Nils Billestrup

Nils Billestrup

Professor


  1. 2024
  2. Published
  3. 2023
  4. Published

    Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

    Urizar, A. I., Prause, Michala Cecilie Burstein, Ingerslev, L. R., Wortham, M., Sui, Y., Sander, M., Williams, K., Barrès, Romain, Larsen, M. R., Christensen, G. L. & Billestrup, Nils, 2023, In: Cell Death and Disease. 14, 7, 16 p., 399.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Targeted Delivery of Butyrate Improves Glucose Homeostasis, Reduces Hepatic Lipid Accumulation and Inflammation in db/db Mice

    Pedersen, Signe Schultz, Prause, Michala Cecilie Burstein, Sørensen, C., Størling, J., Moritz, Thomas, Mariño, E. & Billestrup, Nils, 2023, In: International Journal of Molecular Sciences. 24, 5, 17 p., 4533.

    Research output: Contribution to journalJournal articlepeer-review

  6. 2022
  7. Published

    Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells

    Pedersen, Signe Schultz, Prause, Michala Cecilie Burstein, Williams, K., Barrès, Romain & Billestrup, Nils, 2022, In: Journal of Biological Chemistry. 298, 9, 14 p., 102312.

    Research output: Contribution to journalJournal articlepeer-review

  8. 2021
  9. Published

    Butyrate protects pancreatic beta cells from cytokine-induced dysfunction

    Prause, Michala Cecilie Burstein, Pedersen, Signe Schultz, Tsonkova, V., Qiao, M. & Billestrup, Nils, 2021, In: International Journal of Molecular Sciences. 22, 19, 18 p., 10427.

    Research output: Contribution to journalJournal articlepeer-review

  10. 2019
  11. Published

    Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications

    Urizar, A. I., Prause, Michala Cecilie Burstein, Wortham, M., Sui, Y., Thams, P., Sander, M., Christensen, G. L. & Billestrup, Nils, 2019, In: Molecular and Cellular Endocrinology. 496, 12 p., 110524 .

    Research output: Contribution to journalReviewpeer-review

  12. 2018
  13. Published

    Characterization of the Molecular Mechanisms Underlying Glucose Stimulated Insulin Secretion from Isolated Pancreatic β-cells Using Post-translational Modification Specific Proteomics (PTMomics)

    Kang, T., Jensen, P., Huang, H., Lund Christensen, G., Billestrup, Nils & Larsen, M. R., Jan 2018, In: Molecular and Cellular Proteomics. 17, 1, p. 95-110 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. 2017
  15. Published

    In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes

    Skarbaliene, J., Rigbolt, K. T., Fosgerau, K. & Billestrup, Nils, 15 Nov 2017, In: European Journal of Pharmacology. 815, p. 181-189 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Pannexin-2-deficiency sensitizes pancreatic beta-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo

    Berchtold, L. A., Miani, M., Diep, T. A., Madsen, A. N., Cigliola, V., Colli, M., Miskovic Krivokapic, Jelena, Pociot, Flemming, Eizirik, D. L., Meda, P., Holst, Birgitte, Billestrup, Nils & Storling, J., 2017, In: Molecular and Cellular Endocrinology. 448, p. 108-121 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. 2016
  18. Published

    Regulation of Pancreatic Alpha Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) in vitro.

    Nielsen, S. S., Christensen, G. L., Holst, Jens Juul & Billestrup, Nils, Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p., 27479530 .

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Regulation of Pancreatic α-Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) In Vitro

    Nielsen, S. S., Christensen, G. L., Holst, Jens Juul & Billestrup, Nils, Oct 2016, In: Endocrinology. 157, 10, p. 3809-3820 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Aberrant accumulation of the diabetes autoantigen GAD65 in Golgi membranes in conditions of ER stress and autoimmunity

    Phelps, E. A., Cianciaruso, C., Michael, I. P., Pasquier, M., Kanaani, J., Nano, R., Lavallard, V., Billestrup, Nils, Hubbell, J. A. & Baekkeskov, S., Sep 2016, In: Diabetes. 65, 9, p. 2686-2699

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells

    Prause, Michala Cecilie Burstein, Berchtold, L. A., Urizar, A. I., Trauelsen, Mette, Billestrup, Nils, Mandrup-Poulsen, Thomas & Størling, J., 15 Jan 2016, In: Molecular and Cellular Endocrinology. 420, p. 24-36 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Inflammatory Cytokines Stimulate Bone Morphogenetic Protein-2 Expression and Release from Pancreatic Beta Cells

    Urizar, A. I., Friberg, J., Christensen, D. P., Christensen, G. L. & Billestrup, Nils, 1 Jan 2016, In: Journal of Interferon & Cytokine Research. 36, 1, p. 20-29

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression

    Prause, Michala Cecilie Burstein, Mayer, C. M., Brorsson, C., Frederiksen, K. S., Billestrup, Nils, Storling, J. & Mandrup-Poulsen, Thomas, 2016, In: Journal of Diabetes Research. 2016, 15 p., 1312705.

    Research output: Contribution to journalJournal articlepeer-review

  24. 2015
  25. Published

    Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues

    Lundby, A., Bolvig, P., Hegelund, A. C., Hansen, B. F., Worm, J., Lützen, A., Billestrup, Nils, Bonnesen, C. & Oleksiewicz, M. B., Jul 2015, In: Journal of Applied Toxicology. 35, 7, p. 842-850 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    The Anti-diabetic Effects of GLP-1-gastrin Dual Agonist ZP3022 in ZDF rats

    Skarbaliene, J., Secher, T., Jelsing, J., Ansarullah, Neerup, T. S. R., Billestrup, Nils & Fosgerau, K., Jul 2015, In: Peptides. 69, p. 47-55 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents

    Christensen, G. L., Jacobsen, M. L. B., Wendt, A., Mollet, I. G., Friberg, J., Frederiksen, K. S., Meyer, M., Bruun, C., Eliasson, L. & Billestrup, Nils, Jun 2015, In: Diabetologia. 58, 6, p. 1282-1290 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons

    Kanaani, J., Cianciaruso, C., Phelps, E. A., Pasquier, M., Brioudes, E., Billestrup, Nils & Baekkeskov, S., 2015, In: PLOS ONE. 10, 2, p. 1-24 24 p., e0117130.

    Research output: Contribution to journalJournal articlepeer-review

  29. 2014
  30. Published

    Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy

    Søstrup, B., Gaarn, L. W., Nalla, A., Billestrup, Nils & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1190-7 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Impact of fetal and neonatal environment on beta cell function and development of diabetes

    Nielsen, Jens Høiriis, Haase, T. N., Jaksch, C., Nalla, A., Søstrup, B., Nalla, A. A., Larsen, L., Rasmussen, M., Dalgaard, L. T., Gaarn, L. W., Thams, P., Kofod, H. & Billestrup, Nils, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1109-22 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy

    Nalla, A., Ringholm, L., Søstrup, B., Højrup, P., Thim, L., Levery, S. B., Vakhrushev, Sergey, Billestrup, Nils, Mathiesen, Elisabeth, Damm, Peter & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1181-9 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    CRFR1 activation protects against cytokine-induced beta cell death

    Blaabjerg, L., Christensen, G. L., Matsumoto, M., van der Meulen, T., Huising, M. O., Billestrup, Nils & Vale, W., 16 Oct 2014, In: Journal of Molecular Endocrinology. 53, p. 417-427 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Inhibition of beta cell growth and function by bone morphogenetic proteins

    Bruun, C., Christensen, G. L., Jacobsen, M. L. B., Kanstrup, M. B., Jensen, P. R., Fjordvang, H., Mandrup-Poulsen, Thomas & Billestrup, Nils, 27 Sep 2014, In: Diabetologia. 57, 12, p. 2546-54 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl

    Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, Peter, Mathiesen, Elisabeth, Dahlback, B., Billestrup, Nils & Nielsen, Jens Høiriis, Sep 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.

    Research output: Contribution to journalConference abstract in journalpeer-review

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ID: 15311848