Clare Louise Hawkins

Clare Louise Hawkins

Professor with special responsibilities


  1. Published

    8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response

    Tang, V., Fu, S., Rayner, B. S. & Hawkins, Clare Louise, 2019, In : Redox Biology. 26, 11 p., UNSP 101274.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    8-chloroadenosine alters the metabolic profile and downregulates antioxidant and DNA damage repair pathways in macrophages

    Macer-Wright, J., Sileikaite, I., Rayner, B. & Hawkins, Clare Louise, 2020, In : Chemical Research in Toxicology. 33, 2, p. 402-413

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

    Lok, H. C., Sahni, S., Jansson, P. J., Kovacevic, Z., Hawkins, Clare Louise & Richardson, D. R., 30 Dec 2016, In : The Journal of Biological Chemistry. 291, 53, p. 27042-27061 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation

    Macer-Wright, J. L., Stanley, N. R., Portman, N., Tan, J. T., Bursill, C., Rayner, B. S. & Hawkins, Clare Louise, 2019, In : Chemical Research in Toxicology. 32, 6, p. 1223-1234

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid

    Pan, G., Rayner, B., Zhang, Y., van Reyk, D. & Hawkins, Clare Louise, 2018, In : Archives of Biochemistry and Biophysics. 642, p. 23-30 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart?

    Hawkins, Clare Louise, 2018, In : Acta Physiologica. 223, 4, 3 p., e13106 .

    Research output: Contribution to journalEditorialResearchpeer-review

  7. Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents

    Stanley, N. R., Pattison, D. I. & Hawkins, Clare Louise, 19 Jul 2010, In : Chemical Research in Toxicology. 23, 7, p. 1293-302 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization

    Gamon, Luke Francis, Guo, Chaorui, He, Jianfei, Hägglund, Per Mårten, Hawkins, Clare Louise & Davies, Michael Jonathan, Sep 2020, In : Redox Biology. 36, 101586.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

    Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., Scott, K. F., Ziegler, J. B., Pattison, D. I., Fu, S., Hawkins, Clare Louise, Rees, M. D. & Davies, Michael Jonathan, 15 Apr 2010, In : Biochemical Pharmacology. 79, 8, p. 1156-64 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome

    Gracanin, M., Lam, M. A., Morgan, P. E., Rodgers, K. J., Hawkins, Clare Louise & Davies, Michael Jonathan, 15 Jan 2011, In : Free Radical Biology & Medicine. 50, 2, p. 389-99 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

    Reyes, L., Bishop, D. P., Hawkins, Clare Louise & Rayner, B. S., 2019, In : Antioxidants. 8, 546 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Binding of myeloperoxidase to the extracellular matrix of smooth muscle cells and subsequent matrix modification

    Cai, H., Chuang, Christine, Hawkins, Clare Louise & Davies, Michael Jonathan, 2020, In : Scientific Reports. 13 p., 666.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis

    Ridiandries, A., Tan, J. T. M., Ravindran, D., Williams, H., Medbury, H. J., Lindsay, L., Hawkins, Clare Louise, Prosser, H. C. G. & Bursill, C. A., Mar 2017, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31, 3, p. 1179-1192 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

    Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, Michael Jonathan & Hawkins, Clare Louise, 2017, In : Redox Biology. 12, p. 872-882 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Cellular effects of peptide and protein hydroperoxides

    Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael Jonathan, 15 Apr 2010, In : Free Radical Biology & Medicine. 48, 8, p. 1071-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts

    Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael Jonathan, 30 Nov 2010, In : Free Radical Biology & Medicine. 49, 10, p. 1505-15 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Cellular responses to radical propagation from ion-implanted plasma polymer surfaces

    Stewart, C. A. C., Akhavan, B., Santos, M., Hung, J., Hawkins, Clare Louise, Bao, S., Wise, S. G. & Bilek, M. M. M., 2018, In : Applied Surface Science. 456, p. 701-710

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages

    Love, D., Barrett, T. J., White, M. Y., Cordwell, S. J., Davies, Michael Jonathan & Hawkins, Clare Louise, 2016, In : Free Radical Biology & Medicine. 94, p. 88-98 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space

    Indo, H. P., Majima, H. J., Terada, M., Suenaga, S., Tomita, K., Yamada, S., Higashibata, A., Ishioka, N., Kanekura, T., Nonaka, I., Hawkins, Clare Louise, Davies, Michael Jonathan, Clair, D. K. S. & Mukai, C., 16 Dec 2016, In : Scientific Reports. 6, 10 p., 39015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts

    Reyes, L., Hawkins, Clare Louise & Rayner, B. S., 2019, In : Archives of Biochemistry and Biophysics. 665, p. 132-142

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

    Rayner, B. S., Love, D. T. & Hawkins, Clare Louise, Jun 2014, In : Free Radical Biology & Medicine. 71, p. 240-55 16 p.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  22. Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

    Lloyd, M. M., Grima, M. A., Rayner, B. S., Hadfield, K. A., Davies, Michael Jonathan & Hawkins, Clare Louise, Dec 2013, In : Free Radical Biology & Medicine. 65, p. 1352-62 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development

    Tweeddale, H. J., Hawkins, Clare Louise, Janmie, J. F., Truscott, R. J. W. & Davies, Michael Jonathan, Oct 2016, In : Free Radical Research. 50, 10, p. 1116-1130 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Detection and characterisation of radicals in biological materials using EPR methodology

    Hawkins, Clare Louise & Davies, Michael Jonathan, Feb 2014, In : B B A - Reviews on Cancer. 1840, 2, p. 708-21 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Detection, identification, and quantification of oxidative protein modifications

    Hawkins, Clare Louise & Davies, Michael Jonathan, 2019, In : Journal of Biological Chemistry. 294, 51, p. 19683-19708

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    EPR spin trapping of protein radicals

    Davies, Michael Jonathan & Hawkins, Clare Louise, 2004, In : Free Radical Biology & Medicine. 36, 9, p. 1072-86 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction

    Galougahi, K. K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N. A. S., Davies, Michael Jonathan, Hawkins, Clare Louise, Rasmussen, H. H. & Figtree, G. A., 2014, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 3, 2, p. e000731

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

    Morgan, P. E., Pattison, D. I., Talib, J., Summers, F. A., Harmer, J. A., Celermajer, D. S., Hawkins, Clare Louise & Davies, Michael Jonathan, 1 Nov 2011, In : Free Radical Biology & Medicine. 51, 9, p. 1815-22 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase

    Lim, Y. J., Foo, T. C., Yeung, A. W. S., Tu, X., Ma, Y., Hawkins, Clare Louise, Witting, P. K., Jameson, G. N. L., Terentis, A. C. & Thomas, S. R., 2019, In : Biochemistry. 58, 7, p. 974-986

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates

    Rees, M. D., Hawkins, Clare Louise & Davies, Michael Jonathan, 1 Jul 2004, In : Biochemical Journal. 381, Pt 1, p. 175-84 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Hypochlorite-induced damage to DNA, RNA, and polynucleotides: formation of chloramines and nitrogen-centered radicals

    Hawkins, Clare Louise & Davies, Michael Jonathan, Jan 2002, In : Chemical Research in Toxicology. 15, 1, p. 83-92 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Hypochlorite-mediated fragmentation of hyaluronan, chondroitin sulfates, and related N-acetyl glycosamines: evidence for chloramide intermediates, free radical transfer reactions, and site-specific fragmentation

    Rees, M. D., Hawkins, Clare Louise & Davies, Michael Jonathan, 12 Nov 2003, In : Journal of the American Chemical Society. 125, 45, p. 13719-33 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin

    Szuchman-Sapir, A. J., Pattison, D. I., Ellis, N. A., Hawkins, Clare Louise, Davies, Michael Jonathan & Witting, P. K., 15 Sep 2008, In : Free Radical Biology & Medicine. 45, 6, p. 789-98 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Hypochlorous acid-mediated modification of proteins and its consequences

    Hawkins, Clare Louise, 2020, In : Essays in Biochemistry. 64, 1, p. 75-86

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    Hypochlorous acid-mediated oxidation of lipid components and antioxidants present in low-density lipoproteins: absolute rate constants, product analysis, and computational modeling

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael Jonathan, Apr 2003, In : Chemical Research in Toxicology. 16, 4, p. 439-49 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael Jonathan, 28 Aug 2007, In : Biochemistry. 46, 34, p. 9853-64 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

    Cai, H., Chuang, Christine, Vanichkitrungruang, S., Hawkins, Clare Louise & Davies, Michael Jonathan, 2019, In : Free Radical Biology and Medicine. 134, p. 526-536

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Hypothiocyanous acid - benign or deadly?

    Barrett, T. J. & Hawkins, Clare Louise, 20 Feb 2012, In : Chemical Research in Toxicology. 25, 2, p. 263-73 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

    Lloyd, M. M., van Reyk, D. M., Davies, Michael Jonathan & Hawkins, Clare Louise, 1 Sep 2008, In : Biochemical Journal. 414, 2, p. 271-80 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines

    Summers, F. A., Morgan, P. E., Davies, Michael Jonathan & Hawkins, Clare Louise, Sep 2008, In : Chemical Research in Toxicology. 21, 9, p. 1832-40 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines

    Summers, F. A., Forsman Quigley, A. & Hawkins, Clare Louise, 24 Aug 2012, In : Biochemical and Biophysical Research Communications. 425, 2, p. 157-61 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

    Zhang, Y., Rayner, B. S., Jensen, M. & Hawkins, Clare Louise, 2019, In : Journal of Visualized Experiments. 153, e60541 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Inactivation of protease inhibitors and lysozyme by hypochlorous acid: role of side-chain oxidation and protein unfolding in loss of biological function

    Hawkins, Clare Louise & Davies, Michael Jonathan, Oct 2005, In : Chemical Research in Toxicology. 18, 10, p. 1600-10 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

    Barrett, T. J., Pattison, D. I., Leonard, S. E., Carroll, K. S., Davies, Michael Jonathan & Hawkins, Clare Louise, 15 Mar 2012, In : Free Radical Biology & Medicine. 52, 6, p. 1075-85 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

    Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K., Fu, S., Bottle, S. E., Hawkins, Clare Louise & Davies, Michael Jonathan, May 2014, In : Free Radical Biology & Medicine. 70, p. 96-105 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction

    Abdo, A., Rayner, B. S., van Reyk, D. M. & Hawkins, Clare Louise, 2017, In : Redox Biology. 13, p. 623-632 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Mammalian heme peroxidases: from molecular mechanisms to health implications

    Davies, Michael Jonathan, Hawkins, Clare Louise, Pattison, D. I. & Rees, M. D., Jul 2008, In : Antioxidants & Redox Signaling. 10, 7, p. 1199-234 36 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion

    Indo, H. P., Matsui, H., Chen, J., Zhu, H., Hawkins, Clare Louise, Davies, Michael Jonathan, Yarana, C., Clair, D. K. S. & Majima, H. J., 1 Jul 2015, In : Journal of Clinical Biochemistry and Nutrition. 57, 1, p. 13-20 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway

    Shu, N., Hägglund, Per Mårten, Cai, H., Hawkins, Clare Louise & Davies, Michael Jonathan, Jan 2020, In : Redox Biology. 29, UNSP 101400.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis

    Anzovino, A., Chiang, S., Brown, B. E., Hawkins, Clare Louise, Richardson, D. R. & Huang, M. L., Dec 2017, In : American Journal of Pathology. 187, 12, p. 2858-2875 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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