Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease: comparison with peptide YY

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Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease : comparison with peptide YY. / Schmidt, Peter T; Ljung, Tryggve; Hartmann, Bolette; Hare, Kristine J; Holst, Jens Juul; Hellström, Per M.

I: European journal of gastroenterology & hepatology, Bind 17, Nr. 2, 02.2005, s. 207-12.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Harvard

Schmidt, PT, Ljung, T, Hartmann, B, Hare, KJ, Holst, JJ & Hellström, PM 2005, 'Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease: comparison with peptide YY', European journal of gastroenterology & hepatology, bind 17, nr. 2, s. 207-12.

APA

Schmidt, P. T., Ljung, T., Hartmann, B., Hare, K. J., Holst, J. J., & Hellström, P. M. (2005). Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease: comparison with peptide YY. European journal of gastroenterology & hepatology, 17(2), 207-12.

Vancouver

Schmidt PT, Ljung T, Hartmann B, Hare KJ, Holst JJ, Hellström PM. Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease: comparison with peptide YY. European journal of gastroenterology & hepatology. 2005 feb;17(2):207-12.

Author

Schmidt, Peter T ; Ljung, Tryggve ; Hartmann, Bolette ; Hare, Kristine J ; Holst, Jens Juul ; Hellström, Per M. / Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease : comparison with peptide YY. I: European journal of gastroenterology & hepatology. 2005 ; Bind 17, Nr. 2. s. 207-12.

Bibtex

@article{b38437cc149e4191b52dc69d4314fdef,
title = "Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease: comparison with peptide YY",
abstract = "BACKGROUND AND AIM: Glucagon-like peptide-2 (GLP-2) and peptide YY (PYY) are produced in endocrine L-cells of the intestine and secreted in response to food intake. GLP-2 has a trophic effect on the intestinal epithelium, whereas PYY has pro-absorptive effects. It can be speculated that, in inflammatory bowel disease (IBD), the production and secretion of GLP-2 and PYY could be affected as a part of a regulatory mechanism. Therefore, tissue levels and meal-stimulated secretion of GLP-2 and PYY were studied in IBD patients and compared to controls.METHODS: Outpatients with IBD and control patients were included. Mucosal biopsies were taken from the ileum and colon and the content of GLP-2 and PYY was measured. After colonoscopy the patients took a mixed meal and plasma was collected for 90 min for plasma measurements of GLP-2 and PYY.RESULTS: Tissue levels of GLP-2 in control patients were highest in the terminal ileum (407+/-82 pmol/g tissue, n=10), whereas PYY was highest in the rectum (919+/-249 pmol/g tissue, n=10). In IBD patients with acute inflammation, the content of GLP-2 was similar to controls, whereas PYY was decreased to 72.1+/-17.7{\%} (P=0.03, n=13) of control values. Neither the fasting plasma levels nor the meal responses of GLP-2 and PYY differed between controls and IBD patients.CONCLUSION: The similar responses of GLP-2 and PYY in patients and controls do not support the suggestion that L-cell secretion is altered in IBD. The decreased tissue PYY concentrations may contribute to the diarrhoea of some of these patients.",
keywords = "Colitis, Ulcerative, Colon, Crohn Disease, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Humans, Ileum, Inflammatory Bowel Diseases, Intestinal Mucosa, Peptide YY, Peptides, Postprandial Period, Radioimmunoassay",
author = "Schmidt, {Peter T} and Tryggve Ljung and Bolette Hartmann and Hare, {Kristine J} and Holst, {Jens Juul} and Hellstr{\"o}m, {Per M}",
year = "2005",
month = "2",
language = "English",
volume = "17",
pages = "207--12",
journal = "European Journal of Gastroenterology and Hepatology",
issn = "0954-691X",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease

T2 - comparison with peptide YY

AU - Schmidt, Peter T

AU - Ljung, Tryggve

AU - Hartmann, Bolette

AU - Hare, Kristine J

AU - Holst, Jens Juul

AU - Hellström, Per M

PY - 2005/2

Y1 - 2005/2

N2 - BACKGROUND AND AIM: Glucagon-like peptide-2 (GLP-2) and peptide YY (PYY) are produced in endocrine L-cells of the intestine and secreted in response to food intake. GLP-2 has a trophic effect on the intestinal epithelium, whereas PYY has pro-absorptive effects. It can be speculated that, in inflammatory bowel disease (IBD), the production and secretion of GLP-2 and PYY could be affected as a part of a regulatory mechanism. Therefore, tissue levels and meal-stimulated secretion of GLP-2 and PYY were studied in IBD patients and compared to controls.METHODS: Outpatients with IBD and control patients were included. Mucosal biopsies were taken from the ileum and colon and the content of GLP-2 and PYY was measured. After colonoscopy the patients took a mixed meal and plasma was collected for 90 min for plasma measurements of GLP-2 and PYY.RESULTS: Tissue levels of GLP-2 in control patients were highest in the terminal ileum (407+/-82 pmol/g tissue, n=10), whereas PYY was highest in the rectum (919+/-249 pmol/g tissue, n=10). In IBD patients with acute inflammation, the content of GLP-2 was similar to controls, whereas PYY was decreased to 72.1+/-17.7% (P=0.03, n=13) of control values. Neither the fasting plasma levels nor the meal responses of GLP-2 and PYY differed between controls and IBD patients.CONCLUSION: The similar responses of GLP-2 and PYY in patients and controls do not support the suggestion that L-cell secretion is altered in IBD. The decreased tissue PYY concentrations may contribute to the diarrhoea of some of these patients.

AB - BACKGROUND AND AIM: Glucagon-like peptide-2 (GLP-2) and peptide YY (PYY) are produced in endocrine L-cells of the intestine and secreted in response to food intake. GLP-2 has a trophic effect on the intestinal epithelium, whereas PYY has pro-absorptive effects. It can be speculated that, in inflammatory bowel disease (IBD), the production and secretion of GLP-2 and PYY could be affected as a part of a regulatory mechanism. Therefore, tissue levels and meal-stimulated secretion of GLP-2 and PYY were studied in IBD patients and compared to controls.METHODS: Outpatients with IBD and control patients were included. Mucosal biopsies were taken from the ileum and colon and the content of GLP-2 and PYY was measured. After colonoscopy the patients took a mixed meal and plasma was collected for 90 min for plasma measurements of GLP-2 and PYY.RESULTS: Tissue levels of GLP-2 in control patients were highest in the terminal ileum (407+/-82 pmol/g tissue, n=10), whereas PYY was highest in the rectum (919+/-249 pmol/g tissue, n=10). In IBD patients with acute inflammation, the content of GLP-2 was similar to controls, whereas PYY was decreased to 72.1+/-17.7% (P=0.03, n=13) of control values. Neither the fasting plasma levels nor the meal responses of GLP-2 and PYY differed between controls and IBD patients.CONCLUSION: The similar responses of GLP-2 and PYY in patients and controls do not support the suggestion that L-cell secretion is altered in IBD. The decreased tissue PYY concentrations may contribute to the diarrhoea of some of these patients.

KW - Colitis, Ulcerative

KW - Colon

KW - Crohn Disease

KW - Glucagon-Like Peptide 2

KW - Glucagon-Like Peptides

KW - Humans

KW - Ileum

KW - Inflammatory Bowel Diseases

KW - Intestinal Mucosa

KW - Peptide YY

KW - Peptides

KW - Postprandial Period

KW - Radioimmunoassay

M3 - Journal article

C2 - 15674099

VL - 17

SP - 207

EP - 212

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

SN - 0954-691X

IS - 2

ER -

ID: 132053953