Clare Louise Hawkins
Clare Louise Hawkins

Professor with special responsibilities

ORCID: 0000-0003-2738-5089

Publication year:
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  1. 2020
  2. Published

    Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway

    Shu, N., Hägglund, Per Mårten, Cai, H., Hawkins, Clare Louise & Davies, Michael Jonathan, Jan 2020, In : Redox Biology. 29, UNSP 101400.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Selenomethionine supplementation reduces lesion burden, improves vessel function and modulates the inflammatory response within the setting of atherosclerosis

    Zhang, Y., Cartland, S. P., Henriquez, R., Patel, S., Gammelgaard, Bente, Flouda, Konstantina, Hawkins, Clare Louise & Rayner, B. S., Jan 2020, In : Redox Biology. 29, 11 p., 101409.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2019
  5. Published

    8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response

    Tang, V., Fu, S., Rayner, B. S. & Hawkins, Clare Louise, 2019, In : Redox Biology. 26, 11 p., UNSP 101274.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation

    Macer-Wright, J. L., Stanley, N. R., Portman, N., Tan, J. T., Bursill, C., Rayner, B. S. & Hawkins, Clare Louise, 2019, In : Chemical Research in Toxicology. 32, 6, p. 1223-1234

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

    Reyes, L., Bishop, D. P., Hawkins, Clare Louise & Rayner, B. S., 2019, In : Antioxidants. 8, 546 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts

    Reyes, L., Hawkins, Clare Louise & Rayner, B. S., 2019, In : Nitric Oxide: Biology and Chemistry. 665, p. 132-142

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Detection, identification, and quantification of oxidative protein modifications

    Hawkins, Clare Louise & Davies, Michael Jonathan, 2019, In : Journal of Biological Chemistry. 294, 51, p. 19683-19708

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase

    Lim, Y. J., Foo, T. C., Yeung, A. W. S., Tu, X., Ma, Y., Hawkins, Clare Louise, Witting, P. K., Jameson, G. N. L., Terentis, A. C. & Thomas, S. R., 2019, In : Biochemistry. 58, 7, p. 974-986

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

    Cai, H., Chuang, Christine, Vanichkitrungruang, S., Hawkins, Clare Louise & Davies, Michael Jonathan, 2019, In : Free Radical Biology and Medicine. 134, p. 526-536

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

    Zhang, Y., Rayner, B. S., Jensen, M. & Hawkins, Clare Louise, 2019, In : Journal of Visualized Experiments. 153, e60541 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function

    Vanichkitrungruang, S., Chuang, Christine, Hawkins, Clare Louise, Hammer, A., Hoefler, G., Malle, E. & Davies, Michael Jonathan, 2019, In : Free Radical Biology and Medicine. 136, p. 118-134

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2018
  15. Published

    A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid

    Pan, G., Rayner, B., Zhang, Y., van Reyk, D. & Hawkins, Clare Louise, 2018, In : Archives of Biochemistry and Biophysics. 642, p. 23-30 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart?

    Hawkins, Clare Louise, 2018, In : Acta Physiologica. 223, 4, 3 p., e13106 .

    Research output: Contribution to journal › Editorial › Research › peer-review

  17. Published

    Cellular responses to radical propagation from ion-implanted plasma polymer surfaces

    Stewart, C. A. C., Akhavan, B., Santos, M., Hung, J., Hawkins, Clare Louise, Bao, S., Wise, S. G. & Bilek, M. M. M., 2018, In : Applied Surface Science. 456, p. 701-710

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Protein carbamylation: a key driver of vascular calcification during chronic kidney disease

    Hawkins, Clare Louise, 2018, In : Kidney International. 94, 1, p. 12-14

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  19. Published

    Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation

    Rayner, B. S., Zhang, Y., Brown, B. E., Reyes, L., Cogger, V. C. & Hawkins, Clare Louise, 2018, In : Free Radical Biology and Medicine. 129, p. 25-34

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The dys-regulation of anti-oxidant defense via an impairment of Nrf2 response in the pathology of Friedreich's ataxia: [Meeting Abstract]

    Chiang, S., Anzovino, A., Brown, B. E., Hawkins, Clare Louise, Richardson, D. R. & Huang, M. L. -., 2018, In : Free Radical Biology and Medicine. 120, p. S35-S35 OP-19 .

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  21. 2017
  22. Published

    Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis

    Anzovino, A., Chiang, S., Brown, B. E., Hawkins, Clare Louise, Richardson, D. R. & Huang, M. L., Dec 2017, In : American Journal of Pathology. 187, 12, p. 2858-2875 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis

    Ridiandries, A., Tan, J. T. M., Ravindran, D., Williams, H., Medbury, H. J., Lindsay, L., Hawkins, Clare Louise, Prosser, H. C. G. & Bursill, C. A., Mar 2017, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31, 3, p. 1179-1192 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

    Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, Michael Jonathan & Hawkins, Clare Louise, 2017, In : Redox Biology. 12, p. 872-882 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction

    Abdo, A., Rayner, B. S., van Reyk, D. M. & Hawkins, Clare Louise, 2017, In : Redox Biology. 13, p. 623-632 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

    Indo, H. P., Hawkins, Clare Louise, Nakanishi, I., Matsumoto, K., Matsui, H., Suenaga, S., Davies, Michael Jonathan, St Clair, D. K., Ozawa, T. & Majima, H. J., 2017, Pharmacology of Mitochondria. Springer, Vol. 240. p. 439-456 18 p. (Handbook of Experimental Pharmacology, Vol. 240).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  27. 2016

  28. A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

    Lok, H. C., Sahni, S., Jansson, P. J., Kovacevic, Z., Hawkins, Clare Louise & Richardson, D. R., 30 Dec 2016, In : The Journal of Biological Chemistry. 291, 53, p. 27042-27061 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space

    Indo, H. P., Majima, H. J., Terada, M., Suenaga, S., Tomita, K., Yamada, S., Higashibata, A., Ishioka, N., Kanekura, T., Nonaka, I., Hawkins, Clare Louise, Davies, Michael Jonathan, Clair, D. K. S. & Mukai, C., 16 Dec 2016, In : Scientific Reports. 6, 10 p., 39015.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development

    Tweeddale, H. J., Hawkins, Clare Louise, Janmie, J. F., Truscott, R. J. W. & Davies, Michael Jonathan, Oct 2016, In : Free Radical Research. 50, 10, p. 1116-1130 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia

    Karimi Galougahi, K., Liu, C., Garcia, A., Gentile, C., Fry, N. A., Hamilton, E. J., Hawkins, Clare Louise & Figtree, G. A., 19 Feb 2016, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 5, 2, e002824.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages

    Love, D., Barrett, T. J., White, M. Y., Cordwell, S. J., Davies, Michael Jonathan & Hawkins, Clare Louise, 2016, In : Free Radical Biology & Medicine. 94, p. 88-98 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?

    Ismael, F. O., Barrett, T. J., Sheipouri, D., Brown, B. E., Davies, Michael Jonathan & Hawkins, Clare Louise, 2016, In : P L o S One. 11, 12, 16 p., e0168844.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2015

  35. Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion

    Indo, H. P., Matsui, H., Chen, J., Zhu, H., Hawkins, Clare Louise, Davies, Michael Jonathan, Yarana, C., Clair, D. K. S. & Majima, H. J., 1 Jul 2015, In : Journal of Clinical Biochemistry and Nutrition. 57, 1, p. 13-20 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage

    Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, Michael Jonathan & Hawkins, Clare Louise, Jul 2015, In : Free Radical Biology & Medicine. 84, p. 279-288 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. 2014

  38. Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants

    Bonifay, V., Barrett, T. J., Pattison, D. I., Davies, Michael Jonathan, Hawkins, Clare Louise & Ashby, M. T., 15 Dec 2014, In : Archives of Biochemistry and Biophysics. 564, p. 1-11 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

    Hawkins, Clare Louise, Nov 2014, In : Kidney International. 86, 5, p. 875-7 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

    Rayner, B. S., Love, D. T. & Hawkins, Clare Louise, Jun 2014, In : Free Radical Biology & Medicine. 71, p. 240-55 16 p.

    Research output: Contribution to journal › Journal article › Commissioned › peer-review

  41. Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

    Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K., Fu, S., Bottle, S. E., Hawkins, Clare Louise & Davies, Michael Jonathan, May 2014, In : Free Radical Biology & Medicine. 70, p. 96-105 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Detection and characterisation of radicals in biological materials using EPR methodology

    Hawkins, Clare Louise & Davies, Michael Jonathan, Feb 2014, In : B B A - Reviews on Cancer. 1840, 2, p. 708-21 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  43. Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction

    Galougahi, K. K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N. A. S., Davies, Michael Jonathan, Hawkins, Clare Louise, Rasmussen, H. H. & Figtree, G. A., 2014, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 3, 2, p. e000731

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. 2013

  45. Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

    Lloyd, M. M., Grima, M. A., Rayner, B. S., Hadfield, K. A., Davies, Michael Jonathan & Hawkins, Clare Louise, Dec 2013, In : Free Radical Biology & Medicine. 65, p. 1352-62 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)

    Hadfield, K. A., Pattison, D. I., Brown, B. E., Hou, L., Rye, K., Davies, Michael Jonathan & Hawkins, Clare Louise, 15 Jan 2013, In : Biochemical Journal. 449, 2, p. 531-42 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. 2012

  48. Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines

    Summers, F. A., Forsman Quigley, A. & Hawkins, Clare Louise, 24 Aug 2012, In : Biochemical and Biophysical Research Communications. 425, 2, p. 157-61 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids

    Pattison, D. I., Davies, Michael Jonathan & Hawkins, Clare Louise, Aug 2012, In : Free Radical Research. 46, 8, p. 975-95 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

    Boon, A., Hawkins, Clare Louise, Bisht, K., Coombes, J. S., Bakrania, B., Wagner, K. & Bulmer, A. C., 15 May 2012, In : Free Radical Biology & Medicine. 52, 10, p. 2120-7 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

    Barrett, T. J., Pattison, D. I., Leonard, S. E., Carroll, K. S., Davies, Michael Jonathan & Hawkins, Clare Louise, 15 Mar 2012, In : Free Radical Biology & Medicine. 52, 6, p. 1075-85 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Hypothiocyanous acid - benign or deadly?

    Barrett, T. J. & Hawkins, Clare Louise, 20 Feb 2012, In : Chemical Research in Toxicology. 25, 2, p. 263-73 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes

    Lok, H. C., Suryo Rahmanto, Y., Hawkins, Clare Louise, Kalinowski, D. S., Morrow, C. S., Townsend, A. J., Ponka, P. & Richardson, D. R., 2 Jan 2012, In : The Journal of Biological Chemistry. 287, 1, p. 607-18 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. 2011

  55. High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

    Morgan, P. E., Pattison, D. I., Talib, J., Summers, F. A., Harmer, J. A., Celermajer, D. S., Hawkins, Clare Louise & Davies, Michael Jonathan, 1 Nov 2011, In : Free Radical Biology & Medicine. 51, 9, p. 1815-22 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity

    Yu, Y., Suryo Rahmanto, Y., Hawkins, Clare Louise & Richardson, D. R., Jun 2011, In : Molecular Pharmacology. 79, 6, p. 921-31 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome

    Gracanin, M., Lam, M. A., Morgan, P. E., Rodgers, K. J., Hawkins, Clare Louise & Davies, Michael Jonathan, 15 Jan 2011, In : Free Radical Biology & Medicine. 50, 2, p. 389-99 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. 2010

  59. Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts

    Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael Jonathan, 30 Nov 2010, In : Free Radical Biology & Medicine. 49, 10, p. 1505-15 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation - an EPR study

    Jansson, P. J., Hawkins, Clare Louise, Lovejoy, D. B. & Richardson, D. R., Nov 2010, In : Journal of Inorganic Biochemistry. 104, 11, p. 1224-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

    Lane, A. E., Tan, J. T. M., Hawkins, Clare Louise, Heather, A. K. & Davies, Michael Jonathan, 15 Aug 2010, In : Biochemical Journal. 430, 1, p. 161-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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