5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice

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5'-adenosine monophosphate-activated protein kinase (AMPK) is considered central in regulation of energy status and substrate utilization within cells. In heart failure the energetic state is compromised and substrate metabolism is altered. We hypothesized that this could be linked to changes in AMPK activity and we therefore investigated mitochondrial oxidative phosphorylation capacity from the oxidation of long- and medium-chain fatty acids (LCFA and MCFA) in cardiomyocytes from young and old mice expressing a dominant negative AMPKa2 (AMPKa2-KD) construct and their wildtype (WT) littermates. We found a 35-45% (P¿
Original languageEnglish
Article number00033
JournalFrontiers in Physiology
Number of pages7
Publication statusPublished - 22 Feb 2012

ID: 38566098