Unexpected, isolated activated partial thromboplastin time prolongation: A practical mini-review

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

Standard

Unexpected, isolated activated partial thromboplastin time prolongation : A practical mini-review. / Rasmussen, Katrine Laura; Philips, Malou; Tripodi, Armando; Goetze, Jens Peter.

I: European Journal of Haematology, Bind 104, Nr. 6, 2020, s. 519-525.

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

Harvard

Rasmussen, KL, Philips, M, Tripodi, A & Goetze, JP 2020, 'Unexpected, isolated activated partial thromboplastin time prolongation: A practical mini-review', European Journal of Haematology, bind 104, nr. 6, s. 519-525. https://doi.org/10.1111/ejh.13394

APA

Rasmussen, K. L., Philips, M., Tripodi, A., & Goetze, J. P. (2020). Unexpected, isolated activated partial thromboplastin time prolongation: A practical mini-review. European Journal of Haematology, 104(6), 519-525. https://doi.org/10.1111/ejh.13394

Vancouver

Rasmussen KL, Philips M, Tripodi A, Goetze JP. Unexpected, isolated activated partial thromboplastin time prolongation: A practical mini-review. European Journal of Haematology. 2020;104(6):519-525. https://doi.org/10.1111/ejh.13394

Author

Rasmussen, Katrine Laura ; Philips, Malou ; Tripodi, Armando ; Goetze, Jens Peter. / Unexpected, isolated activated partial thromboplastin time prolongation : A practical mini-review. I: European Journal of Haematology. 2020 ; Bind 104, Nr. 6. s. 519-525.

Bibtex

@article{6b1d49da5dc147778f694f48e19c9867,
title = "Unexpected, isolated activated partial thromboplastin time prolongation: A practical mini-review",
abstract = "A common inquiry in coagulation laboratories is how to interpret an unexpected, isolated prolonged activated partial thromboplastin time (APTT). In this context, isolated means together with a normal prothrombin time (PT) and/or normal international normalized ratio (INR). This finding may lead to contact with laboratory doctors for further advice on a diagnostic strategy. Occasionally, the need for a diagnostic algorithm can be subacute, where surgery has to be postponed until an explanation for the isolated, prolonged APTT has been established. Activated partial thromboplastin time as a coagulation test was developed to monitor patients with hemophilia. Different APTT reagents display considerable differences in their sensitivity to deficiencies of coagulation factors. An isolated, prolonged APTT is seen in (a) individuals/patients with lupus anticoagulants, (b) patients in treatment with anticoagulants, mainly heparin, and (c) patients with deficiencies of specific coagulation factors. In this tutorial review, we summarize what may cause an isolated prolonged APTT and we present a simple diagnostic algorithm to differentiate between lupus anticoagulants (common) and factor deficiencies (rare). The identification of an isolated prolonged APTT as well as the underlying cause can be of the utmost importance in ensuring the correct therapeutic follow-up.",
keywords = "activated partial thromboplastin time, hemophilia, lupus anticoagulants",
author = "Rasmussen, {Katrine Laura} and Malou Philips and Armando Tripodi and Goetze, {Jens Peter}",
year = "2020",
doi = "10.1111/ejh.13394",
language = "English",
volume = "104",
pages = "519--525",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Unexpected, isolated activated partial thromboplastin time prolongation

T2 - A practical mini-review

AU - Rasmussen, Katrine Laura

AU - Philips, Malou

AU - Tripodi, Armando

AU - Goetze, Jens Peter

PY - 2020

Y1 - 2020

N2 - A common inquiry in coagulation laboratories is how to interpret an unexpected, isolated prolonged activated partial thromboplastin time (APTT). In this context, isolated means together with a normal prothrombin time (PT) and/or normal international normalized ratio (INR). This finding may lead to contact with laboratory doctors for further advice on a diagnostic strategy. Occasionally, the need for a diagnostic algorithm can be subacute, where surgery has to be postponed until an explanation for the isolated, prolonged APTT has been established. Activated partial thromboplastin time as a coagulation test was developed to monitor patients with hemophilia. Different APTT reagents display considerable differences in their sensitivity to deficiencies of coagulation factors. An isolated, prolonged APTT is seen in (a) individuals/patients with lupus anticoagulants, (b) patients in treatment with anticoagulants, mainly heparin, and (c) patients with deficiencies of specific coagulation factors. In this tutorial review, we summarize what may cause an isolated prolonged APTT and we present a simple diagnostic algorithm to differentiate between lupus anticoagulants (common) and factor deficiencies (rare). The identification of an isolated prolonged APTT as well as the underlying cause can be of the utmost importance in ensuring the correct therapeutic follow-up.

AB - A common inquiry in coagulation laboratories is how to interpret an unexpected, isolated prolonged activated partial thromboplastin time (APTT). In this context, isolated means together with a normal prothrombin time (PT) and/or normal international normalized ratio (INR). This finding may lead to contact with laboratory doctors for further advice on a diagnostic strategy. Occasionally, the need for a diagnostic algorithm can be subacute, where surgery has to be postponed until an explanation for the isolated, prolonged APTT has been established. Activated partial thromboplastin time as a coagulation test was developed to monitor patients with hemophilia. Different APTT reagents display considerable differences in their sensitivity to deficiencies of coagulation factors. An isolated, prolonged APTT is seen in (a) individuals/patients with lupus anticoagulants, (b) patients in treatment with anticoagulants, mainly heparin, and (c) patients with deficiencies of specific coagulation factors. In this tutorial review, we summarize what may cause an isolated prolonged APTT and we present a simple diagnostic algorithm to differentiate between lupus anticoagulants (common) and factor deficiencies (rare). The identification of an isolated prolonged APTT as well as the underlying cause can be of the utmost importance in ensuring the correct therapeutic follow-up.

KW - activated partial thromboplastin time

KW - hemophilia

KW - lupus anticoagulants

U2 - 10.1111/ejh.13394

DO - 10.1111/ejh.13394

M3 - Review

C2 - 32049377

VL - 104

SP - 519

EP - 525

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 6

ER -

ID: 237416606