Rune Ehrenreich Kuhre

Rune Ehrenreich Kuhre

Assistant Professor

Member of:


    1. 2023
    2. Published

      GDF15 promotes weight loss by enhancing energy expenditure in muscle

      Wang, D., Townsend, L. K., DesOrmeaux, G. J., Frangos, S. M., Batchuluun, B., Dumont, L., Kuhre, R. E., Ahmadi, E., Hu, S., Rebalka, I. A., Gautam, J., Jabile, M. J. T., Pileggi, C. A., Rehal, S., Desjardins, E. M., Tsakiridis, E. E., Lally, J. S. V., Juracic, E. S., Tupling, A. R., Gerstein, H. C. & 9 others, Paré, G., Tsakiridis, T., Harper, M. E., Hawke, T. J., Speakman, J. R., Blondin, D. P., Holloway, G. P., Jørgensen, S. B. & Steinberg, G. R., 2023, In: Nature. 619, 7968, p. 143-150 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    3. Published

      Standard procedures for blood withdrawal in conscious male rats induce stress and profoundly affect glucose tolerance and secretion of glucoregulatory hormones

      Pedersen, K., Andersen, H., Fledelius, C., Holst, Jens Juul, Hjuler, S. T. & Kuhre, Rune Ehrenreich, 2023, In: Molecular Metabolism. 69, 101689.

      Research output: Contribution to journalJournal articlepeer-review

    4. Published

      Weight loss by calorie restriction does not alter appetite-regulating gut hormone responses from perfused rat small intestine

      Gerstenberg, M. K., Andersen, Daniel Bjørklund, Torz, L., Castorena, C. M., Bookout, A. L., Hartmann, Bolette, Rehfeld, Jens Frederik, Petersen, N., Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2023, In: Acta Physiologica. 238, 1, 12 p., e13947.

      Research output: Contribution to journalJournal articlepeer-review

    5. 2022
    6. Published

      Housing-temperature reveals energy intake counter-balances energy expenditure in normal-weight, but not diet-induced obese, male mice

      John, L. M., Petersen, N., Gerstenberg, M. K., Pedersen, Lola Julie Torz, Pedersen, K., Christoffersen, B. Ø. & Kuhre, Rune Ehrenreich, 2022, In: Communications Biology . 5, 1, 13 p., 946.

      Research output: Contribution to journalJournal articlepeer-review

    7. Published

      Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats

      Grunddal, Kaare Villum, Trammell, Sam, Bæch-Laursen, C., Andersen, Daniel Bjørklund, Xu, S. F. S., Andersen, H., Gillum, M. P., Ghiasi, S. M., Novak, Ivana, Tyrberg, B., Li, C., Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2022, In: Diabetologia. 65, p. 1018–1031

      Research output: Contribution to journalJournal articlepeer-review

    8. Published

      Targeting the Gut in Obesity: Signals from the Inner Surface

      Petersen, N., Greiner, T. U., Pedersen, Lola Julie Torz, Bookout, A., Gerstenberg, M. K., Castorena, C. M. & Kuhre, Rune Ehrenreich, 2022, In: Metabolites. 12, 1, 39.

      Research output: Contribution to journalReviewpeer-review

    9. 2021
    10. Published

      Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy humans

      Vestergaard, E. T., Zubanovic, N. B., Rittig, N., Møller, N., Kuhre, Rune Ehrenreich, Holst, Jens Juul, Rehfeld, Jens Frederik & Thomsen, H. H., 2021, In: Diabetes, Obesity and Metabolism. 23, 8, p. 1834-1842

      Research output: Contribution to journalJournal articlepeer-review

    11. Published

      Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms

      Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    12. Published
    13. Published

      Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass

      Jonsson, I., Bojsen-Moller, K. N., Kristiansen, V. B., Veedfald, Simon, Albrechtsen, Nicolai Jacob Wewer, Clausen, T. R., Kuhre, Rune Ehrenreich, Rehfeld, Jens Frederik, Holst, Jens Juul, Madsbad, Sten & Svane, M. S., 2021, In: Frontiers in Endocrinology. 12, 11 p., 681116.

      Research output: Contribution to journalJournal articlepeer-review

    14. Published
    15. Published

      Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals

      Martinussen, C., Svane, M. S., Bojsen-Møller, K. N., Jensen, Christian Zinck, Kristiansen, V. B., Bookout, A. L., Jorgensen, S. B., Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Madsbad, Sten & Kuhre, Rune Ehrenreich, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. p. E443-E452 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    16. Published
    17. Published

      What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?

      Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Holst, Jens Juul & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.

      Research output: Contribution to journalReviewpeer-review

    18. 2020
    19. Published

      An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

      Madsen, Thomas Daugbjerg, Hansen, L. H., Hintze, John, Ye, Z., Jebari, S., Andersen, Daniel Bjørklund, Joshi, Hiren Jitendra, Ju, T., Goetze, Jens P. , Martin, C., Rosenkilde, Mette, Holst, Jens Juul, Kuhre, Rune Ehrenreich, Goth, C. K., Vakhrushev, Sergey & Schjoldager, Katrine Ter-Borch Gram, 2020, In: Nature Communications. 11, 1, 13 p., 4033.

      Research output: Contribution to journalJournal articlepeer-review

    20. Published

      Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

      Eiken, A., Fuglsang, S., Eiken, M., Svane, M. S., Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hansen, S. H., Trammell, Sam, Svenningsen, J. S., Rehfeld, Jens Frederik, Bojsen-Møller, K. N., Jørgensen, N. B., Holst, Jens Juul, Madsbad, Sten, Madsen, J. L. & Dirkse, C., 2020, In: International Journal of Obesity. 44, p. 1872-1883

      Research output: Contribution to journalJournal articlepeer-review

    21. Published

      Ghrelin Does Not Directly Stimulate Secretion of Glucagon-like Peptide-1

      Jepsen, Sara Lind, Vestergaard, E. T., Larraufie, P., Gribble, F. M., Reimann, F., Jorgensen, J. O. L., Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 1, p. 266-275

      Research output: Contribution to journalJournal articlepeer-review

    22. Published

      Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis

      Winther-Sørensen, M., Galsgaard, K. D., Santos, A., Trammell, S. A. J., Sulek, K., Kuhre, R. E., Pedersen, J., Andersen, D. B., Hassing, A. S., Dall, M., Treebak, J. T., Gillum, M. P., Torekov, S. S., Windeløv, J. A., Hunt, J. E., Kjeldsen, S. A. S., Jepsen, S. L., Vasilopoulou, C. G., Knop, F. K., Ørskov, C. & 7 others, Werge, M. P., Bisgaard, Hanne Cathrine, Eriksen, P. L., Vilstrup, H., Gluud, Lise Lotte, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Molecular Metabolism. 42, 18 p., 101080.

      Research output: Contribution to journalJournal articlepeer-review

    23. Published

      Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5

      Trammell, Sam, Svenningsen, J. S., Holst, Jens Juul, Gillum, M. P. & Kuhre, Rune Ehrenreich, 2020, In: Molecules. 25, 14 p., 2371.

      Research output: Contribution to journalJournal articlepeer-review

    24. Published

      In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose-induced inhibition of glucagon secretion

      Xu, S. F. S., Andersen, Daniel Bjørklund, Izarzugaza, J. M. G., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2020, In: Acta Physiologica. 229, 3, 15 p., e13464.

      Research output: Contribution to journalJournal articlepeer-review

    25. Published

      Responses of gut and pancreatic hormones, bile acids, and fibroblast growth factor-21 differ to glucose, protein, and fat ingestion after gastric bypass surgery

      Jensen, C. Z., Bojsen-Møller, K. N., Svane, M. S., Holst, L. M., Hermansen, K., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Kristiansen, V. B., Rehfeld, Jens Frederik, Clausen, T. R., Holst, Jens Juul & Madsbad, Sten, 2020, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 318, 4, p. G661-G672 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    26. Published

      Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine

      Modvig, Ida Marie, Andersen, Daniel Bjørklund, Grunddal, Kaare Villum, Kuhre, Rune Ehrenreich, Martinussen, C., Christiansen, Charlotte Bayer, Ørskov, Cathrine, Larraufie, P., Kay, R. G., Reimann, F., Gribble, F. M., Hartmann, Bolette, Bojsen-Moller, K. N., Madsbad, Sten, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2020, In: International Journal of Obesity. 44, 9, p. 1859-1871

      Research output: Contribution to journalJournal articlepeer-review

    27. 2019
    28. Published

      Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located Calcium-Sensing Receptors

      Modvig, Ida Marie, Kuhre, Rune Ehrenreich & Holst, Jens Juul, Apr 2019, In: Physiological Reports. 7, 8, 13 p., e14056.

      Research output: Contribution to journalJournal articlepeer-review

    29. Published

      Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine

      Booz, V., Christiansen, Charlotte Bayer, Kuhre, Rune Ehrenreich, Saltiel, M. Y., Sociali, G., Schaltenberg, N., Fischer, A. W., Heeren, J., Zocchi, E., Holst, Jens Juul & Bruzzone, S., 2019, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 35, 8 p., e3102.

      Research output: Contribution to journalJournal articlepeer-review

    30. Published

      Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients

      Vestergaard, E. T., Hjelholt, A. J., Kuhre, Rune Ehrenreich, Møller, N., Larraufie, P., Gribble, F. M., Reimann, F., Jessen, N., Holst, Jens Juul & Jørgensen, J. O. L., 2019, In: The Journal of clinical endocrinology and metabolism. 104, 7, p. 2581-2592

      Research output: Contribution to journalJournal articlepeer-review

    31. Published

      Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

      Christiansen, Charlotte Bayer, Trammell, Sam, Albrechtsen, Nicolai Jacob Wewer, Schoonjans, K., Albrechtsen, Reidar, Gillum, M. P., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G574-G584 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    32. Published

      Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine

      Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: Journal of Visualized Experiments. 144, e58533.

      Research output: Contribution to journalJournal articlepeer-review

    33. Published

      Neuromedin U Does Not Act as a Decretin in Rats

      Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, Ida Marie, Mandrup-Poulsen, Thomas, Albrechtsen, Reidar, Rosenkilde, Mette, Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    34. Published

      No direct effect of SGLT2 activity on glucagon secretion

      Kuhre, Rune Ehrenreich, Ghiasi, S. M., Adriaenssens, A. E., Albrechtsen, Nicolai Jacob Wewer, Andersen, Daniel Bjørklund, Aivazidis, A., Chen, L., Mandrup-Poulsen, Thomas, Ørskov, Cathrine, Gribble, F. M., Reimann, F., Wierup, N., Tyrberg, B. & Holst, Jens Juul, 2019, In: Diabetologia. 62, 6, p. 1011-1023

      Research output: Contribution to journalJournal articlepeer-review

    35. 2018
    36. Published

      Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice

      Christiansen, Charlotte Bayer, Jepsen, Sara Lind, Svendsen, B., Balk-Møller, E., Dahlby, T., Kuhre, Rune Ehrenreich, Hartmann, Bolette, Mandrup-Poulsen, Thomas, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2018, In: Physiological Reports. 6, 13, p. 1-8 e13788.

      Research output: Contribution to journalJournal articlepeer-review

    37. Published
    38. 2017
    39. Published
    40. Published

      Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

      Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, Idorn, T., Deacon, Carolyn F., Knop, Filip Krag, Rosenkilde, Mette, Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten & Holst, Jens Juul, Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

      Research output: Contribution to journalJournal articlepeer-review

    41. Published
    42. Published

      A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite

      Albrechtsen, Nicolai Jacob Wewer, Asmar, A., Jensen, F., Törang, S., Simonsen, L., Kuhre, Rune Ehrenreich, Asmar, M., Veedfald, Simon, Plamboeck, A., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Nauck, M. A., Deacon, Carolyn F., Bülow, J., Holst, Jens Juul & Hartmann, Bolette, 1 Sep 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 313, 3, p. E284-E291

      Research output: Contribution to journalJournal articlepeer-review

    43. Published

      Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass

      Nielsen, S., Svane, M. S., Kuhre, Rune Ehrenreich, Clausen, T. R., Kristiansen, V. B., Rehfeld, Jens Frederik, Holst, Jens Juul, Madsbad, Sten & Bojsen-Moller, K. N., Feb 2017, In: Physiological Reports. 5, 3, 11 p., e13140.

      Research output: Contribution to journalJournal articlepeer-review

    44. Published

      Abscisic acid controls the release of insulin from beta-cells, Glucagon-Like Peptide-1 from intestinal L-cells and glucagon from alpha-cells

      Booz, V., Christiansen, Charlotte Bayer, Kuhre, Rune Ehrenreich, Saltiel, M. Y., Sturla, L., Sociali, G., Zocchi, E., Holst, Jens Juul & Bruzzone, S., 2017, In: European Journal of Clinical Investigation. 47, p. 112-113

      Research output: Contribution to journalConference abstract in journal

    45. Published

      Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion

      Saltiel, M. Y., Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Eliasen, R., Conde-Frieboes, K. W., Rosenkilde, Mette & Holst, Jens Juul, 2017, In: Nutrients. 9, 4, 15 p., 418.

      Research output: Contribution to journalJournal articlepeer-review

    46. 2016
    47. Published

      The biology of glucagon and the consequences of hyperglucagonemia

      Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Pedersen, Jens, Knop, Filip Krag & Holst, Jens Juul, 9 Sep 2016, In: Biomarkers in Medicine. 10, 11, p. 1141-1151 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    48. Published

      Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

      Albrechtsen, Nicolai Jacob Wewer, Hornburg, D., Albrechtsen, Reidar, Svendsen, B., Toräng, S., Jepsen, Sara Lind, Kuhre, Rune Ehrenreich, Hansen, M., Janus, C., Floyd, A., Lund, A., Vilsbøll, Tina, Knop, Filip Krag, drb459, drb459, Deacon, Carolyn F., Meissner, F., Mann, Matthias, Holst, Jens Juul & Hartmann, Bolette, May 2016, In: EBioMedicine. 7, p. 112-120 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    49. Published

      The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs

      Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Toräng, S. & Holst, Jens Juul, 2 Feb 2016, In: BMC Research Notes. 9, 1, p. 1-6 6 p., 60.

      Research output: Contribution to journalJournal articlepeer-review

    50. Published

      The regulation of function, growth and survival of GLP-1-producing L-cells.

      Kuhre, Rune Ehrenreich, Holst, Jens Juul & Kappe, C., 1 Jan 2016, In: Clinical Science. 130, 2, p. 79-91 13 p.

      Research output: Contribution to journalReviewpeer-review

    51. Published

      Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes.

      Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Windeløv, Johanne Agerlin, Ørgaard, A., Deacon, Carolyn F., Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 2, p. E302-E309 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    52. Published
    53. Published

      Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

      Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211

      Research output: Contribution to journalJournal articlepeer-review

    54. 2015
    55. Published

      Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine

      Christensen, L. W., Kuhre, Rune Ehrenreich, Janus, C., Svendsen, B. & Holst, Jens Juul, 17 Sep 2015, In: Physiological Reports. 3, 9, p. 1-13 13 p., e122551.

      Research output: Contribution to journalJournal articlepeer-review

    56. Published

      Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2 leading to cell depolarization and calcium influx

      Kuhre, Rune Ehrenreich, Bechmann, L. E., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 21 Apr 2015, In: American Journal of Physiology: Endocrinology and Metabolism. 308, 12, p. E1123–E1130 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    57. Published

      Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide

      Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    58. Published

      Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine

      Kuhre, Rune Ehrenreich, Frost, C. R., Svendsen, B. & Holst, Jens Juul, Feb 2015, In: Diabetes. 64, 2, p. 370-382 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    59. Published

      Stability of glucagon-like peptide-1 and glucagon in human plasma

      Albrechtsen, Nicolai Jacob Wewer, Bak, M. J., Hartmann, Bolette, Christensen, L. W., Kuhre, Rune Ehrenreich, Deacon, Carolyn F. & Holst, Jens Juul, 16 Jan 2015, In: Endocrine Connections. 4, 1, p. 50-57 8 p.

      Research output: Contribution to journalJournal articlepeer-review

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