Steen Larsen

Steen Larsen

Associate Professor

Member of:


  1. Published

    The Effect of Exercise Training on Muscle Coenzyme Q10 in Symptomatic and Asymptomatic Statin Users

    Allard, N. A. E., Orlando, P., Janssen, L., Larsen, Steen, Tiano, L., Hopman, M. T. E. & Timmers, S., 2023, In: JACC: Basic to Translational Science. 8, 12, p. 1592-1594

    Research output: Contribution to journalLetterpeer-review

  2. Published

    Perturbations of NAD+ salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle

    Andersen, M. A., Dall, M., Jensen, Benjamin Anderschou Holbech, Prats Gavalda, Clara, Madsen, S., Basse, A. L., Graae, A., Risis, S., Goldenbaum, J., Quistorff, B., Larsen, Steen, Vienberg, S. G. & Treebak, Jonas Thue, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 314, 4, p. E377-E395 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Normal mitochondrial function and increased fat oxidation capacity in leg and arm muscles in obese humans

    Ara, I., Larsen, Steen, Stallknecht, Bente Merete, Guerra, B., Morales-Alamo, D., Andersen, J. L., Ponce-González, J. G., Guadalupe-Grau, A., Galbo, Henrik, Calbet, J. A. L. & Helge, Jørn Wulff, 2011, In: International Journal of Obesity. 35, 1, p. 99-108 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists

    Ara, I., Auerbach, P., Larsen, Steen, Mata, E., Stallknecht, Bente Merete, Ploug, Thorkil, Prats Gavalda, Clara & Helge, Jørn Wulff, 2020, In: Biomedicines. 8, 5, 10 p., 123.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue

    Bager Christensen, I., Blom, Ida, Dohlmann, T. L., Finger, Fabian Michael, Helge, Jørn Wulff, Gerhart-Hines, Zach, Dela, Flemming & Larsen, Steen, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 10, p. e916-e922 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity

    Basse, A. L., Agerholm, M., Farup, J., Dalbram, E., Nielsen, J., Ørtenblad, N., Altıntaş, A., Ehrlich, A. M., Krag, T., Bruzzone, S., Dall, M., de Guia, R. M., Jensen, J. B., Møller, A. B., Karlsen, A., Kjær, M., Barrès, R., Vissing, J., Larsen, S., Jessen, N. & 1 others, Treebak, Jonas Thue, 2021, In: Molecular Metabolism. 53, 101271.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

    Brandão, B. B., Madsen, S., Rabiee, A., Oliverio, M., Ruiz, G. P., Ferrucci, D. L., Branquinho, J. L., Razolli, D., Pinto, S., Nielsen, T. S., Festuccia, W. T., Martins, A. S., Guerra, B. A., Knittel, T. L., Søgaard, D., Larsen, S., Helge, J. W., Brandauer, J., Velloso, L. A., Emanuelli, B. & 6 others, Kornfeld, J., Kahn, C. R., Vienberg, S. G., Zierath, Juleen R, Treebak, Jonas Thue & Mori, M. A., 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 38, p. 23932-23941

    Research output: Contribution to journalJournal articlepeer-review

  8. Published
  9. Published

    Energy expenditure and intensity of ritual jumping-dancing in male Maasai

    Christensen, Dirk Lund, Westgate, K., Griffiths, L., Sironga, J., Maro, V. P., Helge, Jørn Wulff, Larsen, Steen, Bygbjerg, Ib Christian, Ramaiya, K. L., Jensen, J. & Brage, S., 2023, In: American journal of human biology : the official journal of the Human Biology Council. 35, 9, 10 p., e23907.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Directly measured aerobic fitness in male Maasai of Tanzania

    Christensen, Dirk Lund, Jørgensen, S. W., Koch, L. S., Nordsborg, Nikolai Baastrup, Sironga, J., Ramaiya, K. L., Larsen, Steen, Brage, S., Bygbjerg, Ib Christian, Maro, V. P. & Helge, Jørn Wulff, 2022, In: American Journal of Human Biology. 34, 4, 12 p., e23674.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Peripheral blood mononuclear cells exhibit increased mitochondrial respiration after adjuvant chemo- and radiotherapy for early breast cancer

    Christensen, I. B., Abrahamsen, Marie-Louise Brødsgaard, Ribas, L., Buch-Larsen, K., Marina, D., Andersson, M., Larsen, Steen, Schwarz, Peter, Dela, Flemming & Gillberg, Linn, 2023, In: Cancer Medicine. 12, 16, p. 16985-16996 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Choice of medium affects PBMC quantification, cell size, and downstream respiratory analysis

    Christensen, I. B., Ribas, L., Larsen, Steen, Dela, Flemming & Gillberg, Linn, 2022, bioRxiv, 19 p.

    Research output: Working paperPreprintResearch

  13. Published

    Depleted myocardial coenzyme Q10 in cavalier king charles spaniels with congestive heart failure due to myxomatous mitral valve disease

    Christiansen, L. B., Reimann, Maria Josefine, Schou-Pedersen, A. M. V., Larsen, Steen, Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2021, In: Antioxidants. 10, 2, p. 1-13 13 p., 161.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected

    Christiansen, L. B., Dohlmann, T. L., Ludvigsen, T. P., Parfieniuk, E., Ciborowski, M., Szczerbinski, L., Kretowski, A., Desler, Claus, Tiano, L., Orlando, P., Martinussen, Torben, Olsen, Lisbeth Høier & Larsen, Steen, 2021, In: Scientific Reports. 11, 15 p., 2167.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Mitochondrial adaptations to high intensity interval training in older females and males

    Chrois, K. M., Dohlmann, T. L., Sogaard, D., Hansen, Camilla Collin, Dela, Flemming, Helge, Jørn Wulff & Larsen, Steen, 2020, In: European Journal of Sport Science. 20, 1, p. 135-145

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue

    Chrøis, K. M., Larsen, Steen, Pedersen, J. S., Rygg, M. O., Boilsen, A. E. B., Bendtsen, Flemming & Dela, Flemming, 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, 1, p. 86-91

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice

    Correia, C. M., Præstholm, S. M., Havelund, J. F., Boel, Felix, Siersbæk, M. S., Ebbesen, M. F., Gerhart-Hines, Zach, Heeren, J., Brewer, J., Larsen, Steen, Blagoev, B., Færgeman, N. J. & Grøntved, L., 2023, In: Endocrinology. 164, 10, p. 1-17 164.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes

    Dall, M., Hassing, A. S., Niu, Lili, Nielsen, Thomas Svava, Ingerslev, L. R., Sulek, K., Trammell, Sam, Gillum, M. P., Barrès, Romain, Larsen, Steen, Poulsen, Steen Seier, Mann, Matthias, Ørskov, Cathrine & Treebak, Jonas Thue, 2021, In: Journal of Biological Chemistry. 297, 6, 26 p., 101388.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity

    Dall, M., Trammell, Sam, Asping, M., Hassing, A. S., Agerholm, M., Vienberg, S. G., Gillum, M. P., Larsen, Steen & Treebak, Jonas Thue, 2019, In: The Journal of Biological Chemistry. 294, 36, p. 13304-13326 23 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity

    Damgaard, Mads Vargas, Nielsen, Thomas Svava, Basse, A. L., Chubanava, Sabina, Trost, K., Moritz, Thomas, Dellinger, R. W., Larsen, Steen & Treebak, Jonas Thue, 2022, In: iScience. 25, 2, 21 p., 103863.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Influence of maximal fat oxidation on long-term weight loss maintenance in humans

    Dandanell, S., Husted, Karina Louise Skov, Amdisen, S., Vigelso, A., Dela, Flemming, Larsen, Steen & Helge, Jørn Wulff, Jul 2017, In: Journal of Applied Physiology. 123, 1, p. 267-274 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Effects of one-legged high-intensity interval training on insulin-mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes

    Dela, Flemming, Ingersen, Arthur, Andersen, N. B., Nielsen, M. B., Petersen, H. H. H., Hansen, C. N., Larsen, Steen, Wojtaszewski, Jørgen F P & Helge, Jørn Wulff, 2019, In: Acta Physiologica (Print). 226, 2, 18 p., e13245.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Coenzyme Q10 Supplementation in Statin Treated Patients: A Double-Blinded Randomized Placebo-Controlled Trial

    Dohlmann, T. L., Kuhlman, A. B., Morville, T., Dahl, M., Asping, M., Orlando, P., Silvestri, S., Tiano, L., Helge, Jørn Wulff, Dela, Flemming & Larsen, Steen, 2022, In: Antioxidants. 11, 9, p. 1-12 1698.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Statin Treatment Decreases Mitochondrial Respiration But Muscle Coenzyme Q10 Levels Are Unaltered: The LIFESTAT Study

    Dohlmann, T. L., Morville, T., Kuhlman, A. B., Chrøis, K. M., Helge, Jørn Wulff, Dela, Flemming & Larsen, Steen, Jul 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 7, p. 2501–2508

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men

    Dollerup, O. L., Chubanava, Sabina, Agerholm, M., Søndergård, S. D., Altıntaş, Ali, Møller, A. B., Høyer, K. F., Ringgaard, S., Stødkilde-Jørgensen, H., Lavery, G. G., Barrès, Romain, Larsen, Steen, Prats Gavalda, Clara, Jessen, N. & Treebak, Jonas Thue, 2020, In: Journal of Physiology. 598, 4, p. 731-754

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Simvastatin improves mitochondrial respiration in peripheral blood cells

    Durhuus, J. A., Hansson, Svenja, Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, Steen, Helge, Jørn Wulff, Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, Ian David, Dela, Flemming, Desler, Claus & Rasmussen, Lene Juel, 2020, In: Scientific Reports. 10, 1, 17012.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    A maximal cycle test with good validity and high repeatability in adults of all ages

    Eriksen, L., Tolstrup, J. S., Larsen, Steen, Grønbæk, M. & Helge, Jørn Wulff, Dec 2014, In: International Journal of Sports Medicine. 35, 14, p. 1184-9 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Combined changes in temperature and pH mimicking exercise result in decreased efficiency in muscle mitochondria

    Flensted-Jensen, Mathias, Kleis-Olsen, Ann-Sofie Amalie, Hassø, R. K., Lindtofte, S., Corral Pérez, J., Ortega-Gómez, S. & Larsen, Steen, 2024, In: Journal of applied physiology (Bethesda, Md. : 1985). 136, 1, p. 79-88

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Dietary intervention reverses molecular markers of hepatocellular senescence in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH

    Flensted-Jensen, Mathias, Oró, D., Rørbeck, E. A., Zhang, C., Madsen, M. R., Madsen, A. N., Norlin, J., Feigh, M., Larsen, Steen & Hansen, H. H., 2024, In: BMC Gastroenterology. 24, 1, 18 p., 59.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published
  31. Published

    ETNK1 Mutations in Atypical Chronic Myeloid Leukemia Induce a Mutator Phenotype That Can be Reverted with Phosphoethanolamine

    Fontana, D., Mauri, M., Renso, R., Docci, M., Crespiatico, I., Rost, L. M., Jang, M., Niro, A., D'Aliberti, D., Massimino, L., Bertagna, M., Zambrotta, G., Bossi, M., Citterio, S., Crescenzi, B., Fanelli, F., Cassina, V., Corti, R., Salerno, D., Nardo, L. & 10 others, Chinello, C., Mantegazza, F., Mecucci, C., Magni, F., Cavaletti, G., Bruheim, P., Rea, D., Larsen, Steen, Piazza, R. & Gambacorti-Passerini, C., Nov 2020, In: Blood. 136, Suppl. 2, 3 p., LBA-5.

    Research output: Contribution to journalConference abstract in journalpeer-review

  32. Published

    ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine

    Fontana, D., Mauri, M., Renso, R., Docci, M., Crespiatico, I., Røst, L. M., Jang, M., Niro, A., D’aliberti, D., Massimino, L., Bertagna, M., Zambrotta, G., Bossi, M., Citterio, S., Crescenzi, B., Fanelli, F., Cassina, V., Corti, R., Salerno, D., Nardo, L. & 10 others, Chinello, C., Mantegazza, F., Mecucci, C., Magni, F., Cavaletti, G., Bruheim, P., Rea, D., Larsen, Steen, Gambacorti-passerini, C. & Piazza, R., 2020, In: Nature Communications. 11, 1, 16 p., 5938.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    The training induced increase in whole-body peak fat oxidation rate may be attenuated with aging

    Frandsen, J., Beck, T., Langkilde, C. H., Larsen, Steen, Dela, Flemming & Helge, Jørn Wulff, 2021, In: European Journal of Sport Science. 21, 1, p. 69-76

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Reply to Dutheil et al

    Frandsen, J., Pistoljevic, N., Quesada, J. P., Amaro-Gahete, F. J., Larsen, Steen, Dela, Flemming & Helge, Jørn Wulff, 2020, In: Journal of applied physiology (Bethesda, Md. : 1985). 129, 1, 1 p.

    Research output: Contribution to journalComment/debatepeer-review

  35. Published

    Maximal fat oxidation rate is higher in fit women and unfit women with obesity, compared to normal weight unfit women

    Frandsen, J., Hansen, I. M. D., Wismann, J. F., Olsen, M. H., Brage-Andersen, M. R., Sahl, Ronni Eg, Hansen, M., Ingersen, Arthur, Modvig, J. L., Schmücker, M., brl298, brl298, Dela, Flemming, Larsen, Steen & Helge, Jørn Wulff, 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 11, p. E4389-E4399 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    The influence of age, sex and cardiorespiratory fitness on maximal fat oxidation rate

    Frandsen, J., Amaro-Gahete, F. J., Landgrebe, A., Dela, Flemming, Ruiz, J. R., Helge, Jørn Wulff & Larsen, Steen, 2021, In: Applied Physiology, Nutrition and Metabolism. 46, 10, p. 1241-1247

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Extreme duration exercise affects old and younger men differently

    Frandsen, J., Sahl, R. E., Rømer, T., Thunestvedt Hansen, M., Nielsen, A. B., Lie-Olesen, M. M., Rasmusen, H. K., Søgaard, D., Ingersen, A., Rosenkilde, M., Westerterp, K., Holst, J. J., Andersen, J. L., Markowski, A. R., Blachnio-Zabielska, A., Clemmensen, C., Sacchetti, M., Cataldo, A., Traina, M., Larsen, S. & 2 others, Dela, Flemming & Helge, Jørn Wulff, 2022, In: Acta Physiologica. 235, 3, e13816.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Plasma free fatty acid concentration is closely tied to whole-body peak fat oxidation rate during repeated exercise

    Frandsen, J., Vest, S. D., Ritz, C., Larsen, Steen, Dela, Flemming & Helge, Jørn Wulff, 2019, In: Journal of Applied Physiology. 126, 6, p. 1563-1571 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness

    Galvan-Alvarez, V., Gallego-Selles, A., Martinez-Canton, M., García-Gonzalez, E., Gelabert-Rebato, M., Ponce-Gonzalez, J. G., Larsen, Steen, Morales-Alamo, D., Losa-Reyna, J., Perez-Suarez, I., Dorado, C., Perez-Valera, M., Holmberg, H. C., Boushel, R., de Pablos Velasco, P., Helge, Jørn Wulff, Martin-Rincon, M. & Calbet, J. A. L., 2023, In: Free Radical Biology and Medicine. 209, p. 282-291 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations

    Graae, A-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjølby, M. F., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K. L., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A., Kiens, B. & 10 others, Wojtaszewski, Jørgen F P, Larsen, Steen, Apte, S. S., Häring, H., Vaag, A., Zethelius, B., Pedersen, Oluf Borbye, Treebak, Jonas Thue, Hansen, Torben & Holst, Birgitte, 2019, In: Diabetes. 68, 3, p. 502-514

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Influence of age on leptin induced skeletal muscle signaling

    Guadalupe Grau, A., Larsen, Steen, Guerra, B., Calbet, J. A., Dela, Flemming & Helge, Jørn Wulff, 8 Mar 2014, In: Acta Physiologica. 211, 1, p. 214-228 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Determination and validation of peak fat oxidation in endurance-trained men using an upper body graded exercise test

    Hansen, Mikkel Thunestvedt, Rømer, Tue, Frandsen, J., Larsen, Steen, Dela, Flemming & Helge, Jørn Wulff, 2019, In: Scandinavian Journal of Medicine & Science in Sports. 29, 11, p. 1677-1690

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    The influence of age and aerobic fitness: effects on mitochondrial respiration in skeletal muscle

    Hey-Mogensen, M., Rabøl, R., Stride, N., Helge, Jørn Wulff, Dela, Flemming & Larsen, Steen, 2012, In: Acta Physiologica (Print). 205, 3, p. 423-32 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Effect of 6 weeks of very low-volume high-intensity interval training on oral glucose-stimulated incretin hormone response

    Hindsø, M., Kuhlman, A. B., Dohlmann, T. L., Lund, M. T., Hartmann, Bolette, Holst, Jens Juul, Larsen, Steen & Helge, Jørn Wulff, 2022, In: European Journal of Sport Science. 22, 3, p. 381-389

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Metabolic effects of alternate-day fasting in males with obesity with or without type 2 diabetes

    Ingersen, Arthur, Helset, H. R., Calov, M., Chabanova, E., Harreskov, E. G., Jensen, C., Hansen, C. N., Prats Gavalda, Clara, Helge, Jørn Wulff, Larsen, Steen & Dela, Flemming, 2022, In: Frontiers in Physiology. 13, 1 p., 1061063.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Pre-ischemic succinate dehydrogenase inhibition is protective against ischemia-reperfusion injury in rat and human myocardium with and without diabetes mellitus: [Meeting Abstract]

    Jespersen, N. R., Hjortbak, M. V., Lassen, T. R., Stoettrup, N. B., Johnsen, J., Tonnesen, P. T., Larsen, Steen, Kimose, H. H. & Boetker, H. E., 2019, In: European Heart Journal. 40, S.1, p. 2101-2101 P3487 .

    Research output: Contribution to journalConference abstract in journal

  47. Published

    Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus

    Jespersen, N. R., Hjortbak, M. V., Lassen, T. R., Støttrup, N. B., Johnsen, J., Tonnesen, P. T., Larsen, Steen, Kimose, H. H. & Bøtker, H. E., 2020, In: Scientific Reports. 10, 1, 15 p., 10344.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Determination of the exercise intensity that elicits maximal fat oxidation in individuals with obesity

    Jørgensen, S. D., Præst, C. B., Søndergård, S. D., Skovborg, C., Dela, Flemming, Larsen, Steen & Helge, Jørn Wulff, Apr 2017, In: Applied Physiology, Nutrition and Metabolism. 42, 4, p. 405-412 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. E-pub ahead of print
  50. Published

    Actovegin improves skeletal muscle mitochondrial respiration and functional aerobic capacity in a type 1 diabetic male murine model

    Kosik, B., Larsen, Steen & Bergdahl, A., 2024, In: Applied Physiology, Nutrition and Metabolism. 49, 2, p. 265-272 8 p.

    Research output: Contribution to journalJournal articlepeer-review

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