Use of Genetic Models to Study the Urinary Concentrating Mechanism
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Use of Genetic Models to Study the Urinary Concentrating Mechanism. / Olesen, Emma Tina Bisgaard; Kortenoeven, Marleen L.A.; Fenton, Robert A.
Sodium and Water Homeostasis. red. / Kelly Anne Hyndman; Thomas L. Pannabecker. Springer, 2015. s. 43-72 (Physiology in Health and Disease).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Use of Genetic Models to Study the Urinary Concentrating Mechanism
AU - Olesen, Emma Tina Bisgaard
AU - Kortenoeven, Marleen L.A.
AU - Fenton, Robert A.
PY - 2015
Y1 - 2015
N2 - Maintenance of body water homeostasis is a fundamental homeostatic mechanism in mammals. Understanding the basic mechanisms of how water balance is maintained, or dysfunctional in certain diseases is thus of clinical importance. In recent years, application of transgenic and knockout mouse technology is providing critical new information about urinary concentrating processes and thus mechanisms for maintaining body water homeostasis. In this chapter we provide a brief overview of genetic mouse model generation, and then summarize findings in transgenic and knockout mice pertinent to our understanding of the urinary concentrating mechanism, focusing predominantly on mice in which expression of specific renal transporters or receptors has been deleted.
AB - Maintenance of body water homeostasis is a fundamental homeostatic mechanism in mammals. Understanding the basic mechanisms of how water balance is maintained, or dysfunctional in certain diseases is thus of clinical importance. In recent years, application of transgenic and knockout mouse technology is providing critical new information about urinary concentrating processes and thus mechanisms for maintaining body water homeostasis. In this chapter we provide a brief overview of genetic mouse model generation, and then summarize findings in transgenic and knockout mice pertinent to our understanding of the urinary concentrating mechanism, focusing predominantly on mice in which expression of specific renal transporters or receptors has been deleted.
U2 - 10.1007/978-1-4939-3213-9_3
DO - 10.1007/978-1-4939-3213-9_3
M3 - Book chapter
SN - 978-1-4939-3212-2
T3 - Physiology in Health and Disease
SP - 43
EP - 72
BT - Sodium and Water Homeostasis
A2 - Hyndman, Kelly Anne
A2 - Pannabecker, Thomas L.
PB - Springer
ER -
ID: 161161201