Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction
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Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction. / Dose, Nynne; Michelsen, Marie Mide; Mygind, Naja Dam; Pena, Adam; Ellervik, Christina; Hansen, Peter R; Kanters, Jørgen K; Prescott, Eva; Kastrup, Jens; Steering Committee of the iPOWER study; Gustafsson, Ida; Hansen, Henrik Steen.
I: Journal of Electrocardiology, Bind 51, Nr. 1, 01.2018, s. 15-20.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction
AU - Dose, Nynne
AU - Michelsen, Marie Mide
AU - Mygind, Naja Dam
AU - Pena, Adam
AU - Ellervik, Christina
AU - Hansen, Peter R
AU - Kanters, Jørgen K
AU - Prescott, Eva
AU - Kastrup, Jens
AU - Steering Committee of the iPOWER study
AU - Gustafsson, Ida
AU - Hansen, Henrik Steen
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2018/1
Y1 - 2018/1
N2 - OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD.METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography.RESULTS: Women with angina pectoris had significantly longer QTc intervals (429±20ms) and increased MCS (IQR) (0.73 [0.64-0.80]) compared with the controls (419±20ms) and (0.63 [(0.53-0.73]), respectively (both p<0.001). CFVR was associated with longer QTc interval (p=0.02), but the association was attenuated after multivariable adjustment (p=0.08).CONCLUSION: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.
AB - OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD.METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography.RESULTS: Women with angina pectoris had significantly longer QTc intervals (429±20ms) and increased MCS (IQR) (0.73 [0.64-0.80]) compared with the controls (419±20ms) and (0.63 [(0.53-0.73]), respectively (both p<0.001). CFVR was associated with longer QTc interval (p=0.02), but the association was attenuated after multivariable adjustment (p=0.08).CONCLUSION: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.
KW - Journal Article
U2 - 10.1016/j.jelectrocard.2017.08.017
DO - 10.1016/j.jelectrocard.2017.08.017
M3 - Journal article
C2 - 28939174
VL - 51
SP - 15
EP - 20
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
SN - 0022-0736
IS - 1
ER -
ID: 189664709