Clare Louise Hawkins

Clare Louise Hawkins

Professor with special responsibilities


  1. 2022
  2. Published

    Mapping the modification of histones by the myeloperoxidase-derived oxidant hypochlorous acid (HOCl)

    Hallberg, Line Amalie Egholm, Thorsen, N. W., Hartsema, E. A., Hägglund, Per Mårten & Hawkins, Clare Louise, 2022, In: Free Radical Biology and Medicine. 192, p. 152-164 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    New roles of neutrophils and granulocytic MDSC in autoimmune diseases, inflammation, and anti-microbial immunity

    Odobasic, D., Hawkins, Clare Louise & Radic, M., 2022, In: Frontiers in Immunology. 13, 2 p., 974062.

    Research output: Contribution to journalEditorialResearchpeer-review

  4. Published

    Role of macrophage extracellular traps in innate immunity and inflammatory disease

    Rasmussen, K. H. & Hawkins, Clare Louise, 2022, In: Biochemical Society Transactions. 50, 1, p. 21-32 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Activation and Inhibition of Human Matrix Metalloproteinase-9 (MMP9) by HOCl, Myeloperoxidase and Chloramines

    Wang, Y., Chuang, Christine, Hawkins, Clare Louise & Davies, Michael J., Aug 2022, In: Antioxidants. 11, 8, 22 p., 1616.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Influence of plasma halide, pseudohalide and nitrite ions on myeloperoxidase-mediated protein and extracellular matrix damage

    Xu, Shuqi, Chuang, Christine, Malle, E., Gamon, Luke Francis, Hawkins, Clare Louise & Davies, Michael J., 2022, In: Free Radical Biology and Medicine. 188, p. 162-174

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2021
  8. Published

    Modulation of hypochlorous acid (HOCl) induced damage to vascular smooth muscle cells by thiocyanate and selenium analogues

    Flouda, K., Gammelgaard, Bente, Davies, Michael J. & Hawkins, Clare Louise, May 2021, In: Redox Biology. 41, 101873.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage

    Flouda, K., Mercer, J., Davies, Michael J. & Hawkins, Clare Louise, 2021, In: Free Radical Biology & Medicine. 166, p. 165-177

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Oral pre-treatment with thiocyanate (SCN-) protects against myocardial ischaemia-reperfusion injury in rats

    Hall, L., Guo, C., Tandy, S., Broadhouse, K., Dona, A. C., Malle, E., Bartels, Emil Daniel, Christoffersen, Christina, Grieve, S. M., Figtree, G., Hawkins, Clare Louise & Davies, Michael J., 2021, In: Scientific Reports. 11, 1, 18 p., 12712.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Role of histone modification by hypochlorous acid on vascular cell function

    Hallberg, Line Amalie Egholm, Barlous, K. A. & Hawkins, Clare Louise, 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 593

    Research output: Contribution to journalConference abstract in journalResearch

  12. Published

    Modification of histones by hypochlorous acid and its influence on vascular cell function

    Hallberg, Line Amalie Egholm, Barlous, K. & Hawkins, Clare Louise, 2021, In: Free Radical Biology and Medicine. 165, S1, p. 19

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  13. Published

    Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage

    Hawkins, Clare Louise & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 172, p. 633-651

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    ROLE OF EXTRACELLULAR TRAP RELEASE BY MACROPHAGES DURING THE DEVELOPMENT OF CHRONIC INFLAMMATION.

    Jensen, M., Hägglund, Per Mårten, Zhang, Y., Rayner, B. & Hawkins, Clare Louise, 2021, In: Atherosclerosis. 331, p. E72-E72 PO51.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  15. Published

    The role of RNA oxidation in islet dysfunction in Type 2 diabetes

    Sileikaite, Inga, Davies, Michael J., Mandrup-Poulsen, Thomas & Hawkins, Clare Louise, 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1 , p. S37-S38

    Research output: Contribution to journalConference abstract in journalResearch

  16. Published

    Chlorination and nitration of extracellular matrix by inflammatory myeloperoxidase-derived oxidants in the presence of nitrite

    Xu, Shuqi, Chuang, Christine, Hawkins, Clare Louise & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 566 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  17. 2020
  18. Published

    Binding of myeloperoxidase to the extracellular matrix of smooth muscle cells and subsequent matrix modification

    Cai, H., Chuang, Christine, Hawkins, Clare Louise & Davies, Michael J., 2020, In: Scientific Reports. 13 p., 666.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease

    Davies, Michael J. & Hawkins, Clare Louise, 2020, In: Antioxidants & Redox Signaling. 32, 13, p. 957-981

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization

    Gamon, Luke Francis, Guo, C., He, Jianfei, Hägglund, Per Mårten, Hawkins, Clare Louise & Davies, Michael J., Sep 2020, In: Redox Biology. 36, 9 p., 101586.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Myeloperoxidase Modulates Hydrogen Peroxide Mediated Cellular Damage in Murine Macrophages

    Guo, C., Sileikaite, Inga, Davies, Michael J. & Hawkins, Clare Louise, 2020, In: Antioxidants. 9, 12, 14 p., 1255.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Role of thiocyanate in the modulation of myeloperoxidase-derived oxidant induced damage to macrophages

    Guo, C., Davies, Michael J. & Hawkins, Clare Louise, Sep 2020, In: Redox Biology. 36, 14 p., 101666.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Hypochlorous acid-mediated modification of proteins and its consequences

    Hawkins, Clare Louise, 2020, In: Essays in Biochemistry. 64, 1, p. 75-86

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Dermal fibroblasts have different extracellular matrix profiles induced by TGF-beta, PDGF and IL-6 in a model for skin fibrosis

    Juhl, P., Bondesen, S., Hawkins, Clare Louise, Karsdal, M. A., Bay-Jensen, A., Davies, Michael J. & Siebuhr, A. S., 2020, In: Scientific Reports. 10, 1, 10 p., 17300.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The role of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) in the induction of mitochondrial dysfunction in macrophages

    Love, D. T., Guo, C., Nikelshparg, E. I., Brazhe, N. A., Sosnovtseva, Olga & Hawkins, Clare Louise, 2020, In: Redox Biology. 36, 12 p., 101602.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    8-chloroadenosine alters the metabolic profile and downregulates antioxidant and DNA damage repair pathways in macrophages

    Macer-Wright, J., Sileikaite, Inga, Rayner, B. & Hawkins, Clare Louise, 2020, In: Chemical Research in Toxicology. 33, 2, p. 402-413

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway

    Shu, N., Hägglund, Per Mårten, Cai, H., Hawkins, Clare Louise & Davies, Michael J., Jan 2020, In: Redox Biology. 29, UNSP 101400.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Myeloperoxidase-derived damage to human plasma fibronectin: Modulation by protein binding and thiocyanate ions (SCN)

    Vanichkitrungruang, S., Chuang, Christine, Hawkins, Clare Louise & Davies, Michael J., 2020, In: Redox Biology. 36, 13 p., 101641.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Selenomethionine supplementation reduces lesion burden, improves vessel function and modulates the inflammatory response within the setting of atherosclerosis

    Zhang, Y., Cartland, S. P., Henriquez, R., Patel, S., Gammelgaard, Bente, Flouda, K., Hawkins, Clare Louise & Rayner, B. S., Jan 2020, In: Redox Biology. 29, 11 p., 101409.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2019
  31. Published

    Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

    Cai, H., Chuang, Christine, Vanichkitrungruang, S., Hawkins, Clare Louise & Davies, Michael J., 2019, In: Free Radical Biology and Medicine. 134, p. 526-536

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Detection, identification, and quantification of oxidative protein modifications

    Hawkins, Clare Louise & Davies, Michael J., 2019, In: Journal of Biological Chemistry. 294, 51, p. 19683-19708

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase

    Lim, Y. J., Foo, T. C., Yeung, A. W. S., Tu, X., Ma, Y., Hawkins, Clare Louise, Witting, P. K., Jameson, G. N. L., Terentis, A. C. & Thomas, S. R., 2019, In: Biochemistry. 58, 7, p. 974-986

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation

    Macer-Wright, J. L., Stanley, N. R., Portman, N., Tan, J. T., Bursill, C., Rayner, B. S. & Hawkins, Clare Louise, 2019, In: Chemical Research in Toxicology. 32, 6, p. 1223-1234

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

    Reyes, L., Bishop, D. P., Hawkins, Clare Louise & Rayner, B. S., 2019, In: Antioxidants. 8, 546 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts

    Reyes, L., Hawkins, Clare Louise & Rayner, B. S., 2019, In: Archives of Biochemistry and Biophysics. 665, p. 132-142

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response

    Tang, V., Fu, S., Rayner, B. S. & Hawkins, Clare Louise, 2019, In: Redox Biology. 26, 11 p., UNSP 101274.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function

    Vanichkitrungruang, S., Chuang, Christine, Hawkins, Clare Louise, Hammer, A., Hoefler, G., Malle, E. & Davies, Michael J., 2019, In: Free Radical Biology and Medicine. 136, p. 118-134

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

    Zhang, Y., Rayner, B. S., Jensen, M. & Hawkins, Clare Louise, 2019, In: Journal of Visualized Experiments. 153, e60541 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2018
  41. Published

    The dys-regulation of anti-oxidant defense via an impairment of Nrf2 response in the pathology of Friedreich's ataxia: [Meeting Abstract]

    Chiang, S., Anzovino, A., Brown, B. E., Hawkins, Clare Louise, Richardson, D. R. & Huang, M. L. -., 2018, In: Free Radical Biology and Medicine. 120, p. S35-S35 OP-19 .

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  42. Published

    A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart?

    Hawkins, Clare Louise, 2018, In: Acta Physiologica. 223, 4, 3 p., e13106 .

    Research output: Contribution to journalEditorialResearchpeer-review

  43. Published

    Protein carbamylation: a key driver of vascular calcification during chronic kidney disease

    Hawkins, Clare Louise, 2018, In: Kidney International. 94, 1, p. 12-14

    Research output: Contribution to journalComment/debateResearchpeer-review

  44. Published

    A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid

    Pan, G., Rayner, B., Zhang, Y., van Reyk, D. & Hawkins, Clare Louise, 2018, In: Archives of Biochemistry and Biophysics. 642, p. 23-30 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation

    Rayner, B. S., Zhang, Y., Brown, B. E., Reyes, L., Cogger, V. C. & Hawkins, Clare Louise, 2018, In: Free Radical Biology and Medicine. 129, p. 25-34

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Cellular responses to radical propagation from ion-implanted plasma polymer surfaces

    Stewart, C. A. C., Akhavan, B., Santos, M., Hung, J., Hawkins, Clare Louise, Bao, S., Wise, S. G. & Bilek, M. M. M., 2018, In: Applied Surface Science. 456, p. 701-710

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2017
  48. Published

    Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction

    Abdo, A., Rayner, B. S., van Reyk, D. M. & Hawkins, Clare Louise, 2017, In: Redox Biology. 13, p. 623-632 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis

    Anzovino, A., Chiang, S., Brown, B. E., Hawkins, Clare Louise, Richardson, D. R. & Huang, M. L., Dec 2017, In: American Journal of Pathology. 187, 12, p. 2858-2875 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

    Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, Michael J. & Hawkins, Clare Louise, 2017, In: Redox Biology. 12, p. 872-882 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

    Indo, H. P., Hawkins, Clare Louise, Nakanishi, I., Matsumoto, K., Matsui, H., Suenaga, S., Davies, Michael J., St Clair, D. K., Ozawa, T. & Majima, H. J., 2017, Pharmacology of Mitochondria. Springer, Vol. 240. p. 439-456 18 p. (Handbook of Experimental Pharmacology, Vol. 240).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  52. CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis

    Ridiandries, A., Tan, J. T. M., Ravindran, D., Williams, H., Medbury, H. J., Lindsay, L., Hawkins, Clare Louise, Prosser, H. C. G. & Bursill, C. A., Mar 2017, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31, 3, p. 1179-1192 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. 2016
  54. Published

    Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space

    Indo, H. P., Majima, H. J., Terada, M., Suenaga, S., Tomita, K., Yamada, S., Higashibata, A., Ishioka, N., Kanekura, T., Nonaka, I., Hawkins, Clare Louise, Davies, Michael J., Clair, D. K. S. & Mukai, C., 16 Dec 2016, In: Scientific Reports. 6, 10 p., 39015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?

    Ismael, F. O., Barrett, T. J., Sheipouri, D., Brown, B. E., Davies, Michael J. & Hawkins, Clare Louise, 2016, In: P L o S One. 11, 12, 16 p., e0168844.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia

    Karimi Galougahi, K., Liu, C., Garcia, A., Gentile, C., Fry, N. A., Hamilton, E. J., Hawkins, Clare Louise & Figtree, G. A., 19 Feb 2016, In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 5, 2, e002824.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

    Lok, H. C., Sahni, S., Jansson, P. J., Kovacevic, Z., Hawkins, Clare Louise & Richardson, D. R., 30 Dec 2016, In: The Journal of Biological Chemistry. 291, 53, p. 27042-27061 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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