Nicolai Jacob Wewer Albrechtsen

Nicolai Jacob Wewer Albrechtsen

Associate Professor


  1. 2024
  2. Published

    Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics

    Stampe, N. K., Ottenheijm, Maud Eline, Drici, L., Albrechtsen, Nicolai Jacob Wewer, Nielsen, Annelaura Bach, Christoffersen, Christina, Warming, P. E., Engstrøm, Thomas, Winkel, B. G., Jabbari, R., Tfelt-Hansen, Jacob & Glinge, C., 2024, In: European Heart Journal: Acute Cardiovascular Care. 13, 3, p. 264–272

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes

    Richter, Michael Martin, Thomsen, M. N., Skytte, M. J., Kjeldsen, Sasha Alexandra Sampson, Samkani, A., Frystyk, J., Magkos, Faidon, Holst, Jens Juul, Madsbad, Sten, Krarup, T., Haugaard, Steen Bendix & Albrechtsen, Nicolai Jacob Wewer, 2024, In: Journal of the Endocrine Society. 8, 4, 11 p., bvae008.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Signs of Glucagon Resistance After a Two-Week Hypercaloric Diet Intervention

    Suppli, M. P., Høgedal, A., Bagger, J. I., Chabanova, E., van Hall, Gerrit, Forman, Julie Lyng, Christensen, Mikkel Bring, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 4, p. 955–967 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    The effect of exogenous glucagon on circulating amino acids in individuals with and without type 2 diabetes and obesity

    Grøndahl, M. F. G., Bagger, J. I., Suppli, M. P., van Hall, Gerrit, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina, Christensen, Mikkel Bring, Lund, A. B. & Knop, Filip Krag, 2024, In: Endocrine Connections. 13, 3, 7 p., e230516.

    Research output: Contribution to journalJournal articlepeer-review

  6. 2023
  7. Published

    Universiteterne har brug for en reformpause

    Kropp, K., Vallgårda, Karen Asta Arnfred, Hougaard Laustsen-Kiel, A., Albrechtsen, Nicolai Jacob Wewer, Sylow, Lykke, Damgaard, R. B., Kristensen, Line Burholt, Hansen, N. C., Uusimäki, E., Jønsson, A. B., Høyland-Kroghsbo, Nina Molin, Eriksen, J. J., Rasmussen, Laura Vang, Andersen, P. E., Jensen, Louise Kruse, Lomborg, Stine, Morueta-Holme, Naia, Simonsen, K. B., Zetterberg-Nielsen, S. & Autzen, A., 29 Jan 2023, In: Berlingske Tidende.

    Research output: Contribution to journalContribution to newspaper - Comment/debate

  8. Published

    100 years of glucagon and 100 more

    Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Cherrington, A. D., Finan, B., Gluud, Lise Lotte, Dean, E. D., Campbell, J. E., Bloom, S. R., Tan, T. M., Knop, Filip Krag & Müller, T. D., 2023, In: Diabetologia. 66, p. 1378–1394

    Research output: Contribution to journalReviewpeer-review

  9. Published

    Autoimmune liver diseases and diabetes: A propensity score matched analysis and a proportional meta-analysis

    Jensen, Anne-Sofie Houlberg, Winther-Sørensen, Marie, Burisch, J., Bergquist, A., Ytting, H., Gluud, Lise Lotte & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Liver International. 43, 11, p. 2479-2491 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Autoimmune liver diseases and diabetes

    Jensen, Anne-Sofie Houlberg, Lambert, Henriette Ytting, Winther-Sørensen, Marie, Burisch, J., Bergquist, A., Gluud, Lise Lotte & Albrechtsen, Nicolai Jacob Wewer, 2023, In: European journal of gastroenterology & hepatology. 35, 9, p. 938-947 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Cord blood FGF-21 and GDF-15 levels are affected by maternal exposure to moderate to severe anemia and malaria

    Hjort, Line, Albrechtsen, Nicolai Jacob Wewer, Minja, D., Rasmussen, C., Møller, S. L., Lusingu, J., Theander, Thor Grundtvig, Bygbjerg, Ib Christian, Schmiegelow, Christentze & Grunnet, L. G., 2023, In: Journal of the Endocrine Society. 7, 10, 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol

    Kjeldsen, S. A. S., Richter, M. M., Jensen, N. J., Nilsson, M. S. D., Heinz, N., Nybing, J. D., Linden, F. H., Høgh-Schmidt, E., Boesen, M. P., Madsbad, S., Vilstrup, H., Schiødt, F. V., Møller, A., Nørgaard, K., Schmidt, S., Rashu, E. B., Gluud, L. L., Haugaard, S. B., Holst, J. J., Rungby, J. & 1 others, Albrechtsen, Nicolai Jacob Wewer, 2023, In: Peptides. 161, 10 p., 170938.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Foresight in clinical proteomics: current status, ethical considerations, and future perspectives

    Mundt Madsen, Filip Oskar, Albrechtsen, Nicolai Jacob Wewer, Porsdam Mann, Sebastian, Treit, P., Ghodgaonkar-Steger, M., O’Flaherty, M., Raijmakers, R., Vizcaíno, J. A., Heck, A. J. R. & Mann, Matthias, 2023, In: Open Research Europe. 3, 19 p., 59.

    Research output: Contribution to journalLetterpeer-review

  14. Published

    Hepatic Glucose Production, Ureagenesis, and Lipolysis Quantified using the Perfused Mouse Liver Model

    Winther-Sørensen, Marie, Kemp, I. M., Bisgaard, Hanne Cathrine, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Journal of Visualized Experiments. 2023, 200, e65596.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Hyperglucagonaemia and amino acid alterations in individuals with type 2 diabetes and non-alcoholic fatty liver disease

    Rix, I., Johansen, M. L., Lund, A., Suppli, M. P., Chabanova, E., van Hall, Gerrit, Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Kistorp, Caroline Michaela Nervil & Knop, Filip Krag, 2023, In: Endocrine Connections. 13, 1, 11 p., e230161.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells

    Ferreira, F. P., Pereira, S. S., Costa, M. M., Guimarães, M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2023, In: Molecular and Cellular Biochemistry. 478, 12, p. 2779-2787

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling

    Nagao, H., Cai, W., Brandão, B. B., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Gattu, A. K., Pan, H., Dreyfuss, J. M., Thomas Wunderlich, F., Mann, Matthias & Ronald Kahn, C., 2023, In: Journal of Clinical Investigation. 133, 4, 18 p., e161472.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Markers of Glucagon Resistance Improve With Reductions in Hepatic Steatosis and Body Weight in Type 2 Diabetes

    Kjeldsen, Sasha Alexandra Sampson, Thomsen, M. N., Skytte, M. J., Samkani, A., Richter, Michael Martin, Frystyk, J., Magkos, Faidon, Hansen, E., Thomsen, Henrik S., Holst, Jens Juul, Madsbad, Sten, Haugaard, Steen Bendix, Krarup, T. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Journal of the Endocrine Society. 7, 11, 11 p., bvad122.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Neprilysin activity is increased in metabolic dysfunction-associated steatotic liver disease and normalizes after bariatric surgery or GLP-1 therapy

    Kjeldsen, S. A. S., Gluud, L. L., Werge, M. P., Pedersen, J. S., Bendtsen, F., Alexiadou, K., Tan, T., Torekov, S. S., Iepsen, E. W., Jensen, N. J., Richter, M. M., Goetze, J. P., Rungby, J., Hartmann, B., Holst, J. J., Holst, B., Holt, J., Gustafsson, F., Madsbad, S., Svane, M. S. & 2 others, Bojsen-Møller, K. N. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: iScience. 26, 11, 13 p., 108190.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published
  21. Published

    Postprandial dysfunction in fatty liver disease

    Grandt, J., Jensen, Anne-Sofie Houlberg, Werge, M. P., Rashu, E. B., Møller, A., Junker, A. E., Hobolth, L., Mortensen, C., Johansen, C. D., Vyberg, M., Serizawa, R. R., Møller, Søren, Gluud, Lise Lotte & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Physiological Reports. 11, 8, 15 p., e15653.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Preanalytical impact on the accuracy of measurements of glucagon, GLP-1 and GIP in clinical trials

    Rasmussen, C., Richter, Michael Martin, Jensen, N. J., Heinz, N., Hartmann, Bolette, Holst, Jens Juul, Kjeldsen, Sasha Alexandra Sampson & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Scandinavian Journal of Clinical and Laboratory Investigation. 83, 8, p. 591-598

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Suboptimal diagnostic accuracy of ultrasound and CT for compensated cirrhosis: Evidence from prospective cohort studies

    Hetland, L. E., Kronborg, T. M., Thing, M., Werge, M. P., Junker, A. E., Rashu, E. B., O'Connell, M. B., Olsen, B. H., Jensen, Anne-Sofie Houlberg, Albrechtsen, Nicolai Jacob Wewer, Møller, Søren, Hobolth, L., Mortensen, C., Kimer, N. & Gluud, Lise Lotte, 2023, In: Hepatology Communications. 7, 9, 6 p., e0231.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published
  25. 2022
  26. Published

    A knowledge graph to interpret clinical proteomics data

    Santos, A., Colaço, A. R., Nielsen, Annelaura Bach, Niu, Lili, Strauss, Maximilian, Geyer, P. E., Coscia, F., Albrechtsen, Nicolai Jacob Wewer, Mundt, F., Jensen, Lars Juhl & Mann, Matthias, 2022, In: Nature Biotechnology. 40, p. 692–702

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Acute effects on glucose tolerance by neprilysin inhibition in patients with type 2 diabetes

    Albrechtsen, Nicolai Jacob Wewer, Møller, A., Martinussen, C., Gluud, Lise Lotte, Rashu, E. B., Richter, Michael Martin, Plomgaard, Peter Stendahl, Goetze, Jens P. , Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Gustafsson, Finn, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2022, In: Diabetes, Obesity and Metabolism. 24, 10, p. 2017-2026 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Arginine-induced glucagon secretion and glucagon-induced enhancement of amino acid catabolism are not influenced by ambient glucose levels in mice

    Maruszczak, K., Rasmussen, C., Ceutz, F. R., Ørgaard, A., Elmelund, E., Richter, Michael Martin, Holst, Jens Juul, Winther-Sørensen, Marie & Albrechtsen, Nicolai Jacob Wewer, 2022, In: American Journal of Physiology - Endocrinology and Metabolism. 323, p. E207–E214

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young Men

    Thonsgaard, S., Prickett, T. C. R., Hansen, L. H., Albrechtsen, Nicolai Jacob Wewer, Andersen, U. Ø., Terzic, D., Plomgaard, Peter Stendahl, Gustafsson, Finn, Goetze, Jens P. & Mark, P. D., 2022, In: Clinical Chemistry. 68, 5, p. 713–720 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Dynamic human liver proteome atlas reveals functional insights into disease pathways

    Niu, Lili, Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, Nicolai Jacob Wewer, Klein, S., Ortiz, C., Uschner, F. E., Schierwagen, R., Trebicka, J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 5, 24 p., e10947.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published
  32. Published

    Four weeks treatment with the GLP-1 receptor analogue liraglutide lowers liver fat and concomitantly circulating glucagon in individuals with overweight

    Svane, M. S., Johannesen, H. H., Hansen, Adam Espe, Martinussen, C., Bojsen-Møller, K. N., Hansen, M. L., Deacon, Carolyn F., Keller, S. H., Klausen, Thomas Levin, Loft, A., Kjær, Andreas, Löfgren, J., Madsbad, Sten, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: International Journal of Obesity. 46, 11, p. 2058–2062 8 p.

    Research output: Contribution to journalLetterpeer-review

  33. Published

    Glucagon Clearance is Preserved in Type 2 Diabetes

    Grøndahl, M. F. G., Lund, A., Bagger, J. I., Petersen, Tonny Studsgaard, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina, Christensen, Mikkel Bring & Knop, Filip Krag, 2022, In: Diabetes. 71, 1, db210024.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published
  35. Published

    Gluco-regulatory disturbances in primary biliary cholangitis and non-alcoholic fatty liver disease compared with healthy individuals

    Jensen, Anne-Sofie Houlberg, Ytting, H., Grandt, J., Moller, A., Werge, M., Rashu, E., Hetland, L., Thing, M., Junker, A., Hobolth, L., Mortensen, C., Bendtsen, Flemming, Tofteng, F., Vyberg, M., Serizawa, R., Gluud, Lise Lotte & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Journal of Hepatology. 77, p. S331 1 p., THU477.

    Research output: Contribution to journalConference abstract in journal

  36. Published

    Letter to the Editor regarding to ‘Activation of GLP-1 receptor signalling by sacubitril/valsartan: Implications for patients with poor glycaemic control’

    Albrechtsen, Nicolai Jacob Wewer & Bojsen-Møller, K. N., 2022, In: International Journal of Cardiology. 368, p. 55

    Research output: Contribution to journalLetter

  37. Published

    Long-term changes of pancreatic function in patients with complicated walled-off necrosis

    Nøjgaard, C., Werge, M., Naver, Astrid Vinsand, Wilkens Knudsen, A., Albrechtsen, Nicolai Jacob Wewer, Møller, Søren, Gluud, Lise Lotte & Novovic, Srdan, 2022, In: Scandinavian Journal of Gastroenterology. 57, 10, p. 1257-1263

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Measurement of plasma glucagon in humans: A shift in the performance of a current commercially available radioimmunoassay kit

    Wu, T., Rayner, C. K., Jones, K. L., Horowitz, M., Feinle-Bisset, C., Standfield, S. D., Xie, C., Deacon, Carolyn F., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes, Obesity and Metabolism. 24, 6, p. 1182-1184

    Research output: Contribution to journalLetterpeer-review

  39. Published

    Molecular and in vivo phenotyping of missense variants of the human glucagon receptor

    van der Velden, W. J. C., Lindquist, Peter, Madsen, Jakob Sture, Stassen, R. H. M. J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, M. M., 2022, In: Journal of Biological Chemistry. 298, 2, 101413.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    On measurements of glucagon secretion in healthy, obese, and Roux-en-Y gastric bypass operated individuals using sandwich ELISA

    Albrechtsen, Nicolai Jacob Wewer, Kjeldsen, Sasha Alexandra Sampson, Jensen, N. J., Rungby, Jørgen, Veedfald, Simon, Bojsen-Møller, K. N., Dirksen, C., Jensen, Christian Zinck, Martinussen, C., Madsbad, Sten & Holst, Jens Juul, 2022, In: Scandinavian Journal of Clinical & Laboratory Investigation. 82, 1, p. 75-83

    Research output: Contribution to journalJournal articlepeer-review

  41. Published
  42. Published

    Postprandial dysfunction in metabolic associated fatty liver disease (MAFLD)

    Grandt, J., Jensen, A. S., Werge, M., Rashu, E., Junker, A., Hobolth, L., Mortensen, C., Kristiansen, M., Vyberg, M., Serizawa, R., Møller, Søren, Gluud, Lise Lotte & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Journal of Hepatology. 77, p. S154-S154 1 p., THU068.

    Research output: Contribution to journalConference abstract in journal

  43. Published

    The Liver-Alpha Cell Axis in Health and in Disease

    Richter, Michael Martin, Galsgaard, Katrine Douglas, Elmelund, E., Knop, Filip Krag, Suppli, M. P., Holst, Jens Juul, Winther-Sørensen, Marie, Kjeldsen, Sasha Alexandra Sampson & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes. 71, +, p. 1852–1861

    Research output: Contribution to journalReviewpeer-review

  44. 2021
  45. Published

    Forskningsfriheden i Danmark er under pres

    Albrechtsen, N. J. W., Andersen, P. E., Autzen, A., Bjørn, A., Damgaard, R. B., Burholt, L., Danbolt, M., Ellersgaard, C., Hansen, N. C., Jensen, L. K., Jensen, K. M. Ø., Jønsson, K., Kristensen, P. M., Kropp, K., Levisen, C., Møller, N. M., Nielsen, T. K., Laustsen, A. H., Nielsen, M. W., Simonsen, K. B. & 4 others, Sylow, Lykke, Vallgårda, Karen Asta Arnfred, Zetterberg-Nielsen, S. & Det Unge Akademi, D. U. A., 30 Oct 2021, In: Politiken. p. 5-6 2 p.

    Research output: Contribution to journalContribution to newspaper - Feature article

  46. Published

    On premises and principles for measurement of gastrointestinal peptide hormones

    Albrechtsen, Nicolai Jacob Wewer & Rehfeld, Jens Frederik, Jul 2021, In: Peptides. 141, 11 p., 170545.

    Research output: Contribution to journalReviewpeer-review

  47. Published

    17 forskere: Udflytning splitter selve universitetsuddannelsernes DNA

    Jauffred, Liselotte, Albrechtsen, Nicolai Jacob Wewer, Bjørk, R., Dalsgaard, Peter Winstén, Damgaard, R. B., Dimke, H., Hansen, N. C., Jønsson, Knud Andreas, Kropp, K., Laustsen, A. H., Levisen, C., Jensen, Louise Kruse, Møller, Niels Martin, Nielsen, Mathias Wullum, Andersen, P. E., Sørensen, Thomas Just & Vallgårda, Karen Asta Arnfred, 15 Jun 2021, Altinget.dk.

    Research output: Other contributionCommunication

  48. Published
  49. Published

    Defining NASH from a multi-omics systems biology perspective

    Niu, Lili, Sulek, K., Vasilopoulou, C. G., Santos, A., Albrechtsen, Nicolai Jacob Wewer, Rasmussen, Simon, Meier, F. & Mann, Matthias, 2021, In: Journal of Clinical Medicine. 10, 20, 22 p., 4673.

    Research output: Contribution to journalReviewpeer-review

  50. Published

    Development and evaluation of a glucagon sensitivity test

    Kjeldsen, Sasha Alexandra Sampson, Jensen, N. J., Nilsson, M. S. D., Nybing, J. D., Linden, F. H., Hogh-Schmidt, E., Boesen, Mikael Ploug, Madsbad, Sten, Vilstrup, H. V. A., Rashu, E. B., Gluud, Lise Lotte, Haugaard, Steen Bendix, Holst, Jens Juul, Rungby, Jørgen & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Diabetologia. 64, SUPPL 1, p. 189-189 365.

    Research output: Contribution to journalConference abstract in journal

  51. Published

    Differential effects of bile acids on the postprandial secretion of gut hormones: A randomized crossover study

    McGlone, E. R., Malallah, K., Cuenco, J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vincent, R. P., Ling, C., Khan, O. A., Verma, S., Ahmed, A. R., Walters, J. R. F., Khoo, B., Bloom, S. R. & Tan, T. M. M., 2021, In: American Journal of Physiology - Endocrinology and Metabolism. 320, 4, p. E671-E679

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains

    Nagao, H., Cai, W., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Batista, T. M., Pan, H., Dreyfuss, J. M., Mann, Matthias & Kahn, C. R., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 17, e2019474118.

    Research output: Contribution to journalJournal articlepeer-review

  53. Published
  54. Published

    Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass

    Jonsson, I., Bojsen-Moller, K. N., Kristiansen, V. B., Veedfald, Simon, Albrechtsen, Nicolai Jacob Wewer, Clausen, T. R., Kuhre, Rune Ehrenreich, Rehfeld, Jens Frederik, Holst, Jens Juul, Madsbad, Sten & Svane, M. S., 2021, In: Frontiers in Endocrinology. 12, 11 p., 681116.

    Research output: Contribution to journalJournal articlepeer-review

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ID: 95638859