Clare Louise Hawkins

Clare Louise Hawkins

Professor with special responsibilities


  1. 2002
  2. Published

    Hypochlorite-induced damage to DNA, RNA, and polynucleotides : formation of chloramines and nitrogen-centered radicals. / Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Chemical Research in Toxicology, Vol. 15, No. 1, 01.2002, p. 83-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Superoxide radicals can act synergistically with hypochlorite to induce damage to proteins. / Hawkins, Clare Louise; Rees, Martin D; Davies, Michael Jonathan.

    In: FEBS letters, Vol. 510, No. 1-2, 02.01.2002, p. 41-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Singlet oxygen-mediated protein oxidation : evidence for the formation of reactive side chain peroxides on tyrosine residues. / Wright, Adam; Bubb, William A; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Photochemistry and Photobiology, Vol. 76, No. 1, 07.2002, p. 35-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Reaction of protein chloramines with DNA and nucleosides : evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation. / Hawkins, Clare Louise; Pattison, David I; Davies, Michael Jonathan.

    In: Biochemical Journal, Vol. 365, No. Pt 3, 01.08.2002, p. 605-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2003
  7. Published

    Photo-oxidation of cells generates long-lived intracellular protein peroxides. / Wright, Adam; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 34, No. 6, 15.03.2003, p. 637-47.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Hypochlorous acid-mediated oxidation of lipid components and antioxidants present in low-density lipoproteins : absolute rate constants, product analysis, and computational modeling. / Pattison, David I; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Chemical Research in Toxicology, Vol. 16, No. 4, 04.2003, p. 439-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Hypochlorite-mediated fragmentation of hyaluronan, chondroitin sulfates, and related N-acetyl glycosamines : evidence for chloramide intermediates, free radical transfer reactions, and site-specific fragmentation. / Rees, Martin D; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Journal of the American Chemical Society, Vol. 125, No. 45, 12.11.2003, p. 13719-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2004
  11. Published

    EPR spin trapping of protein radicals. / Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Free Radical Biology & Medicine, Vol. 36, No. 9, 2004, p. 1072-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates. / Rees, Martin D; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Biochemical Journal, Vol. 381, No. Pt 1, 01.07.2004, p. 175-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2005
  14. Inactivation of protease inhibitors and lysozyme by hypochlorous acid : role of side-chain oxidation and protein unfolding in loss of biological function. / Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Chemical Research in Toxicology, Vol. 18, No. 10, 10.2005, p. 1600-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. The role of reactive N-bromo species and radical intermediates in hypobromous acid-induced protein oxidation. / Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 39, No. 7, 01.10.2005, p. 900-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. The role of aromatic amino acid oxidation, protein unfolding, and aggregation in the hypobromous acid-induced inactivation of trypsin inhibitor and lysozyme. / Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Chemical Research in Toxicology, Vol. 18, No. 11, 11.2005, p. 1669-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2006
  18. Sensitizer-mediated photooxidation of histidine residues : evidence for the formation of reactive side-chain peroxides. / Agon, Vanessa V; Bubb, William A; Wright, Adam; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 40, No. 4, 15.02.2006, p. 698-710.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2007
  20. Hypochlorous acid-mediated protein oxidation : how important are chloramine transfer reactions and protein tertiary structure? / Pattison, David I; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Biochemistry, Vol. 46, No. 34, 28.08.2007, p. 9853-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2008
  22. Mammalian heme peroxidases : from molecular mechanisms to health implications. / Davies, Michael Jonathan; Hawkins, Clare Louise; Pattison, David I; Rees, Martin D.

    In: Antioxidants & Redox Signaling, Vol. 10, No. 7, 07.2008, p. 1199-234.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines. / Summers, Fiona A; Morgan, Philip E; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Chemical Research in Toxicology, Vol. 21, No. 9, 09.2008, p. 1832-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid. / Lloyd, Mitchell M; van Reyk, David M; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Biochemical Journal, Vol. 414, No. 2, 01.09.2008, p. 271-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin. / Szuchman-Sapir, Andrea J; Pattison, David I; Ellis, Natasha A; Hawkins, Clare Louise; Davies, Michael Jonathan; Witting, Paul K.

    In: Free Radical Biology & Medicine, Vol. 45, No. 6, 15.09.2008, p. 789-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins. / Morgan, Philip E; Pattison, David I; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 45, No. 9, 01.11.2008, p. 1279-89.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation. / Hawkins, Clare Louise; Pattison, David I; Stanley, Naomi R; Davies, Michael Jonathan.

    In: Biochemical Journal, Vol. 416, No. 3, 15.12.2008, p. 441-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2009
  29. Quantification of protein modification by oxidants. / Hawkins, Clare Louise; Morgan, Philip E; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 46, No. 8, 15.04.2009, p. 965-88.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach. / Pattison, David I; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Chemical Research in Toxicology, Vol. 22, No. 5, 05.2009, p. 807-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Singlet-oxygen-mediated amino acid and protein oxidation : formation of tryptophan peroxides and decomposition products. / Gracanin, Michelle; Hawkins, Clare Louise; Pattison, David I; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 47, No. 1, 01.07.2009, p. 92-102.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. The role of hypothiocyanous acid (HOSCN) in biological systems. / Hawkins, Clare L.

    In: Free Radical Research, Vol. 43, No. 12, 12.2009, p. 1147-58.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  33. 2010
  34. Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. / Koelsch, Maud; Mallak, Roger; Graham, Garry G; Kajer, Tracey; Milligan, Marian K; Nguyen, Ly Q; Newsham, Dawn W; Keh, Jeremy S; Kettle, Anthony J; Scott, Kieran F; Ziegler, John B; Pattison, David I; Fu, Shanlin; Hawkins, Clare Louise; Rees, Martin D; Davies, Michael Jonathan.

    In: Biochemical Pharmacology, Vol. 79, No. 8, 15.04.2010, p. 1156-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Cellular effects of peptide and protein hydroperoxides. / Rahmanto, Aldwin Suryo; Morgan, Philip E; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 48, No. 8, 15.04.2010, p. 1071-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents. / Stanley, Naomi R; Pattison, David I; Hawkins, Clare L.

    In: Chemical Research in Toxicology, Vol. 23, No. 7, 19.07.2010, p. 1293-302.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. / Lane, Amanda E; Tan, Joanne T M; Hawkins, Clare Louise; Heather, Alison K; Davies, Michael Jonathan.

    In: Biochemical Journal, Vol. 430, No. 1, 15.08.2010, p. 161-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation - an EPR study. / Jansson, Patric J; Hawkins, Clare L; Lovejoy, David B; Richardson, Des R.

    In: Journal of Inorganic Biochemistry, Vol. 104, No. 11, 11.2010, p. 1224-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts. / Rahmanto, Aldwin Suryo; Morgan, Philip E; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 49, No. 10, 30.11.2010, p. 1505-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2011
  41. Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome. / Gracanin, Michelle; Lam, Magdalena A; Morgan, Philip E; Rodgers, Kenneth J; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 50, No. 2, 15.01.2011, p. 389-99.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity. / Yu, Yu; Suryo Rahmanto, Yohan; Hawkins, Clare L; Richardson, Des R.

    In: Molecular Pharmacology, Vol. 79, No. 6, 06.2011, p. 921-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase. / Morgan, Philip E; Pattison, David I; Talib, Jihan; Summers, Fiona A; Harmer, Jason A; Celermajer, David S; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 51, No. 9, 01.11.2011, p. 1815-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. 2012
  45. Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes. / Lok, Hiu Chuen; Suryo Rahmanto, Yohan; Hawkins, Clare L; Kalinowski, Danuta S; Morrow, Charles S; Townsend, Alan J; Ponka, Prem; Richardson, Des R.

    In: The Journal of Biological Chemistry, Vol. 287, No. 1, 02.01.2012, p. 607-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Hypothiocyanous acid - benign or deadly? / Barrett, Tessa J; Hawkins, Clare L.

    In: Chemical Research in Toxicology, Vol. 25, No. 2, 20.02.2012, p. 263-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Inactivation of thiol-dependent enzymes by hypothiocyanous acid : role of sulfenyl thiocyanate and sulfenic acid intermediates. / Barrett, Tessa J; Pattison, David I; Leonard, Stephen E; Carroll, Kate S; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Free Radical Biology & Medicine, Vol. 52, No. 6, 15.03.2012, p. 1075-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. / Boon, Ai-Ching; Hawkins, Clare L; Bisht, Kavita; Coombes, Jeff S; Bakrania, Bhavisha; Wagner, Karl-Heinz; Bulmer, Andrew C.

    In: Free Radical Biology & Medicine, Vol. 52, No. 10, 15.05.2012, p. 2120-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Reactions and reactivity of myeloperoxidase-derived oxidants : differential biological effects of hypochlorous and hypothiocyanous acids. / Pattison, David I; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Free Radical Research, Vol. 46, No. 8, 08.2012, p. 975-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines. / Summers, Fiona A; Forsman Quigley, Anna; Hawkins, Clare L.

    In: Biochemical and Biophysical Research Communications, Vol. 425, No. 2, 24.08.2012, p. 157-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 2013
  52. Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins : comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl). / Hadfield, Katrina A; Pattison, David I; Brown, Bronwyn E; Hou, Liming; Rye, Kerry-Anne; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Biochemical Journal, Vol. 449, No. 2, 15.01.2013, p. 531-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. / Lloyd, Mitchell M; Grima, Michael A; Rayner, Benjamin S; Hadfield, Katrina A; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Free Radical Biology & Medicine, Vol. 65, 12.2013, p. 1352-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2014
  55. Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction. / Galougahi, Keyvan Karimi; Liu, Chia-Chi; Gentile, Carmine; Kok, Cindy; Nunez, Andrea; Garcia, Alvaro; Fry, Natasha A S; Davies, Michael Jonathan; Hawkins, Clare Louise; Rasmussen, Helge H; Figtree, Gemma A.

    In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, Vol. 3, No. 2, 2014, p. e000731.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Detection and characterisation of radicals in biological materials using EPR methodology. / Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: B B A - Reviews on Cancer, Vol. 1840, No. 2, 02.2014, p. 708-21.

    Research output: Contribution to journalReviewResearchpeer-review

  57. Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides. / Kajer, Tracey B; Fairfull-Smith, Kathryn E; Yamasaki, Toshihide; Yamada, Ken-ichi; Fu, Shanlin; Bottle, Steven E; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 70, 05.2014, p. 96-105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. / Rayner, Benjamin S; Love, Dominic T; Hawkins, Clare L.

    In: Free Radical Biology & Medicine, Vol. 71, 06.2014, p. 240-55.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  59. Role of cyanate in the induction of vascular dysfunction during uremia : more than protein carbamylation? / Hawkins, Clare L.

    In: Kidney International, Vol. 86, No. 5, 11.2014, p. 875-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants. / Bonifay, Vincent; Barrett, Tessa J; Pattison, David I; Davies, Michael Jonathan; Hawkins, Clare Louise; Ashby, Michael T.

    In: Archives of Biochemistry and Biophysics, Vol. 564, 15.12.2014, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. 2015
  62. Published

    Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants : Second-order rate constants and implications for biological damage. / Carroll, Luke; Pattison, David I.; Fu, Shanlin; Schiesser, Carl H.; Davies, Michael J.; Hawkins, Clare Louise.

    In: Free Radical Biology & Medicine, Vol. 84, 07.2015, p. 279-288.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion. / Indo, Hiroko P.; Matsui, Hirofumi; Chen, Jing; Zhu, Haining; Hawkins, Clare Louise; Davies, Michael J.; Yarana, Chontida; Clair, Daret K St; Majima, Hideyuki J.

    In: Journal of Clinical Biochemistry and Nutrition, Vol. 57, No. 1, 01.07.2015, p. 13-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. 2016
  65. Published

    Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages. / Love, D; Barrett, T.J.; White, M.Y.; Cordwell, S.J.; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Free Radical Biology & Medicine, Vol. 94, 2016, p. 88-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

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