Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes

Publikation: Bidrag til tidsskriftLetterForskningfagfællebedømt

Standard

Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes. / Christensen, M; Sparre-Ulrich, A H; Hartmann, B; Grevstad, U; Rosenkilde, M M; Holst, J J; Vilsbøll, T; Knop, F K.

I: International journal of obesity (2005), Bind 39, Nr. 11, 11.2015, s. 1651-1654.

Publikation: Bidrag til tidsskriftLetterForskningfagfællebedømt

Harvard

Christensen, M, Sparre-Ulrich, AH, Hartmann, B, Grevstad, U, Rosenkilde, MM, Holst, JJ, Vilsbøll, T & Knop, FK 2015, 'Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes', International journal of obesity (2005), bind 39, nr. 11, s. 1651-1654. https://doi.org/10.1038/ijo.2015.136

APA

Christensen, M., Sparre-Ulrich, A. H., Hartmann, B., Grevstad, U., Rosenkilde, M. M., Holst, J. J., ... Knop, F. K. (2015). Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes. International journal of obesity (2005), 39(11), 1651-1654. https://doi.org/10.1038/ijo.2015.136

Vancouver

Christensen M, Sparre-Ulrich AH, Hartmann B, Grevstad U, Rosenkilde MM, Holst JJ o.a. Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes. International journal of obesity (2005). 2015 nov;39(11):1651-1654. https://doi.org/10.1038/ijo.2015.136

Author

Christensen, M ; Sparre-Ulrich, A H ; Hartmann, B ; Grevstad, U ; Rosenkilde, M M ; Holst, J J ; Vilsbøll, T ; Knop, F K. / Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes. I: International journal of obesity (2005). 2015 ; Bind 39, Nr. 11. s. 1651-1654.

Bibtex

@article{58435fabf3e64964864f21373aa25685,
title = "Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes",
abstract = "Treatment with liraglutide leads to weight loss. We investigated whether blood-to-cerebrospinal fluid (CSF) transfer of liraglutide occurs, and if so, whether it associates with clinical weight loss following liraglutide treatment in humans. We performed lumbar puncture and blood sampling in eight patients with type 2 diabetes (mean (range)): age 63 (54-79) years; actual body weight: 90 (75-118) kg treated with 1.8 mg liraglutide for 14 (5-22) months and with a treatment-induced weight loss of 8.4 (7-11) kg. We measured liraglutide in plasma and CSF with a radioimmunoassay specific for the N-terminus of the GLP-1 moiety of liraglutide. Mean plasma liraglutide was 31 (range: 21-63) nmol l(-1). The mean CSF-liraglutide concentration was 6.5 (range: 0.9-13.9) pmol l(-1). Ratio of CSF: plasma-liraglutide concentrations was 0.02 (range: 0.07-0.002){\%} and plasma liraglutide did not correlate with CSF-liraglutide levels (P=0.67). Body weight loss tended to correlate with plasma-liraglutide levels (P=0.06), but not with CSF-liraglutide levels (P=0.69). In conclusion, we measured very low concentrations of liraglutide in CSF, and the levels of CSF liraglutide did not correlate with the actual clinical weight loss in these patients. The amount of liraglutide in plasma tended to correlate with the clinical weight loss.",
author = "M Christensen and Sparre-Ulrich, {A H} and B Hartmann and U Grevstad and Rosenkilde, {M M} and Holst, {J J} and T Vilsb{\o}ll and Knop, {F K}",
year = "2015",
month = "11",
doi = "10.1038/ijo.2015.136",
language = "English",
volume = "39",
pages = "1651--1654",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",
number = "11",

}

RIS

TY - JOUR

T1 - Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes

AU - Christensen, M

AU - Sparre-Ulrich, A H

AU - Hartmann, B

AU - Grevstad, U

AU - Rosenkilde, M M

AU - Holst, J J

AU - Vilsbøll, T

AU - Knop, F K

PY - 2015/11

Y1 - 2015/11

N2 - Treatment with liraglutide leads to weight loss. We investigated whether blood-to-cerebrospinal fluid (CSF) transfer of liraglutide occurs, and if so, whether it associates with clinical weight loss following liraglutide treatment in humans. We performed lumbar puncture and blood sampling in eight patients with type 2 diabetes (mean (range)): age 63 (54-79) years; actual body weight: 90 (75-118) kg treated with 1.8 mg liraglutide for 14 (5-22) months and with a treatment-induced weight loss of 8.4 (7-11) kg. We measured liraglutide in plasma and CSF with a radioimmunoassay specific for the N-terminus of the GLP-1 moiety of liraglutide. Mean plasma liraglutide was 31 (range: 21-63) nmol l(-1). The mean CSF-liraglutide concentration was 6.5 (range: 0.9-13.9) pmol l(-1). Ratio of CSF: plasma-liraglutide concentrations was 0.02 (range: 0.07-0.002)% and plasma liraglutide did not correlate with CSF-liraglutide levels (P=0.67). Body weight loss tended to correlate with plasma-liraglutide levels (P=0.06), but not with CSF-liraglutide levels (P=0.69). In conclusion, we measured very low concentrations of liraglutide in CSF, and the levels of CSF liraglutide did not correlate with the actual clinical weight loss in these patients. The amount of liraglutide in plasma tended to correlate with the clinical weight loss.

AB - Treatment with liraglutide leads to weight loss. We investigated whether blood-to-cerebrospinal fluid (CSF) transfer of liraglutide occurs, and if so, whether it associates with clinical weight loss following liraglutide treatment in humans. We performed lumbar puncture and blood sampling in eight patients with type 2 diabetes (mean (range)): age 63 (54-79) years; actual body weight: 90 (75-118) kg treated with 1.8 mg liraglutide for 14 (5-22) months and with a treatment-induced weight loss of 8.4 (7-11) kg. We measured liraglutide in plasma and CSF with a radioimmunoassay specific for the N-terminus of the GLP-1 moiety of liraglutide. Mean plasma liraglutide was 31 (range: 21-63) nmol l(-1). The mean CSF-liraglutide concentration was 6.5 (range: 0.9-13.9) pmol l(-1). Ratio of CSF: plasma-liraglutide concentrations was 0.02 (range: 0.07-0.002)% and plasma liraglutide did not correlate with CSF-liraglutide levels (P=0.67). Body weight loss tended to correlate with plasma-liraglutide levels (P=0.06), but not with CSF-liraglutide levels (P=0.69). In conclusion, we measured very low concentrations of liraglutide in CSF, and the levels of CSF liraglutide did not correlate with the actual clinical weight loss in these patients. The amount of liraglutide in plasma tended to correlate with the clinical weight loss.

U2 - 10.1038/ijo.2015.136

DO - 10.1038/ijo.2015.136

M3 - Letter

C2 - 26228460

VL - 39

SP - 1651

EP - 1654

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 11

ER -

ID: 150708849