Carolyn F. Deacon

Carolyn F. Deacon

Associate Professor

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    ORCID: 0000-0003-2611-5642

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    1. Published

      Ghrelin secretion in humans - a role for the vagus nerve?

      Veedfald, Simon, Plamboeck, A., Hartmann, Bolette, Vilsbøll, Tina, Knop, Filip Krag, Deacon, Carolyn F., Svendsen, Lars Bo & Holst, Jens Juul, Jun 2018, In: Neurogastroenterology and Motility. 30, 6, e13295.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia

      Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., Jun 2003, In: Diabetologia. 46, 6, p. 798-801 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia

      Meier, J. J., Gallwitz, N., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In: Diabetologia. 46, p. 798-801

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion.

      Deacon, Carolyn F., Plamboeck, A., Møller, Søren & Holst, Jens Juul, 2002, In: American Journal of Physiology: Endocrinology and Metabolism. 282, 4, p. E873-9

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice

      Jolivalt, C., Fineman, M., Deacon, Carolyn F., Carr, R. & Calcutt, N., Nov 2011, In: Diabetes, Obesity and Metabolism. 13, 11, p. 990-1000 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.

      Sturis, J., Gotfredsen, C. F., Rømer, J., Rolin, B., Ribel, U., Brand, C. L., Wilken, M., Wassermann, K., Deacon, Carolyn F., Carr, R. D. & Knudsen, L. B., 2003, In: British Journal of Pharmacology. 140, 1, p. 123-32 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      GLP-1 Is a Coronary Artery Vasodilator in Humans

      Clarke, S. J., Giblett, J. P., Yang, L. L., Hubsch, A., Zhao, T., Aetesam-ur-Rahman, M., West, N. E. J., O'Sullivan, M., Figg, N., Bennett, M., Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Cheriyan, J. & Hoole, S. P., 20 Nov 2018, In: Journal of the American Heart Association. 7, 22, 14 p., e010321.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.

      Deacon, Carolyn F., Plamboeck, A., Rosenkilde, Mette, de Heer, J. & Holst, Jens Juul, 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 3, p. E468-75

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes

      Mentis, N., Vardarli, I., Köthe, L. D., Holst, Jens Juul, Deacon, Carolyn F., Theodorakis, M., Meier, J. J. & Nauck, M. A., 2011, In: Diabetes. 60, 4, p. 1270-1276 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men

      Matikainen, N., Söderlund, S., Björnson, E., Bogl, L. H., Pietiläinen, K. H., Hakkarainen, A., Lundbom, N., Eliasson, B., Räsänen, S. M., Rivellese, A., Patti, L., Prinster, A., Riccardi, G., Després, J., Alméras, N., Holst, Jens Juul, Deacon, Carolyn F., Borén, J. & Taskinen, M., Jun 2017, In: Nutrition, Metabolism & Cardiovascular Diseases. 27, 6, p. 534-542 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Four weeks treatment with the GLP-1 receptor analogue liraglutide lowers liver fat and concomitantly circulating glucagon in individuals with overweight

      Svane, M. S., Johannesen, H. H., Hansen, Adam Espe, Martinussen, C., Bojsen-Møller, K. N., Hansen, M. L., Deacon, Carolyn F., Keller, S. H., Klausen, Thomas Levin, Loft, A., Kjær, Andreas, Löfgren, J., Madsbad, Sten, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: International Journal of Obesity. 46, p. 2058–2062 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      For debate: Are antidiabetic actions of DPP-IV inhibitors mediated by glucagon-like peptide- 1?

      Holst, Jens Juul & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 612-615

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Feedback suppression of meal-induced glucagon-like peptide-1 (GLP-1) secretion mediated through elevations in intact GLP-1 caused by dipeptidyl peptidase-4 inhibition: a randomized, prospective comparison of sitagliptin and vildagliptin treatment

      Baranov, O., Kahle, M., Deacon, Carolyn F., Holst, Jens Juul & Nauck, M. A., Nov 2016, In: Diabetes, Obesity and Metabolism. 18, 11, p. 1100-1109 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs

      Simonsen, L., Holst, Jens Juul & Deacon, Carolyn F., Apr 2006, In: Diabetologia. 49, 4, p. 706-12 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs

      Simonsen, L., Holst, Jens Juul & Deacon, Carolyn F., 2006, In: Diabetologia. 49, 4, p. 706-712 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.

      Simonsen, L., Pilgaard, S., Orskov, C., Rosenkilde, Mette, Hartmann, B., Holst, Jens Juul & Deacon, Carolyn F., 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G288-95

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy

      Andersen, Ove, Haugaard, Steen Bendix, Holst, Jens Juul, Deacon, Carolyn F., Iversen, J., Andersen, U. B., Nielsen, J. O. & Madsbad, Sten, Mar 2005, In: HIV Medicine. 6, 2, p. 91-8 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Enhanced glucagon-like peptide- 1 (GLP-1) response to oral glucose in glucose intolerant HIV-infected patients on antiretroviral therapy

      Andersen, O., Haugaard, S. B., Holst, Jens Juul, Deacon, Carolyn F., Iversen, J., Andersen, U. B., Nielsen, J. O. & Madsbad, S., 2005, In: HIV Medicine. 6, p. 91-98

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

      Ten Kulve, J. S., Veltman, D. J., van Bloemendaal, L., Barkhof, F., Deacon, Carolyn F., Holst, Jens Juul, Konrad, R. J., Sloan, J. H., Drent, M. L., Diamant, M. & IJzerman, R. G., Dec 2015, In: Diabetologia. 58, 12, p. 2688-98 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues

      Ten Kulve, J. S., Veltman, D. J., Gerdes, V. E. A., van Bloemendaal, L., Barkhof, F., Deacon, Carolyn F., Holst, Jens Juul, Drent, M. L., Diamant, M. & IJzerman, R. G., Nov 2017, In: Diabetes Care. 40, 11, p. 1522-1529 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance.

      Rosenstock, J., Foley, J. E., Rendell, M., Landin-Olsson, M., Holst, Jens Juul, Deacon, Carolyn F., Rochotte, E. & Baron, M. A., 2008, In: Diabetes Care. 31, 1, p. 30-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Effects of the dipeptidyl peptidase IV inhibitor, vildagliptin, on glycemic, gut hormone, triglyceride, energy expenditure and energy intake responses to intraduodenal fat infusion in healthy males

      Heruc, G., Horowitz, M., Deacon, Carolyn F., Feinle-Bisset, C., Rayner, C., Luscombe-Marsh, N. & Little, T. J., 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 307, 9, p. E830-E837 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Effects of sitagliptin therapy on markers of low-grade inflammation and cell adhesion molecules in patients with type 2 diabetes

      Tremblay, A., Lamarche, B., Deacon, Carolyn F., Weisnagel, S. & Couture, P., 2014, In: Metabolism. 63, 9, p. 1141-1148 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans, and patients with type 2 diabetes treated with or without metformin

      Wu, T., Ma, J., Bound, M., Checklin, H., Deacon, Carolyn F., Jones, K., Horowitz, M. & Raynor, C., 2014, In: Diabetes. 63, 8, p. 2776-2787 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in type 2 diabetes

      Wu, T., Trahair, L., Bound, M., Deacon, Carolyn F., Horowitz, M., Rayner, C. & Jones, K., 2015, In: Diabetic Medicine. 32, 5, p. 595-600 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and "isoglycemic" intravenous glucose

      Vardarli, I., Arndt, E., Deacon, Carolyn F., Holst, Jens Juul & Nauck, M. A., Feb 2014, In: Diabetes. 63, 2, p. 663-74 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Effects of short-term therapy with glibenclamide and repaglinide on incretin hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus

      Stephens, J. W., Bodvarsdottir, T. B., Wareham, K., Prior, S. L., Bracken, R. M., Lowe, G. D., Rumley, A., Dunseath, G., Luzio, S., Deacon, Carolyn F., Holst, Jens Juul & Bain, S. C., Nov 2011, In: Diabetes Research and Clinical Practice. 94, 2, p. 199-206 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Effects of saxagliptin on β-cell stimulation and insulin secretion in patients with type 2 diabetes

      Henry, R. R., Smith, S., Schwartz, S., Mudaliar, S. R., Deacon, Carolyn F., Holst, Jens Juul, Duan, R. Y., Chen, R. S. & List, J. F., 2011, In: Diabetes, Obesity and Metabolism. 13, 9, p. 850-858 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Effects of a six-week intervention with glucagon-like peptide-1 receptor analogue on pancreatic volume, oedema and DNA synthesis in obese men

      Svane, M. S., Johannesen, Helle Hjorth, Martinussen, C., Bojsen-Moller, K. N., Hansen, M. L., Hansen, A. E., Deacon, Carolyn F., Hartmann, Bolette, Keller, S. H., Loft, A., Kjær, Andreas, Madsbad, Sten, Lofgren, J., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Diabetologia. 63, SUPPL 1, p. S216-S217 442.

      Research output: Contribution to journal › Conference abstract in journal › Research

    30. Published

      Effects of Pioglitazone on Glucose-Dependent Insulinotropic Polypeptide-Mediated Insulin Secretion and Adipocyte Receptor Expression in Patients With Type 2 Diabetes

      Tharp, W. G., Gupta, D., Sideleva, O., Deacon, Carolyn F., Holst, Jens Juul, Elahi, D. & Pratley, R. E., 2020, In: Diabetes. 69, 2, p. 146-157

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure: A Pilot Study

      Clarke, S. J., Pettit, S., Giblett, J. P., Zhao, T., Kydd, A. C., Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Parameshwar, J. & Hoole, S. P., 2019, In: Clinical Therapeutics. 41, 1, p. 118-127 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes

      Foley, J. E., Ligueros-Saylan, M., He, Y., Holst, Jens Juul, Deacon, Carolyn F., Dunning, B. E., Leone-Jones, A., Yu, T. & Kelley, D. E., Oct 2008, In: Hormone and Metabolic Research. Supplement. 40, 10, p. 727-30 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.

      Herman, G. A., Bergman, A., Stevens, C., Kotey, P., Yi, B., Zhao, P., Dietrich, B., Golor, G., Schrodter, A., Keymeulen, B., Lasseter, K. C., Kipnes, M. S., Snyder, K., Hilliard, D., Tanen, M., Cilissen, C., De Smet, M., de Lepeleire, I., Van Dyck, K., Wang, A. Q., Zeng, W., Davies, M. J., Tanaka, W., Holst, Jens Juul, Deacon, Carolyn F., Gottesdiener, K. M. & Wagner, J. A., 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4612-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Effect of Vildagliptin on Glucagon Concentration During Meals in Patients with Type 1 Diabetes

      Foley, J. E., Ligueros-Saylan, M., He, Y. L., Holst, Jens Juul, Deacon, Carolyn F., Dunning, B. E., Leone-Jones, A., Yu, T. & Kelley, D. E., 2008, In: Hormone and Metabolic Research. 40, 10, p. 727-730 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Effect of Sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes

      Tremblay, A., Lamarche, B., Deacon, Carolyn F., Weisnagel, S. & Couture, P., Apr 2011, In: Diabetes, Obesity and Metabolism. 13, 4, p. 366-373 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients

      Yabe, D., Kuroe, A., Watanabe, K., Iwasaki, M., Hamasaki, A., Hamamoto, Y., Harada, N., Yamane, S., Lee, S., Murotani, K., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N., Kurose, T. & Seino, Y., 2015, In: Journal of Diabetes and its Complications. 29, p. 413-421 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes.

      Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Windeløv, Johanne Agerlin, Ørgaard, A., Deacon, Carolyn F., Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 2, p. E302-E309 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Do we know the true mechanism of action of the DPP-4 inhibitors?

      Andersen, E. S., Deacon, Carolyn F. & Holst, Jens Juul, 2018, In: Diabetes, Obesity and Metabolism. 20, 1, p. 34-41 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?

      Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019

      Research output: Contribution to journal › Review › Research › peer-review

    40. Published

      Dissociated incretin hormone response to protein versus fat ingestion in obese subjects

      Lindgren, O., Carr, R., Holst, Jens Juul, Deacon, Carolyn F. & Ahren, B., Jul 2011, In: Diabetes, Obesity and Metabolism Online. 13, 9, p. 863-865 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review

      Deacon, Carolyn F., Jan 2011, In: Diabetes, Obesity and Metabolism. 13, 1, p. 7-18 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    42. Published

      Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety

      Deacon, Carolyn F. & Holst, Jens Juul, Oct 2013, In: Expert Opinion on Pharmacotherapy. 14, 15, p. 2047-58 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1

      Migoya, E. M., Bergeron, R., Miller, J. L., Snyder, R. N. K., Tanen, M., Hilliard, D., Weiss, B., Larson, P., Gutierrez, M., Jiang, G., Liu, F., Pryor, K. A., Yao, J., Zhu, L., Holst, Jens Juul, Deacon, Carolyn F., Herman, G., Thornberry, N., Amatruda, J., Williams-Herman, D., Wagner, J. A. & SinhaRoy, R., 1 Dec 2010, In: Clinical Pharmacology and Therapeutics. 88, 6, p. 801-8 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs

      Hjøllund, K. R., Deacon, Carolyn F. & Holst, Jens Juul, 2011, In: Diabetologia. 54, 8, p. 2206-8 3 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    45. Published

      Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

      Deacon, Carolyn F., Knudsen, L. B., Madsen, K., Wiberg, F. C., Jacobsen, O. & Holst, Jens Juul, 1998, In: Diabetologia. 41, p. 271-278

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes.

      Deacon, Carolyn F. & Holst, Jens Juul, 2005, In: International Journal of Biochemistry & Cell Biology. 38, 5-6, p. 831-44 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs

      Deacon, Carolyn F., Danielsen, P., Klarskov, L., Holst, Jens Juul & Olesen, M., 2001, In: Diabetes. 50, p. 1588-1597

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

      Deacon, Carolyn F., Hughes, T. E. & Holst, Jens Juul, 1998, In: Diabetes. 47, p. 764-769

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective.

      Deacon, Carolyn F. & Holst, Jens Juul, 2002, In: Biochemical and Biophysical Research Communications. 294, 1, p. 1-4 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus

      Deacon, Carolyn F., 2020, In: Nature Reviews Endocrinology. 16, 11, p. 642-653

      Research output: Contribution to journal › Review › Research › peer-review

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