Michael Jonathan Davies

Michael Jonathan Davies

Professor


  1. 2010
  2. Published

    Delivering the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: Cost effectiveness analysis

    Gillett, M., Dallosso, H. M., Dixon, S., Brennan, A., Carey, M. E., Campbell, M. J., Heller, S., Khunti, K., Skinner, Timothy & Davies, Michael Jonathan, 26 Aug 2010, In: BMJ (Online). 341, 7770, c4093.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Screening for type 2 diabetes in a multiethnic setting using known risk factors to identify those at high risk: A cross-sectional study

    Gray, L. J., Tringham, J. R., Davies, Michael Jonathan, Webb, D. R., Jarvis, J., Skinner, Timothy, Farooqi, A. M. & Khunti, K., 1 Dec 2010, In: Vascular Health and Risk Management. 6, 1, p. 837-842 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains

    Kennett, E. C., Rees, M. D., Malle, E., Hammer, A., Whitelock, J. M. & Davies, Michael Jonathan, 15 Jul 2010, In: Free Radical Biology & Medicine. 49, 2, p. 282-93 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Randomised controlled trial of the DESMOND structured education programme for people newly diagnosed with type 2 diabetes: biomedical outcomes, psychosocial measures and illness beliefs at three years

    Khunti, K., Heller, S., Skinner, Timothy, Gray, L. J., Dallosso, H. M., Realf, K., Carey, Matthew Alexander Halkes & Davies, Michael Jonathan, 1 Sep 2010, Diabetologia.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  6. Published

    Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study

    Khunti, K., Taub, N., Tringham, J., Jarvis, J., Farooqi, A., Skinner, Timothy & Davies, Michael Jonathan, 1 Apr 2010, In: Primary Care Diabetes. 4, 1, p. 25-32 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

    Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., Scott, K. F., Ziegler, J. B., Pattison, D. I., Fu, S., Hawkins, Clare Louise, Rees, M. D. & Davies, Michael Jonathan, 15 Apr 2010, In: Biochemical Pharmacology. 79, 8, p. 1156-64 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

    Lane, A. E., Tan, J. T. M., Hawkins, Clare Louise, Heather, A. K. & Davies, Michael Jonathan, 15 Aug 2010, In: Biochemical Journal. 430, 1, p. 161-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: possible links between diabetes and atherosclerosis

    Moheimani, F., Morgan, P. E., van Reyk, D. M. & Davies, Michael Jonathan, Jun 2010, In: B B A - Reviews on Cancer. 1802, 6, p. 561-71 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I

    Nobécourt, E., Tabet, F., Lambert, G., Puranik, R., Bao, S., Yan, L., Davies, Michael Jonathan, Brown, B. E., Jenkins, A. J., Dusting, G. J., Bonnet, D. J., Curtiss, L. K., Barter, P. J. & Rye, K., Apr 2010, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 4, p. 766-72 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3

    Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, Michael Jonathan & Winterbourn, C. C., 1 Dec 2010, In: Biochemical Journal. 432, 2, p. 313-21 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Cellular effects of peptide and protein hydroperoxides

    Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael Jonathan, 15 Apr 2010, In: Free Radical Biology & Medicine. 48, 8, p. 1071-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts

    Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael Jonathan, 30 Nov 2010, In: Free Radical Biology & Medicine. 49, 10, p. 1505-15 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan

    Rees, M. D., Whitelock, J. M., Malle, E., Chuang, Christine, Iozzo, R. V., Nilasaroya, A. & Davies, Michael Jonathan, Jan 2010, In: Matrix Biology. 29, 1, p. 63-73 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Depressive symptoms in the first year from diagnosis of Type 2 diabetes: Results from the DESMOND trial

    Skinner, Timothy, Carey, M. E., Cradock, S., Dallosso, H. M., Daly, H., Davies, Michael Jonathan, Doherty, Y., Heller, S., Khunti, K. & Oliver, L., 1 Aug 2010, In: Diabetic Medicine. 27, 8, p. 965-967 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy

    Sourris, K. C., Harcourt, B. E., Penfold, S. A., Yap, F. Y. T., Morley, A. L., Morgan, P. E., Davies, Michael Jonathan, Baker, S. T., Jerums, G. & Forbes, J. M., 2010, In: Journal of Diabetes Research. 2010, p. 974681

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b5-mediated heme reduction

    Szuchman-Sapir, A. J., Pattison, D. I., Davies, Michael Jonathan & Witting, P. K., 1 Jan 2010, In: Free Radical Biology & Medicine. 48, 1, p. 35-46 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2009
  19. Published

    The prevalence of depression in White-European and South-Asian people with impaired glucose regulation and screen-detected type 2 diabetes mellitus

    Aujla, N., Abrams, K. R., Davies, Michael Jonathan, Taub, N., Skinner, Timothy & Khunti, K., 9 Nov 2009, In: PLoS ONE. 4, 11, e7755.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Hypobromous acid and bromamine production by neutrophils and modulation by superoxide

    Chapman, A. L. P., Skaff, O., Senthilmohan, R., Kettle, A. J. & Davies, Michael Jonathan, 1 Feb 2009, In: Biochemical Journal. 417, 3, p. 773-81 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products

    Gracanin, M., Hawkins, Clare Louise, Pattison, D. I. & Davies, Michael Jonathan, 1 Jul 2009, In: Free Radical Biology & Medicine. 47, 1, p. 92-102 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Quantification of protein modification by oxidants

    Hawkins, Clare Louise, Morgan, P. E. & Davies, Michael Jonathan, 15 Apr 2009, In: Free Radical Biology & Medicine. 46, 8, p. 965-88 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Glycosaminoglycans are fragmented by hydroxyl, carbonate, and nitrogen dioxide radicals in a site-selective manner: implications for peroxynitrite-mediated damage at sites of inflammation

    Kennett, E. C. & Davies, Michael Jonathan, 15 Aug 2009, In: Free Radical Biology & Medicine. 47, 4, p. 389-400 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients

    Morgan, P. E., Sturgess, A. D. & Davies, Michael Jonathan, Feb 2009, In: Free Radical Research. 43, 2, p. 117-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael Jonathan, May 2009, In: Chemical Research in Toxicology. 22, 5, p. 807-17 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides

    Rees, M. D., Bottle, S. E., Fairfull-Smith, K. E., Malle, E., Whitelock, J. M. & Davies, Michael Jonathan, 1 Jul 2009, In: Biochemical Journal. 421, 1, p. 79-86 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance

    Skaff, O., Pattison, D. I. & Davies, Michael Jonathan, 15 Aug 2009, In: Biochemical Journal. 422, 1, p. 111-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2008
  29. Published

    Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: Cluster randomised controlled trial

    Davies, Michael Jonathan, Heller, S., Skinner, Timothy, Campbell, M. J., Carey, M. E., Cradock, S., Dallosso, H. M., Daly, H., Doherty, Y., Eaton, S., Fox, C., Oliver, L., Rantell, K., Rayman, G. & Khunti, K., 1 Mar 2008, In: BMJ. 336, 7642, p. 491-495 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    The DESMOND educational intervention

    Davies, Michael Jonathan, Heller, S., Khunti, K. & Skinner, Timothy, 1 Mar 2008, In: Chronic Illness. 4, 1, p. 38-40 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  31. Mammalian heme peroxidases: from molecular mechanisms to health implications

    Davies, Michael Jonathan, Hawkins, Clare Louise, Pattison, D. I. & Rees, M. D., Jul 2008, In: Antioxidants & Redox Signaling. 10, 7, p. 1199-234 36 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation

    Hawkins, Clare Louise, Pattison, D. I., Stanley, N. R. & Davies, Michael Jonathan, 15 Dec 2008, In: Biochemical Journal. 416, 3, p. 441-52 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid

    Kennett, E. C. & Davies, Michael Jonathan, 1 Sep 2008, In: Free Radical Biology & Medicine. 45, 5, p. 716-25 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Biomedical, lifestyle and psychosocial characteristics of people newly diagnosed with type 2 diabetes: Baseline data from the DESMOND randomized controlled trial

    Khunti, K., Skinner, Timothy, Heller, S., Carey, M. E., Dallosso, H. M. & Davies, Michael Jonathan, 1 Dec 2008, In: Diabetic Medicine. 25, 12, p. 1454-1461 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals

    Lam, M. A., Pattison, D. I., Bottle, S. E., Keddie, D. J. & Davies, Michael Jonathan, Nov 2008, In: Chemical Research in Toxicology. 21, 11, p. 2111-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links

    Lund, Marianne N., Luxford, C., Skibsted, Leif Horsfelt & Davies, Michael Jonathan, 2008, In: Biochemical Journal. 410, 3, p. 565-574 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

    Lloyd, M. M., van Reyk, D. M., Davies, Michael Jonathan & Hawkins, Clare Louise, 1 Sep 2008, In: Biochemical Journal. 414, 2, p. 271-80 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage

    Mizdrak, J., Hains, P. G., Truscott, R. J. W., Jamie, J. F. & Davies, Michael Jonathan, 15 Mar 2008, In: Free Radical Biology & Medicine. 44, 6, p. 1108-19 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins

    Morgan, P. E., Pattison, D. I., Hawkins, Clare Louise & Davies, Michael Jonathan, 1 Nov 2008, In: Free Radical Biology & Medicine. 45, 9, p. 1279-89 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Oxidative damage to extracellular matrix and its role in human pathologies

    Rees, M. D., Kennett, E. C., Whitelock, J. M. & Davies, Michael Jonathan, 15 Jun 2008, In: Free Radical Biology & Medicine. 44, 12, p. 1973-2001 29 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study

    Skaff, O., Pattison, D. I. & Davies, Michael Jonathan, 5 Aug 2008, In: Biochemistry. 47, 31, p. 8237-45 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    'Educator talk' and patient change: Some insights from the DESMOND (Diabetes Education and Self Management for Ongoing and Newly Diagnosed) randomized controlled trial

    Skinner, Timothy, Carey, M. E., Cradock, S., Dallosso, H. M., Daly, H., Davies, Michael Jonathan, Doherty, Y., Heller, S., Khunti, K. & Oliver, L., 1 Sep 2008, In: Diabetic Medicine. 25, 9, p. 1117-1120 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Accumulation of zinc in human atherosclerotic lesions correlates with calcium levels but does not protect against protein oxidation

    Stadler, N., Stanley, N., Heeneman, S., Vacata, V., Daemen, M. J. A. P., Bannon, P. G., Waltenberger, J. & Davies, Michael Jonathan, May 2008, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 5, p. 1024-30 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines

    Summers, F. A., Morgan, P. E., Davies, Michael Jonathan & Hawkins, Clare Louise, Sep 2008, In: Chemical Research in Toxicology. 21, 9, p. 1832-40 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin

    Szuchman-Sapir, A. J., Pattison, D. I., Ellis, N. A., Hawkins, Clare Louise, Davies, Michael Jonathan & Witting, P. K., 15 Sep 2008, In: Free Radical Biology & Medicine. 45, 6, p. 789-98 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Waiting for diabetes: Perceptions of people with pre-diabetes: A qualitative study

    Troughton, J., Jarvis, J., Skinner, Timothy, Robertson, N., Khunti, K. & Davies, Michael Jonathan, 1 Jul 2008, In: Patient Education and Counseling. 72, 1, p. 88-93 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2007
  48. Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages

    Brown, B. E., Rashid, I., van Reyk, D. M. & Davies, Michael Jonathan, Mar 2007, In: F E B S Journal. 274, 6, p. 1530-41 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides

    Dremina, E. S., Sharov, V. S., Davies, Michael Jonathan & Schöneich, C., Oct 2007, In: Chemical Research in Toxicology. 20, 10, p. 1462-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Inhibition of protein tyrosine phosphatases by amino acid, peptide, and protein hydroperoxides: potential modulation of cell signaling by protein oxidation products

    Gracanin, M. & Davies, Michael Jonathan, 15 May 2007, In: Free Radical Biology & Medicine. 42, 10, p. 1543-51 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Degradation of matrix glycosaminoglycans by peroxynitrite/peroxynitrous acid: evidence for a hydroxyl-radical-like mechanism

    Kennett, E. C. & Davies, Michael Jonathan, 15 Apr 2007, In: Free Radical Biology & Medicine. 42, 8, p. 1278-89 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritis

    Morgan, P. E., Sturgess, A. D., Hennessy, A. & Davies, Michael Jonathan, Dec 2007, In: Free Radical Research. 41, 12, p. 1301-12 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Reversible binding of kynurenine to lens proteins: potential protection by glutathione in young lenses

    Parker, N. R., Korlimbinis, A., Jamie, J. F., Davies, Michael Jonathan & Truscott, R. J. W., Aug 2007, In: Investigative Ophthalmology & Visual Science. 48, 8, p. 3705-13 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael Jonathan, 28 Aug 2007, In: Biochemistry. 46, 34, p. 9853-64 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 38036205