Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels

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Standard

Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels. / Engelbrechtsen, Line; Iepsen, Eva Pers Winning; Galijatovic, Ehm Astrid Andersson; Mahendran, Yuvaraj; Lundgren, Julie Rehné; Jonsson, Anna Elisabet; Madsbad, Sten; Holst, Jens Juul; Vestergaard, Henrik; Hansen, Torben; Torekov, Signe Sørensen.

I: Metabolomics, Bind 12, Nr. 12, 181, 12.2016, s. 1-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Engelbrechtsen, L, Iepsen, EPW, Galijatovic, EAA, Mahendran, Y, Lundgren, JR, Jonsson, AE, Madsbad, S, Holst, JJ, Vestergaard, H, Hansen, T & Torekov, SS 2016, 'Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels', Metabolomics, bind 12, nr. 12, 181, s. 1-9. https://doi.org/10.1007/s11306-016-1128-0

APA

Engelbrechtsen, L., Iepsen, E. P. W., Galijatovic, E. A. A., Mahendran, Y., Lundgren, J. R., Jonsson, A. E., ... Torekov, S. S. (2016). Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels. Metabolomics, 12(12), 1-9. [181]. https://doi.org/10.1007/s11306-016-1128-0

Vancouver

Engelbrechtsen L, Iepsen EPW, Galijatovic EAA, Mahendran Y, Lundgren JR, Jonsson AE o.a. Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels. Metabolomics. 2016 dec;12(12):1-9. 181. https://doi.org/10.1007/s11306-016-1128-0

Author

Engelbrechtsen, Line ; Iepsen, Eva Pers Winning ; Galijatovic, Ehm Astrid Andersson ; Mahendran, Yuvaraj ; Lundgren, Julie Rehné ; Jonsson, Anna Elisabet ; Madsbad, Sten ; Holst, Jens Juul ; Vestergaard, Henrik ; Hansen, Torben ; Torekov, Signe Sørensen. / Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels. I: Metabolomics. 2016 ; Bind 12, Nr. 12. s. 1-9.

Bibtex

@article{dd7ae79ed589475c9b4f462e55febd14,
title = "Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels",
abstract = "Introduction Increased levels of circulating branched chain amino acids (BCAAs), as well as phenylalanine, and tyrosine have been suggested to be involved in the pathogenesis of insulin resistance and type 2 diabetes. However, it is unknown how these metabolites are affected by weight loss, and during weight-maintaining treatment with glucagon-like peptide-1 receptor agonist (GLP-1 RA). Objective We aimed to characterize changes in metabolites related to protein turnover and glycolysis after a weight loss intervention followed by long term weight maintenance with/without GLP-1 RA. Methods Fifty-eight obese individuals underwent a diet-induced 12 {\%} body weight loss during 8 weeks. Participants were randomized to weight maintenance with or without administration of the GLP-1 RA liraglutide (1.2 mg/day) for 52 weeks. Metabolomic profiling by high-throughput proton nuclear magnetic resonance spectroscopy was used for quantification of metabolites. Results The weight loss was maintained in both groups and was associated with 9–20 {\%} decreases in plasma concentrations of alanine, phenylalanine, histidine, tyrosine and the BCAAs leucine, isoleucine and valine (p < 0.05). Plasma citrate levels increased during weight loss (p = 5.2 × 10−15) and showed inverse correlation with insulin resistance measured by HOMA–IR levels (r = −0.318, p = 0.025). Valine concentrations were lower in the control group compared to the GLP-1RA group during weight maintenance (p = 0.005). Conclusion Weight loss is associated with marked changes in plasma concentrations of eight amino acids and glycolysis-related metabolites. Levels of the suggested type 2 diabetes risk markers (BCAAs) remain low during long-term weight maintenance.",
author = "Line Engelbrechtsen and Iepsen, {Eva Pers Winning} and Galijatovic, {Ehm Astrid Andersson} and Yuvaraj Mahendran and Lundgren, {Julie Rehn{\'e}} and Jonsson, {Anna Elisabet} and Sten Madsbad and Holst, {Jens Juul} and Henrik Vestergaard and Torben Hansen and Torekov, {Signe S{\o}rensen}",
year = "2016",
month = "12",
doi = "10.1007/s11306-016-1128-0",
language = "English",
volume = "12",
pages = "1--9",
journal = "Metabolomics",
issn = "1573-3882",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels

AU - Engelbrechtsen, Line

AU - Iepsen, Eva Pers Winning

AU - Galijatovic, Ehm Astrid Andersson

AU - Mahendran, Yuvaraj

AU - Lundgren, Julie Rehné

AU - Jonsson, Anna Elisabet

AU - Madsbad, Sten

AU - Holst, Jens Juul

AU - Vestergaard, Henrik

AU - Hansen, Torben

AU - Torekov, Signe Sørensen

PY - 2016/12

Y1 - 2016/12

N2 - Introduction Increased levels of circulating branched chain amino acids (BCAAs), as well as phenylalanine, and tyrosine have been suggested to be involved in the pathogenesis of insulin resistance and type 2 diabetes. However, it is unknown how these metabolites are affected by weight loss, and during weight-maintaining treatment with glucagon-like peptide-1 receptor agonist (GLP-1 RA). Objective We aimed to characterize changes in metabolites related to protein turnover and glycolysis after a weight loss intervention followed by long term weight maintenance with/without GLP-1 RA. Methods Fifty-eight obese individuals underwent a diet-induced 12 % body weight loss during 8 weeks. Participants were randomized to weight maintenance with or without administration of the GLP-1 RA liraglutide (1.2 mg/day) for 52 weeks. Metabolomic profiling by high-throughput proton nuclear magnetic resonance spectroscopy was used for quantification of metabolites. Results The weight loss was maintained in both groups and was associated with 9–20 % decreases in plasma concentrations of alanine, phenylalanine, histidine, tyrosine and the BCAAs leucine, isoleucine and valine (p < 0.05). Plasma citrate levels increased during weight loss (p = 5.2 × 10−15) and showed inverse correlation with insulin resistance measured by HOMA–IR levels (r = −0.318, p = 0.025). Valine concentrations were lower in the control group compared to the GLP-1RA group during weight maintenance (p = 0.005). Conclusion Weight loss is associated with marked changes in plasma concentrations of eight amino acids and glycolysis-related metabolites. Levels of the suggested type 2 diabetes risk markers (BCAAs) remain low during long-term weight maintenance.

AB - Introduction Increased levels of circulating branched chain amino acids (BCAAs), as well as phenylalanine, and tyrosine have been suggested to be involved in the pathogenesis of insulin resistance and type 2 diabetes. However, it is unknown how these metabolites are affected by weight loss, and during weight-maintaining treatment with glucagon-like peptide-1 receptor agonist (GLP-1 RA). Objective We aimed to characterize changes in metabolites related to protein turnover and glycolysis after a weight loss intervention followed by long term weight maintenance with/without GLP-1 RA. Methods Fifty-eight obese individuals underwent a diet-induced 12 % body weight loss during 8 weeks. Participants were randomized to weight maintenance with or without administration of the GLP-1 RA liraglutide (1.2 mg/day) for 52 weeks. Metabolomic profiling by high-throughput proton nuclear magnetic resonance spectroscopy was used for quantification of metabolites. Results The weight loss was maintained in both groups and was associated with 9–20 % decreases in plasma concentrations of alanine, phenylalanine, histidine, tyrosine and the BCAAs leucine, isoleucine and valine (p < 0.05). Plasma citrate levels increased during weight loss (p = 5.2 × 10−15) and showed inverse correlation with insulin resistance measured by HOMA–IR levels (r = −0.318, p = 0.025). Valine concentrations were lower in the control group compared to the GLP-1RA group during weight maintenance (p = 0.005). Conclusion Weight loss is associated with marked changes in plasma concentrations of eight amino acids and glycolysis-related metabolites. Levels of the suggested type 2 diabetes risk markers (BCAAs) remain low during long-term weight maintenance.

U2 - 10.1007/s11306-016-1128-0

DO - 10.1007/s11306-016-1128-0

M3 - Journal article

VL - 12

SP - 1

EP - 9

JO - Metabolomics

JF - Metabolomics

SN - 1573-3882

IS - 12

M1 - 181

ER -

ID: 169159035