Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study

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Type 1 diabetes is associated with T-wave morphology changes : The Thousand & 1 Study. / Isaksen, Jonas L.; Graff, Claus; Ellervik, Christina; Jensen, Jan Skov; Andersen, Henrik Ullits; Rossing, Peter; Kanters, Jørgen K.; Jensen, Magnus Thorsten.

I: Journal of Electrocardiology, Bind 51, Nr. 6, 01.11.2018, s. S72-S77.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Harvard

Isaksen, JL, Graff, C, Ellervik, C, Jensen, JS, Andersen, HU, Rossing, P, Kanters, JK & Jensen, MT 2018, 'Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study', Journal of Electrocardiology, bind 51, nr. 6, s. S72-S77. https://doi.org/10.1016/j.jelectrocard.2018.05.015

APA

Isaksen, J. L., Graff, C., Ellervik, C., Jensen, J. S., Andersen, H. U., Rossing, P., ... Jensen, M. T. (2018). Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study. Journal of Electrocardiology, 51(6), S72-S77. https://doi.org/10.1016/j.jelectrocard.2018.05.015

Vancouver

Isaksen JL, Graff C, Ellervik C, Jensen JS, Andersen HU, Rossing P o.a. Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study. Journal of Electrocardiology. 2018 nov 1;51(6):S72-S77. https://doi.org/10.1016/j.jelectrocard.2018.05.015

Author

Isaksen, Jonas L. ; Graff, Claus ; Ellervik, Christina ; Jensen, Jan Skov ; Andersen, Henrik Ullits ; Rossing, Peter ; Kanters, Jørgen K. ; Jensen, Magnus Thorsten. / Type 1 diabetes is associated with T-wave morphology changes : The Thousand & 1 Study. I: Journal of Electrocardiology. 2018 ; Bind 51, Nr. 6. s. S72-S77.

Bibtex

@article{5286865236c642a6ae07841331427dac,
title = "Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study",
abstract = "Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.",
author = "Isaksen, {Jonas L.} and Claus Graff and Christina Ellervik and Jensen, {Jan Skov} and Andersen, {Henrik Ullits} and Peter Rossing and Kanters, {J{\o}rgen K.} and Jensen, {Magnus Thorsten}",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.jelectrocard.2018.05.015",
language = "English",
volume = "51",
pages = "S72--S77",
journal = "Journal of Electrocardiology",
issn = "0022-0736",
publisher = "Churchill Livingstone",
number = "6",

}

RIS

TY - JOUR

T1 - Type 1 diabetes is associated with T-wave morphology changes

T2 - The Thousand & 1 Study

AU - Isaksen, Jonas L.

AU - Graff, Claus

AU - Ellervik, Christina

AU - Jensen, Jan Skov

AU - Andersen, Henrik Ullits

AU - Rossing, Peter

AU - Kanters, Jørgen K.

AU - Jensen, Magnus Thorsten

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.

AB - Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.

UR - http://www.scopus.com/inward/record.url?scp=85049652745&partnerID=8YFLogxK

U2 - 10.1016/j.jelectrocard.2018.05.015

DO - 10.1016/j.jelectrocard.2018.05.015

M3 - Journal article

C2 - 30007776

VL - 51

SP - S72-S77

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

SN - 0022-0736

IS - 6

ER -

ID: 198564122