Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity

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Standard

Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. / Sogaard, Ditte; Ostergard, Torben; Blachnio-Zabielska, Agnieszka U.; Baranowski, Marcin; Vigelsø Hansen, Andreas; Andersen, Jesper Løvind; Dela, Flemming; Helge, Jorn Wulff.

I: Journal of Diabetes Research, Bind 2016, 2372741, 2016.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Sogaard, D, Ostergard, T, Blachnio-Zabielska, AU, Baranowski, M, Vigelsø Hansen, A, Andersen, JL, Dela, F & Helge, JW 2016, 'Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity', Journal of Diabetes Research, bind 2016, 2372741. https://doi.org/10.1155/2016/2372741

APA

Sogaard, D., Ostergard, T., Blachnio-Zabielska, A. U., Baranowski, M., Vigelsø Hansen, A., Andersen, J. L., ... Helge, J. W. (2016). Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. Journal of Diabetes Research, 2016, [2372741]. https://doi.org/10.1155/2016/2372741

Vancouver

Sogaard D, Ostergard T, Blachnio-Zabielska AU, Baranowski M, Vigelsø Hansen A, Andersen JL o.a. Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. Journal of Diabetes Research. 2016;2016. 2372741. https://doi.org/10.1155/2016/2372741

Author

Sogaard, Ditte ; Ostergard, Torben ; Blachnio-Zabielska, Agnieszka U. ; Baranowski, Marcin ; Vigelsø Hansen, Andreas ; Andersen, Jesper Løvind ; Dela, Flemming ; Helge, Jorn Wulff. / Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. I: Journal of Diabetes Research. 2016 ; Bind 2016.

Bibtex

@article{ee791dce05eb462d87a4af1f2aa10273,
title = "Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity",
abstract = "Ceramide and diacylglycerol (DAG) may be involved in the early phase of insulin resistance but data are inconsistent in man. We evaluated if an increase in insulin sensitivity after endurance training was accompanied by changes in these lipids in skeletal muscle. Nineteen first-degree type 2 diabetes Offsprings (Offsprings) (age:  yrs; BMI:  kg/m2) and sixteen matched Controls (age:  yrs; BMI:  kg/m2) performed 10 weeks of endurance training three times a week at 70{\%} of VO2max on a bicycle ergometer. Before and after the intervention a hyperinsulinemic-euglycemic clamp and VO2max test were performed and muscle biopsies obtained. Insulin sensitivity was significantly lower in Offsprings compared to control subjects () but improved in both groups after 10 weeks of endurance training (Off: {\%}; Con: {\%}, ). The content of muscle ceramide, DAG, and their subspecies were similar between groups and did not change in response to the endurance training except for an overall reduction in C22:0-Cer (). Finally, the intervention induced an increase in AKT protein expression (Off: {\%}; Con: {\%}, ). This study showed no relation between insulin sensitivity and ceramide or DAG content suggesting that ceramide and DAG are not major players in the early phase of insulin resistance in human muscle.",
author = "Ditte Sogaard and Torben Ostergard and Blachnio-Zabielska, {Agnieszka U.} and Marcin Baranowski and {Vigels{\o} Hansen}, Andreas and Andersen, {Jesper L{\o}vind} and Flemming Dela and Helge, {Jorn Wulff}",
year = "2016",
doi = "10.1155/2016/2372741",
language = "English",
volume = "2016",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity

AU - Sogaard, Ditte

AU - Ostergard, Torben

AU - Blachnio-Zabielska, Agnieszka U.

AU - Baranowski, Marcin

AU - Vigelsø Hansen, Andreas

AU - Andersen, Jesper Løvind

AU - Dela, Flemming

AU - Helge, Jorn Wulff

PY - 2016

Y1 - 2016

N2 - Ceramide and diacylglycerol (DAG) may be involved in the early phase of insulin resistance but data are inconsistent in man. We evaluated if an increase in insulin sensitivity after endurance training was accompanied by changes in these lipids in skeletal muscle. Nineteen first-degree type 2 diabetes Offsprings (Offsprings) (age:  yrs; BMI:  kg/m2) and sixteen matched Controls (age:  yrs; BMI:  kg/m2) performed 10 weeks of endurance training three times a week at 70% of VO2max on a bicycle ergometer. Before and after the intervention a hyperinsulinemic-euglycemic clamp and VO2max test were performed and muscle biopsies obtained. Insulin sensitivity was significantly lower in Offsprings compared to control subjects () but improved in both groups after 10 weeks of endurance training (Off: %; Con: %, ). The content of muscle ceramide, DAG, and their subspecies were similar between groups and did not change in response to the endurance training except for an overall reduction in C22:0-Cer (). Finally, the intervention induced an increase in AKT protein expression (Off: %; Con: %, ). This study showed no relation between insulin sensitivity and ceramide or DAG content suggesting that ceramide and DAG are not major players in the early phase of insulin resistance in human muscle.

AB - Ceramide and diacylglycerol (DAG) may be involved in the early phase of insulin resistance but data are inconsistent in man. We evaluated if an increase in insulin sensitivity after endurance training was accompanied by changes in these lipids in skeletal muscle. Nineteen first-degree type 2 diabetes Offsprings (Offsprings) (age:  yrs; BMI:  kg/m2) and sixteen matched Controls (age:  yrs; BMI:  kg/m2) performed 10 weeks of endurance training three times a week at 70% of VO2max on a bicycle ergometer. Before and after the intervention a hyperinsulinemic-euglycemic clamp and VO2max test were performed and muscle biopsies obtained. Insulin sensitivity was significantly lower in Offsprings compared to control subjects () but improved in both groups after 10 weeks of endurance training (Off: %; Con: %, ). The content of muscle ceramide, DAG, and their subspecies were similar between groups and did not change in response to the endurance training except for an overall reduction in C22:0-Cer (). Finally, the intervention induced an increase in AKT protein expression (Off: %; Con: %, ). This study showed no relation between insulin sensitivity and ceramide or DAG content suggesting that ceramide and DAG are not major players in the early phase of insulin resistance in human muscle.

U2 - 10.1155/2016/2372741

DO - 10.1155/2016/2372741

M3 - Journal article

C2 - 27777958

VL - 2016

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 2372741

ER -

ID: 169416792