Mette Rosenkilde

Mette Rosenkilde

Professor

Member of:


    1. 2024
    2. Published

      Advances in incretin-based therapeutics for obesity

      Rosenkilde, Mette, 2024, In: Nature Reviews Endocrinology. 20, p. 67–68 2 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Accepted/In press

      Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes

      Skov-Jeppesen, Kirsa, Christiansen, Charlotte Bayer, Hansen, L. S., Windeløv, Johanne Agerlin, Hedbäck, N., Gasbjerg, Lærke Smidt, Hindsø, M., Svane, M. S., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2024, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity

      Dillemans, L., Yu, K., De Zutter, A., Noppen, S., Gouwy, M., Berghmans, N., Verhallen, L., De Bondt, M., Vanbrabant, L., Brusselmans, S., Martens, E., Schols, D., Verschueren, P., Rosenkilde, Mette, Marques, P. E., Struyf, S. & Proost, P., 2024, In: Cell Communication and Signaling. 22, 1, 23 p., 94.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. 2023
    6. Published

      Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice

      Gabe, M. B. N., Christensen, Liv von Voss, Dal, Jenna Elizabeth Hunt, Gadgaard, S., Gasbjerg, Lærke Smidt, Holst, Jens Juul, Kissow, Hannelouise, Hartmann, Bolette & Rosenkilde, Mette, Jan 2023, In: British Journal of Pharmacology. 180, 13, p. 1674-1689

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Adhesion G protein‐coupled receptor's structure, function and role in biology—Status from the 10th adhesion GPCR workshop in Copenhagen, 2022

      Rosenkilde, Mette & Mathiasen, Signe, 2023, In: Basic & clinical pharmacology & toxicology. 133, 4, p. 281-284

      Research output: Contribution to journalEditorialResearchpeer-review

    8. Published

      Amantadine for COVID-19 treatment (ACT) study: a randomized, double-blinded, placebo-controlled clinical trial

      Weis, Nina, Bollerup, S., Sund, J. D., Glamann, J. B., Vinten, C., Jensen, L. R., Sejling, Christoffer, Kledal, T. N. & Rosenkilde, Mette, 2023, In: Clinical Microbiology and Infection. 29, 10, p. 1313-1319 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5

      Larsen, Olav, Schuermans, S., Walser, Anna Louise Silvia, Louka, S., Lillethorup, I. A., Våbenø, J., Qvortrup, K., Proost, P. & Rosenkilde, Mette, 2023, In: FEBS Letters. 597, 24, p. 3049-3060

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation

      Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells

      Hansen, M. S., Soe, K., Christensen, L. L., Fernandez-Guerra, P., Hansen, N. W., Wyatt, R. A., Martin, C., Hardy, R. S., Andersen, T. L., Olesen, J. B., Hartmann, Bolette, Rosenkilde, Mette, Kassem, M., Rauch, A., Gorvin, C. M. & Frost, M., 2023, In: European Journal of Endocrinology. 188, 1, 14 p., 004.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      GPR162 is a beta cell CART receptor

      Lindqvist, A., Abels, M., Shcherbina, L., Ngara, M., Kryvokhyzha, D., Chriett, S., Riva, M., Fajul, A., Barghouth, M., Luan, C., Eliasson, L., Larsen, Olav, Rosenkilde, Mette, Zhang, E., Renström, E. & Wierup, N., 2023, In: iScience. 26, 12, 15 p., 108416.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection

      Foo, C. X., Bartlett, S., Chew, K. Y., Ngo, M. D., Bielefeldt-Ohmann, H., Arachchige, B. J., Matthews, B., Reed, S., Wang, R., Smith, C., Sweet, M. J., Burr, L., Bisht, K., Shatunova, S., Sinclair, J. E., Parry, R., Yang, Y., Lévesque, J. P., Khromykh, A., Rosenkilde, M. M. & 2 others, Short, K. R. & Ronacher, K., 2023, In: The European respiratory journal. 61, 3, 15 p., 2201306.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Glycine: a long-sought novel ligand for GPR158

      Rosenkilde, Mette & Mathiesen, Jesper M., 2023, In: Trends in Pharmacological Sciences. 44, 8, p. 489-491

      Research output: Contribution to journalLetterResearchpeer-review

    15. Published

      Identification of a Salt Bridge That Is Functionally Important for Chemokine Receptor CXCR1 but not CXCR2

      Våbenø, J., Oliva-Santiago, M., Jørgensen, Astrid Sissel, Karlshøj, S. & Rosenkilde, Mette, 2023, In: ACS Pharmacology and Translational Science. 6, 8, p. 1120-1128 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Ligand entry pathways control the chemical space recognized by GPR183

      Kjær, Viktoria Madeline Skovgaard, Stępniewski, T. M., Medel-Lacruz, B., Reinmuth, L., Ciba, Marija, Ulven, Elisabeth Rexen, Bonomi, M., Selent, J. & Rosenkilde, Mette, 2023, In: Chemical Science. 14, 39, p. 10671-10683

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Long-acting agonists of human and rodent GLP-2 receptors for studies of the physiology and pharmacological potential of the GLP-2 system

      Gadgaard, S., Windeløv, Johanne Agerlin, Schiellerup, S. P., Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, Mette, 2023, In: Biomedicine and Pharmacotherapy. 160, 13 p., 114383.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

      Nybo, Maja Lind, Kvam, J. M., Nielsen, J. E., Frederiksen, H., Spiess, Katja, Jensen, Kristian HR, Gadgaard, S., Walser, Anna Louise Silvia, Thomsen, J. S., Cowin, P., Juul, Anders, Jensen, M. B. & Rosenkilde, Mette, 2023, In: FASEB Journal. 37, 2, 13 p., 22781.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization

      Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis

      Mavri, M., Glišić, S., Senćanski, M., Vrecl, M., Rosenkilde, Mette, Spiess, Katja & Kubale, V., 2023, In: Cellular and Molecular Biology Letters. 28, 1, 19 p., 14.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2

      Ewart, G., Bobardt, M., Bentzen, Bo Hjorth, Yan, Y., Thomson, A., Klumpp, K., Becker, S., Rosenkilde, Mette, Miller, M. & Gallay, P., 2023, In: PLoS Pathogens. 19, 8 August, 20 p., e1011328.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes

      Melchiorsen, Josefine Ulrikke, Sørensen, Kimmie Vestergaard, Bork-Jensen, J., Kizilkaya, Hüsün Sheyma, Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, Rungby, Jørgen, Sørensen, H. T., Vaag, Allan, Nielsen, J. S., Pedersen, Oluf Borbye, Linneberg, Allan René, Hartmann, Bolette, Gjesing, A. P., Holst, Jens Juul, Hansen, Torben, Rosenkilde, Mette & Grarup, Niels, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 11, p. 2821–2833 38 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Re-routing GPR56 signalling using Gα12/13 G protein chimeras

      Faas, Felix, Nørskov, Amalie, Holst, Peter Johannes, Andersson, A. M., Qvortrup, K., Mathiasen, Signe & Rosenkilde, Mette, 2023, In: Basic and Clinical Pharmacology and Toxicology. 133, 4, p. 378-389

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling

      Conceição, F., Sousa, D. M., Tojal, S., Lourenço, C., Carvalho-Maia, C., Estevão-Pereira, H., Lobo, J., Couto, M., Rosenkilde, Mette, Jerónimo, C. & Lamghari, M., 2023, In: Biomolecules. 13, 4, 25 p., 622.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

      Hindsø, M., Hedbäck, N., Svane, M. S., Møller, A., Martinussen, C., Jørgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2023, In: Diabetes. 72, 3, p. 336–347

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide

      Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Meier, J. J., Holst, Jens Juul & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 11, p. 3079-3092

      Research output: Contribution to journalReviewResearchpeer-review

    27. Published

      The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans

      Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      Therapeutic targeting of HCMV-encoded chemokine receptor US28: Progress and challenges

      Berg, Christian & Rosenkilde, Mette, 2023, In: Frontiers in Immunology. 14, 8 p., 1135280.

      Research output: Contribution to journalReviewResearchpeer-review

    29. Published

      “Glyco-sulfo barcodes” regulate chemokine receptor function

      Verhallen, L., Lackman, Jarkko Juhani, Wendt, R., Gustavsson, Martin, Yang, Zhang, Narimatsu, Yoshiki, Sørensen, Daniel Madriz, Lafferty, K. M., Gouwy, M., Marques, P. E., Hjortø, Gertrud Malene, Rosenkilde, Mette, Proost, P. & Goth, C. K., 2023, In: Cellular and Molecular Life Sciences. 80, 2, 18 p., 55.

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. 2022
    31. Published

      A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium tuberculosis Infection

      Ngo, M. D., Bartlett, S., Bielefeldt-Ohmann, H., Foo, C. X., Sinha, R., Arachchige, B. J., Reed, S., Mandrup-Poulsen, Thomas, Rosenkilde, Mette & Ronacher, K., 2022, In: Journal of Infectious Diseases. 225, 12, p. 2219-2228

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published
    33. Published
    34. Published

      Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality

      Mavri, M., Kubale, V., Depledge, D. P., Zuo, J., Huang, C. A., Breuer, J., Vrecl, M., Jarvis, M. A., Jovičić, E. J., Petan, T., Ehlers, B., Rosenkilde, Mette & Spiess, Katja, 2022, In: Frontiers in Endocrinology. 13, 16 p., 862940.

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin

      Ribeiro, R. V. P., Ku, T., Wang, A., Pires, L., Ferreira, V. H., Michaelsen, V., Ali, A., Galasso, M., Moshkelgosha, S., Gazzalle, A., Jeppesen, Mads Gravers, Rosenkilde, Mette, Liu, M., Singer, L. G., Kumar, D., Keshavjee, S., Sinclair, J., Kledal, T. N., Humar, A. & Cypel, M., 2022, In: Journal of Heart and Lung Transplantation. 41, 3, p. 287-297

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation

      Mayendraraj, A., Rosenkilde, Mette & Gasbjerg, Lærke Smidt, 2022, In: Peptides. 151, p. 1-10 170749.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      GPR183 is Dispensable for B1 cell Accumulation and Function, but Affects B2 cell Abundance, in the Omentum and Peritoneal Cavity

      Barington, L., Christensen, Liv von Voss, Pedersen, K. K., Arfelt, K. N., Roumain, M., Jensen, Kristian HR, Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Kearney, J. F., Christensen, Jan Pravsgaard, Hjortø, Gertrud Malene, Muccioli, G. G., Holst, Peter Johannes & Rosenkilde, Mette, 2022, In: Cells. 11, 3, 19 p., 494.

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published
    39. Published

      Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice

      Boer, G. A., Dal, Jenna Elizabeth Hunt, Gabe, M. B. N., Windeløv, Johanne Agerlin, Sparre-Ulrich, A. H., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4486-4499

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Identification of a conserved chemokine receptor motif that enables ligand discrimination

      Larsen, Olav, van der Velden, W. J. C., Mavri, M., Schuermans, S., Rummel, P. C., Karlshøj, S., Gustavsson, Martin, Proost, P., Våbenø, J. & Rosenkilde, Mette, 2022, In: Science Signaling. 15, 724, eabg7042.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor

      Rode, A. K. O., Buus, Terkild Brink, Mraz, Veronika, Al-Jaberi, F. A. H., Lopez, D. V., Ford, Shayne Lavondua, Hennen, S., Eliasen, I. P., Klewe, I. V., Gharehdaghi, L., Dragan, A., Rosenkilde, Mette, Woetmann, Anders , Skov, Lone, Ødum, Niels, Bonefeld, Charlotte Menne, Kongsbak-Wismann, Martin & Geisler, Carsten, 2022, In: Cells. 11, 16, 2587.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published
    43. Published

      N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction

      Gabe, M. B. N., Gasbjerg, Lærke Smidt, Gadgaard, S., Lindquist, Peter, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4473-4485

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats

      Grunddal, Kaare Villum, Trammell, Sam, Bæch-Laursen, C., Andersen, Daniel Bjørklund, Xu, S. F. S., Andersen, H., Gillum, M. P., Ghiasi, S. M., Novak, Ivana, Tyrberg, B., Li, C., Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2022, In: Diabetologia. 65, p. 1018–1031

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Reply to: How Many SARS-CoV-2 "Viroporins" Are Really Ion Channels? [Inkl. Correction]

      Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Landbrug, A., Mujezinovic, A., Bentzen, Bo Hjorth, Kledal, T. N. & Rosenkilde, Mette, 2022, In: Communications Biology . 5, 1, 1 p., 860.

      Research output: Contribution to journalLetterResearchpeer-review

    46. Published

      Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails

      Brandum, E. P., Jørgensen, Astrid Sissel, Calvo, M. B., Spiess, Katja, Peterson, F. C., Yang, Zhang, Volkman, B. F., Veldkamp, C. T., Rosenkilde, Mette, Goth, C. K. & Hjortø, Gertrud Malene, 2022, In: International Journal of Molecular Sciences. 23, 3, 20 p., 1397.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes

      Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

      Lindquist, Peter, Gasbjerg, Lærke Smidt, Mokrosinski, J., Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, Mette, 2022, In: Frontiers in Endocrinology. 13, 14 p., 891586.

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-Terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist

      Berg, Christian, Wedemeyer, M. J., Melynis, M., Schlimgen, R. R., Hansen, L. H., Vabenø, J., Peterson, F. C., Volkman, B. F., Rosenkilde, Mette & Lüttichau, H. R., 2022, In: PLOS Pathogens. 18, 3, e1010355.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses

      Rosenkilde, Mette, Tsutsumi, N., Knerr, Julius Maximilian, Kildedal, Dagmar Fæster & Garcia, K. C., 2022, In: Annual Review of Virology. 9, 1, p. 329-351

      Research output: Contribution to journalReviewResearchpeer-review

    51. 2021
    52. Published

      Effects of endogenous GIP in patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., Skov-Jeppesen, Kirsa, wbf943, wbf943, Jensen, M. H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45

      Research output: Contribution to journalJournal articleResearchpeer-review

    53. Published

      Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

      Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Tzortzini, E., Xue, K., Giller, K., Becker, S., Mujezinovic, A., Bentzen, Bo Hjorth, Andreas, L. B., Kolocouris, A., Kledal, T. N. & Rosenkilde, Mette, 2021, In: Communications Biology. 4, 10 p., 1347.

      Research output: Contribution to journalJournal articleResearchpeer-review

    54. Published

      Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms

      Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

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