Carolyn F. Deacon

Carolyn F. Deacon

Associate Professor

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    ORCID: 0000-0003-2611-5642

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    1. Published

      The incretin enhancer vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed -cell function in patients with type 2 diabetes

      Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, p. 4888-4894

      Research output: Contribution to journal › Journal article › Research

    2. Published

      Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes

      Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., Aug 2005, In: The Journal of clinical endocrinology and metabolism. 90, 8, p. 4888-94 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials

      Madsbad, Sten, Krarup, T., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Krarup, T., Deacon, C. F. & Holst, J. J., 2008, In: Current Opinion in Clinical Nutrition and Metabolic Care. 11, 4, p. 491-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials

      Madsbad, Sten, Krarup, T., Deacon, Carolyn F. & Holst, Jens Juul, Jul 2008, In: Current Opinion in Clinical Nutrition and Metabolic Care. 11, 4, p. 491-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future

      Madsbad, Sten, Kielgast, U., Asmar, M., Deacon, Carolyn F., Torekov, Signe Sørensen & Holst, Jens Juul, May 2011, In: Diabetes, Obesity and Metabolism. 13, 5, p. 394-407 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men

      Lindgren, O., Mari, A., Deacon, Carolyn F., Carr, R. D., Winzell, M. S., Vikman, J. & Ahrén, B., 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 8, p. 2887-92 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Incretin effect after oral amino Acid ingestion in humans

      Lindgren, O., Pacini, G., Tura, A., Holst, Jens Juul, Deacon, Carolyn F. & Ahrén, B., Mar 2015, In: The Journal of clinical endocrinology and metabolism. 100, 3, p. 1172-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans

      Lindgren, O., Carr, R. D., Deacon, Carolyn F., Holst, Jens Juul, Pacini, G., Mari, A. & Ahrén, B., Aug 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 8, p. 2519-2524 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Dissociated incretin hormone response to protein versus fat ingestion in obese subjects

      Lindgren, O., Carr, R., Holst, Jens Juul, Deacon, Carolyn F. & Ahren, B., Jul 2011, In: Diabetes, Obesity and Metabolism Online. 13, 9, p. 863-865 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass.

      Larsen, M. O., Rolin, B., Ribel, U., Wilken, M., Deacon, Carolyn F., Svendsen, O., Gotfredsen, C. F. & Carr, R. D., 2003, In: Experimental Diabesity Research. 4, 2, p. 93-105 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon

      Larger, E., Albrechtsen, Nicolai Jacob Wewer, Hansen, L. H., Gelling, R. W., Capeau, J., Deacon, Carolyn F., Madsen, O. D., Yakushiji, F., Meyts, P. D., Holst, Jens Juul & Nishimura, E., 2016, In: Endocrinology, Diabetes & Metabolism Case Reports. 2016, 6 p., EDM160081.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide

      Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

      Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

      Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?

      Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019

      Research output: Contribution to journal › Review › Research › peer-review

    16. Published

      What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?

      Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Holst, Jens Juul & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.

      Research output: Contribution to journal › Review › Research › peer-review

    17. Published

      Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism

      Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Esser, N., Mongovin, S., Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, Peter Stendahl, Goetze, Jens P. , Goossens, G. H., Blaak, E. E., Deacon, Carolyn F., Rosenkilde, Mette, Zraika, S., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice

      Jolivalt, C., Fineman, M., Deacon, Carolyn F., Carr, R. & Calcutt, N., Nov 2011, In: Diabetes, Obesity and Metabolism. 13, 11, p. 990-1000 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice

      Jepsen, Sara Lind, Grunddal, Kaare Villum, Albrechtsen, Nicolai Jacob Wewer, Engelstoft, M. S., Gabe, M. B. N., Jensen, E. P., Ørskov, Cathrine, Poulsen, Steen Seier, Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, Carolyn F., Schwartz, Thue W., Christ, A. D., Martin, R. E. & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner

      Jepsen, Sara Lind, Albrechtsen, Nicolai Jacob Wewer, Windeløv, Johanne Agerlin, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Farb, T. B., Kissow, Hannelouise, Pedersen, J., Deacon, Carolyn F., Martin, R. E. & Holst, Jens Juul, 2021, In: JCI insight. 6, 4, 15 p., e143228.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow

      Jensen, E. P., Poulsen, Steen Seier, Kissow, Hannelouise, von Holstein-Rathlou, Niels-Henrik, Deacon, Carolyn F., Jensen, B. L., Holst, Jens Juul & Sorensen, Charlotte Mehlin, 15 Apr 2015, In: A J P: Renal Physiology (Online). 308, 8, p. F867-F877 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus.

      Holst, Jens Juul & Deacon, Carolyn F., 2004, In: Current Opinion in Pharmacology. 4, 6, p. 589-96 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Glucagon-like peptide-1, glucose homeostasis and diabetes.

      Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, Tina, Krarup, T. & Madsbad, Sten, 2008, In: Trends in Molecular Medicine. 14, 4, p. 161-8 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      The incretin system and its role in type 2 diabetes mellitus

      Holst, Jens Juul, Vilsbøll, Tina & Deacon, Carolyn F., 2008, In: Molecular and Cellular Endocrinology. 297, 1-2, p. 127-136 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Glucagon-like peptide-1 mediates the therapeutic actions of Dpp-IV inhibitors

      Holst, Jens Juul & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 612-615

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      For debate: Are antidiabetic actions of DPP-IV inhibitors mediated by glucagon-like peptide- 1?

      Holst, Jens Juul & Deacon, Carolyn F., 2005, In: Diabetologia. 48, p. 612-615

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Posttranslational processing of proglucagon and postsecretory fate of proglucagon products.

      Holst, Jens Juul, Ørskov, C., Hartmann, B. & Deacon, Carolyn F., 1997, The Insulinotropic Gut Hormone Glucagon-like Peptide-1.. Basel: Karger, p. 24-48

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    28. Published

      Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors

      Holst, Jens Juul & Deacon, Carolyn F., Apr 2005, In: Diabetologia. 48, 4, p. 612-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Is there a place for incretin therapies in obesity and prediabetes?

      Holst, Jens Juul & Deacon, Carolyn F., 13 Feb 2013, In: Trends in Endocrinology and Metabolism. 24, 3, p. 145-152 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications

      Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Rosenkilde, Mette & Deacon, Carolyn F., 2019, In: Comprehensive Physiology. 9, 4, p. 1339-1381

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      On the treatment of diabetes mellitus with glucagon-like peptide-1.

      Holst, Jens Juul, Deacon, Carolyn F., Toft-Nielsen, M. & Bjerre-Knudsen, L., 1998, In: Annals of the New York Academy of Sciences. 865, p. 336-343

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes

      Holst, Jens Juul & Deacon, Carolyn F., 1998, In: Diabetes. 47, p. 1663-1670

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      New horizons in diabetes therapy

      Holst, Jens Juul & Deacon, Carolyn F., 2007, In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 7, 1, p. 49-55 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Role of GLP-1 analogues and DDP-IV inhibitors in the treatment of type 2 diabetes

      Holst, Jens Juul & Deacon, Carolyn F., 2006, In: Avances en Diabetologia. 22, 2, p. 115-125 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs

      Hjøllund, K. R., Deacon, Carolyn F. & Holst, Jens Juul, 2011, In: Diabetologia. 54, 8, p. 2206-8 3 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    36. Published

      Effects of the dipeptidyl peptidase IV inhibitor, vildagliptin, on glycemic, gut hormone, triglyceride, energy expenditure and energy intake responses to intraduodenal fat infusion in healthy males

      Heruc, G., Horowitz, M., Deacon, Carolyn F., Feinle-Bisset, C., Rayner, C., Luscombe-Marsh, N. & Little, T. J., 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 307, 9, p. E830-E837 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.

      Herman, G. A., Bergman, A., Stevens, C., Kotey, P., Yi, B., Zhao, P., Dietrich, B., Golor, G., Schrodter, A., Keymeulen, B., Lasseter, K. C., Kipnes, M. S., Snyder, K., Hilliard, D., Tanen, M., Cilissen, C., De Smet, M., de Lepeleire, I., Van Dyck, K., Wang, A. Q. & 7 others, Zeng, W., Davies, M. J., Tanaka, W., Holst, Jens Juul, Deacon, Carolyn F., Gottesdiener, K. M. & Wagner, J. A., 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4612-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Effects of saxagliptin on β-cell stimulation and insulin secretion in patients with type 2 diabetes

      Henry, R. R., Smith, S., Schwartz, S., Mudaliar, S. R., Deacon, Carolyn F., Holst, Jens Juul, Duan, R. Y., Chen, R. S. & List, J. F., 2011, In: Diabetes, Obesity and Metabolism. 13, 9, p. 850-858 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT.

      He, Y., Wang, Y., Bullock, J. M., Deacon, Carolyn F., Holst, Jens Juul, Dunning, B. E., Ligueros-Saylan, M. & Foley, J. E., 2007, In: Journal of Clinical Pharmacology. 47, 5, p. 633-41 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus.

      He, Y., Serra, D., Wang, Y., Campestrini, J., Riviere, G., Deacon, Carolyn F., Holst, Jens Juul, Schwartz, S., Nielsen, J. C. & Ligueros-Saylan, M., 2007, In: Clinical Pharmacokinetics. 46, 7, p. 577-88 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Glucose-stimulated prehepatic insulin secretion is associated with circulating alanine, triglyceride, glucagons, lactate and TNF-alfa in patients with HIV-lipodystrophy

      Haugaard, S. B., Andersen, Ove, Pedersen, S., Dela, Flemming, Holst, Jens Juul, Deacon, Carolyn F., Iversen, J. & Madsbad, Sten, 2006, In: HIV Medicine. 7, p. 163-172 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Plasma TNF-x is associated with insulin mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy

      Haugaard, S. B., Andersen, O., Pedersen, S. B., Dela, Flemming & Deacon, Carolyn F., 1996, In: Metabolism - Clinical and Experimental. 55(2), p. 175-182

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      In vivo and in vitro degradation of glucagon-like peptide-2 in humans

      Hartmann, B., Harr, M. B., Jeppesen, P. B., Wojdemann, M., Deacon, Carolyn F., Mortensen, P. B. & Holst, Jens Juul, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, p. 2884-2888

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes

      Hartmann, Bolette, Longo, M., Mathiesen, D. S., Hare, Kristine Juul, Jørgensen, Niklas Rye, Esposito, K., Deacon, Carolyn F., Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. e259-e265 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus

      Hare, K. J., Knop, Filip Krag, Asmar, M., Madsbad, Sten, Deacon, Carolyn F., Holst, Jens Juul & Vilsbøll, Tina, 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 12, p. 4679-87 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

      Hare, K. J., Vilsbøll, Tina, Asmar, M., Deacon, Carolyn F., Knop, Filip Krag & Holst, Jens Juul, 1 Jul 2010, In: Diabetes. 59, 7, p. 1765-70 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Important species differences regarding lymph contribution to gut hormone responses

      Hansen, M., Hjøllund, K. R., Hartmann, Bolette, Plamboeck, A., Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, Sep 2015, In: Peptides. 71, p. 28-31 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Metabolism of glucagon-like peptide-2 in pigs: role of dipeptidyl peptidase IV.

      Hansen, L., Hare, K. J., Hartmann, B., Deacon, Carolyn F., Ugleholdt, Randi Kjærsgaard, Plamboeck, A. & Holst, Jens Juul, 2006, In: Regulatory Peptides. 138, 2-3, p. 126-32 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Glucagon-like peptide-1(7-36)amide is transformed to glucagon-like peptide-1 (9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the intestinal L-cells

      Hansen, L., Deacon, Carolyn F., Ørskov, C. & Holst, Jens Juul, 1999, In: Endokrinologiya. 140, p. 5356-5363

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine

      Hansen, L., Deacon, Carolyn F., Ørskov, Cathrine & Holst, Jens Juul, Nov 1999, In: Molecular Endocrinology. 140, 11, p. 5356-63 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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