Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH)

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Standard

Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH). / Orskov, C; Nielsen, Jens Høiriis.

I: FEBS Letters, Bind 229, Nr. 1, 29.02.1988, s. 175-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Orskov, C & Nielsen, JH 1988, 'Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH)', FEBS Letters, bind 229, nr. 1, s. 175-8.

APA

Orskov, C., & Nielsen, J. H. (1988). Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH). FEBS Letters, 229(1), 175-8.

Vancouver

Orskov C, Nielsen JH. Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH). FEBS Letters. 1988 feb. 29;229(1):175-8.

Author

Orskov, C ; Nielsen, Jens Høiriis. / Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH). I: FEBS Letters. 1988 ; Bind 229, Nr. 1. s. 175-8.

Bibtex

@article{b13b4edd62554ed782bfa89c6f0a1a9f,
title = "Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH)",
abstract = "We studied binding of 125I-labelled truncated-glucagon-like peptide-1 (proglucagon 78-107 amide) to a cloned rat insulin-producing cell line, RIN 5AH, in monolayer culture. Interaction of the peptide with pancreatic insulinoma cells was saturable and time dependent. Half-maximal binding was obtained when the cells were incubated in the presence of 3.3 x 10(-9) mol/l unlabelled truncated-glucagon-like peptide-1 (proglucagon 78-107 amide). Neither glucagon, full-length glucagon-like peptide-1 (proglucagon 72-107 amide) nor gastric inhibitory peptide competed for binding in concentrations up to 10(-6) mol/l.",
keywords = "Adenoma, Islet Cell, Animals, Binding, Competitive, Glucagon, Glucagon-Like Peptide 1, Insulin, Insulinoma, Intestines, Kinetics, Pancreatic Neoplasms, Peptides, Rats, Receptors, Cell Surface, Receptors, Glucagon",
author = "C Orskov and Nielsen, {Jens H{\o}iriis}",
year = "1988",
month = feb,
day = "29",
language = "English",
volume = "229",
pages = "175--8",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH)

AU - Orskov, C

AU - Nielsen, Jens Høiriis

PY - 1988/2/29

Y1 - 1988/2/29

N2 - We studied binding of 125I-labelled truncated-glucagon-like peptide-1 (proglucagon 78-107 amide) to a cloned rat insulin-producing cell line, RIN 5AH, in monolayer culture. Interaction of the peptide with pancreatic insulinoma cells was saturable and time dependent. Half-maximal binding was obtained when the cells were incubated in the presence of 3.3 x 10(-9) mol/l unlabelled truncated-glucagon-like peptide-1 (proglucagon 78-107 amide). Neither glucagon, full-length glucagon-like peptide-1 (proglucagon 72-107 amide) nor gastric inhibitory peptide competed for binding in concentrations up to 10(-6) mol/l.

AB - We studied binding of 125I-labelled truncated-glucagon-like peptide-1 (proglucagon 78-107 amide) to a cloned rat insulin-producing cell line, RIN 5AH, in monolayer culture. Interaction of the peptide with pancreatic insulinoma cells was saturable and time dependent. Half-maximal binding was obtained when the cells were incubated in the presence of 3.3 x 10(-9) mol/l unlabelled truncated-glucagon-like peptide-1 (proglucagon 78-107 amide). Neither glucagon, full-length glucagon-like peptide-1 (proglucagon 72-107 amide) nor gastric inhibitory peptide competed for binding in concentrations up to 10(-6) mol/l.

KW - Adenoma, Islet Cell

KW - Animals

KW - Binding, Competitive

KW - Glucagon

KW - Glucagon-Like Peptide 1

KW - Insulin

KW - Insulinoma

KW - Intestines

KW - Kinetics

KW - Pancreatic Neoplasms

KW - Peptides

KW - Rats

KW - Receptors, Cell Surface

KW - Receptors, Glucagon

M3 - Journal article

C2 - 2831085

VL - 229

SP - 175

EP - 178

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 1

ER -

ID: 47974722