Michael J. Davies

Michael J. Davies

Professor


  1. Published

    Iodide modulates protein damage induced by the inflammation-associated heme enzyme myeloperoxidase

    Gamon, Luke Francis, Dieterich, S., Ignasiak, M. T., Schrameyer, V. & Davies, Michael J., 2020, In: Redox Biology. 28, 12 p., 101331.

    Research output: Contribution to journalJournal articlepeer-review

  2. Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?

    Truscott, R. J. W., Mizdrak, J., Friedrich, M. G., Hooi, M. Y., Lyons, B., Jamie, J. F., Davies, Michael J., Wilmarth, P. A. & David, L. L., Jun 2012, In: Experimental Eye Research. 99, p. 48-54 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Key role of cysteine residues and sulfenic acids in thermal- and H2O2-mediated modification of β-lactoglobulin

    Krämer, A. C., Thulstrup, Peter Waaben, Lund, Marianne N. & Davies, Michael J., 2016, In: Free Radical Biology & Medicine. 97, 8, p. 544–555 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Key role of cysteine residues in thermal- and H2O2-mediated modification of beta-lactoglobulin

    Krämer, A. C., Thulstrup, Peter Waaben, Lund, Marianne N. & Davies, Michael J., 2016, In: Free Radical Biology & Medicine. 96, Suppl. 1, p. S16 1 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  5. Published

    Kinetic analysis of the reactions of hypobromous acid with protein components: implications for cellular damage and use of 3-bromotyrosine as a marker of oxidative stress

    Pattison, D. I. & Davies, Michael J., 27 Apr 2004, In: Biochemistry. 43, 16, p. 4799-809 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Kinetic analysis of the role of histidine chloramines in hypochlorous acid mediated protein oxidation

    Pattison, D. I. & Davies, Michael J., 17 May 2005, In: Biochemistry. 44, 19, p. 7378-87 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols

    Sauerland, M., Mertes, R., Morozzi, C., Eggler, A. L., Gamon, Luke Francis & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 169, p. 1-11 569.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Kinetic data for the reactions of alpha,beta-unsaturated aldehydes shed light on their molecular targets and biological effects

    Sauerland, M., Gamon, Luke Francis & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 596 1 p.

    Research output: Contribution to journalConference abstract in journal

  9. Published

    Kinetics and biological consequences of quinone-induced protein adduction: [Meeting Abstract]

    Shu, N., Lorentzen, Lasse Gøbel & Davies, Michael J., 2018, In: Free Radical Biology and Medicine. 120, S1, p. S55-S55 P-34.

    Research output: Contribution to journalConference abstract in journalpeer-review

  10. Kinetics of hypobromous acid-mediated oxidation of lipid components and antioxidants

    Skaff, O., Pattison, D. I. & Davies, Michael J., Dec 2007, In: Chemical Research in Toxicology. 20, 12, p. 1980-8 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance

    Storkey, C., Pattison, D. I., Ignasiak, M. T., Schiesser, C. H. & Davies, Michael J., Dec 2015, In: Free Radical Biology & Medicine. 89, p. 1049-1056 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Leghemoglobin-derived radicals. Evidence for multiple protein-derived radicals and the initiation of peribacteroid membrane damage

    Moreau, S., Davies, Michael J., Mathieu, C., Hérouart, D. & Puppo, A., 20 Dec 1996, In: The Journal of Biological Chemistry. 271, 51, p. 32557-62 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Lipid oxidation in human low-density lipoprotein induced by metmyoglobin/H2O2: involvement of alpha-tocopheroxyl and phosphatidylcholine alkoxyl radicals

    Witting, P. K., Willhite, C. A., Davies, Michael J. & Stocker, R., Dec 1999, In: Chemical Research in Toxicology. 12, 12, p. 1173-81 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC

    Perez-Hernandez, M., van Opbergen, C. J. M., Bagwan, N., Vissing, C. R., Marron-Linares, G. M., Zhang, M., Vega, E. T., Sorrentino, A., Drici, L., Sulek, K., Zhai, R., Hansen, F. B., Christensen, A. H., Boesgaard, S., Gustafsson, F., Rossing, K., Small, E. M., Davies, M. J., Rothenberg, E., Sato, P. Y. & 6 others, Cerrone, M., Jensen, Thomas Hartvig Lindkær, Qvortrup, Klaus, Bundgård, Henning, Delmar, M. & Lundby, Alicia, 2022, In: Circulation. 146, 11, p. 851-867

    Research output: Contribution to journalJournal articlepeer-review

  15. Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation

    Mertens, K., Lowes, D. A., Webster, N. R., Talib, J., Hall, L., Davies, Michael J., Beattie, J. H. & Galley, H. F., 2015, In: British Journal of Anaesthesia. 114, 6, p. 990-999 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    M. jannaschii FtsZ, a key protein in bacterial cell division, is inactivated by peroxyl radical-mediated methionine oxidation

    Reyes, J. S., Fuentes Lemus, Eduardo, Aspée, A., Davies, Michael J., Monasterio, O. & López-Alarcón, C., 2021, In: Free Radical Biology and Medicine. 166, p. 53-66

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    MODULATION OF ENDOTHELIAL CELL FUNCTION BY THE MYELOPEROXIDASE-DERIVED OXIDANT HYPOCHLOROUS ACID (HOCl) AND ITS CONTRIBUTION TO ATHEROSCLEROSIS

    Rayner, B. S., Lloyd, M. M., Summers, F. A., Davies, Michael J. & Hawkins, Clare Louise, 2014, In: Hypertension.

    Research output: Contribution to journalJournal articlepeer-review

  18. Mammalian heme peroxidases: from molecular mechanisms to health implications

    Davies, Michael J., Hawkins, Clare Louise, Pattison, D. I. & Rees, M. D., Jul 2008, In: Antioxidants & Redox Signaling. 10, 7, p. 1199-234 36 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion

    Indo, H. P., Matsui, H., Chen, J., Zhu, H., Hawkins, Clare Louise, Davies, Michael J., Yarana, C., Clair, D. K. S. & Majima, H. J., 1 Jul 2015, In: Journal of Clinical Biochemistry and Nutrition. 57, 1, p. 13-20 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Markers of protein oxidation: different oxidants give rise to variable yields of bound and released carbonyl products

    Headlam, H. A. & Davies, Michael J., 2004, In: Free Radical Biology & Medicine. 36, 9, p. 1175-84 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Mass-Spectrometry-Based Identification of Cross-Links in Proteins Exposed to Photo-Oxidation and Peroxyl Radicals Using 18O Labeling and Optimized Tandem Mass Spectrometry Fragmentation

    Mariotti, M., Leinisch, F., Leeming, D. J., Svensson, B., Davies, Michael J. & Hägglund, Per Mårten, 2018, In: Journal of Proteome Research. 17, 6, p. 2017-2027

    Research output: Contribution to journalJournal articlepeer-review

  22. Mechanisms and consequences of oxidative damage to extracellular matrix

    Kennett, E. C., Chuang, Christine, Degendorfer, G., Whitelock, J. M. & Davies, Michael J., Oct 2011, In: Biochemical Society Transactions. 39, 5, p. 1279-87 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Mechanisms of degradation of the natural high-potency sweetener (2R,4R)-monatin in mock beverage solutions

    Storkey, C., Pattison, D. I., Gaspard, D. S., Hagestuen, E. D. & Davies, Michael J., 16 Apr 2014, In: Journal of Agricultural and Food Chemistry. 62, 15, p. 3476-87 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Mechanistic view of iodide in oxidative stress: [Meeting Abstract]

    Kciuk, M. I., Davies, Michael J. & Marciniak, B., 2018, In: Free Radical Biology and Medicine. 120, S1, p. S122-S122 P-254.

    Research output: Contribution to journalConference abstract in journalpeer-review

  25. Methylglyoxal-induced modification of arginine residues decreases the activity of NADPH-generating enzymes

    Morgan, P. E., Sheahan, P. J., Pattison, D. I. & Davies, Michael J., Aug 2013, In: Free Radical Biology & Medicine. 61, p. 229-42 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published
  27. Published

    Modification of Cys residues in thioredoxin by p-benzoquinone causes inhibition of its catalytic activity and activation of ASK1/p38-MAPK signalling pathway: [Meeting Abstract]

    Shu, N., Hägglund, Per Mårten & Davies, Michael J., 1 Aug 2019, In: Free Radical Biology and Medicine. 139, S1, p. S9-S9 8.

    Research output: Contribution to journalConference abstract in journal

  28. Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid

    Malle, E., Marsche, G., Arnhold, J. & Davies, Michael J., Apr 2006, In: B B A - Reviews on Cancer. 1761, 4, p. 392-415 24 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Modification of selenocysteine residues in thioredoxin reductase and glutathione peroxidase by p-benzoquinone affects protein structure and function: [Meeting Abstract]

    Shu, N. & Davies, Michael J., 1 Aug 2019, In: Free Radical Biology and Medicine. 139, S1, p. S49-S49 168.

    Research output: Contribution to journalConference abstract in journal

  30. Published

    Modification of the extracellular matrix of the arterial wall by myeloperoxidase contributes to atherosclerosis: [Meeting Absract]

    Cai, H., Chuang, Christine & Davies, Michael J., 2018, In: International Journal of Experimental Pathology. 99, 6, p. A24-A24

    Research output: Contribution to journalConference abstract in journalpeer-review

  31. Published

    Modulation of hypochlorous acid (HOCl) induced damage to vascular smooth muscle cells by thiocyanate and selenium analogues

    Flouda, K., Gammelgaard, Bente, Davies, Michael J. & Hawkins, Clare Louise, May 2021, In: Redox Biology. 41, 101873.

    Research output: Contribution to journalJournal articlepeer-review

  32. Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy

    Sourris, K. C., Harcourt, B. E., Penfold, S. A., Yap, F. Y. T., Morley, A. L., Morgan, P. E., Davies, Michael J., Baker, S. T., Jerums, G. & Forbes, J. M., 2010, In: Journal of Diabetes Research. 2010, p. 974681

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: The Microalbuminuria Education and Medication Optimisation (MEMO) study

    Crasto, W., Jarvis, J., Khunti, K., Skinner, Timothy, Gray, L. J., Brela, J., Troughton, J., Daly, H., Lawrence, I. G., McNally, P. G., Carey, M. E. & Davies, Michael J., 1 Sep 2011, In: Diabetes Research and Clinical Practice. 93, 3, p. 328-336 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation

    Campolo, N., Mastrogiovanni, M., Mariotti, M., Issoglio, F. M., Estrin, D., Hägglund, Per Mårten, Grune, T., Davies, Michael J., Bartesaghi, S. & Radi, R., 2023, In: Journal of Biological Chemistry. 299, 3, 22 p., 102941.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases

    Davies, Michael J., 2021, In: Pharmacology and Therapeutics. 218, 23 p., 107685.

    Research output: Contribution to journalReviewpeer-review

  36. Published

    Myeloperoxidase Alters Lung Cancer Cell Function to Benefit Their Survival

    Cosic-Mujkanovic, N., Valadez-Cosmes, P., Maitz, K., Lueger, A., Mihalic, Z. N., Runtsch, M. C., Kienzl, M., Davies, Michael J., Chuang, Christine, Heinemann, A., Schicho, R., Marsche, G. & Kargl, J., 2023, In: Antioxidants. 12, 8, 17 p., 1587.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Myeloperoxidase Modulates Hydrogen Peroxide Mediated Cellular Damage in Murine Macrophages

    Guo, C., Sileikaite, I., Davies, Michael J. & Hawkins, Clare Louise, 2020, In: Antioxidants. 9, 12, 14 p., 1255.

    Research output: Contribution to journalJournal articlepeer-review

  38. Myeloperoxidase-Derived Oxidants Rapidly and Efficiently Oxidise Protein Zinc-Thiol Clusters

    Cook, N. L., Pattison, David & Davies, Michael J., 2012, In: Free Radical Biology and Medicine. 53, Supl. 2, p. S146 1 p., 355.

    Research output: Contribution to journalConference abstract in journal

  39. Published

    Myeloperoxidase-derived damage to human plasma fibronectin: Modulation by protein binding and thiocyanate ions (SCN)

    Vanichkitrungruang, S., Chuang, Christine, Hawkins, Clare Louise & Davies, Michael J., 2020, In: Redox Biology. 36, 13 p., 101641.

    Research output: Contribution to journalJournal articlepeer-review

  40. Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial cells

    Cook, N. L., Viola, H. M., Sharov, V. S., Hool, L. C., Schöneich, C. & Davies, Michael J., 1 Mar 2012, In: Free Radical Biology & Medicine. 52, 5, p. 951-61 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)

    Hadfield, K. A., Pattison, D. I., Brown, B. E., Hou, L., Rye, K., Davies, Michael J. & Hawkins, Clare Louise, 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 531-42 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins

    Cook, N. L., Pattison, D. I. & Davies, Michael J., 1 Dec 2012, In: Free Radical Biology & Medicine. 53, 11, p. 2072-80 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan

    Rees, M. D., Whitelock, J. M., Malle, E., Chuang, Christine, Iozzo, R. V., Nilasaroya, A. & Davies, Michael J., Jan 2010, In: Matrix Biology. 29, 1, p. 63-73 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

    Davies, Michael J., Jan 2011, In: Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 8-19 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Myoglobin-induced oxidative damage: evidence for radical transfer from oxidized myoglobin to other proteins and antioxidants

    Irwin, J. A., Ostdal, H. & Davies, Michael J., 1 Feb 1999, In: Archives of Biochemistry and Biophysics. 362, 1, p. 94-104 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: a comparison with other osmotic agents and free radical scavengers

    Birinyi-Strachan, L. C., Davies, Michael J., Lewis, R. J. & Nicholson, G. M., Oct 2005, In: Neuropharmacology. 49, 5, p. 669-86 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Nitration alters laminin polymerization: [Meeting Abstract]

    Lorentzen, Lasse Gøbel & Davies, Michael J., 2018, In: Free Radical Biology and Medicine. 120, S1, p. S127-S127 P-271.

    Research output: Contribution to journalConference abstract in journalpeer-review

  48. Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals

    Lam, M. A., Pattison, D. I., Bottle, S. E., Keddie, D. J. & Davies, Michael J., Nov 2008, In: Chemical Research in Toxicology. 21, 11, p. 2111-9 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I

    Nobécourt, E., Tabet, F., Lambert, G., Puranik, R., Bao, S., Yan, L., Davies, Michael J., Brown, B. E., Jenkins, A. J., Dusting, G. J., Bonnet, D. J., Curtiss, L. K., Barter, P. J. & Rye, K., Apr 2010, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 4, p. 766-72 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Novel monohydroxamate drugs attenuate myocardial reperfusion-induced arrhythmias

    Collis, C. S., Rice-Evans, C. & Davies, Michael J., Apr 1996, In: International Journal of Biochemistry & Cell Biology. 28, 4, p. 405-13 9 p.

    Research output: Contribution to journalJournal articlepeer-review

ID: 38036205