Carolyn F. Deacon

Carolyn F. Deacon

Associate Professor


  1. 2019
  2. E-pub ahead of print

    Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice. / Jepsen, Sara L.; Grunddal, Kaare V.; Wewer Albrechtsen, Nicolai J; Engelstoft, Maja S; Gabe, Maria B N; Jensen, Elisa P; Ørskov, Cathrine; Poulsen, Steen S; Rosenkilde, Mette M; Pedersen, Jens; Gribble, Fiona M; Reimann, Frank; Deacon, Carolyn F; Schwartz, Thue W; Christ, Andreas D; Martin, Rainer E; Holst, Jens J.

    In: A J P: Endocrinology and Metabolism (Online), 10.09.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure : A Pilot Study. / Clarke, Sophie J.; Pettit, Stephen; Giblett, Joel P.; Zhao, Tian; Kydd, Anna C.; Albrechtsen, Nicolai J. W.; Deacon, Carolyn F.; Parameshwar, Jayan; Hoole, Stephen P.

    In: Clinical Therapeutics, Vol. 41, No. 1, 2019, p. 118-127.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes. / Deacon, Carolyn F.

    In: Frontiers in Endocrinology, Vol. 10, 80, 2019.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Sacubitril/Valsartan Augments Postprandial Plasma Concentrations of Active GLP-1 When Combined With Sitagliptin in Men. / Wewer Albrechtsen, Nicolai J; Mark, Peter D; Terzic, Dijana; Hansen, Lasse H; Andersen, Ulrik Ø; Hartmann, Bolette; Carr, Richard D; Gustafsson, Finn; Deacon, Carolyn F; Holst, Jens J; Goetze, Jens P; Plomgaard, Peter.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 104, No. 9, 2019, p. 3868-3876.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2018
  7. Published

    GLP-1 Is a Coronary Artery Vasodilator in Humans. / Clarke, Sophie J.; Giblett, Joel P.; Yang, Lucy L.; Hubsch, Annette; Zhao, Tian; Aetesam-ur-Rahman, Muhammad; West, Nick E. J.; O'Sullivan, Michael; Figg, Nichola; Bennett, Martin; Albrechtsen, Nicolai J. Wewer; Deacon, Carolyn F.; Cheriyan, Joseph; Hoole, Stephen P.

    In: Journal of the American Heart Association, Vol. 7, No. 22, e010321, 20.11.2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects. / Samkani, Amirsalar Agertoft; Skytte, Mads J; Thomsen, Mads N; Astrup, Arne; Deacon, Carolyn F; Holst, Jens Juul; Madsbad, Sten; Rehfeld, Jens Frederik; Krarup, Thure; Haugaard, Steen B.

    In: Nutrients, Vol. 10, No. 9, 1285, 09.2018, p. 1-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes? / Andersen, Emilie S.; Lund, A.; Bagger, J. I.; Andreasen, C; Grøndahl, MF; Deacon, Carolyn F.; Hartmann, Bolette; Holst, Jens Juul; Knop, Filip Krag; Lauritsen, Tina Vilsbøll.

    In: Diabetes, Obesity and Metabolism, Vol. 20, No. 8, 08.2018, p. 1937-1943.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Ghrelin secretion in humans - a role for the vagus nerve? / Veedfald, S; Plamboeck, A; Hartmann, B; Vilsbøll, T; Knop, F K; Deacon, C F; Svendsen, L B; Holst, J J.

    In: Neurogastroenterology and Motility, Vol. 30, No. 6, e13295, 06.2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    A review of dipeptidyl peptidase-4 inhibitors : Hot topics from randomized controlled trials. / Deacon, Carolyn F.

    In: Diabetes, Obesity and Metabolism, Vol. 20, 02.2018, p. 34-46.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes. / Deacon, Carolyn F.

    In: Peptides, Vol. 100, 02.2018, p. 150-157.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients. / Samkani, Amirsalar; Skytte, Mads Gustav Juul; Kandel, Daniel; Kjaer, Stine; Astrup, Arne; Deacon, Carolyn F.; Holst, Jens J; Madsbad, Sten; Rehfeld, Jens Frederik; Haugaard, Steen Bendix; Krarup, Thure.

    In: British Journal of Nutrition, Vol. 119, No. 8, 2018, p. 910-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    A review of dipeptidyl peptidase-4 inhibitors. Hot topics from randomised controlled trials. / Deacon, Carolyn F.

    In: Diabetes, Obesity and Metabolism, Vol. 20, No. Suppl. 1, 2018, p. 34-46.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice. / Christiansen, Charlotte B.; Lind, Sara J.; Svendsen, Berit; Balk-Møller, Emilie; Dahlby, Tina; Kuhre, Rune E; Hartmann, Bolette; Mandrup-Poulsen, Thomas; Deacon, Carolyn F; Albrechtsen, Nicolai J. Wewer; Holst, Jens J.

    In: Physiological Reports, Vol. 6, No. 13, e13788, 2018, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published
  17. Published

    Do we know the true mechanism of action of the DPP-4 inhibitors? / Andersen, Emilie S.; Deacon, Carolyn F.; Holst, Jens Juul.

    In: Diabetes, Obesity and Metabolism, Vol. 20, No. 1, 2018, p. 34-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men. / Veedfald, Simon; Wu, Tongzhi; Bound, Michelle; Grivell, Jacqueline; Hartmann, Bolette; Rehfeld, Jens F.; Deacon, Carolyn F.; Horowitz, Michael; Holst, Jens J.; Rayner, Christopher K.

    In: Journal of Clinical Endocrinology & Metabolism, Vol. 103, No. 12, 2018, p. 4409-4418.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides : a randomized trial. / Samkani, Amirsalar; Skytte, Mads Gustav Juul; Anholm, Christian; Astrup, Arne; Deacon, Carolyn F; Holst, Jens Juul; Madsbad, Sten; Boston, Ray; Krarup, Thure; Haugaard, Steen B.

    In: Lipids in Health and Disease, Vol. 17, 295, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2017
  21. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. / Albrechtsen, Nicolai J. Wewer; Kuhre, Rune E.; Hornburg, Daniel; Jensen, Christian Z.; Hornum, Mads; Dirksen, Carsten; Svane, Maria; Gasbjerg, Laerke S.; Jorgensen, Nils B.; Gabe, Maria N.; Balk-Moller, Emilie; Albrechtsen, Reidar; Winther-Sorensen, Marie; Galsgaard, Katrine D.; Meissner, Felix; Jorsal, Tina; Lund, Asger; Vilsboll, Tina; Eliasen, Rasmus; Bojsen-Moller, Kirstine N.; Idorn, Thomas; Deacon, Carolyn F.; Knop, Filip K.; Rosenkilde, Mette M.; Hartmann, Bolette; Feldt-Rasmussen, Bo; Mann, Matthias; Madsbad, Sten; Holst, Jens J.

    In: Cell Reports, Vol. 21, No. 6, 11.2017, p. 1452-1460.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues. / Ten Kulve, Jennifer S; Veltman, Dick J; Gerdes, Victor E A; van Bloemendaal, Liselotte; Barkhof, Frederik; Deacon, Carolyn F; Holst, Jens J; Drent, Madeleine L; Diamant, Michaela; IJzerman, Richard G.

    In: Diabetes Care, Vol. 40, No. 11, 11.2017, p. 1522-1529.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Why is it so difficult to measure glucagon-like peptide-1 in a mouse? / Windeløv, Johanne A; Wewer Albrechtsen, Nicolai J; Kuhre, Rune E; Jepsen, Sara L; Hornburg, Daniel; Pedersen, Jens; Jensen, Elisa P; Galsgaard, Katrine D; Winther-Sørensen, Marie; Ørgaard, Anne; Deacon, Carolyn F; Mann, Matthias; Kissow, Hannelouise; Hartmann, Bolette; Holst, Jens J.

    In: Diabetologia, Vol. 60, No. 10, 10.2017, p. 2066-2075.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite. / Wewer Albrechtsen, Nicolai J; Asmar, Ali; Jensen, Frederik; Törang, Signe; Simonsen, Lene; Kuhre, Rune E; Asmar, Meena; Veedfald, Simon; Plamboeck, Astrid; Knop, Filip K; Vilsbøll, Tina; Madsbad, Sten; Nauck, Michael A; Deacon, Carolyn F; Bülow, Jens; Holst, Jens J; Hartmann, Bolette.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 313, No. 3, 01.09.2017, p. E284-E291.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men. / Matikainen, N; Söderlund, S; Björnson, E; Bogl, L H; Pietiläinen, K H; Hakkarainen, A; Lundbom, N; Eliasson, B; Räsänen, S M; Rivellese, A; Patti, L; Prinster, A; Riccardi, G; Després, J-P; Alméras, N; Holst, J J; Deacon, C F; Borén, J; Taskinen, M-R.

    In: Nutrition, Metabolism & Cardiovascular Diseases, Vol. 27, No. 6, 06.2017, p. 534-542.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia. / Craig, Colleen M; Liu, Li-Fen; Deacon, Carolyn F; Holst, Jens J; McLaughlin, Tracey L.

    In: Diabetologia, Vol. 60, No. 3, 03.2017, p. 531-540.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Addition of a dipeptidyl peptidase-4 inhibitor, sitagliptin, to ongoing therapy with the glucagon-like peptide-1 receptor agonist liraglutide : A randomized controlled trial in patients with type 2 diabetes. / Nauck, Michael A; Kahle, Melanie; Baranov, Oleg; Deacon, Carolyn F; Holst, Jens J.

    In: Diabetes, Obesity and Metabolism, Vol. 19, No. 2, 06.02.2017, p. 200-207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men. / Eelderink, Coby; Noort, Martijn W J; Sozer, Nesli; Koehorst, Martijn; Holst, Jens J; Deacon, Carolyn F; Rehfeld, Jens F; Poutanen, Kaisa; Vonk, Roel J; Oudhuis, Lizette; Priebe, Marion G.

    In: European Journal of Nutrition, Vol. 56, No. 3, 2017, p. 1063-1076.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2016
  30. Published

    Feedback suppression of meal-induced glucagon-like peptide-1 (GLP-1) secretion mediated through elevations in intact GLP-1 caused by dipeptidyl peptidase-4 inhibition : a randomized, prospective comparison of sitagliptin and vildagliptin treatment. / Baranov, Oleg; Kahle, Melanie; Deacon, Carolyn F; Holst, Jens J; Nauck, Michael A.

    In: Diabetes, Obesity and Metabolism, Vol. 18, No. 11, 11.2016, p. 1100-1109.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    The insulinotropic effect of exogenous GLP-1 is not affected by acute vagotomy in anaesthetized pigs. / Veedfald, Simon; Hansen, Marie; Christensen, Louise Wulff; Larsen, Sara Agnete Hjort; Hjøllund, Karina Rahr; Plamboeck, Astrid; Hartmann, Bolette; Deacon, Carolyn F; Holst, Jens Juul.

    In: Experimental Physiology, Vol. 101, No. 7, 30.03.2016, p. 895-912.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Cephalic phase secretion of insulin and other enteropancreatic hormones in humans. / Veedfald, Simon; Plamboeck, Astrid; Deacon, Carolyn F; Hartmann, Bolette; Knop, Filip K; Lauritsen, Tina Vilsbøll; Holst, Jens J.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 310, No. 1, 01.01.2016, p. G43-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes. / Wu, T; Little, TL; Bound, MJ; Borg, M; Zhang, X; Deacon, Carolyn F.; Horowitz, Michael; Jones, KL; Rayner, CK.

    In: Diabetes Care, Vol. 39, No. 4, 2016, p. 511-517.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    A comparative review of DPP-4 inhibitors and sulphonylureas. / Deacon, Carolyn F.; Lebovitz, HE.

    In: Diabetes, Obesity and Metabolism, Vol. 18, 2016, p. 333-347.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas. / Deacon, Carolyn F.; Lebovitz, HE.

    In: Diabetes, Obesity and Metabolism, Vol. 18, No. 4, 2016, p. 333-347.

    Research output: Contribution to journalReviewResearchpeer-review

  37. Published

    Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes. / Albrechtsen, Nicolai Jacob Wewer; Kuhre, Rune Ehrenreich; Windeløv, Johanne Agerlin; Ørgaard, Anne; Deacon, Carolyn F.; Kissow, Hannelouise; Hartmann, Bolette; Holst, Jens Juul.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 311, No. 2, 2016, p. E302-E309.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published
  39. Published

    Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion. / Wewer Albrechtsen, Nicolai J; Veedfald, Simon; Plamboeck, Astrid; Deacon, Carolyn F; Hartmann, Bolette; Knop, Filip K; Lauritsen, Tina Vilsbøll; Holst, Jens J.

    In: Journal of Diabetes Research, Vol. 2016, 8352957, 2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men. / Matikainen, Niina; Björnson, Elias; Söderlund, Sanni; Borén, Christofer; Eliasson, Björn; Pietiläinen, Kirsi H; Bogl, Leonie H; Hakkarainen, Antti; Lundbom, Nina; Rivellese, Angela; Riccardi, Gabriele; Després, Jean-Pierre; Alméras, Natalie; Holst, Jens Juul; Deacon, Carolyn F; Borén, Jan; Taskinen, Marja-Riitta.

    In: PLOS ONE, Vol. 11, No. 1, e0145890, 2016, p. 1-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon. / Larger, Etienne; Albrechtsen, Nicolai Jacob Wewer; Hansen, L.H.; Gelling, R.W.; Capeau, Jaqueline; Deacon, Carolyn F.; Madsen, O.D.; Yakushiji, F; Meyts, P. De; Holst, Jens Juul; Nishimura, Erica.

    In: Endocrinology, Diabetes & Metabolism Case Reports, Vol. 2016, EDM160081, 2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells. / Kuhre, Rune Ehrenreich; Albrechtsen, Nicolai Jacob Wewer; Deacon, Carolyn F.; Balk-Møller, Emilie; Rehfeld, Jens Frederik; Relman, Frank; Gribble, Fiona Mary; Holst, Jens Juul.

    In: Journal of Molecular Endocrinology, Vol. 56, 2016, p. 201-211.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Quantification of the contribution of GLP-1 to mediating insulinotropic effects of DPP-4 inhibition with vildagliptin in healthy subjects and type 2-diabetic patients using exendin [9-39] as a GLP-1 receptor antagonist. / Nauck, Michael A; Kind, J; Köthe, Lars D; Holst, Jens Juul; Deacon, Carolyn F.; Broschag, M; He, YL; Kjems, L; Foley, J.

    In: Diabetes, Vol. 65, No. 8, 2016, p. 2440-2447.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Small intestinal glucose delivery affects the glucose-lowering effect of acute vildagliptin in type 2 diabetes. / Wu, T; Zhang, X; Trahair, LG; Bound, MJ; Little, TL; Deacon, Carolyn F.; Horowitz, M; Jones, KL; Rayner, CK.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 101, No. 12, 2016, p. 4769-4778.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2015
  46. Published

    Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes. / Ten Kulve, Jennifer S; Veltman, Dick J; van Bloemendaal, Liselotte; Barkhof, Frederik; Deacon, Carolyn F; Holst, Jens J; Konrad, Robert J; Sloan, John H; Drent, Madeleine L; Diamant, Michaela; IJzerman, Richard G.

    In: Diabetologia, Vol. 58, No. 12, 12.2015, p. 2688-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    The structure of wheat bread influences the postprandial metabolic response in healthy men. / Eelderink, Coby; Noort, Martijn W J; Sozer, Nesli; Koehorst, Martijn; Holst, Jens J; Deacon, Carolyn F; Rehfeld, Jens F; Poutanen, Kaisa; Vonk, Roel J; Oudhuis, Lizette; Priebe, Marion G.

    In: Food & Function, Vol. 6, No. 10, 10.2015, p. 3236-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Important species differences regarding lymph contribution to gut hormone responses. / Hansen, Marie; Hjøllund, Karina R; Hartmann, Bolette; Plamboeck, Astrid; Deacon, Carolyn F; Albrechtsen, Nicolai Jacob Wewer; Holst, Jens J.

    In: Peptides, Vol. 71, 09.2015, p. 28-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1. / Plamboeck, Astrid; Veedfald, Simon; Deacon, Carolyn F; Hartmann, Bolette; Vilsbøll, Tina; Knop, Filip K; Holst, Jens J.

    In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 309, No. 5, 09.2015, p. R544-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow. / Jensen, Elisa Pouline; Poulsen, Steen Seier; Kissow, Hannelouise; Holstein-Rathlou, Niels-Henrik; Deacon, Carolyn F.; Jensen, Boye L.; Holst, Jens J.; Sorensen, Charlotte M.

    In: A J P: Renal Physiology (Online), Vol. 308, No. 8, 15.04.2015, p. F867-F877.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Measurement of the incretin hormones : glucagon-like peptide-1 and glucose-dependent insulinotropic peptide. / Kuhre, Rune Ehrenreich; Wewer Albrechtsen, Nicolai Jacob; Hartmann, Bolette; Deacon, Carolyn F.; Holst, Jens Juul.

    In: Journal of Diabetes and its Complications, Vol. 29, No. 3, 04.2015, p. 445-450.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Incretin effect after oral amino Acid ingestion in humans. / Lindgren, Ola; Pacini, Giovanni; Tura, Andrea; Holst, Jens Juul; Deacon, Carolyn F; Ahrén, Bo.

    In: The Journal of clinical endocrinology and metabolism, Vol. 100, No. 3, 03.2015, p. 1172-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Stability of glucagon-like peptide-1 and glucagon in human plasma. / Albrechtsen, Nicolai Jacob Wewer; Bak, Monika Judyta; Hartmann, Bolette; Christensen, Louise Wulff; Kuhre, Rune E; Deacon, Carolyn; Holst, Jens Juul.

    In: Endocrine Connections, Vol. 4, No. 1, 16.01.2015, p. 50-57.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors. / Aaboe, K.; Akram, S.; Deacon, C. F.; Holst, J. J.; Madsbad, S.; Krarup, T.

    In: Diabetes, Obesity and Metabolism, Vol. 17, No. 1, 01.2015, p. 74-81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients. / Yabe, Daisuke; Kuroe, Akira; Watanabe, Koin; Iwasaki, Masahiro; Hamasaki, Akihiro; Hamamoto, Yoshiyuki; Harada, Norio; Yamane, Shunsuke; Lee, Soushou; Murotani, Kenta; Deacon, Carolyn F; Holst, Jens Juul; Hirano, Tsutomu; Inagaki, Nobuya; Kurose, Takeshi; Seino, Yutaka.

    In: Journal of Diabetes and its Complications, Vol. 29, 2015, p. 413-421.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in type 2 diabetes. / Wu, T; Trahair, LG; Bound, MJ; Deacon, Carolyn F.; Horowitz, M; Rayner, CK; Jones, KL.

    In: Diabetic Medicine, Vol. 32, No. 5, 2015, p. 595-600.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    The Use of Gastrostomy Tube for the Long-Term Remission of Hyperinsulinemic Hypoglycemia After Roux-en-y Gastric Bypass : A Case Report. / Craig, CM; Lamendola, C; Holst, Jens Juul; Deacon, Carolyn F.; McLaughlin, TL.

    In: aace clinical case reports, Vol. 1, No. 2, 2015, p. e84-e87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. 2014
  59. Published

    The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects. / Rhee, Nicolai Alexander; Østoft, Signe Harring; Holst, Jens Juul; Deacon, Carolyn; Vilsbøll, Tina; Knop, Filip Krag.

    In: European Journal of Endocrinology, Vol. 171, No. 3, 16.06.2014, p. 353-362.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Hyperglucagonaemia analysed by glucagon sandwich ELISA : nonspecific interference or truly elevated levels? / Albrechtsen, Nicolai Jacob Wewer; Hartmann, Bolette; Veedfald, Simon; Windeløv, Johanne A; Plamboeck, Astrid; Bojsen-Møller, Kirstine N; Idorn, Thomas; Feldt-Rasmussen, Bo; Knop, Filip K; Vilsbøll, Tina; Madsbad, Sten; Deacon, Carolyn F; Holst, Jens J.

    In: Diabetologia, Vol. 57, No. 9, 03.06.2014, p. 1919-1926.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and "isoglycemic" intravenous glucose. / Vardarli, Irfan; Arndt, Elisabeth; Deacon, Carolyn F; Holst, Jens Juul; Nauck, Michael A.

    In: Diabetes, Vol. 63, No. 2, 02.2014, p. 663-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Targeting the intestinal L-cell for obesity and type 2 diabetes treatment. / Albrechtsen, Nicolai Jacob Wewer; Kuhre, Rune Ehrenreich; Deacon, Carolyn F.; Holst, Jens Juul.

    In: Expert Review of Endocrinology & Metabolism, Vol. 9, No. 1, 01.01.2014, p. 61-72.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans, and patients with type 2 diabetes treated with or without metformin. / Wu, T; Ma, J; Bound, MJ; Checklin, H; Deacon, Carolyn F.; Jones, KI; Horowitz, M; Raynor, CK.

    In: Diabetes, Vol. 63, No. 8, 2014, p. 2776-2787.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Effects of sitagliptin therapy on markers of low-grade inflammation and cell adhesion molecules in patients with type 2 diabetes. / Tremblay, AJ ; Lamarche, B; Deacon, Carolyn F.; Weisnagel, SJ; Couture, P.

    In: Metabolism, Vol. 63, No. 9, 2014, p. 1141-1148.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Effects of the dipeptidyl peptidase IV inhibitor, vildagliptin, on glycemic, gut hormone, triglyceride, energy expenditure and energy intake responses to intraduodenal fat infusion in healthy males. / Heruc, GA; Horowitz, Michael; Deacon, Carolyn F.; Feinle-Bisset, C; Rayner, CK; Luscombe-Marsh, N; Little, Tanya J.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 307, No. 9, 2014, p. E830-E837.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    No Effect of Aprotinin (Trasylol) on Degradation of Exogenous and Endogenous Glucagon in Human, Mouse and Rat Plasma. / Bak, Monika judyta; Albrechtsen, Nicolai Jacob Wewer; Hartmann, Bolette; Pedersen, Jens; Christensen, Mikkel; Vilsboll, Tina; Knop, Filip Krag; Deacon, Carolyn Fiona; Dragsted, Lars Ove; Holst, Jens Juul.

    In: Journal of Endocrinology and Diabetes, Vol. 1, No. 1, 2014, p. 1-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in humans. / Bak, Monika Judyta; Wewer Albrechtsen, Nicolai Jacob; Pedersen, Jens; Hartmann, Bolette; Christensen, Mikkel; Vilsbøll, Tina; Knop, Filip Krag; Deacon, Carolyn F; Dragsted, Lars Ove; Holst, Jens Juul.

    In: European Journal of Endocrinology, Vol. 170, No. 4, 2014, p. 529-538.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1) : Implications for GLP-1 measurements in clinical studies. / Bak, Monika Judyta; Albrechtsen, Nicolai Jacob Wewer; Pedersen, Jens; Knop, Filip Krag; Vilsbøll Lauritsen, Tina; Jørgensen, Nils B; Hartmann, Bolette; Deacon, Carolyn F.; Dragsted, Lars Ove; Holst, Jens Juul.

    In: Diabetes, Obesity and Metabolism, Vol. 16, No. 11, 2014, p. 1155-1164.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. 2013
  70. Published

    Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes : comparison, efficacy and safety. / Deacon, Carolyn F; Holst, Jens Juul.

    In: Expert Opinion on Pharmacotherapy, Vol. 14, No. 15, 10.2013, p. 2047-58.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty. / Plamboeck, Astrid; Veedfald, Simon; Deacon, Carolyn; Hartmann, Bolette; Wettergren, Andre; Svendsen, Lars Bo; Meisner, Søren; Hovendal, Claus; Knop, Filip Krag; Vilsbøll, Tina; Holst, Jens Juul.

    In: European Journal of Endocrinology, Vol. 169, 23.05.2013, p. 187-201.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty. / Plamboeck, Astrid; Veedfald, Simon; Deacon, Carolyn F; Hartmann, Bolette; Wettergren, Andre; Svendsen, Lars Bo; Meisner, Søren; Hovendahl, Claus; Vilsboll, Tina; Knop, Filip K; Holst, Jens Juul.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 304, 18.04.2013, p. G1117-G1127.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Is there a place for incretin therapies in obesity and prediabetes? / Holst, Jens Juul; Deacon, Carolyn F.

    In: Trends in Endocrinology and Metabolism, Vol. 24, No. 3, 13.02.2013, p. 145-152.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs. / Simonsen, L; Holst, Jens Juul; Madsen, K; Deacon, C F.

    In: Regulatory Peptides, Vol. 181, No. 10, 10.02.2013, p. 17-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Islet-cell dysfunction induced by glucocorticoid treatment : potential role for altered sympathovagal balance? / van Raalte, Daniël H; Kwa, Kelly A A; van Genugten, Renate E; Tushuizen, Maarten E; Holst, Jens Juul; Deacon, Carolyn F; Karemaker, John M; Heine, Robert J; Mari, Andrea; Diamant, Michaela.

    In: Metabolism, Vol. 62, No. 4, 2013, p. 568-577.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. 2012
  77. Published

    Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus. / Rauch, Thomas; Graefe-Mody, Ulrike; Deacon, Carolyn F; Ring, Arne; Holst, Jens Juul; Woerle, Hans-Juergen; Dugi, Klaus A; Heise, Tim.

    In: Diabetes Therapy, Vol. 3, No. 1, 11.2012, p. 10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Commentary: Is endogenous GLP-1 the only important enhancer of glucose-induced insulin secretion in type 2 diabetes? / Deacon, Carolyn F.

    In: Diabetes, Vol. 61, No. 9, 2012, p. 2219-2220.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes—a review and meta analysis. / Deacon, Carolyn F.; Mannucci, E; Ahren, B.

    In: Diabetes, Obesity and Metabolism Online, Vol. 14, No. 8, 2012, p. 762-767.

    Research output: Contribution to journalReviewResearchpeer-review

  80. Published

    Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals. / Rohrer, Stefan; Menge, Björn A; Grüber, Lena; Deacon, Carolyn F; Schmidt, Wolfgang E; Veldhuis, Johannes D; Holst, Jens Juul; Meier, Juris J.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 5, 2012, p. E791-E795.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Linagliptin, a selective DPP-4 inhibitor, inhibits DPP-4, increases incretin levels, lowers glucagon, and improves glycaemic control in patients with Type 2 diabetes. / Rauch, T; Graefe-Mody, U; Deacon, Carolyn F.; Ring, A; Holst, Jens Juul; Woerle, H-J; Dugi, KA; Heise, T.

    In: Diabetes Therapy, Vol. 3, No. 1, 2012, p. 10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    Potential cardiovascular effects of incretin-based therapies. / Deacon, Carolyn F.; Marx, N.

    In: Expert Review of Cardiovascular Therapy, Vol. 10, 2012, p. 337-351.

    Research output: Contribution to journalReviewResearchpeer-review

  83. Published

    The effects of sitagliptin on gastric emptying in healthy humans – a randomised controlled study. / Stevens, JE; Horowitz, M; Deacon, Carolyn F.; Nauck, M; Rayner, CK; Jones, KL.

    In: Alimentary Pharmacology and Therapeutics, Vol. 36, No. 4, 2012, p. 379-390.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. 2011
  85. Published

    Effects of short-term therapy with glibenclamide and repaglinide on incretin hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus. / Stephens, J W; Bodvarsdottir, T B; Wareham, K; Prior, S L; Bracken, R M; Lowe, G D; Rumley, A; Dunseath, G; Luzio, S; Deacon, C F; Holst, Jens Juul; Bain, S C.

    In: Diabetes Research and Clinical Practice, Vol. 94, No. 2, 11.2011, p. 199-206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice. / Jolivalt, CG; Fineman, M; Deacon, Carolyn F.; Carr, RD; Calcutt, NA.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 11, 11.2011, p. 990-1000.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans. / Lindgren, Ola; Carr, Richard D; Deacon, Carolyn F; Holst, Jens Juul; Pacini, Giovanni; Mari, Andrea; Ahrén, Bo.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 8, 08.2011, p. 2519-2524.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes. / Menge, Björn A; Grüber, Lena; Jørgensen, Signe M; Deacon, Carolyn F; Schmidt, Wolfgang E; Veldhuis, Johannes D; Holst, Jens Juul; Meier, Juris J.

    In: Diabetes, Vol. 60, No. 8, 08.2011, p. 2160-2168.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Dissociated incretin hormone response to protein versus fat ingestion in obese subjects. / Lindgren, O; Carr, RD; Holst, Jens Juul; Deacon, Carolyn F.; Ahren, B.

    In: Diabetes, Obesity and Metabolism Online, Vol. 13, No. 9, 07.2011, p. 863-865.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future. / Madsbad, S; Kielgast, U; Asmar, M; Deacon, C F; Torekov, Signe Sørensen; Holst, J J.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 5, 05.2011, p. 394-407.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Effect of Sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes. / Tremblay, AJ; Lamarche, B; Deacon, Carolyn F.; Weisnagel, SJ; Couture, P.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 4, 04.2011, p. 366-373.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published
  93. Published

    Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review. / Deacon, Carolyn F.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 1, 01.2011, p. 7-18.

    Research output: Contribution to journalReviewResearchpeer-review

  94. Published

    Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones. / Olthof, MR; van Dijk, AE; Deacon, Carolyn F.; Heine, RJ; van Dam, RM .

    In: Nutrition & Metabolism, Vol. 8, 2011, p. Artikel 10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs. / Hjøllund, K R; Deacon, C F; Holst, Jens Juul.

    In: Diabetologia, Vol. 54, No. 8, 2011, p. 2206-8.

    Research output: Contribution to journalLetterResearchpeer-review

  96. Published

    Effects of saxagliptin on β-cell stimulation and insulin secretion in patients with type 2 diabetes. / Henry, R R; Smith, Susanne; Schwartz, Saul; Mudaliar, S R; Deacon, C F; Holst, Jens Juul; Duan, R Y; Chen, R S; List, J F.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 9, 2011, p. 850-858.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes. / Mentis, Nikolaos; Vardarli, Irfan; Köthe, Lars D; Holst, Jens Juul; Deacon, Carolyn F; Theodorakis, Michael; Meier, Juris J; Nauck, Michael A.

    In: Diabetes, Vol. 60, No. 4, 2011, p. 1270-1276.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Incretin-based therapies– review of the physiology, pharmacology and emerging clinical experience. / Martin, JH; Deacon, Carolyn F.; Gorrell, MD; Prins, JB.

    In: Internal Medicine Journal (Online), Vol. 41, 2011, p. 299-307.

    Research output: Contribution to journalReviewResearchpeer-review

  99. Published

    Inhibition of DPP-4 with vildagliptin improved insulin secretion in response to oral as well as "isoglycemic" intravenous glucose without numerically changing the incretin effect in patients with type 2 diabetes. / Vardarli, Irfan; Nauck, Michael A; Köthe, Lars D; Deacon, Carolyn F; Holst, Jens Juul; Schweizer, Anja; Foley, James E.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 4, 2011, p. 945-954.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Physiology of incretins in health and disease. / Deacon, Carolyn F.; Ahren, Bo.

    In: Review of Diabetic Studies, Vol. 8, No. 3, 2011, p. 293-306.

    Research output: Contribution to journalReviewResearchpeer-review

  101. Published

    Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes : what is up, what is down? / Nauck, M A; Vardarli, I; Deacon, C F; Holst, Jens Juul; Meier, Joachim.

    In: Diabetologia, Vol. 54, No. 1, 2011, p. 10-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. 2010
  103. Published

    Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1. / Migoya, E M; Bergeron, R; Miller, J L; Snyder, R N K; Tanen, M; Hilliard, D; Weiss, B; Larson, P; Gutierrez, M; Jiang, G; Liu, F.; Pryor, K A; Yao, J; Zhu, L; Holst, Jens Juul; Deacon, C; Herman, G; Thornberry, N; Amatruda, J; Williams-Herman, D; Wagner, J A; SinhaRoy, R.

    In: Clinical Pharmacology and Therapeutics, Vol. 88, No. 6, 01.12.2010, p. 801-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  104. Published

    Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans. / Meier, Juris J; Ritter, Peter R; Jacob, Alexandra; Menge, Bjoern A; Deacon, Carolyn F; Schmidt, Wolfgang E; Nauck, Michael A; Holst, Jens J.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 8, 01.08.2010, p. 4061-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. Published

    The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. / Hare, Kristine J; Vilsbøll, Tina; Asmar, Meena; Deacon, Carolyn F; Knop, Filip K; Holst, Jens Juul.

    In: Diabetes, Vol. 59, No. 7, 01.07.2010, p. 1765-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  106. Published

    Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese : Comparison of type 2 diabetes patients and healthy controls. / Yabe, Daisuke; Kuroe, Akira; Lee, Soushou; Watanabe, Koin; Hyo, Takanori; Hishizawa, Masahiro; Kurose, Takeshi; Deacon, Carolyn F; Holst, Jens Juul; Hirano, Tsutomu; Inagaki, Nobuya; Seino, Yutaka.

    In: Journal of Diabetes Investigation, Vol. 1, No. 1-2, 22.04.2010, p. 56-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus. / Aaboe, K; Knop, F K; Vilsbøll, T; Deacon, C F; Holst, Jens Juul; Madsbad, S; Krarup, Troels Magelund.

    In: Diabetes, Obesity and Metabolism, Vol. 12, No. 4, 01.04.2010, p. 323-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  108. Published

    Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery. / McLaughlin, Tracey; Peck, Marcia; Holst, Jens; Deacon, Carolyn.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 4, 04.2010, p. 1851-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  109. Published

    Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes. / Deacon, Carolyn F; Holst, Jens Juul.

    In: Expert Opinion on Investigational Drugs, Vol. 19, No. 1, 01.2010, p. 133-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  110. Published

    Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls. / Yabe, D; Kuroe, A; Lee, S; Watanabe, K; Hyo, T; Hishizawa, M; Kurose, T; Deacon, Carolyn F.; Holst, Jens Juul; Hirano, T; Inagaki, N; Seino, Y.

    In: Journal of Diabetes Investigation, Vol. 1, No. 1/2, 01.2010, p. 56-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

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