luisa; Binderup, Tina; Rasmussen, Palle; Henriksen, Jonas Rosager; Elema, Dennis Ringkjøbing; Kjær, Andreas; Andresen, Thomas Lars; Petersen, Anncatrine Luisa; Binderup, Tina; Rasmussen, Palle Damkjær; Henriksen, Jonas Rosager; Elema, Dennis Ringkjøbing; Kjær, Andreas; Andresen, Thomas Lars.

In: Biomaterials, Vol. 32, No. 9, 2011, p. 2334-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petersen, AL, Binderup, T, Rasmussen, P, Henriksen, JR, Elema, DR, Kjær, A, Andresen, TL, Petersen, AL, Binderup, T, Rasmussen, PD, Henriksen, JR, Elema, DR, Kjær, A & Andresen, TL 2011, '64Cu loaded liposomes as positron emission tomography imaging agents', Biomaterials, vol. 32, no. 9, pp. 2334-41. https://doi.org/10.1016/j.biomaterials.2010.11.059, https://doi.org/10.1016/j.biomaterials.2010.11.059

APA

Petersen, A. L., Binderup, T., Rasmussen, P., Henriksen, J. R., Elema, D. R., Kjær, A., Andresen, T. L., Petersen, A. L., Binderup, T., Rasmussen, P. D., Henriksen, J. R., Elema, D. R., Kjær, A., & Andresen, T. L. (2011). 64Cu loaded liposomes as positron emission tomography imaging agents. Biomaterials, 32(9), 2334-41. https://doi.org/10.1016/j.biomaterials.2010.11.059, https://doi.org/10.1016/j.biomaterials.2010.11.059

Vancouver

Petersen AL, Binderup T, Rasmussen P, Henriksen JR, Elema DR, Kjær A et al. 64Cu loaded liposomes as positron emission tomography imaging agents. Biomaterials. 2011;32(9):2334-41. https://doi.org/10.1016/j.biomaterials.2010.11.059, https://doi.org/10.1016/j.biomaterials.2010.11.059

Author

Petersen, Anncatrine Luisa ; Binderup, Tina ; Rasmussen, Palle ; Henriksen, Jonas Rosager ; Elema, Dennis Ringkjøbing ; Kjær, Andreas ; Andresen, Thomas Lars ; Petersen, Anncatrine Luisa ; Binderup, Tina ; Rasmussen, Palle Damkjær ; Henriksen, Jonas Rosager ; Elema, Dennis Ringkjøbing ; Kjær, Andreas ; Andresen, Thomas Lars. / 64Cu loaded liposomes as positron emission tomography imaging agents. In: Biomaterials. 2011 ; Vol. 32, No. 9. pp. 2334-41.

Bibtex

@article{05b22a67bc114b25beaaf0a73fd84d9c,
title = "64Cu loaded liposomes as positron emission tomography imaging agents",
abstract = "We have developed a highly efficient method for utilizing liposomes as imaging agents for positron emission tomography (PET) giving high resolution images and allowing direct quantification of tissue distribution and blood clearance. Our approach is based on remote loading of a copper-radionuclide ((64)Cu) using a new ionophore, 2-hydroxyquinoline, to carry (64)Cu(II) across the membrane of preformed liposomes and deliver it to an encapsulated copper-chelator. Using this ionophore we achieved very efficient loading (95.5 ± 1.6%) and retention stability (>99%), which makes the (64)Cu-liposomes highly applicable as PET imaging agents. We show the utility of the (64)Cu-liposomes for quantitative in vivo imaging of healthy and tumor-bearing mice using PET. This remote loading method is a powerful tool for characterizing the in vivo performance of liposome based nanomedicine, and has great potential in diagnostic and therapeutic applications.",
keywords = "Animals, Calorimetry, Copper Radioisotopes, HT29 Cells, Humans, Ligands, Liposomes, Mice, Neoplasms, Particle Size, Positron-Emission Tomography, Static Electricity, Tissue Distribution",
author = "Petersen, {Anncatrine Luisa} and Tina Binderup and Palle Rasmussen and Henriksen, {Jonas Rosager} and Elema, {Dennis Ringkj{\o}bing} and Andreas Kj{\ae}r and Andresen, {Thomas Lars} and Petersen, {Anncatrine Luisa} and Tina Binderup and Rasmussen, {Palle Damkj{\ae}r} and Henriksen, {Jonas Rosager} and Elema, {Dennis Ringkj{\o}bing} and Andreas Kj{\ae}r and Andresen, {Thomas Lars}",
note = "Copyright {\^A}{\textcopyright} 2010 Elsevier Ltd. All rights reserved.",
year = "2011",
doi = "10.1016/j.biomaterials.2010.11.059",
language = "English",
volume = "32",
pages = "2334--41",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - 64Cu loaded liposomes as positron emission tomography imaging agents

AU - Petersen, Anncatrine Luisa

AU - Binderup, Tina

AU - Rasmussen, Palle

AU - Henriksen, Jonas Rosager

AU - Elema, Dennis Ringkjøbing

AU - Kjær, Andreas

AU - Andresen, Thomas Lars

AU - Petersen, Anncatrine Luisa

AU - Binderup, Tina

AU - Rasmussen, Palle Damkjær

AU - Henriksen, Jonas Rosager

AU - Elema, Dennis Ringkjøbing

AU - Kjær, Andreas

AU - Andresen, Thomas Lars

N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.

PY - 2011

Y1 - 2011

N2 - We have developed a highly efficient method for utilizing liposomes as imaging agents for positron emission tomography (PET) giving high resolution images and allowing direct quantification of tissue distribution and blood clearance. Our approach is based on remote loading of a copper-radionuclide ((64)Cu) using a new ionophore, 2-hydroxyquinoline, to carry (64)Cu(II) across the membrane of preformed liposomes and deliver it to an encapsulated copper-chelator. Using this ionophore we achieved very efficient loading (95.5 ± 1.6%) and retention stability (>99%), which makes the (64)Cu-liposomes highly applicable as PET imaging agents. We show the utility of the (64)Cu-liposomes for quantitative in vivo imaging of healthy and tumor-bearing mice using PET. This remote loading method is a powerful tool for characterizing the in vivo performance of liposome based nanomedicine, and has great potential in diagnostic and therapeutic applications.

AB - We have developed a highly efficient method for utilizing liposomes as imaging agents for positron emission tomography (PET) giving high resolution images and allowing direct quantification of tissue distribution and blood clearance. Our approach is based on remote loading of a copper-radionuclide ((64)Cu) using a new ionophore, 2-hydroxyquinoline, to carry (64)Cu(II) across the membrane of preformed liposomes and deliver it to an encapsulated copper-chelator. Using this ionophore we achieved very efficient loading (95.5 ± 1.6%) and retention stability (>99%), which makes the (64)Cu-liposomes highly applicable as PET imaging agents. We show the utility of the (64)Cu-liposomes for quantitative in vivo imaging of healthy and tumor-bearing mice using PET. This remote loading method is a powerful tool for characterizing the in vivo performance of liposome based nanomedicine, and has great potential in diagnostic and therapeutic applications.

KW - Animals

KW - Calorimetry

KW - Copper Radioisotopes

KW - HT29 Cells

KW - Humans

KW - Ligands

KW - Liposomes

KW - Mice

KW - Neoplasms

KW - Particle Size

KW - Positron-Emission Tomography

KW - Static Electricity

KW - Tissue Distribution

U2 - 10.1016/j.biomaterials.2010.11.059

DO - 10.1016/j.biomaterials.2010.11.059

M3 - Journal article

C2 - 21216003

VL - 32

SP - 2334

EP - 2341

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 9

ER -

ID: 33790721