Julien Ochala

Julien Ochala

Associate Professor - Promotion Programme

Member of:

    ORCID: 0000-0002-6358-2920

    Publication year:
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    1 - 50 out of 89Page size: 50
    1. 2024
    2. E-pub ahead of print

      Muscle fibre size and myonuclear positioning in trained and aged humans

      Battey, E., Levy, Y., Pollock, R. D., Pugh, J. N., Close, G. L., Kalakoutis, M., Lazarus, N. R., Harridge, S. D. R., Ochala, Julien & Stroud, M. J., 2024, (E-pub ahead of print) In: Experimental Physiology.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. E-pub ahead of print

      Myonuclear alterations associated with exercise are independent of age in humans

      Battey, E., Ross, J. A., Hoang, A., Wilson, D. G. S., Han, Y., Levy, Y., Pollock, R. D., Kalakoutis, M., Pugh, J. N., Close, G. L., Ellison-Hughes, G. M., Lazarus, N. R., Iskratsch, T., Harridge, S. D. R., Ochala, Julien & Stroud, M. J., 2024, (E-pub ahead of print) In: Journal of Physiology.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 2023
    5. Published

      Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation

      Hau, H. T. A., Kelu, J. J., Ochala, Julien & Hughes, S. M., Jul 2023, In: Developmental Biology. 499, p. 47-58 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      The dawn of the functional genomics era in muscle physiology

      Seaborne, Robert Arthur Elliston & Ochala, Julien, 15 Apr 2023, In: Journal of Physiology. 601, 8, p. 1343-1352

      Research output: Contribution to journal › Review › Research › peer-review

    7. Published

      A rational approach to selective targeting of skeletal myosin

      Katarina Antonovic, A., Ochala, Julien & Fornili, A., 2023, In: Biophysical Journal. 122, 3S1, p. 117a

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Abnormal myosin post-translational modifications and ATP turnover time associated with human congenital myopathy-related RYR1 mutations

      Sonne, A., Antonovic, A. K., Thomsen, Elise Julie Melhedegaard, Akter, F., Andersen, J. L., Jungbluth, H., Witting, N., Vissing, John, Zanoteli, E., Fornili, A. & Ochala, Julien, 2023, In: Acta Physiologica. 239, 2, 14 p., e14035.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity

      Crombie, E. M., Kim, S., Adamson, S., Dong, H., Lu, T. C., Wu, Y., Wu, Y., Levy, Y., Stimple, N., Lam, W. M. R., Hey, H. W. D., Withers, D. J., Hsu, A. L., Bay, B. H., Ochala, Julien & Tsai, S. Y., 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, p. 198–213

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Binding pocket dynamics along the recovery stroke of human β-cardiac myosin

      Akter, F., Ochala, Julien & Fornili, A., 2023, In: PLOS Computational Biology. 19, 5, 14 p., e1011099.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle

      Negoita, F., Addinsall, A. B., Hellberg, K., Bringas, C. F., Hafen, P. S., Sermersheim, T. J., Agerholm, M., Lewis, C. T. A., Ahwazi, D., Ling, N. X. Y., Larsen, J. K., Deshmukh, A. S., Hossain, M. A., Oakhill, J. S., Ochala, J., Brault, J. J., Sankar, U., Drewry, D. H., Scott, J. W., Witczak, C. A. & 1 others, Sakamoto, Kei, 2023, In: Molecular Metabolism. 75, 14 p., 101761.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Comparative study of binding pocket structure and dynamics in cardiac and skeletal myosin

      Antonovic, A. K., Ochala, Julien & Fornili, A., 2023, In: Biophysical Journal. 122, 1, p. 54-62

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Human skeletal myopathy myosin mutations disrupt myosin head sequestration

      Carrington, G., Hau, A., Kosta, S., Dugdale, H. F., Muntoni, F., D’Amico, A., Van den Bergh, P., Romero, N. B., Malfatti, E., Vilchez, J. J., Oldfors, A., Pajusalu, S., Õunap, K., Giralt-Pujol, M., Zanoteli, E., Campbell, K. S., Iwamoto, H., Peckham, M. & Ochala, Julien, 2023, In: JCI insight. 8, 21, p. 1-19 e172322.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State

      Lewis, Christopher T.A. & Ochala, Julien, 2023, In: Physiology. 38, 1, p. 3-9

      Research output: Contribution to journal › Review › Research › peer-review

    15. Published

      Myosin post-translational modifications and function in the presence of myopathy-linked truncating MYH2 mutations

      Sonne, A., Peverelli, L., Hernandez-Lain, A., Domínguez-González, C., Andersen, J. L., Milone, M., Beggs, A. H. & Ochala, Julien, 2023, In: American journal of physiology. Cell physiology. 324, 3, p. C769–C776 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption

      Lewis, C. T. A., Tabrizian, L., Nielsen, J., Laitila, J., Beck, T. N., Olsen, M. S., Ognjanovic, M. M., Aagaard, P., Hokken, R., Laugesen, S., Ingersen, A., Andersen, J. L., Soendenbroe, C., Helge, J. W., Dela, F., Larsen, S., Sahl, R. E., Rømer, T., Hansen, M. T., Frandsen, J. & 2 others, Suetta, Charlotte & Ochala, Julien, 2023, In: The Journal of general physiology. 155, 7, 8 p., e202213268.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Predominant myosin superrelaxed state in canine myocardium with naturally occurring dilated cardiomyopathy

      Ochala, Julien, Lewis, Christopher T.A. , Beck, T., Iwamoto, H., Hessel, A. L., Campbell, K. S. & Pyle, W. G., 2023, In: American journal of physiology. Heart and circulatory physiology. 325, 3, p. H585-H591

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Revisiting specific force loss in human permeabilized single skeletal muscle fibers obtained from older individuals

      Kalakoutis, M., Pollock, R. D., Lazarus, N. R., Atkinson, R. A., George, M., Berber, O., Woledge, R. C., Ochala, Julien & Harridge, S. D. R., 2023, In: American journal of physiology. Cell physiology. 325, 1, p. C172-C185

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies

      Vidal, J., Fernandez, E. A., Wohlwend, M., Laurila, P. P., Lopez-Mejia, A., Ochala, Julien, Lobrinus, A. J., Kayser, B., Lopez-Mejia, I. C., Place, N. & Zanou, N., 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, 6, p. 2882-2897

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. 2022
    21. Published

      Early clinical and pre-clinical therapy development in Nemaline myopathy

      Fisher, G., Mackels, L., Markati, T., Sarkozy, A., Ochala, Julien, Jungbluth, H., Ramdas, S. & Servais, L., 28 Dec 2022, In: Expert Opinion On Therapeutic Targets. 26, 10, p. 853–867

      Research output: Contribution to journal › Review › Research › peer-review

    22. Published

      NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy

      Ranu, N., Laitila, J., Dugdale, H. F., Mariano, J., Kolb, J. S., Wallgren-Pettersson, C., Witting, N., Vissing, J., Vilchez, J. J., Fiorillo, C., Zanoteli, E., Auranen, M., Jokela, M., Tasca, G., Claeys, K. G., Voermans, N. C., Palmio, J., Huovinen, S., Moggio, M., Beck, T. N. & 3 others, Kontrogianni-Konstantopoulos, A., Granzier, H. & Ochala, Julien, 2022, In: Acta Neuropathologica Communications. 10, 185.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Fine-regulation of myosin relaxed states in vertebrate muscle

      Thomsen, Elise Julie Melhedegaard, Sonne, A., Bertelsen, Mads Frost, Vermeulen, E., Ganswindt, A., Wang, T. & Ochala, Julien, 2022, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Myopathy in acute and long-term COVID-19

      Tankisi, H. & Ochala, Julien, 2022, In: Clinical Neurophysiology. 134, p. 141-142

      Research output: Contribution to journal › Letter › Research › peer-review

    25. Published

      PGC-1α regulates myonuclear accretion after moderate endurance training

      Battey, E., Furrer, R., Ross, J., Handschin, C., Ochala, Julien & Stroud, M. J., 2022, In: Journal of Cellular Physiology. 237, 1, p. 696-705

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      The effects of resistance exercise training on mitochondrial myopathy patients

      Di Leo, V., Newman, J., Lawless, C., Robertson, F., Levy, Y., Ochala, Julien, Pickett, S., Hudson, G., Gorman, G., Tuppen, H., Vincent, A. & Russell, O., 2022, In: Neuromuscular Disorders. 32, p. S72-S72 FP.16.

      Research output: Contribution to journal › Conference abstract in journal › Research

    27. 2021
    28. Published

      Can we talk about myoblast fusion?

      Dugdale, H. F. & Ochala, Julien, 2021, In: American Journal of Physiology - Cell Physiology. 321, 3, p. C504-C506

      Research output: Contribution to journal › Review › Research › peer-review

    29. Published

      Methodological considerations in measuring specific force in human single skinned muscle fibres

      Kalakoutis, M., Di Giulio, I., Douiri, A., Ochala, Julien, Harridge, S. D. R. & Woledge, R. C., 2021, In: Acta Physiologica. 233, 3, p. 1-18 e13719.

      Research output: Contribution to journal › Review › Research › peer-review

    30. Published

      Myofibre hyper-contractility in horses expressing the myosin heavy chain myopathy mutation, myh1e321g

      Ochala, Julien, Finno, C. J. & Valberg, S. J., 2021, In: Cells. 10, 12, 3428.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. 2020
    32. Published

      rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy

      Ross, J. A., Tasfaout, H., Levy, Y., Morgan, J., Cowling, B. S., Laporte, J., Zanoteli, E., Romero, N. B., Lowe, D. A., Jungbluth, H., Lawlor, M. W., Mack, D. L. & Ochala, Julien, 19 Oct 2020, In: Acta Neuropathologica Communications. 8, 1, 167.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Using nuclear envelope mutations to explore age-related skeletal muscle weakness

      Battey, E., Stroud, M. J. & Ochala, Julien, 28 Aug 2020, In: Clinical Science. 134, 16, p. 2177-2187 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Physiological impact and disease reversion for the severe form of centronuclear myopathy linked to Dynamin

      Massana Muñoz, X., Kretz, C., Silva-Rojas, R., Ochala, Julien, Menuet, A., Romero, N. B., Cowling, B. S. & Laporte, J., 18 Aug 2020, In: JCI insight. 5, 18, 16 p., e137899.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

      Laitila, J. M., McNamara, E. L., Wingate, C. D., Goullee, H., Ross, J. A., Taylor, R. L., Van Der Pijl, R., Griffiths, L. M., Harries, R., Ravenscroft, G., Clayton, J. S., Sewry, C., Lawlor, M. W., Ottenheijm, C. A. C., Bakker, A. J., Ochala, Julien, Laing, N. G., Wallgren-Pettersson, C., Pelin, K. & Nowak, K. J., 17 Feb 2020, In: Acta Neuropathologica Communications. 8, 1, 18.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Candidate gene expression and coding sequence variants in Warmblood horses with myofibrillar myopathy

      Williams, Z. J., Velez-Irizarry, D., Petersen, J. L., Ochala, Julien, Finno, C. J. & Valberg, S. J., 2020, (Accepted/In press) In: Equine Veterinary Journal.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

      Cramer, A. A. W., Prasad, V., Eftestøl, E., Song, T., Hansson, K. A., Dugdale, H. F., Sadayappan, S., Ochala, Julien, Gundersen, K. & Millay, D. P., 2020, In: Nature Communications. 11, 1, 14 p., 6287.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. 2019

    39. Effect of PGC1-beta ablation on myonuclear organisation

      Beedour, R., Ross, J. A., Levy, Y. & Ochala, Julien, 1 Dec 2019, In: Journal of Muscle Research and Cell Motility. 40, 3-4, p. 335-341 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy

      Ross, J. A., Levy, Y., Ripolone, M., Kolb, J. S., Turmaine, M., Holt, M., Lindqvist, J., Claeys, K. G., Weis, J., Monforte, M., Tasca, G., Moggio, M., Figeac, N., Zammit, P. S., Jungbluth, H., Fiorillo, C., Vissing, J., Witting, N., Granzier, H., Zanoteli, E. & 3 others, Hardeman, E. C., Wallgren-Pettersson, C. & Ochala, Julien, 2019, In: Acta Neuropathologica. 138, 3, p. 477-495 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. 2018

    42. Molecular consequences of the myopathy-related D286G mutation on actin function

      Fan, J., Chan, C., McNamara, E. L., Nowak, K. J., Iwamoto, H. & Ochala, Julien, 1 Dec 2018, In: Frontiers in Physiology. 9, 1756.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action

      Svensson, K., Dent, J. R., Tahvilian, S., Martins, V. F., Sathe, A., Ochala, Julien, Patel, M. S. & Schenk, S., Nov 2018, In: American Journal of Physiology - Endocrinology and Metabolism. 315, 5, p. E1034-E1045

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy

      Buono, S., Ross, J. A., Tasfaout, H., Levy, Y., Kretz, C., Tayefeh, L., Matson, J., Guo, S., Kessler, P., Monia, B. P., Bitoun, M., Ochala, Julien, Laporte, J. & Cowling, B. S., 23 Oct 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. 11066-11071 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

      Levy, Y., Ross, J. A., Niglas, M., Snetkov, V. A., Lynham, S., Liao, C., Puckelwartz, M. J., Hsu, Y., McNally, E. M., Alsheimer, M., Harridge, S. D., Young, S. G., Fong, L. G., Español, Y., Lopez-Otin, C., Kennedy, B. K., Lowe, D. A. & Ochala, Julien, 4 Oct 2018, In: JCI insight. 3, 19

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. SIRT1 regulates nuclear number and domain size in skeletal muscle fibers

      Ross, J. A., Levy, Y., Svensson, K., Philp, A., Schenk, S. & Ochala, Julien, Sep 2018, In: Journal of Cellular Physiology. 233, 9, p. 7157-7163 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction

      Jungbluth, H., Treves, S., Zorzato, F., Sarkozy, A., Ochala, Julien, Sewry, C., Phadke, R., Gautel, M. & Muntoni, F., Mar 2018, In: Nature Reviews. Neurology. 14, 3, p. 151-167 17 p.

      Research output: Contribution to journal › Review › Research › peer-review

    48. Myostatin inhibition using mrk35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice

      Tinklenberg, J. A., Siebers, E. M., Beatka, M. J., Meng, H., Yang, L., Zhang, Z., Ross, J. A., Ochala, Julien, Morris, C., Owens, J. M., Laing, N. G., Nowak, K. J. & Lawlor, M. W., 15 Feb 2018, In: Human Molecular Genetics. 27, 4, p. 638-648 11 p., ddx431.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. 2017

    50. Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres

      Ross, J. A., Pearson, A., Levy, Y., Cardel, B., Handschin, C. & Ochala, Julien, 1 Jun 2017, In: Journal of Cellular Physiology. 232, 6, p. 1270-1274 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Current and future therapeutic approaches to the congenital myopathies

      Jungbluth, H., Ochala, Julien, Treves, S. & Gautel, M., Apr 2017, In: Seminars in Cell and Developmental Biology. 64, p. 191-200 10 p.

      Research output: Contribution to journal › Review › Research › peer-review

    52. 2016
    53. Published

      Novel myosin-based therapies for congenital cardiac and skeletal myopathies

      Ochala, Julien & Sun, Y. B., 1 Oct 2016, In: Journal of Medical Genetics. 53, 10, p. 651-654 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function

      Chan, C., Fan, J., Messer, A. E., Marston, S. B., Iwamoto, H. & Ochala, Julien, 1 Aug 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 8, p. 1453-1458 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle

      Roy, P., Rau, F., Ochala, Julien, Messéant, J., Fraysse, B., Lainé, J., Agbulut, O., Butler-Browne, G., Furling, D. & Ferry, A., 20 Jul 2016, In: Skeletal Muscle. 6, 1, 23.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Modulating myosin restores muscle function in a mouse model of nemaline myopathy

      Lindqvist, J., Levy, Y., Pati-Alam, A., Hardeman, E. C., Gregorevic, P. & Ochala, Julien, 1 May 2016, In: Annals of Neurology. 79, 5, p. 717-725 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. 2015
    58. Published

      Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of High-intensity interval exercise

      Place, N., Ivarsson, N., Venckunas, T., Neyroud, D., Brazaitis, M., Cheng, A. J., Ochala, Julien, Kamandulis, S., Girard, S., Volungevičius, G., Paužas, H., Mekideche, A., Kayser, B., Martinez-Redondo, V., Ruas, J. L., Bruton, J., Truffert, A., Lanner, J. T., Skurvydas, A. & Westerblad, H., 15 Dec 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. 15492-15497 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle

      Gokhin, D. S., Ochala, Julien, Domenighetti, A. A. & Fowler, V. M., 15 Dec 2015, In: Development (Cambridge, England). 142, 24, p. 4351-62 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      X-ray recordings reveal how a human disease-linked skeletal muscle α-actin mutation leads to contractile dysfunction

      Ochala, Julien, Ravenscroft, G., McNamara, E., Nowak, K. J. & Iwamoto, H., Dec 2015, In: Journal of Structural Biology. 192, 3, p. 331-335 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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